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The map label for this gene is aphA [H]

Identifier: 126444797

GI number: 126444797

Start: 1714598

End: 1715620

Strand: Reverse

Name: aphA [H]

Synonym: BURPS668_A1768

Alternate gene names: 126444797

Gene position: 1715620-1714598 (Counterclockwise)

Preceding gene: 126442666

Following gene: 126445033

Centisome position: 54.86

GC content: 70.19

Gene sequence:

>1023_bases
ATGCTGACTTATTTTCATCCGGACCAACTGAAGCACAGTCCGCTCACTTATCTGTCGCGCGGCAAGATGCGCGCGCCGCA
CGAAGTGCCCGAGCGGGCCGTGCGGCTGCTCGGCGCGGTGACCTCGCTCGGCTTCGACGTGCGCGCGCCCGAGGATTTCG
GCGCGGCGCCGCTCGCAGCCGTGCACAGCGAGCCGTATCTGCGCTTTCTCGCCGACGCGCATCGCGAGTGGCGGCGCATC
CCGGAGGACTGGGGGCCCGAGGTGATGTCGAACATCTACGTGCGCGAGCCGAATCCGCTGCGCGGCGTGCTCGCGCAGGC
GGGGTACTATCTCGCGGACGGCAGTTGCCCGATCGGCGAGCACACGTATCGCGCCGCGTACTGGTCCGCGCAGAGCGCGC
TCGCCGGCGCGGCGGCGCTCGGCCGCGGCGCGCGCGATGCGTACGCGCTCTGCCGCCCGCCCGGCCATCATGCGTGCCGC
GACGCGGCGGGCGGCTTCTGCTATCTGAACAACGCGGCGATCGCCGCGCAGGCGTTGCGCGCGCGCCATGCGCGCGTGGC
GATCCTCGATACCGACATGCATCACGGCCAGGGCATCCAGACGCTGTTCTACGATCGCGACGACGTGCTGTACGTGTCGA
TTCACGGCGATCCGACGAACTTCTATCCGGCCGTCACCGGTTACGAAACGGAGCGCGGGGCGGGGCGCGGCGAGGGCTTC
AACGTGAACCTGCCGATGCCGCACGGCTCGCCCGAAGCGGTGTTCATCGCGCAGCTCGAGCGCGCGAGGTCGTGCGTCGA
GCGCTTCGCGCCGGACGTGCTGGTGTTCGCGCTCGGCTTCGACGTGTATCGCGAGGACCCGCAGTCGAAGGTCGCGGTGA
CGACCGAAGGCTTCGGGCGGCTCGGCGCGCTCGTCGGCGGCCTGCGGGTGCCGACGCTGATCGTGCAGGAAGGCGGCTAT
CACCTCGAGACGCTCGAGCGCAACGCCGCCGCGCTGTTTCGCAGTTACGAGGCGGCGCGTTGA

Upstream 100 bases:

>100_bases
GCGCCCGGCGCCGGCGATGCAGGCCGCGCATTCGGGCACGGATGCGGGCACCTTCGCGCAGCCGCATTGACCGATCGATC
GTGGAGCGAAGCGACCCCGC

Downstream 100 bases:

>100_bases
TCGCGCGCGCCTGAGCGCCGGGACGGCGGCTTTTCCGCCCCGACGCCGACGGGTTTCGTTGGTTCGGCACTAGTGGCTGA
TCGAGGCTAGTGCGCCGCCC

Product: deacetylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 340; Mature: 340

Protein sequence:

>340_residues
MLTYFHPDQLKHSPLTYLSRGKMRAPHEVPERAVRLLGAVTSLGFDVRAPEDFGAAPLAAVHSEPYLRFLADAHREWRRI
PEDWGPEVMSNIYVREPNPLRGVLAQAGYYLADGSCPIGEHTYRAAYWSAQSALAGAAALGRGARDAYALCRPPGHHACR
DAAGGFCYLNNAAIAAQALRARHARVAILDTDMHHGQGIQTLFYDRDDVLYVSIHGDPTNFYPAVTGYETERGAGRGEGF
NVNLPMPHGSPEAVFIAQLERARSCVERFAPDVLVFALGFDVYREDPQSKVAVTTEGFGRLGALVGGLRVPTLIVQEGGY
HLETLERNAAALFRSYEAAR

Sequences:

