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The map label for this gene is tfdA [H]

Identifier: 126444971

GI number: 126444971

Start: 886518

End: 887369

Strand: Reverse

Name: tfdA [H]

Synonym: BURPS668_A0908

Alternate gene names: 126444971

Gene position: 887369-886518 (Counterclockwise)

Preceding gene: 126443039

Following gene: 126444500

Centisome position: 28.37

GC content: 66.67

Gene sequence:

>852_bases
GTGGCCTACAAGACGCTGTCCAGTGCGCTCGGCACTGAGGTGTACGGCTTCGATTCGCCGTTTCCGCACGATGCCGAGGC
CGTGCGCGCGCTGATCGAGGCATGGCATGCGGGCGGCATCTGCCGGCTTCGGCGCCAGCGGCTCGACATGGCGGAGTTCG
TCGAGTTCAGCCGGATCTTCGGCAGGCCCGAGCGCGCGCTGAACCAGGAGCGCAAGCTGACCTCGCGCGAAGACCTGCCC
GAACTGATGATCGTGTCGAACATCCTGGAAAACGGCGTGTCGATCGGGCATCTCGGCTCGAAGGAAGCGTACTGGCACAC
CGACATGTGCTACACCGACGTGCCGCCGATCGCGAGCATTCTCTATGCGATCGAGGTGCCCGCGCACGGCGGCAACACCG
AGTTCATGAACATGTACCGCGTGCACGACGCGCTGCCCGCCTCGCTGCGCCGGCAGATCGCCGGCCTGTCGATCAAGCAC
GACCGCAGCTACACGGCCGTCGGCGAGCTGCGCTACGGGTTCGATTCGGTCGTCGACGTGACGACCTGCCCCGGCTCGAT
TCATCCGATCGTGCGCGTCCATCCGGTCACGCAACGGCCGTATCTTTATCTCGGCCGCCGGCTGAACGCGTATGTCGTCG
GCCTGCCCGTCGGCGAATCGGAGGCGCTCCTCGACGAGCTGTGGCGCTATACGCGGCTCGACGGCGTGACGTGGACGCAG
CGCTGGGAAGTCGGCGACATCATGATCTGGGACAACCGCTGCACGATGCACCGGCGCGATGCGTTCGACGCGAACGCGCG
GCGCCTGATGTGGCGCACGCAGATCCAGGCCGATCCGGCGCGGCCGCTGTAG

Upstream 100 bases:

>100_bases
GGCCGGCCGCGCACGTCGCCCGCCGAGAACAAACGCCATTTCATGGCCTTCCTATCCCGCAACGGAGCGACACATGAGCG
AGACGATCACGCGCAGGAAA

Downstream 100 bases:

>100_bases
CGGCCCGCGCATCCGATACGAACGACAGCGAGGCTCAATTGCTCAATCACCGCTCCGCCGCTTTCGCGCGCGTTGCCCGC
GCGCTCGACGCCCGCGGCAA

Product: TauD/TfdA family dioxygenase

Products: Aminoacetaldehyde; CO2; H+; Sulfite; Succinate [C]

Alternate protein names: 2,4-D dioxygenase [H]

Number of amino acids: Translated: 283; Mature: 282

Protein sequence:

>283_residues
MAYKTLSSALGTEVYGFDSPFPHDAEAVRALIEAWHAGGICRLRRQRLDMAEFVEFSRIFGRPERALNQERKLTSREDLP
ELMIVSNILENGVSIGHLGSKEAYWHTDMCYTDVPPIASILYAIEVPAHGGNTEFMNMYRVHDALPASLRRQIAGLSIKH
DRSYTAVGELRYGFDSVVDVTTCPGSIHPIVRVHPVTQRPYLYLGRRLNAYVVGLPVGESEALLDELWRYTRLDGVTWTQ
RWEVGDIMIWDNRCTMHRRDAFDANARRLMWRTQIQADPARPL

Sequences:

>Translated_283_residues
MAYKTLSSALGTEVYGFDSPFPHDAEAVRALIEAWHAGGICRLRRQRLDMAEFVEFSRIFGRPERALNQERKLTSREDLP
ELMIVSNILENGVSIGHLGSKEAYWHTDMCYTDVPPIASILYAIEVPAHGGNTEFMNMYRVHDALPASLRRQIAGLSIKH
DRSYTAVGELRYGFDSVVDVTTCPGSIHPIVRVHPVTQRPYLYLGRRLNAYVVGLPVGESEALLDELWRYTRLDGVTWTQ
RWEVGDIMIWDNRCTMHRRDAFDANARRLMWRTQIQADPARPL
>Mature_282_residues
AYKTLSSALGTEVYGFDSPFPHDAEAVRALIEAWHAGGICRLRRQRLDMAEFVEFSRIFGRPERALNQERKLTSREDLPE
LMIVSNILENGVSIGHLGSKEAYWHTDMCYTDVPPIASILYAIEVPAHGGNTEFMNMYRVHDALPASLRRQIAGLSIKHD
RSYTAVGELRYGFDSVVDVTTCPGSIHPIVRVHPVTQRPYLYLGRRLNAYVVGLPVGESEALLDELWRYTRLDGVTWTQR
WEVGDIMIWDNRCTMHRRDAFDANARRLMWRTQIQADPARPL

Specific function: Involved in degradation of the herbicide 2,4- dichlorophenoxyacetic acid (2,4-D). Is also able to degrade 2- methyl-4-chlorophenoxyacetic acid and 3-chlorobenzoic acid [H]

COG id: COG2175

COG function: function code Q; Probable taurine catabolism dioxygenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tfdA dioxygenase family [H]

Homologues:

Organism=Escherichia coli, GI1786565, Length=184, Percent_Identity=32.0652173913043, Blast_Score=99, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6322971, Length=271, Percent_Identity=27.3062730627306, Blast_Score=84, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003819 [H]

Pfam domain/function: PF02668 TauD [H]

EC number: 1.14.11.17 [C]

Molecular weight: Translated: 32359; Mature: 32228

Theoretical pI: Translated: 7.06; Mature: 7.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAYKTLSSALGTEVYGFDSPFPHDAEAVRALIEAWHAGGICRLRRQRLDMAEFVEFSRIF
CCHHHHHHHHCCEECCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHH
GRPERALNQERKLTSREDLPELMIVSNILENGVSIGHLGSKEAYWHTDMCYTDVPPIASI
CCCHHHHHHHHHCCCHHCCHHHHHHHHHHHCCCEECCCCCCCCEEECCCCCCCCCHHHHH
LYAIEVPAHGGNTEFMNMYRVHDALPASLRRQIAGLSIKHDRSYTAVGELRYGFDSVVDV
HHHEEECCCCCCHHHHHHHHHHHCCCHHHHHHHHCCEEECCCCEEEHHHHHCCCHHEEEE
TTCPGSIHPIVRVHPVTQRPYLYLGRRLNAYVVGLPVGESEALLDELWRYTRLDGVTWTQ
EECCCCCCCEEEEECCCCCCHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCEEE
RWEVGDIMIWDNRCTMHRRDAFDANARRLMWRTQIQADPARPL
EECCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
AYKTLSSALGTEVYGFDSPFPHDAEAVRALIEAWHAGGICRLRRQRLDMAEFVEFSRIF
CHHHHHHHHCCEECCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHH
GRPERALNQERKLTSREDLPELMIVSNILENGVSIGHLGSKEAYWHTDMCYTDVPPIASI
CCCHHHHHHHHHCCCHHCCHHHHHHHHHHHCCCEECCCCCCCCEEECCCCCCCCCHHHHH
LYAIEVPAHGGNTEFMNMYRVHDALPASLRRQIAGLSIKHDRSYTAVGELRYGFDSVVDV
HHHEEECCCCCCHHHHHHHHHHHCCCHHHHHHHHCCEEECCCCEEEHHHHHCCCHHEEEE
TTCPGSIHPIVRVHPVTQRPYLYLGRRLNAYVVGLPVGESEALLDELWRYTRLDGVTWTQ
EECCCCCCCEEEEECCCCCCHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCEEE
RWEVGDIMIWDNRCTMHRRDAFDANARRLMWRTQIQADPARPL
EECCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Ascorbate. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2-Oxoglutarate; O2; Taurine [C]

Specific reaction: 2-Oxoglutarate + O2 + Taurine --> Aminoacetaldehyde + CO2 + H+ + Sulfite + Succinate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3036764; 10777523; 11457355; 11955067 [H]