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The map label for this gene is ilvA [H]

Identifier: 126443580

GI number: 126443580

Start: 1768143

End: 1769750

Strand: Reverse

Name: ilvA [H]

Synonym: BURPS668_A1809

Alternate gene names: 126443580

Gene position: 1769750-1768143 (Counterclockwise)

Preceding gene: 126444481

Following gene: 126442439

Centisome position: 56.59

GC content: 69.4

Gene sequence:

>1608_bases
ATGCAGTCAGACGACGTCGTCACGGAAACCCCCGAAGCGCCCCCCCGCGAAGCCGTCGCGCCCACGGCGATCGCGCCGCG
CGCGCGCACGCTCGACGATTACCTGAAGCTGGTCCTGAACGCGCGCGTGTACGACGTCGCGCGCGAGACGGCGCTCGAAC
GCGCGCGCAGCCTGTCCGCGCGGCTGGGCAACGCCGTCTACCTGAAGCGCGAGGACAACCAGCCGGTGTTCTCGTTCAAG
CTGCGCGGCGCGTACAACAAGATGGCGCACATCCCGGCCGACGCGCTCGCGCGCGGGGTGATCACCGCGTCGGCGGGCAA
CCATGCGCAGGGCGTCGCGTTCTCGGCCGCGCGGATGAACGTGAAGGCGGTGATCGTCGTGCCGGTGACGACGCCGCAGG
TGAAGGTCGACGCGGTGCGCGCGCACGGCGGGCCGACCGTCGAGGTGATCCAGGCGGGCGAATCGTACAGCGACGCGTAC
GCGCACGCGGTGAAGGTGCAGGCCGAGCGCGGCCTCACGTTCGTCCATCCGTTCGACGATCCGTACGTGATCGCGGGCCA
GGGCACGGTGGCGATGGAGATCCTGCGCCAGCATCAGGGGCCGATTCACGCGATCTTCGTGCCGATCGGCGGCGGCGGGC
TCGCGGCGGGCGTGGCCGCGTACGTGAAGGCGGTGCGCCCGGAGATCAAGGTGATCGGCGTGCAGACCGACGATTCGTGC
GCGATGAAGCAATCGCTCGCGGCGGGCCGGCGCATCGAGCTCACCGAGGTGGGGCTCTTCTCCGACGGCACCGCGGTCAA
GCTCGTCGGCGAGGAGACGTTCCGCCTCTGCGCGGCGTATCTCGACGAGGTCGTGACCGTCGATACCGACGCGCTTTGCG
CGGCGATCAAGGACGTGTTCCAGGACACGCGCAGCGTGCTCGAGCCGGCCGGCTCGCTCGCGGTGGCGGGCGCGAAGCGG
TATGCGGAGCAGGCGGGCATCGAGGGCGAGACGCTCGTGGCGGTTACCTCCGGCGCGAACATGAATTTCGACCGGATGCG
CTTCGTCGCCGAGCGCGCCGAGGTGGGCGAGGCGCGCGAGGCGGTGTTCGCGGTGACGATTCCCGAGGAGCGCGGCAGCT
TCAAGCGCTTCTGCGCGCTCGTCGGCGAGCGCAACGTGACCGAGTTCAACTACCGGATCGCCGATGCGCGATCGGCGCAT
CTCTTCGTCGGCGTGCAGATCGGGCATCGCGGCGATTCGGCGACGATCGCGGCGAGCTTCGTCGCGCACGGCTTCGGCAC
CGTCGATCTGAGCGGCGACGAGCTCGCGAAACAGCACGTGCGACACATGGTGGGCGGGCGCTCGCCGCTCGCGCACGACG
AGCGGCTGTTCCGCTTCGAGTTTCCCGAGCGGCCCGGCGCGCTGATGAAGTTCCTGTCGTCGATGGCGCCCGACTGGAAC
ATCAGCCTGTTCCATTACCGCAATCAGGGCGGCGACGCGAGCTCGATCCTCGTCGGCCTGCAAGTGCCGCGGGCGGACCA
CGCGGCGTTCGATCGCTTTCTCGCGGCGCTCGGTTATCCGTATCGCGAGGAAACCGGTCATCCCGCCTATCGGTTGTTTC
TCGGTTGA

Upstream 100 bases:

>100_bases
GGTGGGTTAGCGCGCGTCCGAAAGCAGTCACAGCAAACCCGCCCCGTGAGGCGGGTTTTTTGTTTCCGTCTCCCGGGCAT
CCCTCCCAGGAGAGCCTGTC

Downstream 100 bases:

>100_bases
CGTTCGCCGCGCCGGCCGCGCGCGGGCGCCGGCGCGTAGGCGGCGTCGCGTCCGCGGGATGCGTCGCCCGCGGCTCGCGG
CTCGGCGTCGCGCCCGCGCG

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 535; Mature: 535

Protein sequence:

>535_residues
MQSDDVVTETPEAPPREAVAPTAIAPRARTLDDYLKLVLNARVYDVARETALERARSLSARLGNAVYLKREDNQPVFSFK
LRGAYNKMAHIPADALARGVITASAGNHAQGVAFSAARMNVKAVIVVPVTTPQVKVDAVRAHGGPTVEVIQAGESYSDAY
AHAVKVQAERGLTFVHPFDDPYVIAGQGTVAMEILRQHQGPIHAIFVPIGGGGLAAGVAAYVKAVRPEIKVIGVQTDDSC
AMKQSLAAGRRIELTEVGLFSDGTAVKLVGEETFRLCAAYLDEVVTVDTDALCAAIKDVFQDTRSVLEPAGSLAVAGAKR
YAEQAGIEGETLVAVTSGANMNFDRMRFVAERAEVGEAREAVFAVTIPEERGSFKRFCALVGERNVTEFNYRIADARSAH
LFVGVQIGHRGDSATIAASFVAHGFGTVDLSGDELAKQHVRHMVGGRSPLAHDERLFRFEFPERPGALMKFLSSMAPDWN
ISLFHYRNQGGDASSILVGLQVPRADHAAFDRFLAALGYPYREETGHPAYRLFLG

Sequences:

>Translated_535_residues
MQSDDVVTETPEAPPREAVAPTAIAPRARTLDDYLKLVLNARVYDVARETALERARSLSARLGNAVYLKREDNQPVFSFK
LRGAYNKMAHIPADALARGVITASAGNHAQGVAFSAARMNVKAVIVVPVTTPQVKVDAVRAHGGPTVEVIQAGESYSDAY
AHAVKVQAERGLTFVHPFDDPYVIAGQGTVAMEILRQHQGPIHAIFVPIGGGGLAAGVAAYVKAVRPEIKVIGVQTDDSC
AMKQSLAAGRRIELTEVGLFSDGTAVKLVGEETFRLCAAYLDEVVTVDTDALCAAIKDVFQDTRSVLEPAGSLAVAGAKR
YAEQAGIEGETLVAVTSGANMNFDRMRFVAERAEVGEAREAVFAVTIPEERGSFKRFCALVGERNVTEFNYRIADARSAH
LFVGVQIGHRGDSATIAASFVAHGFGTVDLSGDELAKQHVRHMVGGRSPLAHDERLFRFEFPERPGALMKFLSSMAPDWN
ISLFHYRNQGGDASSILVGLQVPRADHAAFDRFLAALGYPYREETGHPAYRLFLG
>Mature_535_residues
MQSDDVVTETPEAPPREAVAPTAIAPRARTLDDYLKLVLNARVYDVARETALERARSLSARLGNAVYLKREDNQPVFSFK
LRGAYNKMAHIPADALARGVITASAGNHAQGVAFSAARMNVKAVIVVPVTTPQVKVDAVRAHGGPTVEVIQAGESYSDAY
AHAVKVQAERGLTFVHPFDDPYVIAGQGTVAMEILRQHQGPIHAIFVPIGGGGLAAGVAAYVKAVRPEIKVIGVQTDDSC
AMKQSLAAGRRIELTEVGLFSDGTAVKLVGEETFRLCAAYLDEVVTVDTDALCAAIKDVFQDTRSVLEPAGSLAVAGAKR
YAEQAGIEGETLVAVTSGANMNFDRMRFVAERAEVGEAREAVFAVTIPEERGSFKRFCALVGERNVTEFNYRIADARSAH
LFVGVQIGHRGDSATIAASFVAHGFGTVDLSGDELAKQHVRHMVGGRSPLAHDERLFRFEFPERPGALMKFLSSMAPDWN
ISLFHYRNQGGDASSILVGLQVPRADHAAFDRFLAALGYPYREETGHPAYRLFLG

Specific function: Catalyzes the formation of alpha-ketobutyrate from threonine in a two-step reaction. The first step is a dehydration of threonine, followed by rehydration and liberation of ammonia [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=319, Percent_Identity=31.3479623824451, Blast_Score=139, Evalue=1e-32,
Organism=Homo sapiens, GI33469958, Length=319, Percent_Identity=28.2131661442006, Blast_Score=79, Evalue=8e-15,
Organism=Escherichia coli, GI1790207, Length=505, Percent_Identity=53.2673267326733, Blast_Score=508, Evalue=1e-145,
Organism=Escherichia coli, GI1789505, Length=318, Percent_Identity=33.6477987421384, Blast_Score=150, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17537387, Length=342, Percent_Identity=30.9941520467836, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI71991565, Length=334, Percent_Identity=28.4431137724551, Blast_Score=125, Evalue=6e-29,
Organism=Caenorhabditis elegans, GI17508781, Length=298, Percent_Identity=27.1812080536913, Blast_Score=108, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6320930, Length=517, Percent_Identity=47.9690522243714, Blast_Score=464, Evalue=1e-131,
Organism=Saccharomyces cerevisiae, GI6322631, Length=310, Percent_Identity=33.5483870967742, Blast_Score=149, Evalue=8e-37,
Organism=Saccharomyces cerevisiae, GI6319788, Length=270, Percent_Identity=25.9259259259259, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI21355833, Length=327, Percent_Identity=30.2752293577982, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI24645328, Length=255, Percent_Identity=28.6274509803922, Blast_Score=80, Evalue=5e-15,

Paralogues:

None

Copy number: 1344 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005787
- InterPro:   IPR001721 [H]

Pfam domain/function: PF00291 PALP; PF00585 Thr_dehydrat_C [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 57644; Mature: 57644

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQSDDVVTETPEAPPREAVAPTAIAPRARTLDDYLKLVLNARVYDVARETALERARSLSA
CCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
RLGNAVYLKREDNQPVFSFKLRGAYNKMAHIPADALARGVITASAGNHAQGVAFSAARMN
HCCCEEEEEECCCCCEEEEEECCCHHHHHCCCHHHHHCCEEEECCCCCCCCEEEEEEECC
VKAVIVVPVTTPQVKVDAVRAHGGPTVEVIQAGESYSDAYAHAVKVQAERGLTFVHPFDD
EEEEEEEECCCCCEEEEEEECCCCCEEEEEECCCCCHHHHHHEEEEEHHCCEEEEECCCC
PYVIAGQGTVAMEILRQHQGPIHAIFVPIGGGGLAAGVAAYVKAVRPEIKVIGVQTDDSC
CEEEECCCHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHHHHCCCEEEEEEECCCHH
AMKQSLAAGRRIELTEVGLFSDGTAVKLVGEETFRLCAAYLDEVVTVDTDALCAAIKDVF
HHHHHHHCCCEEEEEEECEECCCCEEEEECHHHHHHHHHHHHHHEECCHHHHHHHHHHHH
QDTRSVLEPAGSLAVAGAKRYAEQAGIEGETLVAVTSGANMNFDRMRFVAERAEVGEARE
HHHHHHHCCCCCEEEHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCC
AVFAVTIPEERGSFKRFCALVGERNVTEFNYRIADARSAHLFVGVQIGHRGDSATIAASF
EEEEEEECHHCCCHHHHHHHHCCCCCEEEEEEEECCCCEEEEEEEEEECCCCCHHHHHHH
VAHGFGTVDLSGDELAKQHVRHMVGGRSPLAHDERLFRFEFPERPGALMKFLSSMAPDWN
HHCCCCEEECCHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHCCCCC
ISLFHYRNQGGDASSILVGLQVPRADHAAFDRFLAALGYPYREETGHPAYRLFLG
EEEEEEECCCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCHHCCCCCEEEEECC
>Mature Secondary Structure
MQSDDVVTETPEAPPREAVAPTAIAPRARTLDDYLKLVLNARVYDVARETALERARSLSA
CCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
RLGNAVYLKREDNQPVFSFKLRGAYNKMAHIPADALARGVITASAGNHAQGVAFSAARMN
HCCCEEEEEECCCCCEEEEEECCCHHHHHCCCHHHHHCCEEEECCCCCCCCEEEEEEECC
VKAVIVVPVTTPQVKVDAVRAHGGPTVEVIQAGESYSDAYAHAVKVQAERGLTFVHPFDD
EEEEEEEECCCCCEEEEEEECCCCCEEEEEECCCCCHHHHHHEEEEEHHCCEEEEECCCC
PYVIAGQGTVAMEILRQHQGPIHAIFVPIGGGGLAAGVAAYVKAVRPEIKVIGVQTDDSC
CEEEECCCHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHHHHCCCEEEEEEECCCHH
AMKQSLAAGRRIELTEVGLFSDGTAVKLVGEETFRLCAAYLDEVVTVDTDALCAAIKDVF
HHHHHHHCCCEEEEEEECEECCCCEEEEECHHHHHHHHHHHHHHEECCHHHHHHHHHHHH
QDTRSVLEPAGSLAVAGAKRYAEQAGIEGETLVAVTSGANMNFDRMRFVAERAEVGEARE
HHHHHHHCCCCCEEEHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCC
AVFAVTIPEERGSFKRFCALVGERNVTEFNYRIADARSAHLFVGVQIGHRGDSATIAASF
EEEEEEECHHCCCHHHHHHHHCCCCCEEEEEEEECCCCEEEEEEEEEECCCCCHHHHHHH
VAHGFGTVDLSGDELAKQHVRHMVGGRSPLAHDERLFRFEFPERPGALMKFLSSMAPDWN
HHCCCCEEECCHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHCCCCC
ISLFHYRNQGGDASSILVGLQVPRADHAAFDRFLAALGYPYREETGHPAYRLFLG
EEEEEEECCCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCHHCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA