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The map label for this gene is fabG [C]

Identifier: 126442982

GI number: 126442982

Start: 833983

End: 834984

Strand: Reverse

Name: fabG [C]

Synonym: BURPS668_A0856

Alternate gene names: 126442982

Gene position: 834984-833983 (Counterclockwise)

Preceding gene: 126444369

Following gene: 126445171

Centisome position: 26.7

GC content: 69.26

Gene sequence:

>1002_bases
ATGGAGACGAAGATGCATGCATGGAGCGCGCAACACGTGCCGCCGCAGGGCGGAAAAGTCGCGGTCGTCACGGGGGCCAA
CAGCGGCCTCGGCTGGCAGATCGCGCAAACGCTCGCCGCCAAGGGCGCGCAAGTCGTGATGGGCTGCCGGGATACGGCCA
AGGGCGAACTGGCCGCGCATGCGATCCGCACCCGCTATCCGCGCGCCCGAATCGAAGTCGAGGCGCTCGATCTCGCCGAC
CTCGCCAGCGTCTGCCGTTTCGCCGACGCCGTCGCCGATCGCCACGGCCGCGTCGACATTCTCTGCAACAACGCGGGCGT
GATGTTCCTGCCGCTGCGCCACACGCGCGATGGCTTCGAAATGCAGATGGGCACGAACCACCTCGGCCACTTCGCGTTGA
CGGGGCTGTTGCTGCCCGCGTTGCGCGCATCGCACCGCGCGCGCGTCGTGACGATGTCGAGCGGCTTCAACCGGCTCGGC
AAGATCCGCCTCGACAACATGCTCGCCGAGCGCGGCTACAACAAGTACCGCGCGTATTGCGACAGCAAGCTCGCGAACCT
GATGTTCACGCTCGAGCTGCAGCGCCGCTTCGATCAAGCGTGCCTGCCGATCCTGAGCGTGGCCGCGCACCCCGGCTATG
CGGCCACCCACCTGCAGTTCGCGGGCCCCGAAATGGCGAACTCGTCGCTCGGCACGTTCGCGATGCGCCTGTCGAACCGG
CTCGTCGCCCAATCGGCCGATGTCGGCGCGCTGCCCGCGATCCATGCGGCGACGGCGGTCGACGTCGACGGCGGCGCATA
CATCGGCCCGGCCCATCTCTGCGAGACGCGCGGCTATCCCGCCGAGGCACGCATCCCGCGTCAGGCGCGCGACGTGCGCA
TGGGCAAGCGCCTGTGGGAAAAATCCGAGCAACTGACCGGCGTGCGCTATCTCGACACGCCGCCGCCGCCCGGTTCGCGC
CGCCGCGCATCGCGCGACGACGCGACGTTCGGCGCGCTCTGA

Upstream 100 bases:

>100_bases
GGGCGCGAACGGCTTGAATCGCCGACGCTCCATCGCACCGCCCCGGAGCCCGTCCGCGCCTGCGACGGGTTCGCGAGCGC
CGCCCGACGGCGCGCCATCG

Downstream 100 bases:

>100_bases
AGCATTTCGCCAAGCCCAGGCTCGCCGCTTCTTCCGCCGCCGCGCGCGGCGGTCGAGCGGCTTTTTTTCATGCCGCGACG
CCCTGCCGCTTGCCGATTGC

Product: dehydrogenase

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 333; Mature: 333

Protein sequence:

>333_residues
METKMHAWSAQHVPPQGGKVAVVTGANSGLGWQIAQTLAAKGAQVVMGCRDTAKGELAAHAIRTRYPRARIEVEALDLAD
LASVCRFADAVADRHGRVDILCNNAGVMFLPLRHTRDGFEMQMGTNHLGHFALTGLLLPALRASHRARVVTMSSGFNRLG
KIRLDNMLAERGYNKYRAYCDSKLANLMFTLELQRRFDQACLPILSVAAHPGYAATHLQFAGPEMANSSLGTFAMRLSNR
LVAQSADVGALPAIHAATAVDVDGGAYIGPAHLCETRGYPAEARIPRQARDVRMGKRLWEKSEQLTGVRYLDTPPPPGSR
RRASRDDATFGAL

Sequences:

>Translated_333_residues
METKMHAWSAQHVPPQGGKVAVVTGANSGLGWQIAQTLAAKGAQVVMGCRDTAKGELAAHAIRTRYPRARIEVEALDLAD
LASVCRFADAVADRHGRVDILCNNAGVMFLPLRHTRDGFEMQMGTNHLGHFALTGLLLPALRASHRARVVTMSSGFNRLG
KIRLDNMLAERGYNKYRAYCDSKLANLMFTLELQRRFDQACLPILSVAAHPGYAATHLQFAGPEMANSSLGTFAMRLSNR
LVAQSADVGALPAIHAATAVDVDGGAYIGPAHLCETRGYPAEARIPRQARDVRMGKRLWEKSEQLTGVRYLDTPPPPGSR
RRASRDDATFGAL
>Mature_333_residues
METKMHAWSAQHVPPQGGKVAVVTGANSGLGWQIAQTLAAKGAQVVMGCRDTAKGELAAHAIRTRYPRARIEVEALDLAD
LASVCRFADAVADRHGRVDILCNNAGVMFLPLRHTRDGFEMQMGTNHLGHFALTGLLLPALRASHRARVVTMSSGFNRLG
KIRLDNMLAERGYNKYRAYCDSKLANLMFTLELQRRFDQACLPILSVAAHPGYAATHLQFAGPEMANSSLGTFAMRLSNR
LVAQSADVGALPAIHAATAVDVDGGAYIGPAHLCETRGYPAEARIPRQARDVRMGKRLWEKSEQLTGVRYLDTPPPPGSR
RRASRDDATFGAL

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI166795268, Length=293, Percent_Identity=38.5665529010239, Blast_Score=174, Evalue=8e-44,
Organism=Homo sapiens, GI186928839, Length=295, Percent_Identity=38.9830508474576, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI225579078, Length=300, Percent_Identity=39, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI10190746, Length=306, Percent_Identity=36.6013071895425, Blast_Score=158, Evalue=7e-39,
Organism=Homo sapiens, GI193804850, Length=302, Percent_Identity=31.7880794701987, Blast_Score=138, Evalue=6e-33,
Organism=Homo sapiens, GI19923931, Length=264, Percent_Identity=37.8787878787879, Blast_Score=132, Evalue=4e-31,
Organism=Homo sapiens, GI7706523, Length=305, Percent_Identity=33.4426229508197, Blast_Score=131, Evalue=8e-31,
Organism=Homo sapiens, GI146231950, Length=298, Percent_Identity=36.5771812080537, Blast_Score=125, Evalue=5e-29,
Organism=Homo sapiens, GI72534732, Length=159, Percent_Identity=29.559748427673, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI13375997, Length=159, Percent_Identity=29.559748427673, Blast_Score=75, Evalue=7e-14,
Organism=Escherichia coli, GI1787335, Length=210, Percent_Identity=30.4761904761905, Blast_Score=68, Evalue=7e-13,
Organism=Escherichia coli, GI87082100, Length=247, Percent_Identity=29.9595141700405, Blast_Score=68, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI193207620, Length=303, Percent_Identity=30.03300330033, Blast_Score=117, Evalue=6e-27,
Organism=Caenorhabditis elegans, GI17532805, Length=312, Percent_Identity=29.8076923076923, Blast_Score=114, Evalue=8e-26,
Organism=Caenorhabditis elegans, GI17558006, Length=205, Percent_Identity=35.609756097561, Blast_Score=108, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17505416, Length=212, Percent_Identity=30.6603773584906, Blast_Score=108, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI71992402, Length=315, Percent_Identity=28.2539682539683, Blast_Score=101, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI17532791, Length=302, Percent_Identity=28.1456953642384, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI32565532, Length=207, Percent_Identity=32.8502415458937, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17535059, Length=299, Percent_Identity=26.7558528428094, Blast_Score=85, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI72001364, Length=209, Percent_Identity=32.5358851674641, Blast_Score=82, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI115533174, Length=290, Percent_Identity=25.1724137931034, Blast_Score=64, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI115533172, Length=290, Percent_Identity=25.1724137931034, Blast_Score=64, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6324820, Length=158, Percent_Identity=34.1772151898734, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6324148, Length=202, Percent_Identity=29.2079207920792, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28573296, Length=295, Percent_Identity=35.9322033898305, Blast_Score=155, Evalue=4e-38,
Organism=Drosophila melanogaster, GI22024069, Length=297, Percent_Identity=33.3333333333333, Blast_Score=145, Evalue=5e-35,
Organism=Drosophila melanogaster, GI19921754, Length=303, Percent_Identity=35.973597359736, Blast_Score=144, Evalue=7e-35,
Organism=Drosophila melanogaster, GI45554248, Length=293, Percent_Identity=34.8122866894198, Blast_Score=142, Evalue=3e-34,
Organism=Drosophila melanogaster, GI24640117, Length=293, Percent_Identity=34.8122866894198, Blast_Score=142, Evalue=3e-34,
Organism=Drosophila melanogaster, GI161076371, Length=203, Percent_Identity=40.3940886699507, Blast_Score=136, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24656154, Length=269, Percent_Identity=35.3159851301115, Blast_Score=132, Evalue=2e-31,
Organism=Drosophila melanogaster, GI19922628, Length=269, Percent_Identity=35.3159851301115, Blast_Score=132, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24586328, Length=293, Percent_Identity=33.4470989761092, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI20129347, Length=303, Percent_Identity=30.6930693069307, Blast_Score=128, Evalue=5e-30,
Organism=Drosophila melanogaster, GI45553409, Length=302, Percent_Identity=29.8013245033113, Blast_Score=121, Evalue=5e-28,
Organism=Drosophila melanogaster, GI24647948, Length=302, Percent_Identity=29.8013245033113, Blast_Score=121, Evalue=5e-28,
Organism=Drosophila melanogaster, GI24647946, Length=302, Percent_Identity=29.8013245033113, Blast_Score=121, Evalue=7e-28,
Organism=Drosophila melanogaster, GI24647931, Length=200, Percent_Identity=35.5, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI21358495, Length=221, Percent_Identity=29.4117647058824, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 36165; Mature: 36165

Theoretical pI: Translated: 10.04; Mature: 10.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METKMHAWSAQHVPPQGGKVAVVTGANSGLGWQIAQTLAAKGAQVVMGCRDTAKGELAAH
CCCCCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHCCCEEEEECCCCCCHHHHHH
AIRTRYPRARIEVEALDLADLASVCRFADAVADRHGRVDILCNNAGVMFLPLRHTRDGFE
HHHHCCCCCEEEEEECCHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEEEEECCCCCCCE
MQMGTNHLGHFALTGLLLPALRASHRARVVTMSSGFNRLGKIRLDNMLAERGYNKYRAYC
EECCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCHHHHHHH
DSKLANLMFTLELQRRFDQACLPILSVAAHPGYAATHLQFAGPEMANSSLGTFAMRLSNR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHCCCCHHHHHHHHHHH
LVAQSADVGALPAIHAATAVDVDGGAYIGPAHLCETRGYPAEARIPRQARDVRMGKRLWE
HHHCCCCCCCCCHHHHHEEEECCCCCEECHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHH
KSEQLTGVRYLDTPPPPGSRRRASRDDATFGAL
HHHHHCCEEEECCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
METKMHAWSAQHVPPQGGKVAVVTGANSGLGWQIAQTLAAKGAQVVMGCRDTAKGELAAH
CCCCCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHCCCEEEEECCCCCCHHHHHH
AIRTRYPRARIEVEALDLADLASVCRFADAVADRHGRVDILCNNAGVMFLPLRHTRDGFE
HHHHCCCCCEEEEEECCHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEEEEECCCCCCCE
MQMGTNHLGHFALTGLLLPALRASHRARVVTMSSGFNRLGKIRLDNMLAERGYNKYRAYC
EECCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCHHHHHHH
DSKLANLMFTLELQRRFDQACLPILSVAAHPGYAATHLQFAGPEMANSSLGTFAMRLSNR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHCCCCHHHHHHHHHHH
LVAQSADVGALPAIHAATAVDVDGGAYIGPAHLCETRGYPAEARIPRQARDVRMGKRLWE
HHHCCCCCCCCCHHHHHEEEECCCCCEECHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHH
KSEQLTGVRYLDTPPPPGSRRRASRDDATFGAL
HHHHHCCEEEECCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8383668 [H]