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The map label for this gene is folE [H]

Identifier: 126442309

GI number: 126442309

Start: 1709649

End: 1710281

Strand: Reverse

Name: folE [H]

Synonym: BURPS668_A1761

Alternate gene names: 126442309

Gene position: 1710281-1709649 (Counterclockwise)

Preceding gene: 126444743

Following gene: 126442956

Centisome position: 54.69

GC content: 67.77

Gene sequence:

>633_bases
ATGCATCAAACGGGAAACGAGCGCGCGTGCGGCGCGCACGATCAACCGCATGCGGAAATCCGGCGCACGGGCCGGTTCGA
TCCCGTCGCATTCGAGGCGGCGGTTCGCGCGCTGCTCGAGGCGAGCGGCATCGAGATCGACAGCGCGCACACCGGCCGCA
CTGCGCAGCGTGTGCGCGAGCTCTGGCAGCGGCGTTTGCTCGACGGCTACGAAGTCGATCCGGCTCAGGCGCTGGGCGCG
GGCTTCGACGATCCGCGCGAGGACATGGTGATCGTCCGCAGCATCGCCGTGCACGGCGTGTGCCCGCATCATTTGCTGCC
GTTTCGCGGCGTCGCCCATGTGGCGTATCTGCCGGGCGGGCGCTTGCACGGCTTCGGACGCATCGCGCGCATGATCGACG
CGATCAGCCATCGCTATACGTATCAGGAGTGGATCACGCACCGGATCGCGACGGCGCTCGTGACGCATGGTCAGGCGCGC
GGCGCGGCGTGCCTGATCGAGGCCGAGCAGCTGTGCCTGTTGATGGGCGAGAACCGGCGAGGCGACGAGCGTGTGATCAC
GCAGTGCTACGCCGGCGAATTCGAGCGCGACGTTCAGGCCCGCAACGAGTTTCTTCGCGGCATCCACCGTTAG

Upstream 100 bases:

>100_bases
TCGCGACTCCGGCCGCCCCGGACGCCGGGCGCAGGCGAGTGCCCGGCGCGGTCGCCATGGGCATGTCGACGAAATTGCGG
GTGTTTCAAAGGGAACGCAA

Downstream 100 bases:

>100_bases
GCGACGCCGGCGGCGCGCCGCGGCCGGCGTTTGCCGGATGCGGGCGCGGCCCGGCCGATGCGGCTCGCGTCTTGCGTCAT
TCGCGGGCGGCGGCGTGCGT

Product: GTP cyclohydrolase I

Products: NA

Alternate protein names: GTP cyclohydrolase I; GTP-CH-I [H]

Number of amino acids: Translated: 210; Mature: 210

Protein sequence:

>210_residues
MHQTGNERACGAHDQPHAEIRRTGRFDPVAFEAAVRALLEASGIEIDSAHTGRTAQRVRELWQRRLLDGYEVDPAQALGA
GFDDPREDMVIVRSIAVHGVCPHHLLPFRGVAHVAYLPGGRLHGFGRIARMIDAISHRYTYQEWITHRIATALVTHGQAR
GAACLIEAEQLCLLMGENRRGDERVITQCYAGEFERDVQARNEFLRGIHR

Sequences:

>Translated_210_residues
MHQTGNERACGAHDQPHAEIRRTGRFDPVAFEAAVRALLEASGIEIDSAHTGRTAQRVRELWQRRLLDGYEVDPAQALGA
GFDDPREDMVIVRSIAVHGVCPHHLLPFRGVAHVAYLPGGRLHGFGRIARMIDAISHRYTYQEWITHRIATALVTHGQAR
GAACLIEAEQLCLLMGENRRGDERVITQCYAGEFERDVQARNEFLRGIHR
>Mature_210_residues
MHQTGNERACGAHDQPHAEIRRTGRFDPVAFEAAVRALLEASGIEIDSAHTGRTAQRVRELWQRRLLDGYEVDPAQALGA
GFDDPREDMVIVRSIAVHGVCPHHLLPFRGVAHVAYLPGGRLHGFGRIARMIDAISHRYTYQEWITHRIATALVTHGQAR
GAACLIEAEQLCLLMGENRRGDERVITQCYAGEFERDVQARNEFLRGIHR

Specific function: Tetrahydrofolate biosynthesis; first step. [C]

COG id: COG0302

COG function: function code H; GTP cyclohydrolase I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase I family [H]

Homologues:

Organism=Homo sapiens, GI66932968, Length=141, Percent_Identity=33.3333333333333, Blast_Score=96, Evalue=2e-20,
Organism=Homo sapiens, GI4503949, Length=141, Percent_Identity=33.3333333333333, Blast_Score=96, Evalue=2e-20,
Organism=Homo sapiens, GI66932970, Length=111, Percent_Identity=31.5315315315315, Blast_Score=74, Evalue=8e-14,
Organism=Homo sapiens, GI66932972, Length=89, Percent_Identity=37.0786516853933, Blast_Score=73, Evalue=2e-13,
Organism=Escherichia coli, GI1788476, Length=122, Percent_Identity=31.1475409836066, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17560486, Length=143, Percent_Identity=36.3636363636364, Blast_Score=110, Evalue=7e-25,
Organism=Saccharomyces cerevisiae, GI6321706, Length=180, Percent_Identity=28.8888888888889, Blast_Score=89, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24656796, Length=131, Percent_Identity=32.824427480916, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24656791, Length=131, Percent_Identity=32.824427480916, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24656782, Length=131, Percent_Identity=32.824427480916, Blast_Score=89, Evalue=2e-18,

Paralogues:

None

Copy number: 420 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001474
- InterPro:   IPR020602
- InterPro:   IPR018234 [H]

Pfam domain/function: PF01227 GTP_cyclohydroI [H]

EC number: =3.5.4.16 [H]

Molecular weight: Translated: 23574; Mature: 23574

Theoretical pI: Translated: 7.41; Mature: 7.41

Prosite motif: PS00859 GTP_CYCLOHYDROL_1_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHQTGNERACGAHDQPHAEIRRTGRFDPVAFEAAVRALLEASGIEIDSAHTGRTAQRVRE
CCCCCCCCCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHCCCEECCCCCCHHHHHHHH
LWQRRLLDGYEVDPAQALGAGFDDPREDMVIVRSIAVHGVCPHHLLPFRGVAHVAYLPGG
HHHHHCCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHCCCCHHCCCCCHHHHHEECCCC
RLHGFGRIARMIDAISHRYTYQEWITHRIATALVTHGQARGAACLIEAEQLCLLMGENRR
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHCCCCC
GDERVITQCYAGEFERDVQARNEFLRGIHR
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MHQTGNERACGAHDQPHAEIRRTGRFDPVAFEAAVRALLEASGIEIDSAHTGRTAQRVRE
CCCCCCCCCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHCCCEECCCCCCHHHHHHHH
LWQRRLLDGYEVDPAQALGAGFDDPREDMVIVRSIAVHGVCPHHLLPFRGVAHVAYLPGG
HHHHHCCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHCCCCHHCCCCCHHHHHEECCCC
RLHGFGRIARMIDAISHRYTYQEWITHRIATALVTHGQARGAACLIEAEQLCLLMGENRR
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHCCCCC
GDERVITQCYAGEFERDVQARNEFLRGIHR
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]