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The map label for this gene is lgrB [H]

Identifier: 126443980

GI number: 126443980

Start: 1576949

End: 1580425

Strand: Reverse

Name: lgrB [H]

Synonym: BURPS668_A1646

Alternate gene names: 126443980

Gene position: 1580425-1576949 (Counterclockwise)

Preceding gene: 126443958

Following gene: 126443101

Centisome position: 50.53

GC content: 70.2

Gene sequence:

>3477_bases
ATGACCCAATCTGTTTTCGCCCGGTTCGAGCAAGTGTGCCGCAGCAATGCGCAAGCGGTCGCGCTGGAGAGCGCCGAGCA
CCGTCTCACGTACGCGCAGCTGCATGACCGGGTCGCGTCGATCGGCGCGCGTCTCGCCGCGGCGGGCGTCACGCCCGGCA
CGCTGCTCGGCATCTTCCTGCCGCGCGACGTGCGGCTGCCGGCCGCGCTCCTGGCGTCGCTCGGAAGCGGCGCCGTATAC
GTGCCGCTCACCGAGAAGTATCCGCCCGAGCGCCTGCGCGAGATCATCGAGACGCACGGCATCGAGCACGTCGTCACGAC
CGAGGCGCTCGCCTCGCAGTTGCCCGCGTCGTGCGGCAAGATCGTGCTGCCCGCCGAGGGTTCGGAGACGGCCGGCCCGC
GGCCCGCCGGCGAGCGCGCCGACTGGCGGCCCGCGGGCGAGCGGGCGCGGAACGCGCCCGTCTACGTCGTGTTCACGTCC
GGCTCGACGGGCACGCCGAAGGGCGTGCTGATCGGCGAGCGCAATCTCGGCAATCTGATCGACTGGTACGCGGCGTCCTT
TAGCGCCGAGCAGCGGCGCTCGGTGCTCGCGTCGACGCAGATCACGTTCGACCTGTCGGTGTTCGAGCTGATCTGCACGC
TCTGCACGGGCAGCAAGGTCGTGATCGTCGAGAACGTGCTGCAGTTGCTCGACGAAGGCGCGCCGTGCGACGTGAGCCTG
ATCAACACGGTGCCGTCGGCGGCGCGCGAGCTGGTGCGCCACCGCAAGTTCCCGGCGGCCGCGCGCGTCGTGAATCTGGC
GGGCGAGGCGCTGTATCAGGATCTCGTCGACGACATCTACGAGGCCGCGCCGCAGCTCGAGCAGGTGTTCAATCTGTACG
GCCCGTCCGAGGACACGACGTACTCGACGGGCCATGCGGTGCCGCGCGGCGGCGCGAGCCGCACGGTCAGCATCGGCCGC
TCGCTGCCGGGCAAGCGTGCGCACATCCTGTCCGACGCGCTCACGCCCGTCGCGCCGGGCGAGGTCGGCGAAATCTGCCT
GAGCGGCGAAGGCGTCGCGCTCGGCTATCTGAACGACGCGACGCTGACGGCCGAGAAATTTCCGACGATCGGGCACGGCC
CGCTCGCCGGCGAGCGTATCTACCGCACGGGCGACCTCGGCAGCATCGACGGCGACGGCCTGCTGCGCTATCTCGGGCGC
GCGGACCGGCAGGTGAAGGTGCGCGGCGTGCGCATCGAGCCCGGCGAGGTCGAGGTCGCGCTGCGCAGCATCGACGGCAT
CGCGGATGCGGCGGTGGTGAAGATCGCCGATGCGGCGAACAACGATCAGCTCGTCGCGCTCGTGGTCGCGCAGCCGTCGT
GCCCGGCCGAGCATGCGATCCTGGACCGGCTGCAGGCGCTGATCCCGGCGTTCATGGTGCCCTCGCGCGTCGAGCGCATC
GACGCGATCCCGCTGAACGGCAACGGCAAGACCGATCGCACGAAGCTCGAGCAGATCGCCGGCGCGCTGTTCGGCGCGGC
