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The map label for this gene is dxs [H]

Identifier: 126443346

GI number: 126443346

Start: 2445881

End: 2447785

Strand: Reverse

Name: dxs [H]

Synonym: BURPS668_A2534

Alternate gene names: 126443346

Gene position: 2447785-2445881 (Counterclockwise)

Preceding gene: 126442384

Following gene: 126442661

Centisome position: 78.27

GC content: 67.45

Gene sequence:

>1905_bases
ATGTACGACTTGCTGAAAACCATCGACGATCCGGCGGACCTGCGCCGTCTCGATCGTCGCCAACTGCAGCCGCTCGCCGA
CGAGCTGCGCGCGTTCGTCCTCGACAGCGTGTCGAAGACGGGCGGCCATTTGTCGTCCAATCTCGGCACGGTCGAGCTGA
CGATCGCGCTGCATTACGTGTTCAATACGCCGGACGACCGGATCGTGTGGGACGTCGGTCACCAGACCTATCCGCACAAG
ATCCTGACGGGCCGCCGCGACGGGATGAAGACGCTGCGCCAGTTCGACGGCATCTCGGGCTTTCCGCGCCGCTCGGAATC
CGAATACGACACGTTCGGCACCGCGCACTCGAGCACGTCGATCTCGGCCGCGCTCGGGATGGCGATCGGCAGCAAGCTGA
ACGGCGACGACCGCTTCTCGATCGCGGTGATCGGCGACGGCGCGATGACGGCCGGCATGGCGTTCGAGGCGATGAACAAC
GCGGGCGTGTCGGAGGACGCGAAGCTGCTCGTGATCCTGAACGACAACGACATGTCGATCTCGCCGCCCGTCGGCGCGCT
GAATCGCCATCTCGCGCGCCTGATGTCGGGCCGCTTCTACGCGGCCGCGCGTGCGGGCGTGGAGCGCGTGCTGAGCGTCG
CGCCGCCCGTGCTGGAGCTCGCGCGCAAGCTCGAGGAGCATGCGAAGGGCATGGTCGTGCCGGCCACCCTCTTCGAGGAA
TTCGGCTTCAACTACATCGGGCCGATCGACGGCCACGATCTCGATTCGCTGATCCCGACGCTGCAGAACATCAAGGAGCT
GCGCGGGCCGCAGTTCCTGCACGTCGTGACGAAGAAGGGCCAGGGCTACAAGCTCGCCGAGGCCGACCCGGTGCTCTATC
ACGGGCCCGGCAAGTTCAACCCGGCGGAAGGCATCAAACCGTCGACGACGCCCGCGAAGAAGACCTACACGCAAGTGTTC
GGCGAATGGCTGTGCGACGCGGCGGAACTCGATGCGCGCGTGGTCGGCATCACGCCCGCGATGCGCGAAGGCTCGGGCAT
GGTCGAGTTCGAGAAGCGCTTCCCGGAGCGCTACTACGACGTCGGCATCGCCGAGCAGCACGCGGTGACGTTCGCGGGCG
GCCTCGCGACGGAAGGGCTCAAGCCTGTCGTGGCGATCTATTCGACGTTCCTGCAGCGCGCTTATGATCAGCTGATTCAC
GACGTCGCGCTGCAGAACCTGCCCGTCGTGTTCGCGATCGACCGCGCGGGCCTCGTCGGCGCGGACGGCGCGACGCACGC
GGGCGCGTACGATCTCGCGTTCCTGCGCTGCATTCCGAACATGACGGTGATGGCCGCGTCGGACGAGAACGAGTGCCGCC
AGATGCTGCATACCGCGCTGCAACAGCCGAACCCGACCGCCGTGCGTTATCCGCGCGGCGCGGGCACGGGCGTTGCCACC
GTCAAGGCGTTTACCGAGATCCCGCTCGGCAAGGGCGAAGTGCGCCGCCGCACGTCGCAGCCGGACGGCAAGCGCATCGC
GATTCTCGCGTTCGGCACGATGGTGGCGCCGTCGCTCGCGGCGGCCGACGCGCTTGACGCGACCGTCGCGAACATGCGCT
TCGTGAAGCCGATCGACGCCGAGCTCGTGCAAGCGCTCGCGCGGACGCACGACTACCTCGTCACCGTCGAGGAAGGCTGC
GTGATGGGCGGCGCGGGTTCCGCGTGCGTCGAGGCGATGATGGAAAGCGGCGTCGTCCGCCCGGTGCTGCAGCTCGGCTT
GCCGGACCGTTTCGTCGATCACGGCGATCCGGCGAAGCTGCTGTCGCTGTGCGGCCTCGACGGCGACGGCATCGCCAAAT
CGATTCGCGAACGCTTCCTGAGCCACGCGGCGGACGTCGCGAGCCCGGCGAAGCGCGTCGCATAA

Upstream 100 bases:

>100_bases
TGAACCGGGTCAGCTGACGCGAAAGCCCGCCGCCGCGCCCACGCCACGGGTGGGTGCGCAAGAAGTGCGGGCGCGTTTGT
TTTCCTACAATGGAACGACG

Downstream 100 bases:

>100_bases
CGTCGCTTCACGTCGCATCGGGCCGCCGCGCGGCGGGCGCGCGACGGCTTTCCCCCGAAAGCATGGGCCTGCGGGCCCAT
GTTGCATTTCCGGCAGGTCA

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS [H]

Number of amino acids: Translated: 634; Mature: 634

Protein sequence:

>634_residues
MYDLLKTIDDPADLRRLDRRQLQPLADELRAFVLDSVSKTGGHLSSNLGTVELTIALHYVFNTPDDRIVWDVGHQTYPHK
ILTGRRDGMKTLRQFDGISGFPRRSESEYDTFGTAHSSTSISAALGMAIGSKLNGDDRFSIAVIGDGAMTAGMAFEAMNN
AGVSEDAKLLVILNDNDMSISPPVGALNRHLARLMSGRFYAAARAGVERVLSVAPPVLELARKLEEHAKGMVVPATLFEE
FGFNYIGPIDGHDLDSLIPTLQNIKELRGPQFLHVVTKKGQGYKLAEADPVLYHGPGKFNPAEGIKPSTTPAKKTYTQVF
GEWLCDAAELDARVVGITPAMREGSGMVEFEKRFPERYYDVGIAEQHAVTFAGGLATEGLKPVVAIYSTFLQRAYDQLIH
DVALQNLPVVFAIDRAGLVGADGATHAGAYDLAFLRCIPNMTVMAASDENECRQMLHTALQQPNPTAVRYPRGAGTGVAT
VKAFTEIPLGKGEVRRRTSQPDGKRIAILAFGTMVAPSLAAADALDATVANMRFVKPIDAELVQALARTHDYLVTVEEGC
VMGGAGSACVEAMMESGVVRPVLQLGLPDRFVDHGDPAKLLSLCGLDGDGIAKSIRERFLSHAADVASPAKRVA

Sequences:

