Click here to switch to the map view.

The map label for this gene is sicA [H]

Identifier: 126444531

GI number: 126444531

Start: 2101122

End: 2101637

Strand: Reverse

Name: sicA [H]

Synonym: BURPS668_A2163

Alternate gene names: 126444531

Gene position: 2101637-2101122 (Counterclockwise)

Preceding gene: 126443467

Following gene: 126443663

Centisome position: 67.2

GC content: 65.5

Gene sequence:

>516_bases
ATGACGCAACGCGACGTGAACATAGACGACATCGAGGCGCAGGAAATGGCGGCGGCGCTGCTGGACGCGGTCCAGAACGG
CGCGACGCTGAAGGACCTGCATCAGGTGCCGCAGGACCTGATGGACGGCATCTATGCGTTCGCGTACCGCTTCTACCAGC
AGGGGCGGCTCGACGACGCGGAGGTGTTCTTCCGCTTTCTGTGCATCTACGACTTCTACAACGCCGAATACGCGATGGGG
CTCGCGGCGGTGTGCCAGTTGAAGAAGGAGTACGCGCGGGCGATCGATCTGTATGCACTCGCGTATTCGCTGTCGAAGGA
CGACCACCGGCCGATGTTCCACACCGGCCAATGCCATCTGCTGATGGGCAAGGCGGCGCTCGCGCGGCGCTGCTTCGGCA
TCGTCGCCGAGCGCTCGCGCGACGAGCGCCTCGCGCAGAAGGCGCAGTCCTATCTCGACGGGCTCGACGAAGTGGGCGCC
GACGCGGCGCCCGCATCCGCCGGGAACGACCACTAG

Upstream 100 bases:

>100_bases
ATTTTCCCCGGCGCGCGGCGCGTAATGTGACAACCGTCATTCGACGGCACCGCAACGCGCCGACATCCATGTGACTGAAG
GAACCAAACGAGGTGACGGC

Downstream 100 bases:

>100_bases
CCAACAGGAGCTGATCGTATGTCATCGGGAGTGCAGGGCGGACCGGCCGCCCACGCGAACGCTTACCAGACCCATCCGCT
GCGCGACGCGGCGAGCGCGC

Product: type III secretion, low calcium response chaperone LcrH/SycD

Products: NA

Alternate protein names: Salmonella invasin chaperone [H]

Number of amino acids: Translated: 171; Mature: 170

Protein sequence:

>171_residues
MTQRDVNIDDIEAQEMAAALLDAVQNGATLKDLHQVPQDLMDGIYAFAYRFYQQGRLDDAEVFFRFLCIYDFYNAEYAMG
LAAVCQLKKEYARAIDLYALAYSLSKDDHRPMFHTGQCHLLMGKAALARRCFGIVAERSRDERLAQKAQSYLDGLDEVGA
DAAPASAGNDH

Sequences:

>Translated_171_residues
MTQRDVNIDDIEAQEMAAALLDAVQNGATLKDLHQVPQDLMDGIYAFAYRFYQQGRLDDAEVFFRFLCIYDFYNAEYAMG
LAAVCQLKKEYARAIDLYALAYSLSKDDHRPMFHTGQCHLLMGKAALARRCFGIVAERSRDERLAQKAQSYLDGLDEVGA
DAAPASAGNDH
>Mature_170_residues
TQRDVNIDDIEAQEMAAALLDAVQNGATLKDLHQVPQDLMDGIYAFAYRFYQQGRLDDAEVFFRFLCIYDFYNAEYAMGL
AAVCQLKKEYARAIDLYALAYSLSKDDHRPMFHTGQCHLLMGKAALARRCFGIVAERSRDERLAQKAQSYLDGLDEVGAD
AAPASAGNDH

Specific function: Type III secretion-associated chaperone required for sipB and sipC stabilization. Prevents premature association of sipB with sipC, which may lead to their targeting for degradation. Along with invF, required for transcription activation of sigDE (sopB pi

COG id: COG0457

COG function: function code R; FOG: TPR repeat

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lcrH/sycD chaperone family [H]

Homologues:

Organism=Escherichia coli, GI1789215, Length=150, Percent_Identity=36.6666666666667, Blast_Score=110, Evalue=4e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005415
- InterPro:   IPR016379
- InterPro:   IPR011716
- InterPro:   IPR011990 [H]

Pfam domain/function: PF07720 TPR_3 [H]

EC number: NA

Molecular weight: Translated: 19171; Mature: 19040

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQRDVNIDDIEAQEMAAALLDAVQNGATLKDLHQVPQDLMDGIYAFAYRFYQQGRLDDA
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
EVFFRFLCIYDFYNAEYAMGLAAVCQLKKEYARAIDLYALAYSLSKDDHRPMFHTGQCHL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCHHH
LMGKAALARRCFGIVAERSRDERLAQKAQSYLDGLDEVGADAAPASAGNDH
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
TQRDVNIDDIEAQEMAAALLDAVQNGATLKDLHQVPQDLMDGIYAFAYRFYQQGRLDDA
CCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
EVFFRFLCIYDFYNAEYAMGLAAVCQLKKEYARAIDLYALAYSLSKDDHRPMFHTGQCHL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCHHH
LMGKAALARRCFGIVAERSRDERLAQKAQSYLDGLDEVGADAAPASAGNDH
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA