Click here to switch to the map view.

The map label for this gene is napA [H]

Identifier: 126442763

GI number: 126442763

Start: 1598198

End: 1599430

Strand: Reverse

Name: napA [H]

Synonym: BURPS668_A1654

Alternate gene names: 126442763

Gene position: 1599430-1598198 (Counterclockwise)

Preceding gene: 126443761

Following gene: 126442531

Centisome position: 51.14

GC content: 69.99

Gene sequence:

>1233_bases
ATGGTTATGTGGTTATTGCAGCTCGCGGCGATCATCGCCGCGTGCGCCTGCTTCGGTTGGCTCGCGCAACGCGTCGGGCA
AGCGAAAGTGGTCGGCGAGCTGGCCGCGGGCATCGTGCTCGGCCCGGCCGTGCTCGGCGCGATCGATTCGAACGTTCATG
CGATGATCTTCGGCCCCGCCGCGTCGTCGGGCATGGCGCAACTGGGCGAGGTCGGCGTGATCGCGCTGATGTTCCAGATC
GGGCTGCACATGAATCTCGGCGGCGCGCCGACGCTGCGTTCGCTGAGGAAGATGCCGCCCGCGGTGGTGGTGGCCGGAAT
CGGCATGCTGCTGCCGCTGGCGGGCGGCATGGCGATCGGCTGTCTGTCGCACGACGCGCTCGCGCCGCGAATCGCCGCGT
GGCCTTACGTGCTGTTCTGCGGCGTCGCGCTGTCGGTCTCCGCGCTGCCGGTGATGGCGAGAATCGTCATCGACATGGAG
CTCGTCGATGCGCCGCCGTCGCTGCTCGCATTGTCGGCCGCGATGCTGACCGACCTCGCGGGCTGGATCATGCTCGCGTT
CGTCTCGGCCATCGCCGTCGCCGGCGCGGATGCCGCCGGGCCCTCGCATATCGTCGTCGGCATCGCCGCGTTCGTGCTGC
TGGCGAAGCTCGCCGCGCGGTTCGTCGTCACGCCGCTCGCCGCCGATGCGGCGAAGCGGGCGTCGCCCGCGAGGCTGATG
AGCGTCGTCGTGCCGTACGTGCTGGTTTGCGCGTGGGCGACCACGGCGATCGGCGTGCACAGCGCGTTCGGCGCGCTGCT
CGCCGCCGTGATGCTGCGCGGCGTGCCGGGGCTGCAGGCGCAATGGGAGCGCCAGATGGAAGGCTTCGTGAACGCGGTGC
TGCTGCCCGTGTTCTTCGTCCATTCGGGGCTGCGCGTCACCTTCGACAGCTTCGACGGCGCCTCGCCGTGGCTGTGGCTC
GTGCCGTTCCTGTGCGTCGCGTTCGTCGGCAAGTTCGGCGGCGCGTATCTCGGCGCGCGCCTCTGCGGAATGAACCGGGG
CGACGCGGCGCTCGTCGGCTCGCTGATGAACACGCGCGGGCTCGTCGAGCTGGTCGTGTTGTCGGCGGGGCTGCAGATCC
ATGCGCTGTCGCAAAGCGCCTATGCGGTGCTTCTGCTCGTCGCGCTGACGACGACGGCGATGACGACGCCGTTCGTCCGG
TTGTGGCGGCGCGCGGTATTGCGCCCCGCCTGA

Upstream 100 bases:

>100_bases
TTGCATTGTACTGACGCGGCTTTGGCGGCCGAATGTCGGCCGGGACACGAACGCTGTCGGATCGCCCGCCATCACGCCGG
TCGAGCCGAGGAGGATCCGG

Downstream 100 bases:

>100_bases
CGCCGCGACGCTCGGTTGCGGCGGCCCCTCATCCTGAACGGCTTGCTCACATGGACAGAAGATCGATCATCGCCGACGAC
GGGCGCGAGCTGAACGCGTT

Product: monovalent cation:proton antiporter-2 (CPA2) family protein

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 410; Mature: 410

Protein sequence:

>410_residues
MVMWLLQLAAIIAACACFGWLAQRVGQAKVVGELAAGIVLGPAVLGAIDSNVHAMIFGPAASSGMAQLGEVGVIALMFQI
GLHMNLGGAPTLRSLRKMPPAVVVAGIGMLLPLAGGMAIGCLSHDALAPRIAAWPYVLFCGVALSVSALPVMARIVIDME
LVDAPPSLLALSAAMLTDLAGWIMLAFVSAIAVAGADAAGPSHIVVGIAAFVLLAKLAARFVVTPLAADAAKRASPARLM
SVVVPYVLVCAWATTAIGVHSAFGALLAAVMLRGVPGLQAQWERQMEGFVNAVLLPVFFVHSGLRVTFDSFDGASPWLWL
VPFLCVAFVGKFGGAYLGARLCGMNRGDAALVGSLMNTRGLVELVVLSAGLQIHALSQSAYAVLLLVALTTTAMTTPFVR
LWRRAVLRPA