GCCGCCCGCCGACGACATCCAGGCGCGCGTCGCGCAGATCGTCGCCAAGCTGATGTCTCGAACCGACGTGGCGGCCGATG
CCGATTTCTTTCGGATCGGCGGCAACTCGCTGCTGAGCGCGCAGCTCACGTTCATGCTGCAGAAGCAGTTCTCGGTGACG
CTCAGCATTGCCGACGTGTTTCGCCATCGGACGATCGACGCGCTCGCGGCGATCATTCGCGAACGAACCCACAAGGCCGC
GCAGACGGCGCCTGCGGCCGCCGGCCAACAGCCGGCGGCGGTGCGATCGACCTCCGGCGGCGCAGGCGCCGGGCAGCCGG
TGGTGTTCGCCACGCCCGCGCAACGCGGAATCTGGCTGCTCGAAAACAGCCCCGGCGGCCGGGCGGTGTCGAACGCGCCG
CTCGTGTTCGAGTATGCGGGCACGCTCGAGCGCGCGCTGCTCGAGCGGTGCGTGACGCAACTGCTCGAGCGCCACGCGAT
CCTGCGCAGCAACTATGTGTGGGAGGACGGCAGCCTGCGGATCAAGTGCAACGCGCCCGTGCCGTTTCGCGTCGAGACGG
TCGATCTCGGTTCGCTGGCGCCCGACGCCCAGCAGGCGAAGGCGCGCGAGCTGGTCGCGCGGGAGGCCATGCGCCCGTTC
GATCTGCGCCGCGATCCGATGCTGCGCGTGACCGACATCGCGTTCGGCGAGCGCGCGGGCCAACTGGTGTTCGTGTTCCA
TCACATCGCGGTCGACGATCGGGCGCTGAACATCGTGTTCTCCGAATTGCAGCGGCTCTACGCCGCGGGCGGCGACCCGG
CGGCGATCGGCGCCGCGCCGGCCCGGCAGTTCGCCGATTACGCGGCGGCGGTGCGCGAGGCGAGCGCGCGGCTCGGCGAG
CATCTCGATTACTGGCGGCACAAGCTGGCCGATTACCGCGGCGCGACGCCGTATCTGGTCGACCCGCAGGCGAAGCCCGC
CGCGCGCTTCGCCGGACGGCTGCACCTGCATCGCGTGGCGCGGCACGTGAGCCGGCAGCTCGACGCGGCCGCCGCGCGCC
GCGGGCTCACGCCGTTCGCGCTGTTCGCGGCCGCCGTGGCGTGCATCGTGCACCGGGCGTCCGGCAGCGACGACGTGACG
ATCGGCACGTTCTTCTCGAATCGCGATCATTTCCAGGACAACGATCTCGTCGGCTTCTTCGTCAACACGCTGCCGCTGCG
CGTGCGGATCGACGCCGGCTGGGACGTCGATCAGCTCGCGCAGGCGATGTCGGCGACGCTCGCGCAAGCGCATGCGCACC
GCGACGTGACGACCGAAGACGTGTTCGACGCGTTGCAGGCCAACAACGCGCTGCGCCGCGCGGCATTCCGCGTGATGGTC
AACCTCGAGCCGGAGCAGGCGGAGGTGCTGACGATGGGCGCGCTGAGCGCGCGCCGGATGCTGCTCGACCGGCATGTCGC
GAAGTACGACCTGCTGTTCTCGCTGCGCAAGGAGGACGGCGACTATCGCGTGCTCGTCGAATACAACACGGAGCTCTACG
ACGGCGACGTCATGGCGGGCGTCTGCGCCAATCTCGACCGCTCGCTCGCGGCGCTGACAGGCACGGCGAGCGAGCGGCTC
GACGCGATCGCGCTGCCGGATCCGCTCGAGCGCGGCGCGCCGGGCGATGCCGCCGCCGGCCCGGCCGACGCCGATGCGCC
GGCGGCCGCGGCGGCCGATATCGATCTGCGCGAGGTGGTGCGCGACATCTGGGCGAGCGAGGTCGGCCACCGGACGTTCG
GCGACGACGACAACTTCTTCGACATCGGCGGCAGCTCGCTCAAGATCATGACGGTCTACGAGAAGCTGTCGAACTTCCTG
AAGCGCCACGGCATCGAGAAGGAAATCGACATCGTCGACCTGTTCGAGCACGTGAGCGTCGCGGCGCTGACCGATTTCCT
CGGAGCCTTGATCGAACATGACGCAATCGCACAGTGA

Upstream 100 bases:

>100_bases
GGTCGAGCACATCGAAACGAAGCTGCTCGAGAAGGCCGCTCAGCTTGAAGTCAGCCAATAACGCCATGAACACGACTGTT
GAATTTGATGGAGCCCAGCC

Downstream 100 bases:

>100_bases
CACGGGCGCGCATGCGGCCGGCGCGCCGGAAGCCGGCCCGATGGACATCGCGATCGTCGGCCTGAGCGCGCGCGTGCCCG
GCGCGGGCGACGCCGACGCG

Product: putative non-ribosomal peptide synthase/polyketide synthase

Products: pyrophosphate; AMP; enterobactin; pyrophosphate; L-Seryl-AMP [C]

Alternate protein names: ATP-dependent alanine adenylase; AlaA; Alanine activase; ATP-dependent D-leucine adenylase; D-LeuA; D-leucine activase; Leucine racemase [ATP-hydrolyzing]; ATP-dependent alanine adenylase; AlaA; Alanine activase; ATP-dependent D-valine adenylase; D-ValA; D-valine activase; Valine racemase [ATP-hydrolyzing] [H]

Number of amino acids: Translated: 1158; Mature: 1157

Protein sequence:

>1158_residues
MTQSVFARFEQVCRSNAQAVALESAEHRLTYAQLHDRVASIGARLAAAGVTPGTLLGIFLPRDVRLPAALLASLGSGAVY
VPLTEKYPPERLREIIETHGIEHVVTTEALASQLPASCGKIVLPAEGSETAGPRPAGERADWRPAGERARNAPVYVVFTS
GSTGTPKGVLIGERNLGNLIDWYAASFSAEQRRSVLASTQITFDLSVFELICTLCTGSKVVIVENVLQLLDEGAPCDVSL
INTVPSAARELVRHRKFPAAARVVNLAGEALYQDLVDDIYEAAPQLEQVFNLYGPSEDTTYSTGHAVPRGGASRTVSIGR
SLPGKRAHILSDALTPVAPGEVGEICLSGEGVALGYLNDATLTAEKFPTIGHGPLAGERIYRTGDLGSIDGDGLLRYLGR
ADRQVKVRGVRIEPGEVEVALRSIDGIADAAVVKIADAANNDQLVALVVAQPSCPAEHAILDRLQALIPAFMVPSRVERI
DAIPLNGNGKTDRTKLEQIAGALFGAAPPADDIQARVAQIVAKLMSRTDVAADADFFRIGGNSLLSAQLTFMLQKQFSVT
LSIADVFRHRTIDALAAIIRERTHKAAQTAPAAAGQQPAAVRSTSGGAGAGQPVVFATPAQRGIWLLENSPGGRAVSNAP
LVFEYAGTLERALLERCVTQLLERHAILRSNYVWEDGSLRIKCNAPVPFRVETVDLGSLAPDAQQAKARELVAREAMRPF
DLRRDPMLRVTDIAFGERAGQLVFVFHHIAVDDRALNIVFSELQRLYAAGGDPAAIGAAPARQFADYAAAVREASARLGE
HLDYWRHKLADYRGATPYLVDPQAKPAARFAGRLHLHRVARHVSRQLDAAAARRGLTPFALFAAAVACIVHRASGSDDVT
IGTFFSNRDHFQDNDLVGFFVNTLPLRVRIDAGWDVDQLAQAMSATLAQAHAHRDVTTEDVFDALQANNALRRAAFRVMV
NLEPEQAEVLTMGALSARRMLLDRHVAKYDLLFSLRKEDGDYRVLVEYNTELYDGDVMAGVCANLDRSLAALTGTASERL
DAIALPDPLERGAPGDAAAGPADADAPAAAAADIDLREVVRDIWASEVGHRTFGDDDNFFDIGGSSLKIMTVYEKLSNFL
KRHGIEKEIDIVDLFEHVSVAALTDFLGALIEHDAIAQ

Sequences:

>Translated_1158_residues
MTQSVFARFEQVCRSNAQAVALESAEHRLTYAQLHDRVASIGARLAAAGVTPGTLLGIFLPRDVRLPAALLASLGSGAVY
VPLTEKYPPERLREIIETHGIEHVVTTEALASQLPASCGKIVLPAEGSETAGPRPAGERADWRPAGERARNAPVYVVFTS
GSTGTPKGVLIGERNLGNLIDWYAASFSAEQRRSVLASTQITFDLSVFELICTLCTGSKVVIVENVLQLLDEGAPCDVSL
INTVPSAARELVRHRKFPAAARVVNLAGEALYQDLVDDIYEAAPQLEQVFNLYGPSEDTTYSTGHAVPRGGASRTVSIGR
SLPGKRAHILSDALTPVAPGEVGEICLSGEGVALGYLNDATLTAEKFPTIGHGPLAGERIYRTGDLGSIDGDGLLRYLGR
ADRQVKVRGVRIEPGEVEVALRSIDGIADAAVVKIADAANNDQLVALVVAQPSCPAEHAILDRLQALIPAFMVPSRVERI
DAIPLNGNGKTDRTKLEQIAGALFGAAPPADDIQARVAQIVAKLMSRTDVAADADFFRIGGNSLLSAQLTFMLQKQFSVT
LSIADVFRHRTIDALAAIIRERTHKAAQTAPAAAGQQPAAVRSTSGGAGAGQPVVFATPAQRGIWLLENSPGGRAVSNAP
LVFEYAGTLERALLERCVTQLLERHAILRSNYVWEDGSLRIKCNAPVPFRVETVDLGSLAPDAQQAKARELVAREAMRPF
DLRRDPMLRVTDIAFGERAGQLVFVFHHIAVDDRALNIVFSELQRLYAAGGDPAAIGAAPARQFADYAAAVREASARLGE
HLDYWRHKLADYRGATPYLVDPQAKPAARFAGRLHLHRVARHVSRQLDAAAARRGLTPFALFAAAVACIVHRASGSDDVT
IGTFFSNRDHFQDNDLVGFFVNTLPLRVRIDAGWDVDQLAQAMSATLAQAHAHRDVTTEDVFDALQANNALRRAAFRVMV
NLEPEQAEVLTMGALSARRMLLDRHVAKYDLLFSLRKEDGDYRVLVEYNTELYDGDVMAGVCANLDRSLAALTGTASERL
DAIALPDPLERGAPGDAAAGPADADAPAAAAADIDLREVVRDIWASEVGHRTFGDDDNFFDIGGSSLKIMTVYEKLSNFL
KRHGIEKEIDIVDLFEHVSVAALTDFLGALIEHDAIAQ
>Mature_1157_residues
TQSVFARFEQVCRSNAQAVALESAEHRLTYAQLHDRVASIGARLAAAGVTPGTLLGIFLPRDVRLPAALLASLGSGAVYV
PLTEKYPPERLREIIETHGIEHVVTTEALASQLPASCGKIVLPAEGSETAGPRPAGERADWRPAGERARNAPVYVVFTSG
STGTPKGVLIGERNLGNLIDWYAASFSAEQRRSVLASTQITFDLSVFELICTLCTGSKVVIVENVLQLLDEGAPCDVSLI
NTVPSAARELVRHRKFPAAARVVNLAGEALYQDLVDDIYEAAPQLEQVFNLYGPSEDTTYSTGHAVPRGGASRTVSIGRS
LPGKRAHILSDALTPVAPGEVGEICLSGEGVALGYLNDATLTAEKFPTIGHGPLAGERIYRTGDLGSIDGDGLLRYLGRA
DRQVKVRGVRIEPGEVEVALRSIDGIADAAVVKIADAANNDQLVALVVAQPSCPAEHAILDRLQALIPAFMVPSRVERID
AIPLNGNGKTDRTKLEQIAGALFGAAPPADDIQARVAQIVAKLMSRTDVAADADFFRIGGNSLLSAQLTFMLQKQFSVTL
SIADVFRHRTIDALAAIIRERTHKAAQTAPAAAGQQPAAVRSTSGGAGAGQPVVFATPAQRGIWLLENSPGGRAVSNAPL
VFEYAGTLERALLERCVTQLLERHAILRSNYVWEDGSLRIKCNAPVPFRVETVDLGSLAPDAQQAKARELVAREAMRPFD
LRRDPMLRVTDIAFGERAGQLVFVFHHIAVDDRALNIVFSELQRLYAAGGDPAAIGAAPARQFADYAAAVREASARLGEH
LDYWRHKLADYRGATPYLVDPQAKPAARFAGRLHLHRVARHVSRQLDAAAARRGLTPFALFAAAVACIVHRASGSDDVTI
GTFFSNRDHFQDNDLVGFFVNTLPLRVRIDAGWDVDQLAQAMSATLAQAHAHRDVTTEDVFDALQANNALRRAAFRVMVN
LEPEQAEVLTMGALSARRMLLDRHVAKYDLLFSLRKEDGDYRVLVEYNTELYDGDVMAGVCANLDRSLAALTGTASERLD
AIALPDPLERGAPGDAAAGPADADAPAAAAADIDLREVVRDIWASEVGHRTFGDDDNFFDIGGSSLKIMTVYEKLSNFLK
RHGIEKEIDIVDLFEHVSVAALTDFLGALIEHDAIAQ

