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The map label for this gene is cirA [C]

Identifier: 126444863

GI number: 126444863

Start: 403694

End: 405988

Strand: Reverse

Name: cirA [C]

Synonym: BURPS668_A0440

Alternate gene names: 126444863

Gene position: 405988-403694 (Counterclockwise)

Preceding gene: 126443754

Following gene: 126443331

Centisome position: 12.98

GC content: 68.41

Gene sequence:

>2295_bases
TTGGCGCGGCAGCCGCTTCGCGCCGCGCTGTTCGGGGCCTTCGGCCTCTATGCGGCGGCCGCGCGCGCCGCCGGCCCCGC
TTCCGAACCCGCGGCCGCCGCGCCGCCGGCCGCCGCATCCGCCGCATCCACGTCGCAGGTGCGGCACGCGGCGATCGCCG
CCGCGCGCAAGGACGCGCCGGCACTCGATCCGATCACCGTCACCGCGACGCGCACCGCGTCGGCCGCGAGCCGCACCGCG
GCGAGCGTATCGGTGATCACCGATTCAGACCTCGAGGAGCAGCAGGCCGACAACATCAAGGACGCGCTGCGCTACGAGCC
GGGCGTCACCGTGCGACGCACCGCGTACCGTCCGGCGAACGCCGCGCTCGGCGGCGGCCGCGACGGCGATTCGAGCATCA
ACATCCGCGGCCTCGAAGGCAACCGCGTGCTGCTGATGGAAGACGGCATCCGGCTGCCGAGCGCGTTCTCGTTCGGCCCG
CTCGAAGCCGGCCGCGGCGATTACGCCGATCTCGACACGCTCGCGCGCATCGAGATCCTGCGCGGTCCGGCGTCCGCGCT
GTATGGCAGCGACGGTCTGACGGGCGCCGTCAACTTCATCACGAAAGATCCGTCCGATCTGCTGTCGATCCATCGAAAAA
AGACCTATTTCTCGTTCCGGCCGAGCTACGACTCGGTCGACCGCAGCATCGGCGCGACCGTGACGGCGGCAGGCGGCAAC
GATCGCGTGCAGGCGATGCTGATCGCGTCCGGGCGCCGCGGCCACGAACTCGACACGCACGGCGACGACAATTCCGCGAG
CACGCGGCGCACGCGCGCGAATCCTCAGGATGTCTACACGGAATCGCTGCTCGGCAAGCTGACGATCACGCCGACCGCGC
GCGACACGATCAAGCTCGCCGCCGAAACGGTGCGGCGGCGGATCGACACGAACGTGCTGTCGGCGATCAATCCGCCGACA
ACGCTCGGCCTCACCGCGAACGACAGGCTCGAGCGCAACCGCTTCAGTATCGACTACGATTTGCGCGACGCCGCCGCGCG
CGGGTTCCAGACCGCGCACGTGCAGTTCTACTATCAGGAGTCGACGCAGGATCAGGACGCGTTCGAGACGCGCGGCGGGC
GGCTCCAATCGCGTTCGCGCTCGAACCACTACAGCGAGCGCGCGCTCGGCGGCTCCGCGTTCGCCGAGAGCGGCTTCGCG
ACCGGGCCGCTCGCGCACAAGCTGCTGTACGGCGTCGACGGCAGCATCGACCGCATCAAGAGCCTGCGCGAGGGCACCGT
CGCGAGCCCCGGCGAATCGTTCCCGAACAAGGCGTTTCCGGACACCGACTACTCGCTGTTCGGCGCGTTCGTGCAGGATC
AGATCGGCTTCGGCAAGCTGCTCGTCACGCCGGGCCTGCGCTTCGACGCGTATCGGCTCAGCCCGAGCTCGGGCGATCCG
CTGTTCACCGGCAAGACGGTCAGCTCGAGCGATCACGAGCTGTCGCCGCGCGTCGCGATGCTCTATGAAGTGTCGCCCGC
GCTGATTCCCTACGCGCAGTATGCGCACGGCTTTCGCACGCCGACGCCCGATCAGGTCAACAACAGCTTCTCGAATCCGA
TCTATGGCTATACATCGATCGGCAATCCGAACCTGAAGCCCGAGACGAGCGACACGCTCGAAGCGGGCCTGCGCGGCACG
CTCGGCACCGGCTACGGGCCGCTGCGCTACAGCGTCGCCGCGTTCGCCGGCCGCTATCGCAACTTCATCTCGCAGCGCAC
GGTAGGCGGCAGTGGCCGGCCGAACGATCCGCTCGTGTTCCAGTACGTGAACTTCGCGAACGCGCGCATTCACGGCTTCG
AGGGACGCGCCGAATGGGTGATGCCGAATGGCTTCACGCTGAAGACGGCGATGGCGTTCACGAAGGGCACGACGCAGGAC
AACGGCGCGGCGAGCGAGCCGCTCGATACGGTCAACCCGTTCTCCGCCGTGTTCGGCGTGCGCTACGAGCCGAGCGAGCG
CTGGTTCGCGCAGGCGGACCTGCTGTGGCAGGCGGGCAAGCGCGGCCGCGACGTGTCGTCGGCCGCGTGCCAGAAAAAGA
CCTGCTTCACGCCGCCGTCGTCGTTCGTCGTCGATCTGCGCGGCGGCTACCGCTTCAACAAGCACGTGAGCGCCTACCTC
GGCATTCACAACCTGTTCGACCGCAAGTACTGGAACTGGTCGGACGTGCGCGGCATCGCCGCCGATTCGAACGTGCTCGA
CGCATACACCGCCCCGGGCCGCAGCGTCGCGGTCAGCATGAAGGTGGATTTCTGA

Upstream 100 bases:

>100_bases
CGCCGTCCAGACGCGCGGGCGCCAGCCAGGTGCACGCGTCACCCAGCCAGCCTCCGGGCTCAAACGTCACTGGGAGACCA
ACACCGTGCATCAACCTCTG

Downstream 100 bases:

>100_bases
TGCGGCCCGCACGCTTTTTTCCCAACCCGACCGCCCGGCAATCGAGGATCTCCGACATGATGAACACCGCCGCCCCCGCC
GCTTCGCCCGCCCGCGCGCT

Product: TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 764; Mature: 763

Protein sequence:

>764_residues
MARQPLRAALFGAFGLYAAAARAAGPASEPAAAAPPAAASAASTSQVRHAAIAAARKDAPALDPITVTATRTASAASRTA
ASVSVITDSDLEEQQADNIKDALRYEPGVTVRRTAYRPANAALGGGRDGDSSINIRGLEGNRVLLMEDGIRLPSAFSFGP
LEAGRGDYADLDTLARIEILRGPASALYGSDGLTGAVNFITKDPSDLLSIHRKKTYFSFRPSYDSVDRSIGATVTAAGGN
DRVQAMLIASGRRGHELDTHGDDNSASTRRTRANPQDVYTESLLGKLTITPTARDTIKLAAETVRRRIDTNVLSAINPPT
TLGLTANDRLERNRFSIDYDLRDAAARGFQTAHVQFYYQESTQDQDAFETRGGRLQSRSRSNHYSERALGGSAFAESGFA
TGPLAHKLLYGVDGSIDRIKSLREGTVASPGESFPNKAFPDTDYSLFGAFVQDQIGFGKLLVTPGLRFDAYRLSPSSGDP
LFTGKTVSSSDHELSPRVAMLYEVSPALIPYAQYAHGFRTPTPDQVNNSFSNPIYGYTSIGNPNLKPETSDTLEAGLRGT
LGTGYGPLRYSVAAFAGRYRNFISQRTVGGSGRPNDPLVFQYVNFANARIHGFEGRAEWVMPNGFTLKTAMAFTKGTTQD
NGAASEPLDTVNPFSAVFGVRYEPSERWFAQADLLWQAGKRGRDVSSAACQKKTCFTPPSSFVVDLRGGYRFNKHVSAYL
GIHNLFDRKYWNWSDVRGIAADSNVLDAYTAPGRSVAVSMKVDF

Sequences:

>Translated_764_residues
MARQPLRAALFGAFGLYAAAARAAGPASEPAAAAPPAAASAASTSQVRHAAIAAARKDAPALDPITVTATRTASAASRTA
ASVSVITDSDLEEQQADNIKDALRYEPGVTVRRTAYRPANAALGGGRDGDSSINIRGLEGNRVLLMEDGIRLPSAFSFGP
LEAGRGDYADLDTLARIEILRGPASALYGSDGLTGAVNFITKDPSDLLSIHRKKTYFSFRPSYDSVDRSIGATVTAAGGN
DRVQAMLIASGRRGHELDTHGDDNSASTRRTRANPQDVYTESLLGKLTITPTARDTIKLAAETVRRRIDTNVLSAINPPT
TLGLTANDRLERNRFSIDYDLRDAAARGFQTAHVQFYYQESTQDQDAFETRGGRLQSRSRSNHYSERALGGSAFAESGFA
TGPLAHKLLYGVDGSIDRIKSLREGTVASPGESFPNKAFPDTDYSLFGAFVQDQIGFGKLLVTPGLRFDAYRLSPSSGDP
LFTGKTVSSSDHELSPRVAMLYEVSPALIPYAQYAHGFRTPTPDQVNNSFSNPIYGYTSIGNPNLKPETSDTLEAGLRGT
LGTGYGPLRYSVAAFAGRYRNFISQRTVGGSGRPNDPLVFQYVNFANARIHGFEGRAEWVMPNGFTLKTAMAFTKGTTQD
NGAASEPLDTVNPFSAVFGVRYEPSERWFAQADLLWQAGKRGRDVSSAACQKKTCFTPPSSFVVDLRGGYRFNKHVSAYL
GIHNLFDRKYWNWSDVRGIAADSNVLDAYTAPGRSVAVSMKVDF
>Mature_763_residues
ARQPLRAALFGAFGLYAAAARAAGPASEPAAAAPPAAASAASTSQVRHAAIAAARKDAPALDPITVTATRTASAASRTAA
SVSVITDSDLEEQQADNIKDALRYEPGVTVRRTAYRPANAALGGGRDGDSSINIRGLEGNRVLLMEDGIRLPSAFSFGPL
EAGRGDYADLDTLARIEILRGPASALYGSDGLTGAVNFITKDPSDLLSIHRKKTYFSFRPSYDSVDRSIGATVTAAGGND
RVQAMLIASGRRGHELDTHGDDNSASTRRTRANPQDVYTESLLGKLTITPTARDTIKLAAETVRRRIDTNVLSAINPPTT
LGLTANDRLERNRFSIDYDLRDAAARGFQTAHVQFYYQESTQDQDAFETRGGRLQSRSRSNHYSERALGGSAFAESGFAT
GPLAHKLLYGVDGSIDRIKSLREGTVASPGESFPNKAFPDTDYSLFGAFVQDQIGFGKLLVTPGLRFDAYRLSPSSGDPL
FTGKTVSSSDHELSPRVAMLYEVSPALIPYAQYAHGFRTPTPDQVNNSFSNPIYGYTSIGNPNLKPETSDTLEAGLRGTL
GTGYGPLRYSVAAFAGRYRNFISQRTVGGSGRPNDPLVFQYVNFANARIHGFEGRAEWVMPNGFTLKTAMAFTKGTTQDN
GAASEPLDTVNPFSAVFGVRYEPSERWFAQADLLWQAGKRGRDVSSAACQKKTCFTPPSSFVVDLRGGYRFNKHVSAYLG
IHNLFDRKYWNWSDVRGIAADSNVLDAYTAPGRSVAVSMKVDF

Specific function: Acts as a receptor for hemoglobin or the hemoglobin/haptoglobin complex of the human host and is required for heme uptake [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell outer membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tonB-dependent receptor family. Hemoglobin/haptoglobin binding protein subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788478, Length=700, Percent_Identity=24.8571428571429, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1790405, Length=149, Percent_Identity=35.5704697986577, Blast_Score=76, Evalue=8e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012910
- InterPro:   IPR006970
- InterPro:   IPR000531
- InterPro:   IPR010949
- InterPro:   IPR010917 [H]

Pfam domain/function: PF07715 Plug; PF04886 PT; PF00593 TonB_dep_Rec [H]

EC number: NA

Molecular weight: Translated: 82292; Mature: 82161

Theoretical pI: Translated: 9.28; Mature: 9.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARQPLRAALFGAFGLYAAAARAAGPASEPAAAAPPAAASAASTSQVRHAAIAAARKDAP
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
ALDPITVTATRTASAASRTAASVSVITDSDLEEQQADNIKDALRYEPGVTVRRTAYRPAN
CCCCEEEEEECCHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCC
AALGGGRDGDSSINIRGLEGNRVLLMEDGIRLPSAFSFGPLEAGRGDYADLDTLARIEIL
CCCCCCCCCCCCEEEEECCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHH
RGPASALYGSDGLTGAVNFITKDPSDLLSIHRKKTYFSFRPSYDSVDRSIGATVTAAGGN
CCCHHHHCCCCCCCEEEEEEECCHHHHHHHHHHHEEEEECCCHHHHHHHCCCEEEECCCC
DRVQAMLIASGRRGHELDTHGDDNSASTRRTRANPQDVYTESLLGKLTITPTARDTIKLA
CCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCEEEECCCCHHHHHHH
AETVRRRIDTNVLSAINPPTTLGLTANDRLERNRFSIDYDLRDAAARGFQTAHVQFYYQE
HHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCEEEEECHHHHHHCCCEEEEEEEEECC
STQDQDAFETRGGRLQSRSRSNHYSERALGGSAFAESGFATGPLAHKLLYGVDGSIDRIK
CCCCHHHHHHCCCCCCCCCCCCCHHHHHCCCHHHHCCCCCCCHHHHHHHHCCCCCHHHHH
SLREGTVASPGESFPNKAFPDTDYSLFGAFVQDQIGFGKLLVTPGLRFDAYRLSPSSGDP
HHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEECCCCEEEEEEECCCCCCC
LFTGKTVSSSDHELSPRVAMLYEVSPALIPYAQYAHGFRTPTPDQVNNSFSNPIYGYTSI
EEECCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHCCCCCCCCHHHCCCCCCCCEEEECC
GNPNLKPETSDTLEAGLRGTLGTGYGPLRYSVAAFAGRYRNFISQRTVGGSGRPNDPLVF
CCCCCCCCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEE
QYVNFANARIHGFEGRAEWVMPNGFTLKTAMAFTKGTTQDNGAASEPLDTVNPFSAVFGV
EEECCCCCEEECCCCCEEEECCCCEEEEEEHHHHCCCCCCCCCCCCCCCCCCHHHHHHCC
RYEPSERWFAQADLLWQAGKRGRDVSSAACQKKTCFTPPSSFVVDLRGGYRFNKHVSAYL
EECCCHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCCCCCCEEEECCCCEEECCHHHHHH
GIHNLFDRKYWNWSDVRGIAADSNVLDAYTAPGRSVAVSMKVDF
HHHHHHHCCCCCHHHCCCEECCCCEEECCCCCCCEEEEEEEECC
>Mature Secondary Structure 
ARQPLRAALFGAFGLYAAAARAAGPASEPAAAAPPAAASAASTSQVRHAAIAAARKDAP
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
ALDPITVTATRTASAASRTAASVSVITDSDLEEQQADNIKDALRYEPGVTVRRTAYRPAN
CCCCEEEEEECCHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCC
AALGGGRDGDSSINIRGLEGNRVLLMEDGIRLPSAFSFGPLEAGRGDYADLDTLARIEIL
CCCCCCCCCCCCEEEEECCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHH
RGPASALYGSDGLTGAVNFITKDPSDLLSIHRKKTYFSFRPSYDSVDRSIGATVTAAGGN
CCCHHHHCCCCCCCEEEEEEECCHHHHHHHHHHHEEEEECCCHHHHHHHCCCEEEECCCC
DRVQAMLIASGRRGHELDTHGDDNSASTRRTRANPQDVYTESLLGKLTITPTARDTIKLA
CCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCEEEECCCCHHHHHHH
AETVRRRIDTNVLSAINPPTTLGLTANDRLERNRFSIDYDLRDAAARGFQTAHVQFYYQE
HHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCEEEEECHHHHHHCCCEEEEEEEEECC
STQDQDAFETRGGRLQSRSRSNHYSERALGGSAFAESGFATGPLAHKLLYGVDGSIDRIK
CCCCHHHHHHCCCCCCCCCCCCCHHHHHCCCHHHHCCCCCCCHHHHHHHHCCCCCHHHHH
SLREGTVASPGESFPNKAFPDTDYSLFGAFVQDQIGFGKLLVTPGLRFDAYRLSPSSGDP
HHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEECCCCEEEEEEECCCCCCC
LFTGKTVSSSDHELSPRVAMLYEVSPALIPYAQYAHGFRTPTPDQVNNSFSNPIYGYTSI
EEECCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHCCCCCCCCHHHCCCCCCCCEEEECC
GNPNLKPETSDTLEAGLRGTLGTGYGPLRYSVAAFAGRYRNFISQRTVGGSGRPNDPLVF
CCCCCCCCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEE
QYVNFANARIHGFEGRAEWVMPNGFTLKTAMAFTKGTTQDNGAASEPLDTVNPFSAVFGV
EEECCCCCEEECCCCCEEEECCCCEEEEEEHHHHCCCCCCCCCCCCCCCCCCHHHHHHCC
RYEPSERWFAQADLLWQAGKRGRDVSSAACQKKTCFTPPSSFVVDLRGGYRFNKHVSAYL
EECCCHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCCCCCCEEEECCCCEEECCHHHHHH
GIHNLFDRKYWNWSDVRGIAADSNVLDAYTAPGRSVAVSMKVDF
HHHHHHHCCCCCHHHCCCEECCCCEEECCCCCCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800; 10675023 [H]