Click here to switch to the map view.

The map label for this gene is glcD [H]

Identifier: 126443645

GI number: 126443645

Start: 1826020

End: 1827513

Strand: Reverse

Name: glcD [H]

Synonym: BURPS668_A1873

Alternate gene names: 126443645

Gene position: 1827513-1826020 (Counterclockwise)

Preceding gene: 126443548

Following gene: 126442323

Centisome position: 58.43

GC content: 72.16

Gene sequence:

>1494_bases
ATGCGCGAAGTGACCGACGACGGACAGCAGTGGGACGGGCGGGCGGCGGCTTTCGCGGGCGTGCCGCCCGGCGGCGGCGC
GCCTGCCGCGTTCGCCACGCCGCAGACGATCGGGCGCTGTGTCGAGGCGTTGCGCGCGATCGTCGGCGAGCGCCTCGCAG
TCGGGCGCGCGGTGCGCGAGCAGCACGGCAAGGACATCTCGTTCCATCCGGGCGCGCCGCCCGACGCCGTCGCGTTCGTG
CGGACGACGGCCGAGGTCGCCGAGATCACACGCGCGTGCCATCGGCTGCGCGTGCCGCTGATTCCGTTCGGCACCGGCAC
GTCGTGCGAGGGGCACATCGCCGCGCTGCGCGGTGGCGTATGCATCGATCTGTCCGGCATGAACCGGATTCTGCGCGTGA
GCGCCGAGGATCTCGACTGCACGGTCGAGGCGGGGGTGACGCGCAAGCAGCTCAATGCGCACCTGCGCGACACGGGGCTC
TTCTTTCCGATCGACCCGGGCGCGGACGCGTCGATCGGCGGCATGTGCTCGACGCGCGCGTCCGGCACGAACGCGGTGCG
CTACGGGACGATGCGCGAGAGCGTGCTCGCGCTCGAAGTCGTGCTGCCGAACGGCGACGTCGTCTCGGTCGGCTCGCGTG
CGCGCAAGTCGGCGGCGGGCTACGATCTCGCGCGCCTGTTCGTCGGCGCGGAAGGCACGCTCGGCACGATCACGGGCGTC
ACGCTGCGGCTGCATCCGCGCCCGGACCGGTTATCCGCCGCGGTGTGCGGTTTCCCGGACCTGAAGGCCGCGGTCGACTC
GGTGATCGGCGTCATCCGCAGCGGCGTGCCGATCGCGCGCGTCGAGTTGCTCGACGCACTGCAGATCGTCGCGTGCAACC
GCTATGCGAAGCTGAGCCTCGACGAGCGGCCGACGCTCTTTTTCGAGTTCGCGGGGTTCGGCGCGGCCGTCGACGAGCAG
ATCGACTGGGTCGGGGAGATTTGCGCGGGCCACGGCGGCGGTGAGTTCCGCTGGGCGTCGCGCCCGGAGGAGCGCAGCGC
GCTGTGGGCGGCGCGGCACGACGCGTGGTGGGCGGCGCTCGCGCTGCGGCCCGGCTGCGAGGGGATGCCGACCGATTCGT
GCGTGCCCGTGTCGCGGCTCGCGGAGGCGGTGCTCGCCGCGCGCGCGGACGTGGACGCGCTCGGCCTCGTCGCGACGATC
TGCGGGCACGTCGGCGACGGCAACTTTCACGTATGCATTGCGATCGATCCGGCCGACGCGGACGAACTCGCGCGCGCAAC
CGAGCTGAACCGGCGGCTCGCGCTGCGCGCGATCGCGTTGGGCGGCACCTGCACGGGCGAGCACGGCGTCGGTTACGGGA
AGATCGGCTACCTGGAGCGCGAGCATCCGACGGCGCTGCAACTGATGGCGGCCGTCAAGCGTGCGCTCGATCCGCGCGGC
ATCATGAATCCGGGCAAGGTGCTGCATCACGACCGGTATCCGCCGTTCGACTGA

Upstream 100 bases:

>100_bases
GCGCGGGGCGCGCGCGGCGGCGCGGGGATGGGGGCGGCCCCGCGTGTGCGCGGGCTGCGCGCCGCGGCGAGCGGGCGCGA
TCGACGAACGGAGGCGACGC

Downstream 100 bases:

>100_bases
GTTCTGGACGGCGCGCGGGCGGGGCGAGCGGCCGATCCGGCCGTGCGCGGCCCGACCCGGCGGGCCGGCCGACGAACGGA
CGCGGCGCGGCGTGCGTCGC

Product: putative glycolate oxidase subunit GlcD

Products: pyruvate; ferrocytochrome c

Alternate protein names: NA

Number of amino acids: Translated: 497; Mature: 497

Protein sequence:

>497_residues
MREVTDDGQQWDGRAAAFAGVPPGGGAPAAFATPQTIGRCVEALRAIVGERLAVGRAVREQHGKDISFHPGAPPDAVAFV
RTTAEVAEITRACHRLRVPLIPFGTGTSCEGHIAALRGGVCIDLSGMNRILRVSAEDLDCTVEAGVTRKQLNAHLRDTGL
FFPIDPGADASIGGMCSTRASGTNAVRYGTMRESVLALEVVLPNGDVVSVGSRARKSAAGYDLARLFVGAEGTLGTITGV
TLRLHPRPDRLSAAVCGFPDLKAAVDSVIGVIRSGVPIARVELLDALQIVACNRYAKLSLDERPTLFFEFAGFGAAVDEQ
IDWVGEICAGHGGGEFRWASRPEERSALWAARHDAWWAALALRPGCEGMPTDSCVPVSRLAEAVLAARADVDALGLVATI
CGHVGDGNFHVCIAIDPADADELARATELNRRLALRAIALGGTCTGEHGVGYGKIGYLEREHPTALQLMAAVKRALDPRG
IMNPGKVLHHDRYPPFD

Sequences:

>Translated_497_residues
MREVTDDGQQWDGRAAAFAGVPPGGGAPAAFATPQTIGRCVEALRAIVGERLAVGRAVREQHGKDISFHPGAPPDAVAFV
RTTAEVAEITRACHRLRVPLIPFGTGTSCEGHIAALRGGVCIDLSGMNRILRVSAEDLDCTVEAGVTRKQLNAHLRDTGL
FFPIDPGADASIGGMCSTRASGTNAVRYGTMRESVLALEVVLPNGDVVSVGSRARKSAAGYDLARLFVGAEGTLGTITGV
TLRLHPRPDRLSAAVCGFPDLKAAVDSVIGVIRSGVPIARVELLDALQIVACNRYAKLSLDERPTLFFEFAGFGAAVDEQ
IDWVGEICAGHGGGEFRWASRPEERSALWAARHDAWWAALALRPGCEGMPTDSCVPVSRLAEAVLAARADVDALGLVATI
CGHVGDGNFHVCIAIDPADADELARATELNRRLALRAIALGGTCTGEHGVGYGKIGYLEREHPTALQLMAAVKRALDPRG
IMNPGKVLHHDRYPPFD
>Mature_497_residues
MREVTDDGQQWDGRAAAFAGVPPGGGAPAAFATPQTIGRCVEALRAIVGERLAVGRAVREQHGKDISFHPGAPPDAVAFV
RTTAEVAEITRACHRLRVPLIPFGTGTSCEGHIAALRGGVCIDLSGMNRILRVSAEDLDCTVEAGVTRKQLNAHLRDTGL
FFPIDPGADASIGGMCSTRASGTNAVRYGTMRESVLALEVVLPNGDVVSVGSRARKSAAGYDLARLFVGAEGTLGTITGV
TLRLHPRPDRLSAAVCGFPDLKAAVDSVIGVIRSGVPIARVELLDALQIVACNRYAKLSLDERPTLFFEFAGFGAAVDEQ
IDWVGEICAGHGGGEFRWASRPEERSALWAARHDAWWAALALRPGCEGMPTDSCVPVSRLAEAVLAARADVDALGLVATI
CGHVGDGNFHVCIAIDPADADELARATELNRRLALRAIALGGTCTGEHGVGYGKIGYLEREHPTALQLMAAVKRALDPRG
IMNPGKVLHHDRYPPFD

Specific function: Unknown

COG id: COG0277

COG function: function code C; FAD/FMN-containing dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Homo sapiens, GI37595756, Length=453, Percent_Identity=54.083885209713, Blast_Score=493, Evalue=1e-139,
Organism=Homo sapiens, GI37595754, Length=476, Percent_Identity=51.4705882352941, Blast_Score=483, Evalue=1e-136,
Organism=Homo sapiens, GI119964728, Length=421, Percent_Identity=30.8788598574822, Blast_Score=161, Evalue=2e-39,
Organism=Homo sapiens, GI4501993, Length=222, Percent_Identity=28.8288288288288, Blast_Score=101, Evalue=1e-21,
Organism=Escherichia coli, GI1789351, Length=419, Percent_Identity=31.0262529832936, Blast_Score=177, Evalue=1e-45,
Organism=Escherichia coli, GI1787977, Length=498, Percent_Identity=27.5100401606426, Blast_Score=125, Evalue=8e-30,
Organism=Escherichia coli, GI48994907, Length=438, Percent_Identity=24.2009132420091, Blast_Score=102, Evalue=7e-23,
Organism=Escherichia coli, GI48994914, Length=192, Percent_Identity=26.0416666666667, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71992373, Length=461, Percent_Identity=46.2039045553145, Blast_Score=408, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI71992381, Length=461, Percent_Identity=44.9023861171367, Blast_Score=392, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI71992392, Length=378, Percent_Identity=48.1481481481481, Blast_Score=367, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI17534361, Length=453, Percent_Identity=26.4900662251656, Blast_Score=130, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17556096, Length=457, Percent_Identity=22.7571115973742, Blast_Score=99, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6320027, Length=491, Percent_Identity=37.0672097759674, Blast_Score=301, Evalue=2e-82,
Organism=Saccharomyces cerevisiae, GI6320764, Length=433, Percent_Identity=27.2517321016166, Blast_Score=145, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6320023, Length=483, Percent_Identity=25.6728778467909, Blast_Score=144, Evalue=2e-35,
Organism=Drosophila melanogaster, GI18921117, Length=432, Percent_Identity=28.7037037037037, Blast_Score=153, Evalue=3e-37,
Organism=Drosophila melanogaster, GI24639277, Length=432, Percent_Identity=28.7037037037037, Blast_Score=153, Evalue=3e-37,
Organism=Drosophila melanogaster, GI24639275, Length=432, Percent_Identity=28.7037037037037, Blast_Score=153, Evalue=3e-37,
Organism=Drosophila melanogaster, GI24653753, Length=459, Percent_Identity=27.2331154684096, Blast_Score=114, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR016164
- InterPro:   IPR016168
- InterPro:   IPR004113
- InterPro:   IPR004490
- InterPro:   IPR006094
- InterPro:   IPR016171 [H]

Pfam domain/function: PF02913 FAD-oxidase_C; PF01565 FAD_binding_4 [H]

EC number: 1.1.2.4

Molecular weight: Translated: 52503; Mature: 52503

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MREVTDDGQQWDGRAAAFAGVPPGGGAPAAFATPQTIGRCVEALRAIVGERLAVGRAVRE
CCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
QHGKDISFHPGAPPDAVAFVRTTAEVAEITRACHRLRVPLIPFGTGTSCEGHIAALRGGV
HCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCHHEECCCE
CIDLSGMNRILRVSAEDLDCTVEAGVTRKQLNAHLRDTGLFFPIDPGADASIGGMCSTRA
EEEECCCCEEEEEECCCCCEEEECCCCHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCC
SGTNAVRYGTMRESVLALEVVLPNGDVVSVGSRARKSAAGYDLARLFVGAEGTLGTITGV
CCCCEEEECCHHHCEEEEEEEECCCCEEECCHHHHHHHCCCCEEHHEECCCCCCEEEEEE
TLRLHPRPDRLSAAVCGFPDLKAAVDSVIGVIRSGVPIARVELLDALQIVACNRYAKLSL
EEEECCCCCHHCEECCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCEEEECC
DERPTLFFEFAGFGAAVDEQIDWVGEICAGHGGGEFRWASRPEERSALWAARHDAWWAAL
CCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCEEEEE
ALRPGCEGMPTDSCVPVSRLAEAVLAARADVDALGLVATICGHVGDGNFHVCIAIDPADA
EECCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCEEEEEEECCCCH
DELARATELNRRLALRAIALGGTCTGEHGVGYGKIGYLEREHPTALQLMAAVKRALDPRG
HHHHHHHHHHHHHEEEEEEECCCCCCCCCCCCCCCCCEECCCCHHHHHHHHHHHHCCCCC
IMNPGKVLHHDRYPPFD
CCCCCHHHCCCCCCCCC
>Mature Secondary Structure
MREVTDDGQQWDGRAAAFAGVPPGGGAPAAFATPQTIGRCVEALRAIVGERLAVGRAVRE
CCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
QHGKDISFHPGAPPDAVAFVRTTAEVAEITRACHRLRVPLIPFGTGTSCEGHIAALRGGV
HCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCHHEECCCE
CIDLSGMNRILRVSAEDLDCTVEAGVTRKQLNAHLRDTGLFFPIDPGADASIGGMCSTRA
EEEECCCCEEEEEECCCCCEEEECCCCHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCC
SGTNAVRYGTMRESVLALEVVLPNGDVVSVGSRARKSAAGYDLARLFVGAEGTLGTITGV
CCCCEEEECCHHHCEEEEEEEECCCCEEECCHHHHHHHCCCCEEHHEECCCCCCEEEEEE
TLRLHPRPDRLSAAVCGFPDLKAAVDSVIGVIRSGVPIARVELLDALQIVACNRYAKLSL
EEEECCCCCHHCEECCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCEEEECC
DERPTLFFEFAGFGAAVDEQIDWVGEICAGHGGGEFRWASRPEERSALWAARHDAWWAAL
CCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCEEEEE
ALRPGCEGMPTDSCVPVSRLAEAVLAARADVDALGLVATICGHVGDGNFHVCIAIDPADA
EECCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCEEEEEEECCCCH
DELARATELNRRLALRAIALGGTCTGEHGVGYGKIGYLEREHPTALQLMAAVKRALDPRG
HHHHHHHHHHHHHEEEEEEECCCCCCCCCCCCCCCCCEECCCCHHHHHHHHHHHHCCCCC
IMNPGKVLHHDRYPPFD
CCCCCHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (R)-lactate; ferricytochrome c

Specific reaction: (R)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377 [H]