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The map label for this gene is cobB2 [H]

Identifier: 126443091

GI number: 126443091

Start: 2430759

End: 2431697

Strand: Reverse

Name: cobB2 [H]

Synonym: BURPS668_A2518

Alternate gene names: 126443091

Gene position: 2431697-2430759 (Counterclockwise)

Preceding gene: 126443825

Following gene: 126442608

Centisome position: 77.75

GC content: 70.18

Gene sequence:

>939_bases
ATGACCGTTTCCGCCGTTGTTTCGCCGCAGCCGCAGCCACCGTCGTCATCGCCGTCGCCGGACGCGGCGTCGTTTGCCGA
TCCGCGCGCGCTCGATGCGCTGCATGCGTTCGTCGAGCGGCATCCGCGCCTGTTCGTGCTCACGGGCGCGGGCATCAGTA
CCGATTCCGGCATTCCCGGCTATCGCGACCGCAACGGCGCATGGATGCGCTCGCAGCCGATTCAGTATCGCGAGTTTCTC
GATTCCGATCATGCGCGCCGCCGCTACTGGGCGCGCAGCATGCTCGGCTGGCCCGTGGTCGGGCGCGCGCAGCCGAACGC
GTCGCATCATGCGCTCGCGCGGCTCGGCGCGGCGGCACGCATCGGGCGGCTCGTCACGCAAAACGTCGACGGGCTGCATC
AGCGCGCGGGCAGCGTCGACGTCATCGAGCTGCACGGCGGCATCGGCGGTGTCACATGTCTCGATTGCGGTGCGCATCAC
GCGCGCGCGTCGATCCAGCACGTTCTCGAAGCGGAGAATCCCGAGCTGCTCGGCGCTCGAGCGCAGCCCGCCGCCGATGG
CGACGCGCATCTCGAATGGAGCGCGCTCGACCATTTTCGCGTGCCCGCATGCCCCGCGTGCGGCGGGCTGCTGAAGCCGG
CCGTCGTATTTTTCGGCGAGAACGTGCCGCGCGAGCGCGTCGCGGCCGCCGCGCGCGCGCTCGACGACGCCGACGCGATG
CTCGTCGTCGGCTCGTCGCTGATGGTGTATTCCGGCTATCGGTTCTGCGTGTGGGCGAACGACCAGCGCAAGCCGATCGT
CGCGATCAACCTCGGGCACACCCGCGCCGATCCGCTGCTGACGCTGAAGGTCGAGGCGTCGTGCGGGCAGGCGCTCGCCG
CGCTCATCGCACGTCTCGGGCTTGCGCAGCGCGACGCGCACGGCTCGCCTCACGTCTGA

Upstream 100 bases:

>100_bases
TCGGCCTCGTCGTGCCCGGCGTTCTGTATTATGTGACGGCACGCAGGCAGACCGCGCATGTCCCCGAGCGGCTGATCCTG
CCGGACGAGCCCTCATTGCC

Downstream 100 bases:

>100_bases
TTCGATCTTCCCGATTCATTTCGTCATGCCGATCGATTCCGCTTCGCGCCAATGGGCGCCCGCCGCAGAACGCAATCGCG
AGCCGATTCTCGCCGTGCTG

Product: NAD-dependent deacetylase

Products: NA

Alternate protein names: Regulatory protein SIR2 homolog 2 [H]

Number of amino acids: Translated: 312; Mature: 311

Protein sequence:

>312_residues
MTVSAVVSPQPQPPSSSPSPDAASFADPRALDALHAFVERHPRLFVLTGAGISTDSGIPGYRDRNGAWMRSQPIQYREFL
DSDHARRRYWARSMLGWPVVGRAQPNASHHALARLGAAARIGRLVTQNVDGLHQRAGSVDVIELHGGIGGVTCLDCGAHH
ARASIQHVLEAENPELLGARAQPAADGDAHLEWSALDHFRVPACPACGGLLKPAVVFFGENVPRERVAAAARALDDADAM
LVVGSSLMVYSGYRFCVWANDQRKPIVAINLGHTRADPLLTLKVEASCGQALAALIARLGLAQRDAHGSPHV

Sequences:

>Translated_312_residues
MTVSAVVSPQPQPPSSSPSPDAASFADPRALDALHAFVERHPRLFVLTGAGISTDSGIPGYRDRNGAWMRSQPIQYREFL
DSDHARRRYWARSMLGWPVVGRAQPNASHHALARLGAAARIGRLVTQNVDGLHQRAGSVDVIELHGGIGGVTCLDCGAHH
ARASIQHVLEAENPELLGARAQPAADGDAHLEWSALDHFRVPACPACGGLLKPAVVFFGENVPRERVAAAARALDDADAM
LVVGSSLMVYSGYRFCVWANDQRKPIVAINLGHTRADPLLTLKVEASCGQALAALIARLGLAQRDAHGSPHV
>Mature_311_residues
TVSAVVSPQPQPPSSSPSPDAASFADPRALDALHAFVERHPRLFVLTGAGISTDSGIPGYRDRNGAWMRSQPIQYREFLD
SDHARRRYWARSMLGWPVVGRAQPNASHHALARLGAAARIGRLVTQNVDGLHQRAGSVDVIELHGGIGGVTCLDCGAHHA
RASIQHVLEAENPELLGARAQPAADGDAHLEWSALDHFRVPACPACGGLLKPAVVFFGENVPRERVAAAARALDDADAML
VVGSSLMVYSGYRFCVWANDQRKPIVAINLGHTRADPLLTLKVEASCGQALAALIARLGLAQRDAHGSPHV

Specific function: Modulates the activities of several enzymes which are inactive in their acetylated form [H]

COG id: COG0846

COG function: function code K; NAD-dependent protein deacetylases, SIR2 family

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 deacetylase sirtuin-type domain [H]

Homologues:

Organism=Homo sapiens, GI6912662, Length=269, Percent_Identity=44.6096654275093, Blast_Score=230, Evalue=1e-60,
Organism=Homo sapiens, GI6912664, Length=295, Percent_Identity=30.5084745762712, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI300795542, Length=301, Percent_Identity=28.5714285714286, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI13787215, Length=274, Percent_Identity=31.3868613138686, Blast_Score=118, Evalue=6e-27,
Organism=Homo sapiens, GI7657575, Length=222, Percent_Identity=29.7297297297297, Blast_Score=92, Evalue=6e-19,
Organism=Escherichia coli, GI308199517, Length=271, Percent_Identity=30.6273062730627, Blast_Score=80, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71990482, Length=282, Percent_Identity=39.7163120567376, Blast_Score=218, Evalue=5e-57,
Organism=Caenorhabditis elegans, GI71990487, Length=284, Percent_Identity=39.4366197183099, Blast_Score=213, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI17567771, Length=273, Percent_Identity=37.3626373626374, Blast_Score=206, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI17541892, Length=284, Percent_Identity=27.8169014084507, Blast_Score=94, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI17505510, Length=124, Percent_Identity=32.258064516129, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI28571445, Length=269, Percent_Identity=44.6096654275093, Blast_Score=226, Evalue=2e-59,
Organism=Drosophila melanogaster, GI28571443, Length=219, Percent_Identity=44.2922374429224, Blast_Score=187, Evalue=6e-48,
Organism=Drosophila melanogaster, GI28571441, Length=219, Percent_Identity=44.2922374429224, Blast_Score=187, Evalue=6e-48,
Organism=Drosophila melanogaster, GI24648389, Length=219, Percent_Identity=25.5707762557078, Blast_Score=83, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003000 [H]

Pfam domain/function: PF02146 SIR2 [H]

EC number: 3.5.1.- [C]

Molecular weight: Translated: 33294; Mature: 33163

Theoretical pI: Translated: 7.95; Mature: 7.95

Prosite motif: PS50305 SIRTUIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVSAVVSPQPQPPSSSPSPDAASFADPRALDALHAFVERHPRLFVLTGAGISTDSGIPG
CCEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCC
YRDRNGAWMRSQPIQYREFLDSDHARRRYWARSMLGWPVVGRAQPNASHHALARLGAAAR
CCCCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHCCCCEECCCCCCCHHHHHHHHHHHHH
IGRLVTQNVDGLHQRAGSVDVIELHGGIGGVTCLDCGAHHARASIQHVLEAENPELLGAR
HHHHHHHCHHHHHHHCCCEEEEEECCCCCCEEEECCCCHHHHHHHHHHHHCCCCCEECCC
AQPAADGDAHLEWSALDHFRVPACPACGGLLKPAVVFFGENVPRERVAAAARALDDADAM
CCCCCCCCCEEEEHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCEE
LVVGSSLMVYSGYRFCVWANDQRKPIVAINLGHTRADPLLTLKVEASCGQALAALIARLG
EEECCEEEEECCEEEEEEECCCCCCEEEEECCCCCCCCEEEEEECCCHHHHHHHHHHHHC
LAQRDAHGSPHV
CHHCCCCCCCCC
>Mature Secondary Structure 
TVSAVVSPQPQPPSSSPSPDAASFADPRALDALHAFVERHPRLFVLTGAGISTDSGIPG
CEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCC
YRDRNGAWMRSQPIQYREFLDSDHARRRYWARSMLGWPVVGRAQPNASHHALARLGAAAR
CCCCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHCCCCEECCCCCCCHHHHHHHHHHHHH
IGRLVTQNVDGLHQRAGSVDVIELHGGIGGVTCLDCGAHHARASIQHVLEAENPELLGAR
HHHHHHHCHHHHHHHCCCEEEEEECCCCCCEEEECCCCHHHHHHHHHHHHCCCCCEECCC
AQPAADGDAHLEWSALDHFRVPACPACGGLLKPAVVFFGENVPRERVAAAARALDDADAM
CCCCCCCCCEEEEHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCEE
LVVGSSLMVYSGYRFCVWANDQRKPIVAINLGHTRADPLLTLKVEASCGQALAALIARLG
EEECCEEEEECCEEEEEEECCCCCCEEEEECCCCCCCCEEEEEECCCHHHHHHHHHHHHC
LAQRDAHGSPHV
CHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]