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The map label for this gene is hscA [H]

Identifier: 228993425

GI number: 228993425

Start: 2364402

End: 2365163

Strand: Reverse

Name: hscA [H]

Synonym: BURPS668_A2446

Alternate gene names: 228993425

Gene position: 2365163-2364402 (Counterclockwise)

Preceding gene: 126443551

Following gene: 126444323

Centisome position: 75.63

GC content: 71.52

Gene sequence:

>762_bases
ATGACCGATACACCCGATGCGACCCTTCCGGCCGACGCGCCGCCGAACGACGCGCCCGCCGCCGGCGCGCGCCGCGACAC
GGGCGGCGACGGCAGTCGCGACGCGCCGCCGCCGCGCACGCGGATCAAGCTCTGCGGGTTGTCGAACGCGGCCGATATCG
ACTGGGCGGCCGAGCTCGGCGCCGATGCGATCGGCCTCGTGTTCTACCCGAAGAGCCCGCGCGCGGTGACGCTCGAGCAG
GCGGCCGCGCTCGCCGCACGCGTGCCGCCGTTCGTATCGGTGGTCGGCCTGTTCGTGAACCCGACCGAGGACGAGATCGC
CCGCGTCGCGAACGCGGTGCCGCTCACGCTGCTGCAATTCCATGGCGACGAGACGCCCGGGCAGTGCGCGTCGCTCGCGG
CGGCGGCGCGCCTGCCTTGGCTGCGCGCGTTGCGCGTGGGCGTGGCGACGCAGCCGGCCGATTTGGTAGAATCGGCACTT
CACTATTCGGCAGCCCGCGGCCTGTTGTTCGACACCCTCGTCGAGCACTACGGCGGCAGCGGCAAGGTCTTCGATTGGTC
ACTTATCCCAGCAGAGCTCGCGCGTCGGGCCGTTTTGAGTGGTGGGTTGAACGCGCAAAACGTCGGTGACGCGATCCGTC
AGGTGCGTCCGTTCGCGGTCGATGTCTCGAGCGGCATCGAAGCGCCGGGCGCGAAGGGCGTGAAGGATCGCGCCCGCATG
GCGGCGTTCGTGCGCGCGGTGCGCGAGGCGGACGCCGGGTGA

Upstream 100 bases:

>100_bases
TCGCGCACGTCGGCTATCCGGCCGAATTCGCGGTGCCGCCCGCACAACTCGGCAGCGTGCCGTGGAGCAGCGTGTGGGCC
GATCTGGACGGACGAACATG

Downstream 100 bases:

>100_bases
TGCCAGTCCGCGCGGCGGGCGCCGGGAATCGAGAGCCCGGCGCGCCGCGTGGTCGAACCGAGAGTGACGTCATGTATAAC
CTTCCCGATGATCGCGGCCA

Product: N-(5'-phosphoribosyl)anthranilate isomerase

Products: NA

Alternate protein names: PRAI [H]

Number of amino acids: Translated: 253; Mature: 252

Protein sequence:

>253_residues
MTDTPDATLPADAPPNDAPAAGARRDTGGDGSRDAPPPRTRIKLCGLSNAADIDWAAELGADAIGLVFYPKSPRAVTLEQ
AAALAARVPPFVSVVGLFVNPTEDEIARVANAVPLTLLQFHGDETPGQCASLAAAARLPWLRALRVGVATQPADLVESAL
HYSAARGLLFDTLVEHYGGSGKVFDWSLIPAELARRAVLSGGLNAQNVGDAIRQVRPFAVDVSSGIEAPGAKGVKDRARM
AAFVRAVREADAG

Sequences:

>Translated_253_residues
MTDTPDATLPADAPPNDAPAAGARRDTGGDGSRDAPPPRTRIKLCGLSNAADIDWAAELGADAIGLVFYPKSPRAVTLEQ
AAALAARVPPFVSVVGLFVNPTEDEIARVANAVPLTLLQFHGDETPGQCASLAAAARLPWLRALRVGVATQPADLVESAL
HYSAARGLLFDTLVEHYGGSGKVFDWSLIPAELARRAVLSGGLNAQNVGDAIRQVRPFAVDVSSGIEAPGAKGVKDRARM
AAFVRAVREADAG
>Mature_252_residues
TDTPDATLPADAPPNDAPAAGARRDTGGDGSRDAPPPRTRIKLCGLSNAADIDWAAELGADAIGLVFYPKSPRAVTLEQA
AALAARVPPFVSVVGLFVNPTEDEIARVANAVPLTLLQFHGDETPGQCASLAAAARLPWLRALRVGVATQPADLVESALH
YSAARGLLFDTLVEHYGGSGKVFDWSLIPAELARRAVLSGGLNAQNVGDAIRQVRPFAVDVSSGIEAPGAKGVKDRARMA
AFVRAVREADAG

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0135

COG function: function code E; Phosphoribosylanthranilate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpF family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=208, Percent_Identity=32.2115384615385, Blast_Score=80, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6320210, Length=225, Percent_Identity=27.5555555555556, Blast_Score=80, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR001240
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00697 PRAI [H]

EC number: =5.3.1.24 [H]

Molecular weight: Translated: 26275; Mature: 26144

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDTPDATLPADAPPNDAPAAGARRDTGGDGSRDAPPPRTRIKLCGLSNAADIDWAAELG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHCC
ADAIGLVFYPKSPRAVTLEQAAALAARVPPFVSVVGLFVNPTEDEIARVANAVPLTLLQF
CCEEEEEEECCCCCEEHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHCHHHHHEE
HGDETPGQCASLAAAARLPWLRALRVGVATQPADLVESALHYSAARGLLFDTLVEHYGGS
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GKVFDWSLIPAELARRAVLSGGLNAQNVGDAIRQVRPFAVDVSSGIEAPGAKGVKDRARM
CCEEEEECCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEECCCCCCCCCCCCHHHHHHH
AAFVRAVREADAG
HHHHHHHHHHCCC
>Mature Secondary Structure 
TDTPDATLPADAPPNDAPAAGARRDTGGDGSRDAPPPRTRIKLCGLSNAADIDWAAELG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHCC
ADAIGLVFYPKSPRAVTLEQAAALAARVPPFVSVVGLFVNPTEDEIARVANAVPLTLLQF
CCEEEEEEECCCCCEEHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHCHHHHHEE
HGDETPGQCASLAAAARLPWLRALRVGVATQPADLVESALHYSAARGLLFDTLVEHYGGS
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GKVFDWSLIPAELARRAVLSGGLNAQNVGDAIRQVRPFAVDVSSGIEAPGAKGVKDRARM
CCEEEEECCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEECCCCCCCCCCCCHHHHHHH
AAFVRAVREADAG
HHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA