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The map label for this gene is gyaR [H]

Identifier: 126443816

GI number: 126443816

Start: 1884335

End: 1885267

Strand: Reverse

Name: gyaR [H]

Synonym: BURPS668_A1937

Alternate gene names: 126443816

Gene position: 1885267-1884335 (Counterclockwise)

Preceding gene: 126442930

Following gene: 126444002

Centisome position: 60.28

GC content: 72.35

Gene sequence:

>933_bases
ATGAAGCCTCGATTGCTCGTGCTGATCCCGCTGCGCGACCACGCGCATGCACACATTGCCGACGTCTTCGACATCCTCTA
CGCCCTCACGCCCGACCAGCGCCGCCGCGCGATCGCCGAGCGCGGCGCCGCCGTGCAGGCGGTGCTGACGAACGGCACGA
CGGGCCTCTTCGCCGACGAGATCGCCCGCCTGCCGACGCTGGAATTCGTCGCCGCGCTGGGTGCCGGTTACGAGAACATC
GCGCTCGACGATGCGCGCTCGCGCGGCATCACGGTCGTCAACGGCGCGGGCACGAACGACGATTGCGTCGCCGATCACGC
GTTCGCGCTGCTGCTCGCCGCGGTGCGCGCCGTTCCGAAGCTCGATGCGGCATGCCGTGCGGGCGTGTGGCGCGATGCGC
TGCCGATGCGGCCGAACGTGTCCGGCAAGAAGCTCGGGATCGTCGGGCTCGGCAACATCGGGCAGAAGATCGCGCGCCGC
GCGGCGGGCTTCGATCTCGAGATCGGCTATCACAACCGGCGGCCGCGCGAGGGTGCCGCGTACCGCTATTTCGCCGGGCT
CGACGCGCTCGCGCACTGGGCGGACTTTCTCGTCGTCGCGACGCCGGGCGGCGCGGCGACGCACCACCTGATCGACGCGC
GCATCCTCGATGCGCTCGGCGAGCGCGGCTTTCTCGTCAACGTGTCGCGCGGCAGCGTCGTCGATACGGCGGCGCTCGCC
GACGCGTTGCGCGAGGGGCGCGTCGCGGGCGCGGGGCTCGACGTCTACGAAGGCGAGCCGCAGCCGCCGCGCGCGCTCGC
GGCGCTCGACAGCGTCGTGCTGACGCCGCATGTGGGCGGCTGGTCGCCGGAGGCGCTCGAGCGCTCGGTGCGCCAGTTCC
TCGAGAACGCGGCGCGCCATTTCGCGGGGCGGCCGGTCCTGACGCCGATCTGA

Upstream 100 bases:

>100_bases
GATGCGCCCAGCCGAGCCCGTTCGCCGAATAGGGCTTCCCGGCGGCGCGATGTGCGCCATTGTTACACTGGCGTCAACGC
TCCTTCCCCCGACGTTTGCC

Downstream 100 bases:

>100_bases
CGAACGACCATTCCGATACCAACCCACCAGGAGGCGCGATGTCGACCTACACGGCAGAAGTGGCATGGCAGAAGCAGGAA
AGCGAGACGTTTGCGGACAA

Product: 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 310; Mature: 310

Protein sequence:

>310_residues
MKPRLLVLIPLRDHAHAHIADVFDILYALTPDQRRRAIAERGAAVQAVLTNGTTGLFADEIARLPTLEFVAALGAGYENI
ALDDARSRGITVVNGAGTNDDCVADHAFALLLAAVRAVPKLDAACRAGVWRDALPMRPNVSGKKLGIVGLGNIGQKIARR
AAGFDLEIGYHNRRPREGAAYRYFAGLDALAHWADFLVVATPGGAATHHLIDARILDALGERGFLVNVSRGSVVDTAALA
DALREGRVAGAGLDVYEGEPQPPRALAALDSVVLTPHVGGWSPEALERSVRQFLENAARHFAGRPVLTPI

Sequences:

>Translated_310_residues
MKPRLLVLIPLRDHAHAHIADVFDILYALTPDQRRRAIAERGAAVQAVLTNGTTGLFADEIARLPTLEFVAALGAGYENI
ALDDARSRGITVVNGAGTNDDCVADHAFALLLAAVRAVPKLDAACRAGVWRDALPMRPNVSGKKLGIVGLGNIGQKIARR
AAGFDLEIGYHNRRPREGAAYRYFAGLDALAHWADFLVVATPGGAATHHLIDARILDALGERGFLVNVSRGSVVDTAALA
DALREGRVAGAGLDVYEGEPQPPRALAALDSVVLTPHVGGWSPEALERSVRQFLENAARHFAGRPVLTPI
>Mature_310_residues
MKPRLLVLIPLRDHAHAHIADVFDILYALTPDQRRRAIAERGAAVQAVLTNGTTGLFADEIARLPTLEFVAALGAGYENI
ALDDARSRGITVVNGAGTNDDCVADHAFALLLAAVRAVPKLDAACRAGVWRDALPMRPNVSGKKLGIVGLGNIGQKIARR
AAGFDLEIGYHNRRPREGAAYRYFAGLDALAHWADFLVVATPGGAATHHLIDARILDALGERGFLVNVSRGSVVDTAALA
DALREGRVAGAGLDVYEGEPQPPRALAALDSVVLTPHVGGWSPEALERSVRQFLENAARHFAGRPVLTPI

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=248, Percent_Identity=31.8548387096774, Blast_Score=118, Evalue=9e-27,
Organism=Homo sapiens, GI6912396, Length=222, Percent_Identity=33.7837837837838, Blast_Score=116, Evalue=2e-26,
Organism=Homo sapiens, GI61743967, Length=286, Percent_Identity=29.3706293706294, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI4557497, Length=286, Percent_Identity=29.3706293706294, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI145580578, Length=271, Percent_Identity=29.1512915129151, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI4557499, Length=271, Percent_Identity=29.1512915129151, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI145580575, Length=271, Percent_Identity=29.1512915129151, Blast_Score=97, Evalue=2e-20,
Organism=Escherichia coli, GI87082289, Length=297, Percent_Identity=30.6397306397306, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI1789279, Length=243, Percent_Identity=32.0987654320988, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI1787645, Length=246, Percent_Identity=24.390243902439, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1788660, Length=121, Percent_Identity=35.5371900826446, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI87081824, Length=138, Percent_Identity=31.8840579710145, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17532191, Length=261, Percent_Identity=29.8850574712644, Blast_Score=107, Evalue=9e-24,
Organism=Caenorhabditis elegans, GI25147481, Length=287, Percent_Identity=27.1777003484321, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6324055, Length=307, Percent_Identity=32.5732899022801, Blast_Score=132, Evalue=6e-32,
Organism=Saccharomyces cerevisiae, GI6320925, Length=266, Percent_Identity=28.5714285714286, Blast_Score=112, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6322116, Length=262, Percent_Identity=27.0992366412214, Blast_Score=103, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6321253, Length=172, Percent_Identity=31.9767441860465, Blast_Score=83, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6324964, Length=277, Percent_Identity=24.9097472924188, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6325144, Length=170, Percent_Identity=31.1764705882353, Blast_Score=76, Evalue=6e-15,
Organism=Drosophila melanogaster, GI28574286, Length=289, Percent_Identity=30.7958477508651, Blast_Score=118, Evalue=6e-27,
Organism=Drosophila melanogaster, GI45551003, Length=285, Percent_Identity=29.1228070175439, Blast_Score=111, Evalue=7e-25,
Organism=Drosophila melanogaster, GI24585514, Length=285, Percent_Identity=29.1228070175439, Blast_Score=111, Evalue=7e-25,
Organism=Drosophila melanogaster, GI28574282, Length=285, Percent_Identity=29.1228070175439, Blast_Score=111, Evalue=7e-25,
Organism=Drosophila melanogaster, GI45552429, Length=285, Percent_Identity=29.1228070175439, Blast_Score=110, Evalue=8e-25,
Organism=Drosophila melanogaster, GI28574284, Length=285, Percent_Identity=29.1228070175439, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI28571528, Length=247, Percent_Identity=33.6032388663968, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI19921140, Length=246, Percent_Identity=32.9268292682927, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24585516, Length=253, Percent_Identity=27.6679841897233, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24646446, Length=244, Percent_Identity=29.9180327868852, Blast_Score=91, Evalue=7e-19,
Organism=Drosophila melanogaster, GI24646448, Length=244, Percent_Identity=29.9180327868852, Blast_Score=91, Evalue=7e-19,
Organism=Drosophila melanogaster, GI24646452, Length=244, Percent_Identity=29.9180327868852, Blast_Score=91, Evalue=7e-19,
Organism=Drosophila melanogaster, GI24646450, Length=244, Percent_Identity=29.9180327868852, Blast_Score=91, Evalue=7e-19,
Organism=Drosophila melanogaster, GI62472511, Length=244, Percent_Identity=29.9180327868852, Blast_Score=91, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 32963; Mature: 32963

Theoretical pI: Translated: 7.79; Mature: 7.79

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPRLLVLIPLRDHAHAHIADVFDILYALTPDQRRRAIAERGAAVQAVLTNGTTGLFADE
CCCCEEEEEECCCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCEEEEEEECCCCCHHHHH
IARLPTLEFVAALGAGYENIALDDARSRGITVVNGAGTNDDCVADHAFALLLAAVRAVPK
HHHCCHHHHHHHHCCCCCCEEECCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHH
LDAACRAGVWRDALPMRPNVSGKKLGIVGLGNIGQKIARRAAGFDLEIGYHNRRPREGAA
HHHHHHCCCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHCCCEEEECCCCCCCCCCCC
YRYFAGLDALAHWADFLVVATPGGAATHHLIDARILDALGERGFLVNVSRGSVVDTAALA
CHHHHHHHHHHHHHCEEEEECCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHH
DALREGRVAGAGLDVYEGEPQPPRALAALDSVVLTPHVGGWSPEALERSVRQFLENAARH
HHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHEECCCCCCCCHHHHHHHHHHHHHHHHHH
FAGRPVLTPI
HCCCCCCCCC
>Mature Secondary Structure
MKPRLLVLIPLRDHAHAHIADVFDILYALTPDQRRRAIAERGAAVQAVLTNGTTGLFADE
CCCCEEEEEECCCCCHHHHHHHHHHHHHCCCHHHHHHHHHCCCEEEEEEECCCCCHHHHH
IARLPTLEFVAALGAGYENIALDDARSRGITVVNGAGTNDDCVADHAFALLLAAVRAVPK
HHHCCHHHHHHHHCCCCCCEEECCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHH
LDAACRAGVWRDALPMRPNVSGKKLGIVGLGNIGQKIARRAAGFDLEIGYHNRRPREGAA
HHHHHHCCCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHCCCEEEECCCCCCCCCCCC
YRYFAGLDALAHWADFLVVATPGGAATHHLIDARILDALGERGFLVNVSRGSVVDTAALA
CHHHHHHHHHHHHHCEEEEECCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHH
DALREGRVAGAGLDVYEGEPQPPRALAALDSVVLTPHVGGWSPEALERSVRQFLENAARH
HHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHEECCCCCCCCHHHHHHHHHHHHHHHHHH
FAGRPVLTPI
HCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA