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The map label for this gene is folC [H]

Identifier: 284159981

GI number: 284159981

Start: 2359043

End: 2360356

Strand: Reverse

Name: folC [H]

Synonym: BURPS668_A2441

Alternate gene names: 284159981

Gene position: 2360356-2359043 (Counterclockwise)

Preceding gene: 126445476

Following gene: 126443152

Centisome position: 75.47

GC content: 68.72

Gene sequence:

>1314_bases
ATGAGCACTTTTCCCACTCTCGACGCGTGGCTTTCGCATCTCGAAAGCGCGCACCCCGTCGGCATCGACATGGGCCTCGC
CCGCATCGGCCAGGTCAAGGACGCGCTGAAGCTCGCATTCGCGTGCCCGGTGATCACGGTCGGCGGCACGAACGGCAAGG
GCTCGACCTGCGCGTTCATCGAGACGATCCTCGTGCGCGCGGGCTACAAGGTCGGCTGCCACACGTCGCCGCACCTGCTG
CGCTTTAACGAGCGCGCGCGCCTCGACGGGCGGATCGTCGACGACGAGGAACTGCTGCCGCACTTCGAGGCGGTCGAGGC
GGCGCGCACGAGCCTGCCGGAGGCGGTGTCGCTCACGTACTTCGAGTTCACGACGCTCGCGATCATGCATTTGTTCGCAT
CGCGCGGGCTCGACGCGGTGATTCTCGAAGTGGGGCTCGGCGGCCGGCTCGACGCGGTCAACGTGATCGACGCCGATTGC
GCGATCGTGACGAGCATCGACGTCGACCACATCGAATATCTCGGCGACACGCGCGAGAAGATCGCGTTCGAGAAGGCGGG
CATCTTCCGGCCGGGCAAGCCCGCGATCTGCGGCGACCCGGCGCCGCCGCAGACGCTCGTCGACCACGCGGGCGCGATCG
GCGCGGATCTGTGGCTCGTCGGGCGCGATTTCCGCTTCTCGACGCAGCCGGGCAGCGAGCGCCAGCAGTGGACGTACGCC
GGCCGCGACAAGCGCTATCCGGCGCTCGCGTATCCGGCGCTGCGCGGCGCGAACCAGTTGCTCAACGCGTCGGCGGCGCT
CGCCGCGCTCGAGGCGCTGCGCGAGCGGCTGCCCGTGTCCGCGCAGGACATCCGGCTCGGGCTCGCGAACGTCGAGCTGC
CGGGGCGCTTCCAGGTGCTGCCCGGCAAGCCGCTCGTGCTGCTCGACGTCGCGCATAACCCGCACGCGGCCGCGGTGCTC
GCGCAGAACCTCGATTCGATGGGCTACTACCCGTACACGCACGCGGTGTTCGGCGCGATGGCCGACAAGGATCTCGCGGG
AATCGTCGAGCGGCTGAAGGGCGCGATCGATCACTGGCATCTGACCGATTTGCCGCTGCCGCGCGCGGCGTCGGCCGACG
TGCTCGAGCGCGTGCTGCGCGGCGCGGGCGTCGAGCACGGCGCGCAGCACAACATCACGCGCCATGCGGGCCCGGCCGAT
GCATTCCTCGATGCACTAAAAAGCGCATCCGACAATGATAGAATCGTGGTTTTCGGTAGCTTCTACACGGTAGCGGGCGT
GATGCCCGTCGTGGACCGCCGCCATGACCACTGA

Upstream 100 bases:

>100_bases
ATGATCGCACGTCCGCGCGTCGCTCGGCTTGCGCCGAGCGGCGCGTTTGTTTTTTGGCGTATTCGCCTCGATGCGCCGCT
TTGATTCGAAGTTGGATTCG

Downstream 100 bases:

>100_bases
CTGACGGGTAGCTTCGGGTTCAGCCATACATGGGAATTTTCTCGTTCGGCAAGAAAGAGGACGACGCGCCGCCCAGGCGC
GGGTCGCGGTCCGGCGCCCG

Product: FolC bifunctional protein

Products: NA

Alternate protein names: Folylpoly-gamma-glutamate synthetase; FPGS; Tetrahydrofolylpolyglutamate synthase; Tetrahydrofolate synthase [H]

Number of amino acids: Translated: 437; Mature: 436

Protein sequence:

>437_residues
MSTFPTLDAWLSHLESAHPVGIDMGLARIGQVKDALKLAFACPVITVGGTNGKGSTCAFIETILVRAGYKVGCHTSPHLL
RFNERARLDGRIVDDEELLPHFEAVEAARTSLPEAVSLTYFEFTTLAIMHLFASRGLDAVILEVGLGGRLDAVNVIDADC
AIVTSIDVDHIEYLGDTREKIAFEKAGIFRPGKPAICGDPAPPQTLVDHAGAIGADLWLVGRDFRFSTQPGSERQQWTYA
GRDKRYPALAYPALRGANQLLNASAALAALEALRERLPVSAQDIRLGLANVELPGRFQVLPGKPLVLLDVAHNPHAAAVL
AQNLDSMGYYPYTHAVFGAMADKDLAGIVERLKGAIDHWHLTDLPLPRAASADVLERVLRGAGVEHGAQHNITRHAGPAD
AFLDALKSASDNDRIVVFGSFYTVAGVMPVVDRRHDH

Sequences:

>Translated_437_residues
MSTFPTLDAWLSHLESAHPVGIDMGLARIGQVKDALKLAFACPVITVGGTNGKGSTCAFIETILVRAGYKVGCHTSPHLL
RFNERARLDGRIVDDEELLPHFEAVEAARTSLPEAVSLTYFEFTTLAIMHLFASRGLDAVILEVGLGGRLDAVNVIDADC
AIVTSIDVDHIEYLGDTREKIAFEKAGIFRPGKPAICGDPAPPQTLVDHAGAIGADLWLVGRDFRFSTQPGSERQQWTYA
GRDKRYPALAYPALRGANQLLNASAALAALEALRERLPVSAQDIRLGLANVELPGRFQVLPGKPLVLLDVAHNPHAAAVL
AQNLDSMGYYPYTHAVFGAMADKDLAGIVERLKGAIDHWHLTDLPLPRAASADVLERVLRGAGVEHGAQHNITRHAGPAD
AFLDALKSASDNDRIVVFGSFYTVAGVMPVVDRRHDH
>Mature_436_residues
STFPTLDAWLSHLESAHPVGIDMGLARIGQVKDALKLAFACPVITVGGTNGKGSTCAFIETILVRAGYKVGCHTSPHLLR
FNERARLDGRIVDDEELLPHFEAVEAARTSLPEAVSLTYFEFTTLAIMHLFASRGLDAVILEVGLGGRLDAVNVIDADCA
IVTSIDVDHIEYLGDTREKIAFEKAGIFRPGKPAICGDPAPPQTLVDHAGAIGADLWLVGRDFRFSTQPGSERQQWTYAG
RDKRYPALAYPALRGANQLLNASAALAALEALRERLPVSAQDIRLGLANVELPGRFQVLPGKPLVLLDVAHNPHAAAVLA
QNLDSMGYYPYTHAVFGAMADKDLAGIVERLKGAIDHWHLTDLPLPRAASADVLERVLRGAGVEHGAQHNITRHAGPADA
FLDALKSASDNDRIVVFGSFYTVAGVMPVVDRRHDH

Specific function: Conversion of folates to polyglutamate derivatives [H]

COG id: COG0285

COG function: function code H; Folylpolyglutamate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the folylpolyglutamate synthase family [H]

Homologues:

Organism=Homo sapiens, GI66932984, Length=363, Percent_Identity=33.0578512396694, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI66932990, Length=363, Percent_Identity=33.0578512396694, Blast_Score=140, Evalue=3e-33,
Organism=Escherichia coli, GI1788654, Length=430, Percent_Identity=41.8604651162791, Blast_Score=294, Evalue=1e-80,
Organism=Caenorhabditis elegans, GI17553150, Length=303, Percent_Identity=32.3432343234323, Blast_Score=125, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI71984923, Length=303, Percent_Identity=32.3432343234323, Blast_Score=125, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI17553148, Length=303, Percent_Identity=32.3432343234323, Blast_Score=124, Evalue=7e-29,
Organism=Saccharomyces cerevisiae, GI6323760, Length=438, Percent_Identity=27.1689497716895, Blast_Score=126, Evalue=7e-30,
Organism=Saccharomyces cerevisiae, GI6324815, Length=300, Percent_Identity=30.3333333333333, Blast_Score=117, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24641571, Length=151, Percent_Identity=39.0728476821192, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24581568, Length=167, Percent_Identity=35.3293413173653, Blast_Score=96, Evalue=7e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018109
- InterPro:   IPR001645
- InterPro:   IPR004101
- InterPro:   IPR013221 [H]

Pfam domain/function: PF08245 Mur_ligase_M [H]

EC number: =6.3.2.17 [H]

Molecular weight: Translated: 47124; Mature: 46993

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: PS01011 FOLYLPOLYGLU_SYNT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTFPTLDAWLSHLESAHPVGIDMGLARIGQVKDALKLAFACPVITVGGTNGKGSTCAFI
CCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCHHHHH
ETILVRAGYKVGCHTSPHLLRFNERARLDGRIVDDEELLPHFEAVEAARTSLPEAVSLTY
HHHHHHCCCEECCCCCCCEEEECCCCCCCCEEECHHHHCCHHHHHHHHHHCCCCHHEEHH
FEFTTLAIMHLFASRGLDAVILEVGLGGRLDAVNVIDADCAIVTSIDVDHIEYLGDTREK
HHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEEEECCCEEEEEECCHHHHHHHCCHHHH
IAFEKAGIFRPGKPAICGDPAPPQTLVDHAGAIGADLWLVGRDFRFSTQPGSERQQWTYA
HHHHHCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCEEEEEECCEEECCCCCCCCCCEEEC
GRDKRYPALAYPALRGANQLLNASAALAALEALRERLPVSAQDIRLGLANVELPGRFQVL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHEEEEECCCCCCCEEEC
PGKPLVLLDVAHNPHAAAVLAQNLDSMGYYPYTHAVFGAMADKDLAGIVERLKGAIDHWH
CCCCEEEEEECCCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCC
LTDLPLPRAASADVLERVLRGAGVEHGAQHNITRHAGPADAFLDALKSASDNDRIVVFGS
CCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEEC
FYTVAGVMPVVDRRHDH
HHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
STFPTLDAWLSHLESAHPVGIDMGLARIGQVKDALKLAFACPVITVGGTNGKGSTCAFI
CCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCHHHHH
ETILVRAGYKVGCHTSPHLLRFNERARLDGRIVDDEELLPHFEAVEAARTSLPEAVSLTY
HHHHHHCCCEECCCCCCCEEEECCCCCCCCEEECHHHHCCHHHHHHHHHHCCCCHHEEHH
FEFTTLAIMHLFASRGLDAVILEVGLGGRLDAVNVIDADCAIVTSIDVDHIEYLGDTREK
HHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEEEECCCEEEEEECCHHHHHHHCCHHHH
IAFEKAGIFRPGKPAICGDPAPPQTLVDHAGAIGADLWLVGRDFRFSTQPGSERQQWTYA
HHHHHCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCEEEEEECCEEECCCCCCCCCCEEEC
GRDKRYPALAYPALRGANQLLNASAALAALEALRERLPVSAQDIRLGLANVELPGRFQVL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHEEEEECCCCCCCEEEC
PGKPLVLLDVAHNPHAAAVLAQNLDSMGYYPYTHAVFGAMADKDLAGIVERLKGAIDHWH
CCCCEEEEEECCCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCC
LTDLPLPRAASADVLERVLRGAGVEHGAQHNITRHAGPADAFLDALKSASDNDRIVVFGS
CCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEEC
FYTVAGVMPVVDRRHDH
HHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]