>Translated_634_residues
MYDLLKTIDDPADLRRLDRRQLQPLADELRAFVLDSVSKTGGHLSSNLGTVELTIALHYVFNTPDDRIVWDVGHQTYPHK
ILTGRRDGMKTLRQFDGISGFPRRSESEYDTFGTAHSSTSISAALGMAIGSKLNGDDRFSIAVIGDGAMTAGMAFEAMNN
AGVSEDAKLLVILNDNDMSISPPVGALNRHLARLMSGRFYAAARAGVERVLSVAPPVLELARKLEEHAKGMVVPATLFEE
FGFNYIGPIDGHDLDSLIPTLQNIKELRGPQFLHVVTKKGQGYKLAEADPVLYHGPGKFNPAEGIKPSTTPAKKTYTQVF
GEWLCDAAELDARVVGITPAMREGSGMVEFEKRFPERYYDVGIAEQHAVTFAGGLATEGLKPVVAIYSTFLQRAYDQLIH
DVALQNLPVVFAIDRAGLVGADGATHAGAYDLAFLRCIPNMTVMAASDENECRQMLHTALQQPNPTAVRYPRGAGTGVAT
VKAFTEIPLGKGEVRRRTSQPDGKRIAILAFGTMVAPSLAAADALDATVANMRFVKPIDAELVQALARTHDYLVTVEEGC
VMGGAGSACVEAMMESGVVRPVLQLGLPDRFVDHGDPAKLLSLCGLDGDGIAKSIRERFLSHAADVASPAKRVA
>Mature_634_residues
MYDLLKTIDDPADLRRLDRRQLQPLADELRAFVLDSVSKTGGHLSSNLGTVELTIALHYVFNTPDDRIVWDVGHQTYPHK
ILTGRRDGMKTLRQFDGISGFPRRSESEYDTFGTAHSSTSISAALGMAIGSKLNGDDRFSIAVIGDGAMTAGMAFEAMNN
AGVSEDAKLLVILNDNDMSISPPVGALNRHLARLMSGRFYAAARAGVERVLSVAPPVLELARKLEEHAKGMVVPATLFEE
FGFNYIGPIDGHDLDSLIPTLQNIKELRGPQFLHVVTKKGQGYKLAEADPVLYHGPGKFNPAEGIKPSTTPAKKTYTQVF
GEWLCDAAELDARVVGITPAMREGSGMVEFEKRFPERYYDVGIAEQHAVTFAGGLATEGLKPVVAIYSTFLQRAYDQLIH
DVALQNLPVVFAIDRAGLVGADGATHAGAYDLAFLRCIPNMTVMAASDENECRQMLHTALQQPNPTAVRYPRGAGTGVAT
VKAFTEIPLGKGEVRRRTSQPDGKRIAILAFGTMVAPSLAAADALDATVANMRFVKPIDAELVQALARTHDYLVTVEEGC
VMGGAGSACVEAMMESGVVRPVLQLGLPDRFVDHGDPAKLLSLCGLDGDGIAKSIRERFLSHAADVASPAKRVA

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) [H]

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=638, Percent_Identity=23.1974921630094, Blast_Score=111, Evalue=2e-24,
Organism=Homo sapiens, GI4507521, Length=638, Percent_Identity=23.1974921630094, Blast_Score=111, Evalue=2e-24,
Organism=Homo sapiens, GI225637463, Length=302, Percent_Identity=26.8211920529801, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI225637461, Length=300, Percent_Identity=27, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI225637459, Length=300, Percent_Identity=27, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI156564403, Length=251, Percent_Identity=25.8964143426295, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI133778974, Length=416, Percent_Identity=24.0384615384615, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1786622, Length=617, Percent_Identity=56.4019448946515, Blast_Score=729, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=410, Percent_Identity=25.609756097561, Blast_Score=80, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17538422, Length=249, Percent_Identity=26.5060240963855, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24666278, Length=646, Percent_Identity=24.6130030959752, Blast_Score=96, Evalue=6e-20,
Organism=Drosophila melanogaster, GI45551847, Length=666, Percent_Identity=23.8738738738739, Blast_Score=93, Evalue=6e-19,
Organism=Drosophila melanogaster, GI45550715, Length=666, Percent_Identity=23.8738738738739, Blast_Score=93, Evalue=6e-19,
Organism=Drosophila melanogaster, GI24645119, Length=581, Percent_Identity=24.2685025817556, Blast_Score=92, Evalue=8e-19,
Organism=Drosophila melanogaster, GI21358145, Length=245, Percent_Identity=28.5714285714286, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24650940, Length=245, Percent_Identity=28.5714285714286, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.7 [H]

Molecular weight: Translated: 68310; Mature: 68310

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYDLLKTIDDPADLRRLDRRQLQPLADELRAFVLDSVSKTGGHLSSNLGTVELTIALHYV
CCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEEEE
FNTPDDRIVWDVGHQTYPHKILTGRRDGMKTLRQFDGISGFPRRSESEYDTFGTAHSSTS
ECCCCCCEEEECCCCCCCCHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCHHCCCCCCCCH
ISAALGMAIGSKLNGDDRFSIAVIGDGAMTAGMAFEAMNNAGVSEDAKLLVILNDNDMSI
HHHHHHHHHCCCCCCCCCEEEEEEECCHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCC
SPPVGALNRHLARLMSGRFYAAARAGVERVLSVAPPVLELARKLEEHAKGMVVPATLFEE
CCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCEEEHHHHHHH
FGFNYIGPIDGHDLDSLIPTLQNIKELRGPQFLHVVTKKGQGYKLAEADPVLYHGPGKFN
CCCCEECCCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCEEECCCCCEEEECCCCCC
PAEGIKPSTTPAKKTYTQVFGEWLCDAAELDARVVGITPAMREGSGMVEFEKRFPERYYD
CCCCCCCCCCCHHHHHHHHHHHHHCCHHHCCCEEEECCCCHHCCCCCCHHHHHCCHHHHC
VGIAEQHAVTFAGGLATEGLKPVVAIYSTFLQRAYDQLIHDVALQNLPVVFAIDRAGLVG
CCCCCHHHEEEECCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCEEC
ADGATHAGAYDLAFLRCIPNMTVMAASDENECRQMLHTALQQPNPTAVRYPRGAGTGVAT
CCCCCCCCHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHCCCCCCEEECCCCCCCCHHH
VKAFTEIPLGKGEVRRRTSQPDGKRIAILAFGTMVAPSLAAADALDATVANMRFVKPIDA
HHHHHHCCCCCCHHHHCCCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHCEECCCCCH
ELVQALARTHDYLVTVEEGCVMGGAGSACVEAMMESGVVRPVLQLGLPDRFVDHGDPAKL
HHHHHHHCCCCEEEEEECCEEECCCCHHHHHHHHHCCCHHHHHHHCCCHHHCCCCCHHHH
LSLCGLDGDGIAKSIRERFLSHAADVASPAKRVA
HHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHCC
>Mature Secondary Structure
MYDLLKTIDDPADLRRLDRRQLQPLADELRAFVLDSVSKTGGHLSSNLGTVELTIALHYV
CCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEEEE
FNTPDDRIVWDVGHQTYPHKILTGRRDGMKTLRQFDGISGFPRRSESEYDTFGTAHSSTS
ECCCCCCEEEECCCCCCCCHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCHHCCCCCCCCH
ISAALGMAIGSKLNGDDRFSIAVIGDGAMTAGMAFEAMNNAGVSEDAKLLVILNDNDMSI
HHHHHHHHHCCCCCCCCCEEEEEEECCHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCC
SPPVGALNRHLARLMSGRFYAAARAGVERVLSVAPPVLELARKLEEHAKGMVVPATLFEE
CCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCEEEHHHHHHH
FGFNYIGPIDGHDLDSLIPTLQNIKELRGPQFLHVVTKKGQGYKLAEADPVLYHGPGKFN
CCCCEECCCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCEEECCCCCEEEECCCCCC
PAEGIKPSTTPAKKTYTQVFGEWLCDAAELDARVVGITPAMREGSGMVEFEKRFPERYYD
CCCCCCCCCCCHHHHHHHHHHHHHCCHHHCCCEEEECCCCHHCCCCCCHHHHHCCHHHHC
VGIAEQHAVTFAGGLATEGLKPVVAIYSTFLQRAYDQLIHDVALQNLPVVFAIDRAGLVG
CCCCCHHHEEEECCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCEEC
ADGATHAGAYDLAFLRCIPNMTVMAASDENECRQMLHTALQQPNPTAVRYPRGAGTGVAT
CCCCCCCCHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHCCCCCCEEECCCCCCCCHHH
VKAFTEIPLGKGEVRRRTSQPDGKRIAILAFGTMVAPSLAAADALDATVANMRFVKPIDA
HHHHHHCCCCCCHHHHCCCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHCEECCCCCH
ELVQALARTHDYLVTVEEGCVMGGAGSACVEAMMESGVVRPVLQLGLPDRFVDHGDPAKL
HHHHHHHCCCCEEEEEECCEEECCCCHHHHHHHHHCCCHHHHHHHCCCHHHCCCCCHHHH
LSLCGLDGDGIAKSIRERFLSHAADVASPAKRVA
HHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA