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The map label for this gene is udg [H]

Identifier: 126444725

GI number: 126444725

Start: 2520254

End: 2521675

Strand: Reverse

Name: udg [H]

Synonym: BURPS668_A2622

Alternate gene names: 126444725

Gene position: 2521675-2520254 (Counterclockwise)

Preceding gene: 126443720

Following gene: 126444661

Centisome position: 80.63

GC content: 68.78

Gene sequence:

>1422_bases
ATGAATCTGACTATCATCGGCAGCGGTTATGTAGGGCTCGTCACCGGCGCGTGTCTCGCGGACATCGGCCACGACGTGTT
CTGTCTCGACGTCGACAGCAAGAAGATCGACGTCCTGAACAACGGCGGCGTGCCGATTCACGAGCCGGGGCTCGGGGAGA
TCATCGCGCGCAACCGCGCGGCGGGCCGCCTGCAGTTCTCGACCGATGTCGAGGCGGCCGTCGCGCACGGCGACGTGCAG
TTCATCGCGGTCGGCACGCCGCCCGACGAGGACGGCTCCGCGGACCTGCAGTACGTGCTTGCCGCGGCGCGCAACATCGG
CCGCCACATGAACGGGTTCAAGGTGATCGTCGACAAGTCGACGGTGCCCGTCGGCACGGCCGAGCGTGTGCGCGCGGCGG
TCGCGGACGAGCTGAAGGCGCGCGGCGAGGATTCGATGTTCTCGGTCGTGTCGAACCCCGAGTTCCTGAAGGAGGGGGCG
GCCGTCGAGGATTTCACGCGGCCCGACCGGATCGTGATCGGCTGCGACGACGACGTGCCCGGCGAGCGCGCGCGCGAGCT
GATGAAGAAGCTCTATGCGCCGTTCAATCGCAATCACGAACGCACGCTCTACATGGACGTGCGCTCGGCCGAGTTCACGA
AGTATGCGGCGAACGCGATGCTCGCGACGCGCATCTCTTTCATGAACGAGCTCGCGAATCTCGCGGAGCGCTTCGGCGCG
GACATCGAGGCGGTGCGGCGCGGAATCGGCTCCGATCCGCGCATCGGCTATCACTTCCTGTACGCGGGCTGCGGCTACGG
CGGCTCGTGCTTTCCGAAGGACGTCGAAGCGCTGATCCGCACGGCGGCCGAGCATGGGCAGGCGCTGCGCGTGCTGCAGG
CGGTGTCCGCCGTCAACGACGAGCAAAAGCACGTGCTCGCGAGGAAAGTCGTCGCGCGCTTCGGCGGCGATCTGACGGGC
CGGCGCTTCGGCGTGTGGGGGCTCGCGTTCAAGCCGAACACCGACGACATGCGCGAAGCGCCGAGCCGCGCGCTGATTGC
GGCGCTGCTGTCGCGCGGCGCGCACGTCGTCGCCTACGATCCGGTCGCGCAGGACGAAGCGCGGCGCGTGCTCGCGATCG
ATCTGGGCGAGTGCCCGGATGCGCTCGGGCGGCTCTCGTTCGCCGACGACGAGGCGCAGGTGGCGCAGGACGCGGACGCG
CTCGTGATCGTCACCGAATGGAAGGCGTTCAAGAGTCCGGATTTCGCGGCGCTCGGCAAGCGCTGGAAAACACCCGTGAT
TTTCGACGGACGCAATCTGTACGAGCCGATCGCGATGCGCGAGCTCGGCATCGAGTACTACCCGATCGGGCGGCCCGGCG
CGGCGCCGCGCACGGCGGCGGGCGAGTCCGACGCCGCTCGCGCCGCGCGCGTCGGCGCGTGA

Upstream 100 bases:

>100_bases
CAAGATCGTCGCGCTGACGTTGTGGAAAGGCTTCACCGGCAGCAACGCGTACTGAGCGCGGTCATGCGCTTACGACTCAC
TGGGTAAAGAGGTTCGACAG

Downstream 100 bases:

>100_bases
GCGGGCCGCCATGGGTTCGAGCATGTTTCGCAACATTCTGATCGTATGCCGCGCGAACGTGTGCCGCAGCCCGGCCGCGG
AGTTGCTGTTCAGGTCGATG

Product: UDP-glucose 6-dehydrogenase

Products: NA

Alternate protein names: UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH [H]

Number of amino acids: Translated: 473; Mature: 473

Protein sequence:

>473_residues
MNLTIIGSGYVGLVTGACLADIGHDVFCLDVDSKKIDVLNNGGVPIHEPGLGEIIARNRAAGRLQFSTDVEAAVAHGDVQ
FIAVGTPPDEDGSADLQYVLAAARNIGRHMNGFKVIVDKSTVPVGTAERVRAAVADELKARGEDSMFSVVSNPEFLKEGA
AVEDFTRPDRIVIGCDDDVPGERARELMKKLYAPFNRNHERTLYMDVRSAEFTKYAANAMLATRISFMNELANLAERFGA
DIEAVRRGIGSDPRIGYHFLYAGCGYGGSCFPKDVEALIRTAAEHGQALRVLQAVSAVNDEQKHVLARKVVARFGGDLTG
RRFGVWGLAFKPNTDDMREAPSRALIAALLSRGAHVVAYDPVAQDEARRVLAIDLGECPDALGRLSFADDEAQVAQDADA
LVIVTEWKAFKSPDFAALGKRWKTPVIFDGRNLYEPIAMRELGIEYYPIGRPGAAPRTAAGESDAARAARVGA

Sequences:

>Translated_473_residues
MNLTIIGSGYVGLVTGACLADIGHDVFCLDVDSKKIDVLNNGGVPIHEPGLGEIIARNRAAGRLQFSTDVEAAVAHGDVQ
FIAVGTPPDEDGSADLQYVLAAARNIGRHMNGFKVIVDKSTVPVGTAERVRAAVADELKARGEDSMFSVVSNPEFLKEGA
AVEDFTRPDRIVIGCDDDVPGERARELMKKLYAPFNRNHERTLYMDVRSAEFTKYAANAMLATRISFMNELANLAERFGA
DIEAVRRGIGSDPRIGYHFLYAGCGYGGSCFPKDVEALIRTAAEHGQALRVLQAVSAVNDEQKHVLARKVVARFGGDLTG
RRFGVWGLAFKPNTDDMREAPSRALIAALLSRGAHVVAYDPVAQDEARRVLAIDLGECPDALGRLSFADDEAQVAQDADA
LVIVTEWKAFKSPDFAALGKRWKTPVIFDGRNLYEPIAMRELGIEYYPIGRPGAAPRTAAGESDAARAARVGA
>Mature_473_residues
MNLTIIGSGYVGLVTGACLADIGHDVFCLDVDSKKIDVLNNGGVPIHEPGLGEIIARNRAAGRLQFSTDVEAAVAHGDVQ
FIAVGTPPDEDGSADLQYVLAAARNIGRHMNGFKVIVDKSTVPVGTAERVRAAVADELKARGEDSMFSVVSNPEFLKEGA
AVEDFTRPDRIVIGCDDDVPGERARELMKKLYAPFNRNHERTLYMDVRSAEFTKYAANAMLATRISFMNELANLAERFGA
DIEAVRRGIGSDPRIGYHFLYAGCGYGGSCFPKDVEALIRTAAEHGQALRVLQAVSAVNDEQKHVLARKVVARFGGDLTG
RRFGVWGLAFKPNTDDMREAPSRALIAALLSRGAHVVAYDPVAQDEARRVLAIDLGECPDALGRLSFADDEAQVAQDADA
LVIVTEWKAFKSPDFAALGKRWKTPVIFDGRNLYEPIAMRELGIEYYPIGRPGAAPRTAAGESDAARAARVGA

Specific function: Unknown

COG id: COG1004

COG function: function code M; Predicted UDP-glucose 6-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=473, Percent_Identity=35.9408033826639, Blast_Score=268, Evalue=7e-72,
Organism=Homo sapiens, GI296040438, Length=375, Percent_Identity=36.2666666666667, Blast_Score=219, Evalue=4e-57,
Organism=Homo sapiens, GI296040443, Length=323, Percent_Identity=36.2229102167183, Blast_Score=187, Evalue=2e-47,
Organism=Escherichia coli, GI1788340, Length=370, Percent_Identity=29.1891891891892, Blast_Score=158, Evalue=7e-40,
Organism=Escherichia coli, GI48994968, Length=426, Percent_Identity=27.9342723004695, Blast_Score=133, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI17560350, Length=464, Percent_Identity=34.9137931034483, Blast_Score=258, Evalue=5e-69,
Organism=Drosophila melanogaster, GI17136908, Length=465, Percent_Identity=34.8387096774194, Blast_Score=250, Evalue=1e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR021157
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: =1.1.1.22 [H]