>Translated_340_residues
MLTYFHPDQLKHSPLTYLSRGKMRAPHEVPERAVRLLGAVTSLGFDVRAPEDFGAAPLAAVHSEPYLRFLADAHREWRRI
PEDWGPEVMSNIYVREPNPLRGVLAQAGYYLADGSCPIGEHTYRAAYWSAQSALAGAAALGRGARDAYALCRPPGHHACR
DAAGGFCYLNNAAIAAQALRARHARVAILDTDMHHGQGIQTLFYDRDDVLYVSIHGDPTNFYPAVTGYETERGAGRGEGF
NVNLPMPHGSPEAVFIAQLERARSCVERFAPDVLVFALGFDVYREDPQSKVAVTTEGFGRLGALVGGLRVPTLIVQEGGY
HLETLERNAAALFRSYEAAR
>Mature_340_residues
MLTYFHPDQLKHSPLTYLSRGKMRAPHEVPERAVRLLGAVTSLGFDVRAPEDFGAAPLAAVHSEPYLRFLADAHREWRRI
PEDWGPEVMSNIYVREPNPLRGVLAQAGYYLADGSCPIGEHTYRAAYWSAQSALAGAAALGRGARDAYALCRPPGHHACR
DAAGGFCYLNNAAIAAQALRARHARVAILDTDMHHGQGIQTLFYDRDDVLYVSIHGDPTNFYPAVTGYETERGAGRGEGF
NVNLPMPHGSPEAVFIAQLERARSCVERFAPDVLVFALGFDVYREDPQSKVAVTTEGFGRLGALVGGLRVPTLIVQEGGY
HLETLERNAAALFRSYEAAR

Specific function: Acts on many types of acetylpolyamines has high affinity towards acetylputrescine, acetylcadaverine, acetylspermidine, and acetylspermine [H]

COG id: COG0123

COG function: function code BQ; Deacetylases, including yeast histone deacetylase and acetoin utilization protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histone deacetylase family [H]

Homologues:

Organism=Homo sapiens, GI20070354, Length=224, Percent_Identity=37.5, Blast_Score=119, Evalue=3e-27,
Organism=Homo sapiens, GI13128864, Length=331, Percent_Identity=31.1178247734139, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI148539870, Length=224, Percent_Identity=37.5, Blast_Score=116, Evalue=2e-26,
Organism=Homo sapiens, GI169234807, Length=224, Percent_Identity=37.5, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI17158039, Length=219, Percent_Identity=34.2465753424658, Blast_Score=109, Evalue=3e-24,
Organism=Homo sapiens, GI13128860, Length=315, Percent_Identity=26.031746031746, Blast_Score=108, Evalue=9e-24,
Organism=Homo sapiens, GI30795204, Length=217, Percent_Identity=33.6405529953917, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI30795202, Length=217, Percent_Identity=33.6405529953917, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI153085395, Length=194, Percent_Identity=36.5979381443299, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI8923769, Length=213, Percent_Identity=30.0469483568075, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI262073088, Length=211, Percent_Identity=31.2796208530806, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI226529806, Length=223, Percent_Identity=35.4260089686099, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI62750347, Length=195, Percent_Identity=37.4358974358974, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI62750349, Length=195, Percent_Identity=37.4358974358974, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI293336691, Length=290, Percent_Identity=26.2068965517241, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI13128862, Length=232, Percent_Identity=27.1551724137931, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI262073092, Length=156, Percent_Identity=31.4102564102564, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17540334, Length=202, Percent_Identity=39.1089108910891, Blast_Score=127, Evalue=6e-30,
Organism=Caenorhabditis elegans, GI17540332, Length=202, Percent_Identity=39.1089108910891, Blast_Score=127, Evalue=8e-30,
Organism=Caenorhabditis elegans, GI193206283, Length=202, Percent_Identity=39.1089108910891, Blast_Score=127, Evalue=9e-30,
Organism=Caenorhabditis elegans, GI193209491, Length=288, Percent_Identity=30.9027777777778, Blast_Score=113, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17561978, Length=307, Percent_Identity=26.7100977198697, Blast_Score=108, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI17508561, Length=312, Percent_Identity=25.9615384615385, Blast_Score=104, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI17534739, Length=284, Percent_Identity=27.4647887323944, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17537347, Length=223, Percent_Identity=29.1479820627803, Blast_Score=91, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI25154022, Length=219, Percent_Identity=28.310502283105, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI25154020, Length=219, Percent_Identity=28.310502283105, Blast_Score=72, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6324307, Length=221, Percent_Identity=35.2941176470588, Blast_Score=127, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6323999, Length=232, Percent_Identity=28.8793103448276, Blast_Score=104, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6321244, Length=283, Percent_Identity=26.8551236749117, Blast_Score=99, Evalue=9e-22,
Organism=Saccharomyces cerevisiae, GI6325325, Length=148, Percent_Identity=28.3783783783784, Blast_Score=69, Evalue=8e-13,
Organism=Drosophila melanogaster, GI281360799, Length=233, Percent_Identity=38.6266094420601, Blast_Score=114, Evalue=9e-26,
Organism=Drosophila melanogaster, GI281360801, Length=233, Percent_Identity=38.6266094420601, Blast_Score=114, Evalue=9e-26,
Organism=Drosophila melanogaster, GI24641720, Length=233, Percent_Identity=38.6266094420601, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24657891, Length=318, Percent_Identity=27.0440251572327, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24644244, Length=214, Percent_Identity=31.7757009345794, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI24642142, Length=240, Percent_Identity=35.8333333333333, Blast_Score=105, Evalue=6e-23,
Organism=Drosophila melanogaster, GI24642144, Length=240, Percent_Identity=35.8333333333333, Blast_Score=105, Evalue=6e-23,
Organism=Drosophila melanogaster, GI281360899, Length=240, Percent_Identity=35.8333333333333, Blast_Score=105, Evalue=6e-23,
Organism=Drosophila melanogaster, GI24642146, Length=240, Percent_Identity=35.8333333333333, Blast_Score=104, Evalue=7e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000286 [H]

Pfam domain/function: PF00850 Hist_deacetyl [H]

EC number: NA

Molecular weight: Translated: 37274; Mature: 37274

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTYFHPDQLKHSPLTYLSRGKMRAPHEVPERAVRLLGAVTSLGFDVRAPEDFGAAPLAA
CCCCCCHHHCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHH
VHSEPYLRFLADAHREWRRIPEDWGPEVMSNIYVREPNPLRGVLAQAGYYLADGSCPIGE
HCCCHHHHHHHHHHHHHHCCCCCCCHHHHHCEEEECCCHHHHHHHHCCEEEECCCCCCCC
HTYRAAYWSAQSALAGAAALGRGARDAYALCRPPGHHACRDAAGGFCYLNNAAIAAQALR
CHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCHHHHHCCCCEEEECCHHHHHHHHH
ARHARVAILDTDMHHGQGIQTLFYDRDDVLYVSIHGDPTNFYPAVTGYETERGAGRGEGF
HHCCEEEEEECCCCCCCCCEEEEECCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCE
NVNLPMPHGSPEAVFIAQLERARSCVERFAPDVLVFALGFDVYREDPQSKVAVTTEGFGR
EEEECCCCCCCCEEHHHHHHHHHHHHHHHCCHHEEHHHHHHHHHCCCCCEEEEEECCHHH
LGALVGGLRVPTLIVQEGGYHLETLERNAAALFRSYEAAR
HHHHHCCCCCCEEEEECCCCEEHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLTYFHPDQLKHSPLTYLSRGKMRAPHEVPERAVRLLGAVTSLGFDVRAPEDFGAAPLAA
CCCCCCHHHCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHH
VHSEPYLRFLADAHREWRRIPEDWGPEVMSNIYVREPNPLRGVLAQAGYYLADGSCPIGE
HCCCHHHHHHHHHHHHHHCCCCCCCHHHHHCEEEECCCHHHHHHHHCCEEEECCCCCCCC
HTYRAAYWSAQSALAGAAALGRGARDAYALCRPPGHHACRDAAGGFCYLNNAAIAAQALR
CHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCHHHHHCCCCEEEECCHHHHHHHHH
ARHARVAILDTDMHHGQGIQTLFYDRDDVLYVSIHGDPTNFYPAVTGYETERGAGRGEGF
HHCCEEEEEECCCCCCCCCEEEEECCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCE
NVNLPMPHGSPEAVFIAQLERARSCVERFAPDVLVFALGFDVYREDPQSKVAVTTEGFGR
EEEECCCCCCCCEEHHHHHHHHHHHHHHHCCHHEEHHHHHHHHHCCCCCEEEEEECCHHH
LGALVGGLRVPTLIVQEGGYHLETLERNAAALFRSYEAAR
HHHHHCCCCCCEEEEECCCCEEHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8824626; 3207420 [H]