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The map label for this gene is fabD [H]

Identifier: 126444543

GI number: 126444543

Start: 1371852

End: 1373165

Strand: Reverse

Name: fabD [H]

Synonym: BURPS668_A1475

Alternate gene names: 126444543

Gene position: 1373165-1371852 (Counterclockwise)

Preceding gene: 126445270

Following gene: 126445245

Centisome position: 43.91

GC content: 69.86

Gene sequence:

>1314_bases
GTGCGCTTCGCGCGCGCCTGCGGCCGTCGACCGGCCGTCGACCGACGCGGGCAATCGACGCGGGAACGGTCCGCTTCGCA
CGGCGCGCCGCCGGCTGGGCCCGCATTGACCGATGCGCGACGCGCGGGAGGCGAGATGCTGAATACTTTCATGTTTCCGG
GCCAAGGTTCGCAAGCGAAGGGAATGGGCGGCGCCCTGTTCGATCGCTTCGCCGATCTCACCGCGCAGGCCGACGCCGTG
CTCGGTTATTCGATCCGCACGCTGTGCGTCGACGATCCGCGCGACGAGCTCGGCCGCACGCAATTCACGCAGCCGGCGCT
ATACGTCGTCAATGCCTTGACGTACTACGCGAAATGCGAGGACAGCGGCGAGACGCCCGATTTTCTCGCCGGCCACAGCC
TGGGCGAATTCAACGCGCTGCTCGCGGCGGGCTGCTTCGACTTCGAGACCGGCCTGAAGCTCGTCGCCCGGCGCGCAGAG
TTGATGAGCCAGGCCCGCGACGGCGCGATGGCCGCGATCGTCAACGCGAGCCGCGAGCAGATCGAGCGCACGCTCGACGA
GCACGGCCTCGTCGATACCGCGATCGCGAACGACAACACGCCGTCACAACTCGTCATCTCCGGCCCGGCCCACGAAATCG
CGCGGGCCGAGGCGCTGTTCCAGCACGATCGGGTGCGGTATCTGCGGCTCAATACCAGCGGCGCGTTCCACTCGAAATTC
ATGCGGCCCGCGCAGCAGGCGTTCGCCGCGCATCTACAGTCGTTCCGGCTCGCGGACCCGGCGATCCCGGTGATCTCGAA
CGTATCGGCGCGCCCTTACGAGAACGGCCGCGTGAGCGAAGGGCTCGCGCAGCAGATCGCAAGCCCGGTGCGATGGTGCG
AGAGCATTCGCTATCTGCTCGCGCTGGCCGCCGGGCGCGGAGAAGCGATCGAATTCACCGAGCTCGGACACGGCGACGTA
CTGACACGGCTCGTCCATACGATCCGGCGGCAGACACCGGCGCCGGCGGCGGCCCCGGCGGCGGCCGCGACGCCGGCGCG
CGCTCGCCCGACGCCGCCCGGCGAGCCCGAGCGGCCCGCGCAGCAGACGGCGGCCGCGCCGCGCGCATCCGACTCCGCAT
CGCTCGGCGCGGCCGAACGGGTCGCCGCGTGGAATCGGGACTACCCCGTCGGCACCCGCGTTCGCTCGTCGCTGATACAC
GACGACGTTCTCGAAACGCGGACCCCGGCAACCGTGCTGTTCGGCCACCGCGCCGCGGTGTACATGAAGGGCTACAACGG
CTACTTCGATCTCGCCGAAGTGACGCCCGCCTGA

Upstream 100 bases:

>100_bases
GTTTTTCTATTCCAAGTTTCGCCGCCGCTGAAACGCCTGCCGCCTCGCCTTGCTATAGTGCGTTCGACCCCGGCGAGTCG
CGCATCCGGCCGCGGCGCAC

Downstream 100 bases:

>100_bases
GCGCGCGACGCGCGCCCGAAGCCGGCGCGCCTCAACGTCGCCGCCCCGCCGGTCGCGCCGCGCCCTCGGAAACGGGCGCG
GCCGTTGGCGCGCGCGGCAG

Product: malonyl CoA-acyl carrier protein transacylase

Products: NA

Alternate protein names: Malonyl CoA-acyl carrier protein transacylase; MCT [H]

Number of amino acids: Translated: 437; Mature: 437

Protein sequence:

>437_residues
MRFARACGRRPAVDRRGQSTRERSASHGAPPAGPALTDARRAGGEMLNTFMFPGQGSQAKGMGGALFDRFADLTAQADAV
LGYSIRTLCVDDPRDELGRTQFTQPALYVVNALTYYAKCEDSGETPDFLAGHSLGEFNALLAAGCFDFETGLKLVARRAE
LMSQARDGAMAAIVNASREQIERTLDEHGLVDTAIANDNTPSQLVISGPAHEIARAEALFQHDRVRYLRLNTSGAFHSKF
MRPAQQAFAAHLQSFRLADPAIPVISNVSARPYENGRVSEGLAQQIASPVRWCESIRYLLALAAGRGEAIEFTELGHGDV
LTRLVHTIRRQTPAPAAAPAAAATPARARPTPPGEPERPAQQTAAAPRASDSASLGAAERVAAWNRDYPVGTRVRSSLIH
DDVLETRTPATVLFGHRAAVYMKGYNGYFDLAEVTPA

Sequences:

>Translated_437_residues
MRFARACGRRPAVDRRGQSTRERSASHGAPPAGPALTDARRAGGEMLNTFMFPGQGSQAKGMGGALFDRFADLTAQADAV
LGYSIRTLCVDDPRDELGRTQFTQPALYVVNALTYYAKCEDSGETPDFLAGHSLGEFNALLAAGCFDFETGLKLVARRAE
LMSQARDGAMAAIVNASREQIERTLDEHGLVDTAIANDNTPSQLVISGPAHEIARAEALFQHDRVRYLRLNTSGAFHSKF
MRPAQQAFAAHLQSFRLADPAIPVISNVSARPYENGRVSEGLAQQIASPVRWCESIRYLLALAAGRGEAIEFTELGHGDV
LTRLVHTIRRQTPAPAAAPAAAATPARARPTPPGEPERPAQQTAAAPRASDSASLGAAERVAAWNRDYPVGTRVRSSLIH
DDVLETRTPATVLFGHRAAVYMKGYNGYFDLAEVTPA
>Mature_437_residues
MRFARACGRRPAVDRRGQSTRERSASHGAPPAGPALTDARRAGGEMLNTFMFPGQGSQAKGMGGALFDRFADLTAQADAV
LGYSIRTLCVDDPRDELGRTQFTQPALYVVNALTYYAKCEDSGETPDFLAGHSLGEFNALLAAGCFDFETGLKLVARRAE
LMSQARDGAMAAIVNASREQIERTLDEHGLVDTAIANDNTPSQLVISGPAHEIARAEALFQHDRVRYLRLNTSGAFHSKF
MRPAQQAFAAHLQSFRLADPAIPVISNVSARPYENGRVSEGLAQQIASPVRWCESIRYLLALAAGRGEAIEFTELGHGDV
LTRLVHTIRRQTPAPAAAPAAAATPARARPTPPGEPERPAQQTAAAPRASDSASLGAAERVAAWNRDYPVGTRVRSSLIH
DDVLETRTPATVLFGHRAAVYMKGYNGYFDLAEVTPA

Specific function: Probably involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism. Probably has an acyl transferase activity and could also have a flavin mononucleotide-dependent oxidoreductas

COG id: COG0331

COG function: function code I; (acyl-carrier-protein) S-malonyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the N-terminal section; belongs to the fabD family [H]

Homologues:

Organism=Homo sapiens, GI51243059, Length=329, Percent_Identity=31.6109422492401, Blast_Score=125, Evalue=9e-29,
Organism=Homo sapiens, GI27477045, Length=129, Percent_Identity=37.984496124031, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI1787334, Length=290, Percent_Identity=34.4827586206897, Blast_Score=146, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI71984332, Length=297, Percent_Identity=29.6296296296296, Blast_Score=98, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI17550940, Length=171, Percent_Identity=30.4093567251462, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24665753, Length=306, Percent_Identity=31.0457516339869, Blast_Score=114, Evalue=1e-25,

Paralogues:

None

Copy number: 500 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004136
- InterPro:   IPR001227
- InterPro:   IPR014043
- InterPro:   IPR016035
- InterPro:   IPR013785
- InterPro:   IPR004410
- InterPro:   IPR016036
- InterPro:   IPR014179 [H]

Pfam domain/function: PF00698 Acyl_transf_1; PF03060 NPD [H]

EC number: =2.3.1.39 [H]

Molecular weight: Translated: 47035; Mature: 47035

Theoretical pI: Translated: 7.96; Mature: 7.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFARACGRRPAVDRRGQSTRERSASHGAPPAGPALTDARRAGGEMLNTFMFPGQGSQAK
CCCHHHHCCCCCCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCC
GMGGALFDRFADLTAQADAVLGYSIRTLCVDDPRDELGRTQFTQPALYVVNALTYYAKCE
CCCHHHHHHHHHHHHHHHHHHCCEEEEEECCCCHHHHCCCCCCCHHHHHHHHHHHHHCCC
DSGETPDFLAGHSLGEFNALLAAGCFDFETGLKLVARRAELMSQARDGAMAAIVNASREQ
CCCCCCCHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
IERTLDEHGLVDTAIANDNTPSQLVISGPAHEIARAEALFQHDRVRYLRLNTSGAFHSKF
HHHHHHHCCCEEEEECCCCCCCEEEEECCHHHHHHHHHHHHHCCEEEEEEECCCHHHHHH
MRPAQQAFAAHLQSFRLADPAIPVISNVSARPYENGRVSEGLAQQIASPVRWCESIRYLL
HHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
ALAAGRGEAIEFTELGHGDVLTRLVHTIRRQTPAPAAAPAAAATPARARPTPPGEPERPA
HHHCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCHHCCCCCCCCCCCCCCCCCH
QQTAAAPRASDSASLGAAERVAAWNRDYPVGTRVRSSLIHDDVLETRTPATVLFGHRAAV
HHHHCCCCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCEEE
YMKGYNGYFDLAEVTPA
EEECCCCEEECCCCCCC
>Mature Secondary Structure
MRFARACGRRPAVDRRGQSTRERSASHGAPPAGPALTDARRAGGEMLNTFMFPGQGSQAK
CCCHHHHCCCCCCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCC
GMGGALFDRFADLTAQADAVLGYSIRTLCVDDPRDELGRTQFTQPALYVVNALTYYAKCE
CCCHHHHHHHHHHHHHHHHHHCCEEEEEECCCCHHHHCCCCCCCHHHHHHHHHHHHHCCC
DSGETPDFLAGHSLGEFNALLAAGCFDFETGLKLVARRAELMSQARDGAMAAIVNASREQ
CCCCCCCHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
IERTLDEHGLVDTAIANDNTPSQLVISGPAHEIARAEALFQHDRVRYLRLNTSGAFHSKF
HHHHHHHCCCEEEEECCCCCCCEEEEECCHHHHHHHHHHHHHCCEEEEEEECCCHHHHHH
MRPAQQAFAAHLQSFRLADPAIPVISNVSARPYENGRVSEGLAQQIASPVRWCESIRYLL
HHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
ALAAGRGEAIEFTELGHGDVLTRLVHTIRRQTPAPAAAPAAAATPARARPTPPGEPERPA
HHHCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCHHCCCCCCCCCCCCCCCCCH
QQTAAAPRASDSASLGAAERVAAWNRDYPVGTRVRSSLIHDDVLETRTPATVLFGHRAAV
HHHHCCCCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCEEE
YMKGYNGYFDLAEVTPA
EEECCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]