Specific function: Activates the 3rd to 6th amino acids (Ala, D-Leu, Ala and D-Val) in linear gramicidin and catalyzes the formation of the peptide bond between them. This enzyme is also responsible for the epimerization of the 4th (D-Leu) and the 6th (D-Val) amino acids [H

COG id: COG1020

COG function: function code Q; Non-ribosomal peptide synthetase modules and related proteins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 4 acyl carrier domains [H]

Homologues:

Organism=Homo sapiens, GI45580730, Length=479, Percent_Identity=23.3820459290188, Blast_Score=103, Evalue=1e-21,
Organism=Homo sapiens, GI38505220, Length=483, Percent_Identity=24.0165631469979, Blast_Score=92, Evalue=3e-18,
Organism=Homo sapiens, GI42544132, Length=528, Percent_Identity=23.4848484848485, Blast_Score=80, Evalue=1e-14,
Organism=Escherichia coli, GI1786801, Length=599, Percent_Identity=31.2186978297162, Blast_Score=213, Evalue=6e-56,
Organism=Escherichia coli, GI1788107, Length=557, Percent_Identity=21.5439856373429, Blast_Score=98, Evalue=2e-21,
Organism=Escherichia coli, GI1786810, Length=165, Percent_Identity=31.5151515151515, Blast_Score=66, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17550940, Length=460, Percent_Identity=23.9130434782609, Blast_Score=125, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17556356, Length=621, Percent_Identity=23.3494363929147, Blast_Score=116, Evalue=8e-26,
Organism=Caenorhabditis elegans, GI32564420, Length=446, Percent_Identity=25.1121076233184, Blast_Score=89, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI32564422, Length=446, Percent_Identity=25.1121076233184, Blast_Score=89, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17557194, Length=541, Percent_Identity=21.6266173752311, Blast_Score=85, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17531443, Length=372, Percent_Identity=23.3870967741935, Blast_Score=80, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17538037, Length=543, Percent_Identity=21.5469613259669, Blast_Score=80, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17560308, Length=535, Percent_Identity=21.6822429906542, Blast_Score=78, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17559526, Length=363, Percent_Identity=26.4462809917355, Blast_Score=77, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17558820, Length=363, Percent_Identity=22.8650137741047, Blast_Score=74, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17560140, Length=316, Percent_Identity=25.3164556962025, Blast_Score=72, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI32563687, Length=373, Percent_Identity=22.5201072386059, Blast_Score=72, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6319699, Length=353, Percent_Identity=25.2124645892351, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24648676, Length=550, Percent_Identity=27.4545454545455, Blast_Score=136, Evalue=7e-32,
Organism=Drosophila melanogaster, GI21355181, Length=535, Percent_Identity=23.3644859813084, Blast_Score=82, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24648260, Length=364, Percent_Identity=24.1758241758242, Blast_Score=80, Evalue=9e-15,
Organism=Drosophila melanogaster, GI19922652, Length=518, Percent_Identity=24.1312741312741, Blast_Score=78, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24581924, Length=358, Percent_Identity=25.1396648044693, Blast_Score=71, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010071
- InterPro:   IPR009081
- InterPro:   IPR020845
- InterPro:   IPR000873
- InterPro:   IPR001242
- InterPro:   IPR010060
- InterPro:   IPR006163
- InterPro:   IPR020806
- InterPro:   IPR006162 [H]

Pfam domain/function: PF00501 AMP-binding; PF00668 Condensation; PF00550 PP-binding [H]

EC number: 2.7.7.- [C]

Molecular weight: Translated: 124522; Mature: 124390

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: PS00012 PHOSPHOPANTETHEINE ; PS50075 ACP_DOMAIN ; PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQSVFARFEQVCRSNAQAVALESAEHRLTYAQLHDRVASIGARLAAAGVTPGTLLGIFL
CCHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHEEEEC
PRDVRLPAALLASLGSGAVYVPLTEKYPPERLREIIETHGIEHVVTTEALASQLPASCGK
CCCCCCHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCC
IVLPAEGSETAGPRPAGERADWRPAGERARNAPVYVVFTSGSTGTPKGVLIGERNLGNLI
EEEECCCCCCCCCCCCCCCCCCCCCHHHCCCCCEEEEEECCCCCCCCEEEEECCCCCHHH
DWYAASFSAEQRRSVLASTQITFDLSVFELICTLCTGSKVVIVENVLQLLDEGAPCDVSL
HHHHHHCCHHHHHHHHHHHEEEEEHHHHHHHHHHHCCCEEEHHHHHHHHHCCCCCCCCHH
INTVPSAARELVRHRKFPAAARVVNLAGEALYQDLVDDIYEAAPQLEQVFNLYGPSEDTT
HHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
YSTGHAVPRGGASRTVSIGRSLPGKRAHILSDALTPVAPGEVGEICLSGEGVALGYLNDA
CCCCCCCCCCCCCCEEECCCCCCCCHHHHHHHHCCCCCCCCCCCEEECCCCEEEEECCCC
TLTAEKFPTIGHGPLAGERIYRTGDLGSIDGDGLLRYLGRADRQVKVRGVRIEPGEVEVA
EEEHHHCCCCCCCCCCCCCEEECCCCCCCCHHHHHHHHCCCCCEEEEEEEEECCCHHHHH
LRSIDGIADAAVVKIADAANNDQLVALVVAQPSCPAEHAILDRLQALIPAFMVPSRVERI
HHHHCCHHHHHHEEEECCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHCHHHHHHH
DAIPLNGNGKTDRTKLEQIAGALFGAAPPADDIQARVAQIVAKLMSRTDVAADADFFRIG
EEEECCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEC
GNSLLSAQLTFMLQKQFSVTLSIADVFRHRTIDALAAIIRERTHKAAQTAPAAAGQQPAA
CCHHHHHHHHHHHHHHHHEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCE
VRSTSGGAGAGQPVVFATPAQRGIWLLENSPGGRAVSNAPLVFEYAGTLERALLERCVTQ
EECCCCCCCCCCCEEEECCCCCCEEEEECCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHH
LLERHAILRSNYVWEDGSLRIKCNAPVPFRVETVDLGSLAPDAQQAKARELVAREAMRPF
HHHHHHHHHCCCEEECCCEEEEECCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCC
DLRRDPMLRVTDIAFGERAGQLVFVFHHIAVDDRALNIVFSELQRLYAAGGDPAAIGAAP
CCCCCCCEEEEEEHHCCCCCCEEEEEEEHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCHH
ARQFADYAAAVREASARLGEHLDYWRHKLADYRGATPYLVDPQAKPAARFAGRLHLHRVA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHHHHHHH
RHVSRQLDAAAARRGLTPFALFAAAVACIVHRASGSDDVTIGTFFSNRDHFQDNDLVGFF
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCEEEEE
VNTLPLRVRIDAGWDVDQLAQAMSATLAQAHAHRDVTTEDVFDALQANNALRRAAFRVMV
ECCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCHHHHHHHHHEEE
NLEPEQAEVLTMGALSARRMLLDRHVAKYDLLFSLRKEDGDYRVLVEYNTELYDGDVMAG
ECCCCHHHEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCEEECCCHHHH
VCANLDRSLAALTGTASERLDAIALPDPLERGAPGDAAAGPADADAPAAAAADIDLREVV
HHHCCHHHHHHHHCCHHHHCCEECCCCHHHCCCCCCCCCCCCCCCCCCHHHCCCCHHHHH
RDIWASEVGHRTFGDDDNFFDIGGSSLKIMTVYEKLSNFLKRHGIEKEIDIVDLFEHVSV
HHHHHHHHCCCCCCCCCCEEECCCCCEEEHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
AALTDFLGALIEHDAIAQ
HHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TQSVFARFEQVCRSNAQAVALESAEHRLTYAQLHDRVASIGARLAAAGVTPGTLLGIFL
CHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHEEEEC
PRDVRLPAALLASLGSGAVYVPLTEKYPPERLREIIETHGIEHVVTTEALASQLPASCGK
CCCCCCHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCC
IVLPAEGSETAGPRPAGERADWRPAGERARNAPVYVVFTSGSTGTPKGVLIGERNLGNLI
EEEECCCCCCCCCCCCCCCCCCCCCHHHCCCCCEEEEEECCCCCCCCEEEEECCCCCHHH
DWYAASFSAEQRRSVLASTQITFDLSVFELICTLCTGSKVVIVENVLQLLDEGAPCDVSL
HHHHHHCCHHHHHHHHHHHEEEEEHHHHHHHHHHHCCCEEEHHHHHHHHHCCCCCCCCHH
INTVPSAARELVRHRKFPAAARVVNLAGEALYQDLVDDIYEAAPQLEQVFNLYGPSEDTT
HHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
YSTGHAVPRGGASRTVSIGRSLPGKRAHILSDALTPVAPGEVGEICLSGEGVALGYLNDA
CCCCCCCCCCCCCCEEECCCCCCCCHHHHHHHHCCCCCCCCCCCEEECCCCEEEEECCCC
TLTAEKFPTIGHGPLAGERIYRTGDLGSIDGDGLLRYLGRADRQVKVRGVRIEPGEVEVA
EEEHHHCCCCCCCCCCCCCEEECCCCCCCCHHHHHHHHCCCCCEEEEEEEEECCCHHHHH
LRSIDGIADAAVVKIADAANNDQLVALVVAQPSCPAEHAILDRLQALIPAFMVPSRVERI
HHHHCCHHHHHHEEEECCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHCHHHHHHH
DAIPLNGNGKTDRTKLEQIAGALFGAAPPADDIQARVAQIVAKLMSRTDVAADADFFRIG
EEEECCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEC
GNSLLSAQLTFMLQKQFSVTLSIADVFRHRTIDALAAIIRERTHKAAQTAPAAAGQQPAA
CCHHHHHHHHHHHHHHHHEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCE
VRSTSGGAGAGQPVVFATPAQRGIWLLENSPGGRAVSNAPLVFEYAGTLERALLERCVTQ
EECCCCCCCCCCCEEEECCCCCCEEEEECCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHH
LLERHAILRSNYVWEDGSLRIKCNAPVPFRVETVDLGSLAPDAQQAKARELVAREAMRPF
HHHHHHHHHCCCEEECCCEEEEECCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCC
DLRRDPMLRVTDIAFGERAGQLVFVFHHIAVDDRALNIVFSELQRLYAAGGDPAAIGAAP
CCCCCCCEEEEEEHHCCCCCCEEEEEEEHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCHH
ARQFADYAAAVREASARLGEHLDYWRHKLADYRGATPYLVDPQAKPAARFAGRLHLHRVA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHHHHHHH
RHVSRQLDAAAARRGLTPFALFAAAVACIVHRASGSDDVTIGTFFSNRDHFQDNDLVGFF
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCEEEEE
VNTLPLRVRIDAGWDVDQLAQAMSATLAQAHAHRDVTTEDVFDALQANNALRRAAFRVMV
ECCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCHHHHHHHHHEEE
NLEPEQAEVLTMGALSARRMLLDRHVAKYDLLFSLRKEDGDYRVLVEYNTELYDGDVMAG
ECCCCHHHEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCEEECCCHHHH
VCANLDRSLAALTGTASERLDAIALPDPLERGAPGDAAAGPADADAPAAAAADIDLREVV
HHHCCHHHHHHHHCCHHHHCCEECCCCHHHCCCCCCCCCCCCCCCCCCHHHCCCCHHHHH
RDIWASEVGHRTFGDDDNFFDIGGSSLKIMTVYEKLSNFLKRHGIEKEIDIVDLFEHVSV
HHHHHHHHCCCCCCCCCCEEECCCCCEEEHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
AALTDFLGALIEHDAIAQ
HHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Phosphopantetheine. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 6 ATP; L-serine; 2,3-dihydroxybenzoate [C]

Specific reaction: 6 ATP + 3 L-serine + 3 2,3-dihydroxybenzoate = 6 pyrophosphate + 6 AMP + enterobactin ATP + L-serine = pyrophosphate + L-Seryl-AMP 6 ATP + 3 L-serine + 3 2,3-dihydroxybenzoate = 6 pyrophosphate + 6 AMP + enterobactin ATP + L-serine = pyrophosphate + L-Ser

General reaction: Transferases; Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA