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The map label for this gene is uvrY [H]

Identifier: 126443832

GI number: 126443832

Start: 1165917

End: 1166564

Strand: Reverse

Name: uvrY [H]

Synonym: BURPS668_A1228

Alternate gene names: 126443832

Gene position: 1166564-1165917 (Counterclockwise)

Preceding gene: 126443090

Following gene: 126442715

Centisome position: 37.3

GC content: 66.82

Gene sequence:

>648_bases
ATGATCAAGGTTCTGATTGCCGACGACCACGCGCTCGTGCGCGACGGTCTGCGCCATATCCTGCAGAATGCGTCCGGCTA
CGAAGTCGCCGGTGAAGCGTTCGACAGCGCGACGACGATCGCGCTCGTGCGCTCGACGCCCGCGCAAGTGCTCGTGCTCG
ATCTGTCGATGCCGGGCCGCAACGGCGTCGAGCTGATCAAGCAGATCAAGGAGGAGAAGCCCGCGCTGCGGATCCTGGTG
CTGACGATGCATGCGGAGCAGCAGTACGCGGTGCGCGCGTTCCGCGCGGGCGCCTCCGGCTATCTGACGAAGGAGAGCGC
GAGCTCGGAGCTCGTCGGCGCGGTGACGAAGGTCGCCTCGGGCGGCGTCTACGTGAGCCTCGCGATGGCCGAGCGCTTCG
CGCAGAGCCTGAACGAGCCGGCGGAGACGCTGCCGCACCACCGGCTGTCGGACCGCGAGTTCGACGTGTTCCGCCGGATC
GCCTCCGGCCAGACGCTCACGCAGATCGCCGACGAGCTGTGCGTGAGCGCGAAGACGGTCAGCACGTACAAGACGCGGAT
TCTCCAGAAGATGCAGATGCCGCACGAAGCGGCGCTCGTGCGCTACGCGTTGCGGCACAAGCTGATCGACGATCCGGACG
AGGATTGA

Upstream 100 bases:

>100_bases
GCGGCTCGCAGCCACGCAACGGCCCGGCGTTGTTCGCGCCGCGCGCCGCTCGCCGGTCGGCCTCCTCGATGCAGTCGACT
CGACAGGAAGATTTCCACCC

Downstream 100 bases:

>100_bases
CGCACGCCGCGCATGGCCGCGCGCTTCGGCGCGCGAGGCCGACGCGCGGCGCGGCGGGCATGCGCTCGCCGCGCCGCCTT
ACAGATTGAATGCTTTCGAC

Product: LuxR family DNA-binding response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 215; Mature: 215

Protein sequence:

>215_residues
MIKVLIADDHALVRDGLRHILQNASGYEVAGEAFDSATTIALVRSTPAQVLVLDLSMPGRNGVELIKQIKEEKPALRILV
LTMHAEQQYAVRAFRAGASGYLTKESASSELVGAVTKVASGGVYVSLAMAERFAQSLNEPAETLPHHRLSDREFDVFRRI
ASGQTLTQIADELCVSAKTVSTYKTRILQKMQMPHEAALVRYALRHKLIDDPDED

Sequences:

>Translated_215_residues
MIKVLIADDHALVRDGLRHILQNASGYEVAGEAFDSATTIALVRSTPAQVLVLDLSMPGRNGVELIKQIKEEKPALRILV
LTMHAEQQYAVRAFRAGASGYLTKESASSELVGAVTKVASGGVYVSLAMAERFAQSLNEPAETLPHHRLSDREFDVFRRI
ASGQTLTQIADELCVSAKTVSTYKTRILQKMQMPHEAALVRYALRHKLIDDPDED
>Mature_215_residues
MIKVLIADDHALVRDGLRHILQNASGYEVAGEAFDSATTIALVRSTPAQVLVLDLSMPGRNGVELIKQIKEEKPALRILV
LTMHAEQQYAVRAFRAGASGYLTKESASSELVGAVTKVASGGVYVSLAMAERFAQSLNEPAETLPHHRLSDREFDVFRRI
ASGQTLTQIADELCVSAKTVSTYKTRILQKMQMPHEAALVRYALRHKLIDDPDED

Specific function: Member of the two-component regulatory system UvrY/BarA involved in the regulation of carbon metabolism via the CsrA/CsrB regulatory system. UvrY activates the transcription of the untranslated csrB RNA and of barA, in an autoregulatory loop. Mediates the

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788222, Length=211, Percent_Identity=36.4928909952607, Blast_Score=149, Evalue=2e-37,
Organism=Escherichia coli, GI1786747, Length=209, Percent_Identity=30.622009569378, Blast_Score=109, Evalue=1e-25,
Organism=Escherichia coli, GI1788521, Length=201, Percent_Identity=33.3333333333333, Blast_Score=100, Evalue=5e-23,
Organism=Escherichia coli, GI1790102, Length=201, Percent_Identity=30.3482587064677, Blast_Score=100, Evalue=5e-23,
Organism=Escherichia coli, GI1788712, Length=207, Percent_Identity=25.6038647342995, Blast_Score=98, Evalue=3e-22,
Organism=Escherichia coli, GI1788546, Length=204, Percent_Identity=32.843137254902, Blast_Score=96, Evalue=1e-21,
Organism=Escherichia coli, GI1787473, Length=182, Percent_Identity=31.3186813186813, Blast_Score=87, Evalue=8e-19,
Organism=Escherichia coli, GI87082052, Length=104, Percent_Identity=37.5, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1790299, Length=120, Percent_Identity=33.3333333333333, Blast_Score=61, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 23640; Mature: 23640

Theoretical pI: Translated: 6.90; Mature: 6.90

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKVLIADDHALVRDGLRHILQNASGYEVAGEAFDSATTIALVRSTPAQVLVLDLSMPGR
CEEEEEECCHHHHHHHHHHHHCCCCCCCHHHHHHCCHHEEEEEECCCCEEEEEEECCCCC
NGVELIKQIKEEKPALRILVLTMHAEQQYAVRAFRAGASGYLTKESASSELVGAVTKVAS
CHHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHHC
GGVYVSLAMAERFAQSLNEPAETLPHHRLSDREFDVFRRIASGQTLTQIADELCVSAKTV
CCEEEEHHHHHHHHHHHCCHHHHCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHH
STYKTRILQKMQMPHEAALVRYALRHKLIDDPDED
HHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MIKVLIADDHALVRDGLRHILQNASGYEVAGEAFDSATTIALVRSTPAQVLVLDLSMPGR
CEEEEEECCHHHHHHHHHHHHCCCCCCCHHHHHHCCHHEEEEEECCCCEEEEEEECCCCC
NGVELIKQIKEEKPALRILVLTMHAEQQYAVRAFRAGASGYLTKESASSELVGAVTKVAS
CHHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHHC
GGVYVSLAMAERFAQSLNEPAETLPHHRLSDREFDVFRRIASGQTLTQIADELCVSAKTV
CCEEEEHHHHHHHHHHHCCHHHHCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHH
STYKTRILQKMQMPHEAALVRYALRHKLIDDPDED
HHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]