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The map label for this gene is lysA [H]

Identifier: 126444939

GI number: 126444939

Start: 480180

End: 481439

Strand: Reverse

Name: lysA [H]

Synonym: BURPS668_A0527

Alternate gene names: 126444939

Gene position: 481439-480180 (Counterclockwise)

Preceding gene: 126442591

Following gene: 126442954

Centisome position: 15.39

GC content: 71.19

Gene sequence:

>1260_bases
ATGAACGCGAACCTCCACGCCTTCACTGCCGCGGACGCCGCGCCGAGCACCGAATACTGGTGGGCGCGCGAGCGGCTGCA
CTACCGCGGCAACGCGCTGCATTTCTGCGGCCGCGACGTCGCCGAACTCGCGGCCGCGTTCGCCGAGCCGGTGTTCCTGT
ACGACCCGCAGCGCGCGCTCGACAACGTCGCGCGCCTGCAACGCGCGCTCGGCGACCTGCAACGCGGCGATTTCCGCCTC
CATTACGCGATGAAGGCGAATCGCTTTCGCCCATTGCTGTCCGAGCTGCGGCGCTCGCCGCTCTTCGGCATCGACGCATG
CTCGCCCGAGGAGCTGCGCGAGGCGCTCGCATGCGGTTTCGCGCCCGAGCGGATCTCGTACACCGCGCACGGGATGATGC
CGGACGAAGCCGCGCTCCTCGCCGCGCTGCCGGGCGTGCACGTGAACTGCGACACGCTGAGCGCGATCGCGCTGCTCGGC
AGCCGCTCGCCCGGGCGCGAGATCGGCATTCGCGTGAACCCGGGCGTCGGCATCGGCTACGGCGACAGCGAGCGGCTGAG
CTACGCGGGCGCGGCGGTGACGAAGTTCGGCATCTACGCGGAGCAGTTCGGCGCGGCGCTCGAGCTCGCCGCGCGGCACG
GCCTGGCCGTGACATGGCTGCATTGCCACGCGGGCTGCGGCTATCTCGATGCGCAGCTCGAATCGTTCGAGCGCGTGCTC
GACGCGCTCGACGCGTTCGCCGCGCGCGTGCCGGGGCTGCGCGGCATCAACCTCGGCGGCGGGCTCGGACTGCCGCACCG
CGCGACGGATCGGCCGCTCGATCTCGAGCGCTGGCGCGCGGCCGTGCACGCGCGCTTCGGCGGCCGGCCGCTCGCGATCG
CGATCGAACCCGGCGACTTCATCGCGAAGGACGCCGGCATGCTCGTGCTGCGCGTGGCATACGTCGAGCTCAAGCGCAAC
CGCCGCTTCGTCGGGTTGAACGGCGGCTTCAATCTCGCGATCGAACCCGCGTTCTACGATCTGCCGTGCGAGCCCGTGCC
GTGCGTGCGCCGGCCGGGCCCCGCGCAATCGGTGTGCGTCGCCGGCAACATCAACGAAGCGCTCGACGTGTGGGGCAACG
ACGTGAGCCTGCCGCCCGTCGAGCCGGGCGATTTCATCGCACTGCTGAACGCGGGCGGCTATGCGTCGTCGATGAGCTCG
AACCATTGCCTGCGCGGGCAGTTCCGCGAGCTCGCGCTGTTCGACGCCGCACCGCACTGA

Upstream 100 bases:

>100_bases
GCGCGAAAGCGCCGCAAGCGCTCGCGGCGGCCGCTCAGGCGCTCGATCTCGCGCCGCTCTTCTCCCACTCGAACGCAACC
GCTCACCCGGCCGCCCATCG

Downstream 100 bases:

>100_bases
TCTCAACCTCAACGACAAGGAGCCCCAGCGTGTCCTCGCTTTCACAGCAATTGAGCGCTCTCGGCAGCCGGATCTTCACG
AGCGCGCCGTTCGGCCCCGG

Product: putative diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 419; Mature: 419

Protein sequence:

>419_residues
MNANLHAFTAADAAPSTEYWWARERLHYRGNALHFCGRDVAELAAAFAEPVFLYDPQRALDNVARLQRALGDLQRGDFRL
HYAMKANRFRPLLSELRRSPLFGIDACSPEELREALACGFAPERISYTAHGMMPDEAALLAALPGVHVNCDTLSAIALLG
SRSPGREIGIRVNPGVGIGYGDSERLSYAGAAVTKFGIYAEQFGAALELAARHGLAVTWLHCHAGCGYLDAQLESFERVL
DALDAFAARVPGLRGINLGGGLGLPHRATDRPLDLERWRAAVHARFGGRPLAIAIEPGDFIAKDAGMLVLRVAYVELKRN
RRFVGLNGGFNLAIEPAFYDLPCEPVPCVRRPGPAQSVCVAGNINEALDVWGNDVSLPPVEPGDFIALLNAGGYASSMSS
NHCLRGQFRELALFDAAPH

Sequences:

>Translated_419_residues
MNANLHAFTAADAAPSTEYWWARERLHYRGNALHFCGRDVAELAAAFAEPVFLYDPQRALDNVARLQRALGDLQRGDFRL
HYAMKANRFRPLLSELRRSPLFGIDACSPEELREALACGFAPERISYTAHGMMPDEAALLAALPGVHVNCDTLSAIALLG
SRSPGREIGIRVNPGVGIGYGDSERLSYAGAAVTKFGIYAEQFGAALELAARHGLAVTWLHCHAGCGYLDAQLESFERVL
DALDAFAARVPGLRGINLGGGLGLPHRATDRPLDLERWRAAVHARFGGRPLAIAIEPGDFIAKDAGMLVLRVAYVELKRN
RRFVGLNGGFNLAIEPAFYDLPCEPVPCVRRPGPAQSVCVAGNINEALDVWGNDVSLPPVEPGDFIALLNAGGYASSMSS
NHCLRGQFRELALFDAAPH
>Mature_419_residues
MNANLHAFTAADAAPSTEYWWARERLHYRGNALHFCGRDVAELAAAFAEPVFLYDPQRALDNVARLQRALGDLQRGDFRL
HYAMKANRFRPLLSELRRSPLFGIDACSPEELREALACGFAPERISYTAHGMMPDEAALLAALPGVHVNCDTLSAIALLG
SRSPGREIGIRVNPGVGIGYGDSERLSYAGAAVTKFGIYAEQFGAALELAARHGLAVTWLHCHAGCGYLDAQLESFERVL
DALDAFAARVPGLRGINLGGGLGLPHRATDRPLDLERWRAAVHARFGGRPLAIAIEPGDFIAKDAGMLVLRVAYVELKRN
RRFVGLNGGFNLAIEPAFYDLPCEPVPCVRRPGPAQSVCVAGNINEALDVWGNDVSLPPVEPGDFIALLNAGGYASSMSS
NHCLRGQFRELALFDAAPH

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Escherichia coli, GI1789203, Length=407, Percent_Identity=31.2039312039312, Blast_Score=141, Evalue=8e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 45334; Mature: 45334

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNANLHAFTAADAAPSTEYWWARERLHYRGNALHFCGRDVAELAAAFAEPVFLYDPQRAL
CCCCEEEEEECCCCCCCHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHCCEEEECCHHHH
DNVARLQRALGDLQRGDFRLHYAMKANRFRPLLSELRRSPLFGIDACSPEELREALACGF
HHHHHHHHHHHHHCCCCEEEEEEEHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCC
APERISYTAHGMMPDEAALLAALPGVHVNCDTLSAIALLGSRSPGREIGIRVNPGVGIGY
CHHHCCEEECCCCCCHHHHHHHCCCCEECHHHHHHHHHHCCCCCCCEEEEEECCCCEECC
GDSERLSYAGAAVTKFGIYAEQFGAALELAARHGLAVTWLHCHAGCGYLDAQLESFERVL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHH
DALDAFAARVPGLRGINLGGGLGLPHRATDRPLDLERWRAAVHARFGGRPLAIAIEPGDF
HHHHHHHHHCCCCCEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCH
IAKDAGMLVLRVAYVELKRNRRFVGLNGGFNLAIEPAFYDLPCEPVPCVRRPGPAQSVCV
HHHCCCHHHHHHHHHHHHCCCEEEEECCCCEEEECCEEECCCCCCCCCCCCCCCCCCEEE
AGNINEALDVWGNDVSLPPVEPGDFIALLNAGGYASSMSSNHCLRGQFRELALFDAAPH
ECCCHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHEEEECCCCC
>Mature Secondary Structure
MNANLHAFTAADAAPSTEYWWARERLHYRGNALHFCGRDVAELAAAFAEPVFLYDPQRAL
CCCCEEEEEECCCCCCCHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHCCEEEECCHHHH
DNVARLQRALGDLQRGDFRLHYAMKANRFRPLLSELRRSPLFGIDACSPEELREALACGF
HHHHHHHHHHHHHCCCCEEEEEEEHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCC
APERISYTAHGMMPDEAALLAALPGVHVNCDTLSAIALLGSRSPGREIGIRVNPGVGIGY
CHHHCCEEECCCCCCHHHHHHHCCCCEECHHHHHHHHHHCCCCCCCEEEEEECCCCEECC
GDSERLSYAGAAVTKFGIYAEQFGAALELAARHGLAVTWLHCHAGCGYLDAQLESFERVL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHH
DALDAFAARVPGLRGINLGGGLGLPHRATDRPLDLERWRAAVHARFGGRPLAIAIEPGDF
HHHHHHHHHCCCCCEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCH
IAKDAGMLVLRVAYVELKRNRRFVGLNGGFNLAIEPAFYDLPCEPVPCVRRPGPAQSVCV
HHHCCCHHHHHHHHHHHHCCCEEEEECCCCEEEECCEEECCCCCCCCCCCCCCCCCCEEE
AGNINEALDVWGNDVSLPPVEPGDFIALLNAGGYASSMSSNHCLRGQFRELALFDAAPH
ECCCHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]