Molecular weight: Translated: 51030; Mature: 51030

Theoretical pI: Translated: 5.53; Mature: 5.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLTIIGSGYVGLVTGACLADIGHDVFCLDVDSKKIDVLNNGGVPIHEPGLGEIIARNRA
CEEEEEECCHHHHHHHHHHHHCCCCEEEEECCCCEEEEECCCCCCCCCCCCHHHHHCCCC
AGRLQFSTDVEAAVAHGDVQFIAVGTPPDEDGSADLQYVLAAARNIGRHMNGFKVIVDKS
CCEEEECCCHHHHEECCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECC
TVPVGTAERVRAAVADELKARGEDSMFSVVSNPEFLKEGAAVEDFTRPDRIVIGCDDDVP
CCCCCCHHHHHHHHHHHHHHCCCCCCEEECCCHHHHHCCCCHHHCCCCCEEEEECCCCCC
GERARELMKKLYAPFNRNHERTLYMDVRSAEFTKYAANAMLATRISFMNELANLAERFGA
HHHHHHHHHHHCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DIEAVRRGIGSDPRIGYHFLYAGCGYGGSCFPKDVEALIRTAAEHGQALRVLQAVSAVND
CHHHHHHCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
EQKHVLARKVVARFGGDLTGRRFGVWGLAFKPNTDDMREAPSRALIAALLSRGAHVVAYD
HHHHHHHHHHHHHHCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCEEEEEC
PVAQDEARRVLAIDLGECPDALGRLSFADDEAQVAQDADALVIVTEWKAFKSPDFAALGK
CCCCCCCCEEEEEECCCCHHHHCCCCCCCCHHHHHCCCCEEEEEEECCCCCCCCHHHHHH
RWKTPVIFDGRNLYEPIAMRELGIEYYPIGRPGAAPRTAAGESDAARAARVGA
CCCCCEEECCCCHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCHHHHHHHCCC
>Mature Secondary Structure
MNLTIIGSGYVGLVTGACLADIGHDVFCLDVDSKKIDVLNNGGVPIHEPGLGEIIARNRA
CEEEEEECCHHHHHHHHHHHHCCCCEEEEECCCCEEEEECCCCCCCCCCCCHHHHHCCCC
AGRLQFSTDVEAAVAHGDVQFIAVGTPPDEDGSADLQYVLAAARNIGRHMNGFKVIVDKS
CCEEEECCCHHHHEECCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECC
TVPVGTAERVRAAVADELKARGEDSMFSVVSNPEFLKEGAAVEDFTRPDRIVIGCDDDVP
CCCCCCHHHHHHHHHHHHHHCCCCCCEEECCCHHHHHCCCCHHHCCCCCEEEEECCCCCC
GERARELMKKLYAPFNRNHERTLYMDVRSAEFTKYAANAMLATRISFMNELANLAERFGA
HHHHHHHHHHHCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DIEAVRRGIGSDPRIGYHFLYAGCGYGGSCFPKDVEALIRTAAEHGQALRVLQAVSAVND
CHHHHHHCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
EQKHVLARKVVARFGGDLTGRRFGVWGLAFKPNTDDMREAPSRALIAALLSRGAHVVAYD
HHHHHHHHHHHHHHCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCEEEEEC
PVAQDEARRVLAIDLGECPDALGRLSFADDEAQVAQDADALVIVTEWKAFKSPDFAALGK
CCCCCCCCEEEEEECCCCHHHHCCCCCCCCHHHHHCCCCEEEEEEECCCCCCCCHHHHHH
RWKTPVIFDGRNLYEPIAMRELGIEYYPIGRPGAAPRTAAGESDAARAARVGA
CCCCCEEECCCCHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]