Sequences:

>Translated_410_residues
MVMWLLQLAAIIAACACFGWLAQRVGQAKVVGELAAGIVLGPAVLGAIDSNVHAMIFGPAASSGMAQLGEVGVIALMFQI
GLHMNLGGAPTLRSLRKMPPAVVVAGIGMLLPLAGGMAIGCLSHDALAPRIAAWPYVLFCGVALSVSALPVMARIVIDME
LVDAPPSLLALSAAMLTDLAGWIMLAFVSAIAVAGADAAGPSHIVVGIAAFVLLAKLAARFVVTPLAADAAKRASPARLM
SVVVPYVLVCAWATTAIGVHSAFGALLAAVMLRGVPGLQAQWERQMEGFVNAVLLPVFFVHSGLRVTFDSFDGASPWLWL
VPFLCVAFVGKFGGAYLGARLCGMNRGDAALVGSLMNTRGLVELVVLSAGLQIHALSQSAYAVLLLVALTTTAMTTPFVR
LWRRAVLRPA
>Mature_410_residues
MVMWLLQLAAIIAACACFGWLAQRVGQAKVVGELAAGIVLGPAVLGAIDSNVHAMIFGPAASSGMAQLGEVGVIALMFQI
GLHMNLGGAPTLRSLRKMPPAVVVAGIGMLLPLAGGMAIGCLSHDALAPRIAAWPYVLFCGVALSVSALPVMARIVIDME
LVDAPPSLLALSAAMLTDLAGWIMLAFVSAIAVAGADAAGPSHIVVGIAAFVLLAKLAARFVVTPLAADAAKRASPARLM
SVVVPYVLVCAWATTAIGVHSAFGALLAAVMLRGVPGLQAQWERQMEGFVNAVLLPVFFVHSGLRVTFDSFDGASPWLWL
VPFLCVAFVGKFGGAYLGARLCGMNRGDAALVGSLMNTRGLVELVVLSAGLQIHALSQSAYAVLLLVALTTTAMTTPFVR
LWRRAVLRPA

Specific function: This is a Na(+)/H(+) antiporter. It can mediate sodium uptake when a transmembrane pH gradient is applied [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6322367, Length=410, Percent_Identity=25.3658536585366, Blast_Score=144, Evalue=2e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 42390; Mature: 42390

Theoretical pI: Translated: 9.15; Mature: 9.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVMWLLQLAAIIAACACFGWLAQRVGQAKVVGELAAGIVLGPAVLGAIDSNVHAMIFGPA
CHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCC
ASSGMAQLGEVGVIALMFQIGLHMNLGGAPTLRSLRKMPPAVVVAGIGMLLPLAGGMAIG
CCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHCCHHEE
CLSHDALAPRIAAWPYVLFCGVALSVSALPVMARIVIDMELVDAPPSLLALSAAMLTDLA
HHCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
GWIMLAFVSAIAVAGADAAGPSHIVVGIAAFVLLAKLAARFVVTPLAADAAKRASPARLM
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
SVVVPYVLVCAWATTAIGVHSAFGALLAAVMLRGVPGLQAQWERQMEGFVNAVLLPVFFV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
HSGLRVTFDSFDGASPWLWLVPFLCVAFVGKFGGAYLGARLCGMNRGDAALVGSLMNTRG
HCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCHHHHHHHHHHHHH
LVELVVLSAGLQIHALSQSAYAVLLLVALTTTAMTTPFVRLWRRAVLRPA
HHHHHHHHCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MVMWLLQLAAIIAACACFGWLAQRVGQAKVVGELAAGIVLGPAVLGAIDSNVHAMIFGPA
CHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCC
ASSGMAQLGEVGVIALMFQIGLHMNLGGAPTLRSLRKMPPAVVVAGIGMLLPLAGGMAIG
CCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHCCHHEE
CLSHDALAPRIAAWPYVLFCGVALSVSALPVMARIVIDMELVDAPPSLLALSAAMLTDLA
HHCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
GWIMLAFVSAIAVAGADAAGPSHIVVGIAAFVLLAKLAARFVVTPLAADAAKRASPARLM
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
SVVVPYVLVCAWATTAIGVHSAFGALLAAVMLRGVPGLQAQWERQMEGFVNAVLLPVFFV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
HSGLRVTFDSFDGASPWLWLVPFLCVAFVGKFGGAYLGARLCGMNRGDAALVGSLMNTRG
HCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCHHHHHHHHHHHHH
LVELVVLSAGLQIHALSQSAYAVLLLVALTTTAMTTPFVRLWRRAVLRPA
HHHHHHHHCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1312090; 1325937 [H]