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The map label for this gene is fabD [H]

Identifier: 126443050

GI number: 126443050

Start: 476892

End: 477791

Strand: Reverse

Name: fabD [H]

Synonym: BURPS668_A0524

Alternate gene names: 126443050

Gene position: 477791-476892 (Counterclockwise)

Preceding gene: 126443917

Following gene: 126442476

Centisome position: 15.28

GC content: 72.67

Gene sequence:

>900_bases
ATGAAGGCACTGATTTTCCCGGGGCAGGGCGCGCAGGCGGCCGGCATGGGCGCCGGTCTCTTCGAGCGGTTTCCGGAGAT
CGTCGCGACGGCTAACGACGTGATGGGCCTGTCGATCGAACGGCTTTGCCTCGACGATCCGCACGGCCAGCTCGCCGACA
CCCGCTACGCTCAGCCCGCGATCTTCGTCGTCAACGCGCTCCACCTCGCCGCATGGCGCGACGCGCACGACACGGGCGAC
GGCGCGCCCGTGTGGCTCGCCGGACACAGCCTCGGCGAATACAGCGCGCTCCTCGCCGCCGGCGTGTTCGACTTTCGCAC
CGGGCTCGAGATCGTCAAGCGGCGCGGCGAGCTGTTCGCATCGGCGGGCGGCGGCGCGATGGCGGCCGTCGTCGGCGTGA
CCGCCGTCGAGCTCGGCCGCCGGCTGCGCGCCGCCGGCTTCGACGACATCGATCTCGCGAACCTCAACAGCGCCGAGCAG
ACGGTGATCGCCGGCCCGGCCGCATCGGTCGACGCCGCCGCGAGCATGCTCGACGCGGGCGGCGACGTCACCGTTCATCC
GCTGAAGGTGAGCGGCGCCTTTCACTCGCGCCGCATGACGCCGCTCAAGCCCGCGTTCGAGGCGTTCGTCTCGCGCTTCG
CGCTCGCCGAGCCCGCGCGGCCCGTCGTGTCGAACGTGACCGCCCGCCCGTATCAGCCGCCGGGCACGCCCGCCGACTAT
CTCGTCGAGCAGCTCGATCAGCCGGTGCGCTGGCGCGACAGCGTCCGCCACATGCTGCGCGCGGGCGTCGACGAGTGGAT
CGAGCTCGGCCCCGGCCGCCGGATCCTCACGCGCCTCGTCGACGCGATCCGGCTCGAACCGCCCGAGCGGCACGCCGCGC
CGCAACCCGCACTCCCTTGA

Upstream 100 bases:

>100_bases
GGAACGCATCGACCGCCTGCAGCACAAGCTCGGCGGTGTCGTCGCGATCTCGATGCTCGTCGCGCTCGGCATCGGCGGCT
ATCTGTTCGCAGGAGGATAA

Downstream 100 bases:

>100_bases
AGAGGACCGATCCGACATGTCATCCATCCAATCCGCCCTCGCCGCCTGCCGCTCGCTCACCGCGCCGCCGCCGCTCGCGC
CCGCGGCCAATTTCGCCGAC

Product: malonyl CoA-acyl carrier protein transacylase

Products: NA

Alternate protein names: AT [H]

Number of amino acids: Translated: 299; Mature: 299

Protein sequence:

>299_residues
MKALIFPGQGAQAAGMGAGLFERFPEIVATANDVMGLSIERLCLDDPHGQLADTRYAQPAIFVVNALHLAAWRDAHDTGD
GAPVWLAGHSLGEYSALLAAGVFDFRTGLEIVKRRGELFASAGGGAMAAVVGVTAVELGRRLRAAGFDDIDLANLNSAEQ
TVIAGPAASVDAAASMLDAGGDVTVHPLKVSGAFHSRRMTPLKPAFEAFVSRFALAEPARPVVSNVTARPYQPPGTPADY
LVEQLDQPVRWRDSVRHMLRAGVDEWIELGPGRRILTRLVDAIRLEPPERHAAPQPALP

Sequences:

>Translated_299_residues
MKALIFPGQGAQAAGMGAGLFERFPEIVATANDVMGLSIERLCLDDPHGQLADTRYAQPAIFVVNALHLAAWRDAHDTGD
GAPVWLAGHSLGEYSALLAAGVFDFRTGLEIVKRRGELFASAGGGAMAAVVGVTAVELGRRLRAAGFDDIDLANLNSAEQ
TVIAGPAASVDAAASMLDAGGDVTVHPLKVSGAFHSRRMTPLKPAFEAFVSRFALAEPARPVVSNVTARPYQPPGTPADY
LVEQLDQPVRWRDSVRHMLRAGVDEWIELGPGRRILTRLVDAIRLEPPERHAAPQPALP
>Mature_299_residues
MKALIFPGQGAQAAGMGAGLFERFPEIVATANDVMGLSIERLCLDDPHGQLADTRYAQPAIFVVNALHLAAWRDAHDTGD
GAPVWLAGHSLGEYSALLAAGVFDFRTGLEIVKRRGELFASAGGGAMAAVVGVTAVELGRRLRAAGFDDIDLANLNSAEQ
TVIAGPAASVDAAASMLDAGGDVTVHPLKVSGAFHSRRMTPLKPAFEAFVSRFALAEPARPVVSNVTARPYQPPGTPADY
LVEQLDQPVRWRDSVRHMLRAGVDEWIELGPGRRILTRLVDAIRLEPPERHAAPQPALP

Specific function: Involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism. It catalyzes the transfer of the malonyl-CoA group to the acyl-carrier-protein AcpK (Mal-AcpK) [H]

COG id: COG0331

COG function: function code I; (acyl-carrier-protein) S-malonyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabD family [H]

Homologues:

Organism=Homo sapiens, GI51243059, Length=293, Percent_Identity=31.0580204778157, Blast_Score=111, Evalue=7e-25,
Organism=Homo sapiens, GI27477045, Length=110, Percent_Identity=40.9090909090909, Blast_Score=66, Evalue=4e-11,
Organism=Escherichia coli, GI1787334, Length=292, Percent_Identity=35.2739726027397, Blast_Score=143, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI71984332, Length=299, Percent_Identity=26.7558528428094, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17550940, Length=299, Percent_Identity=26.4214046822742, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24665753, Length=289, Percent_Identity=29.4117647058824, Blast_Score=101, Evalue=6e-22,

Paralogues:

None

Copy number: 500 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001227
- InterPro:   IPR014043
- InterPro:   IPR016035
- InterPro:   IPR004410
- InterPro:   IPR016036 [H]

Pfam domain/function: PF00698 Acyl_transf_1 [H]

EC number: =2.3.1.39 [H]

Molecular weight: Translated: 31788; Mature: 31788

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: PS00658 FORK_HEAD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKALIFPGQGAQAAGMGAGLFERFPEIVATANDVMGLSIERLCLDDPHGQLADTRYAQPA
CCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCCCCH
IFVVNALHLAAWRDAHDTGDGAPVWLAGHSLGEYSALLAAGVFDFRTGLEIVKRRGELFA
HHHHHHHHHHHHCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEE
SAGGGAMAAVVGVTAVELGRRLRAAGFDDIDLANLNSAEQTVIAGPAASVDAAASMLDAG
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHCC
GDVTVHPLKVSGAFHSRRMTPLKPAFEAFVSRFALAEPARPVVSNVTARPYQPPGTPADY
CCEEEEEEEECCCHHHCCCCCCCHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCCCHHH
LVEQLDQPVRWRDSVRHMLRAGVDEWIELGPGRRILTRLVDAIRLEPPERHAAPQPALP
HHHHHCCCHHHHHHHHHHHHHCHHHHHHCCCCHHHHHHHHHHHHCCCCHHCCCCCCCCC
>Mature Secondary Structure
MKALIFPGQGAQAAGMGAGLFERFPEIVATANDVMGLSIERLCLDDPHGQLADTRYAQPA
CCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCCCCH
IFVVNALHLAAWRDAHDTGDGAPVWLAGHSLGEYSALLAAGVFDFRTGLEIVKRRGELFA
HHHHHHHHHHHHCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEE
SAGGGAMAAVVGVTAVELGRRLRAAGFDDIDLANLNSAEQTVIAGPAASVDAAASMLDAG
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHCC
GDVTVHPLKVSGAFHSRRMTPLKPAFEAFVSRFALAEPARPVVSNVTARPYQPPGTPADY
CCEEEEEEEECCCHHHCCCCCCCHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCCCHHH
LVEQLDQPVRWRDSVRHMLRAGVDEWIELGPGRRILTRLVDAIRLEPPERHAAPQPALP
HHHHHCCCHHHHHHHHHHHHHCHHHHHHCCCCHHHHHHHHHHHHCCCCHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA