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The map label for this gene is map [H]

Identifier: 126209484

GI number: 126209484

Start: 2257069

End: 2257875

Strand: Direct

Name: map [H]

Synonym: APL_2030

Alternate gene names: 126209484

Gene position: 2257069-2257875 (Clockwise)

Preceding gene: 126209483

Following gene: 126209489

Centisome position: 99.23

GC content: 42.63

Gene sequence:

>807_bases
ATGAGCAAGATTCCATTAAGAACAGAAGAAGAGATTGAGAAATTACGTGTCGCTTGTAAATTAGCCTCCGACGTATTGGT
AATGATTGAGCCGTATGTAAAAGAAGGCGTAAGCACCGCAGAATTAGACCGCATTTGTCATGAATATATCGTGAACGAGC
AGAAGGCGATTCCGGCGTGTTTAAATTATCACGGCTTCCCGAATGCAACTTGTATTTCATTAAATGAAGTGGTGTGTCAC
GGTATTCCGAGTGCGGATCGTAAATTGAAAAAAGGCGATATTTTAAATATTGACGTAACGGTGATTAAAGACGGTTACTA
TGGCGATAATTCGAAAATGTATGTGGTCGGTGAGCCGAGCATCCGTGATAAGCGTTTAATTGAAGTGACATTAGAATCGC
TTTATATCGGTTTACGTACGGTAAAACCGGGCATTCGTTTAAAAGAAATCGGTAAAACCATTCAGCGATATGTGGAAAAA
CAAGGTTTCTCGGTGGTGCGTGAATATTGCGGTCACGGTATCGGTACCGAATTCCATTGCGATCCGCAAGTGCTTCACTA
CAATTCTGATGACGGTGGCGTAGTATTGCAAGAAGGTATGGTGTTTACCATTGAGCCGATGGTCAATGCGGGTAAAAAAG
AAATCCGCAATATGCCGGACGGTTGGACGGTGAAAACCAAAGATCGCAGCCATTCGGCGCAGTTTGAACACCAAATTGTG
GTGACTAAAGAAGGCTGTGAAGTGATGACGATTCGTGATGAAGAAATTGCCGAAGGCAGAATTTCTCGCATGATGAAAAA
CGTTTAA

Upstream 100 bases:

>100_bases
GGGGATTATGCTGAAAAAAGGTATAATCCCCTTACTTTTTTCTGCGTATTTGCAAGAAAATTGAGAAATTTAACCGCTTA
AATTAAGAAGAGAGAACAGT

Downstream 100 bases:

>100_bases
TCGTGATAAATAAAAAATCCACCGTACAAGCGGTGGATTTTTTATGGTTTTTGCAATGAGATGTAACTAAGCCTTAGTCA
GGATTTCTAACAGTTCGGCT

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 268; Mature: 267

Protein sequence:

>268_residues
MSKIPLRTEEEIEKLRVACKLASDVLVMIEPYVKEGVSTAELDRICHEYIVNEQKAIPACLNYHGFPNATCISLNEVVCH
GIPSADRKLKKGDILNIDVTVIKDGYYGDNSKMYVVGEPSIRDKRLIEVTLESLYIGLRTVKPGIRLKEIGKTIQRYVEK
QGFSVVREYCGHGIGTEFHCDPQVLHYNSDDGGVVLQEGMVFTIEPMVNAGKKEIRNMPDGWTVKTKDRSHSAQFEHQIV
VTKEGCEVMTIRDEEIAEGRISRMMKNV

Sequences:

>Translated_268_residues
MSKIPLRTEEEIEKLRVACKLASDVLVMIEPYVKEGVSTAELDRICHEYIVNEQKAIPACLNYHGFPNATCISLNEVVCH
GIPSADRKLKKGDILNIDVTVIKDGYYGDNSKMYVVGEPSIRDKRLIEVTLESLYIGLRTVKPGIRLKEIGKTIQRYVEK
QGFSVVREYCGHGIGTEFHCDPQVLHYNSDDGGVVLQEGMVFTIEPMVNAGKKEIRNMPDGWTVKTKDRSHSAQFEHQIV
VTKEGCEVMTIRDEEIAEGRISRMMKNV
>Mature_267_residues
SKIPLRTEEEIEKLRVACKLASDVLVMIEPYVKEGVSTAELDRICHEYIVNEQKAIPACLNYHGFPNATCISLNEVVCHG
IPSADRKLKKGDILNIDVTVIKDGYYGDNSKMYVVGEPSIRDKRLIEVTLESLYIGLRTVKPGIRLKEIGKTIQRYVEKQ
GFSVVREYCGHGIGTEFHCDPQVLHYNSDDGGVVLQEGMVFTIEPMVNAGKKEIRNMPDGWTVKTKDRSHSAQFEHQIVV
TKEGCEVMTIRDEEIAEGRISRMMKNV

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=251, Percent_Identity=44.2231075697211, Blast_Score=232, Evalue=2e-61,
Organism=Homo sapiens, GI40385867, Length=248, Percent_Identity=38.7096774193548, Blast_Score=196, Evalue=2e-50,
Organism=Escherichia coli, GI1786364, Length=259, Percent_Identity=66.7953667953668, Blast_Score=365, Evalue=1e-102,
Organism=Escherichia coli, GI1788728, Length=250, Percent_Identity=24, Blast_Score=74, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI71996291, Length=251, Percent_Identity=45.0199203187251, Blast_Score=223, Evalue=8e-59,
Organism=Saccharomyces cerevisiae, GI6323273, Length=266, Percent_Identity=40.6015037593985, Blast_Score=217, Evalue=2e-57,
Organism=Drosophila melanogaster, GI21355531, Length=253, Percent_Identity=44.6640316205534, Blast_Score=223, Evalue=8e-59,
Organism=Drosophila melanogaster, GI24583427, Length=249, Percent_Identity=40.9638554216867, Blast_Score=200, Evalue=1e-51,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 30245; Mature: 30114

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00680 MAP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKIPLRTEEEIEKLRVACKLASDVLVMIEPYVKEGVSTAELDRICHEYIVNEQKAIPAC
CCCCCCCCHHHHHHHHHHHHHHHCCEEEECHHHHCCCCHHHHHHHHHHHHHCCCCCCHHH
LNYHGFPNATCISLNEVVCHGIPSADRKLKKGDILNIDVTVIKDGYYGDNSKMYVVGEPS
HCCCCCCCCEEEEHHHHHHCCCCCHHHHCCCCCEEEEEEEEEECCEECCCCEEEEEECCC
IRDKRLIEVTLESLYIGLRTVKPGIRLKEIGKTIQRYVEKQGFSVVREYCGHGIGTEFHC
CCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCEEC
DPQVLHYNSDDGGVVLQEGMVFTIEPMVNAGKKEIRNMPDGWTVKTKDRSHSAQFEHQIV
CCEEEEEECCCCCEEEECCEEEEEEHHHCCCHHHHHCCCCCCEEEECCCCCCCCCEEEEE
VTKEGCEVMTIRDEEIAEGRISRMMKNV
EEECCCEEEEECCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SKIPLRTEEEIEKLRVACKLASDVLVMIEPYVKEGVSTAELDRICHEYIVNEQKAIPAC
CCCCCCCHHHHHHHHHHHHHHHCCEEEECHHHHCCCCHHHHHHHHHHHHHCCCCCCHHH
LNYHGFPNATCISLNEVVCHGIPSADRKLKKGDILNIDVTVIKDGYYGDNSKMYVVGEPS
HCCCCCCCCEEEEHHHHHHCCCCCHHHHCCCCCEEEEEEEEEECCEECCCCEEEEEECCC
IRDKRLIEVTLESLYIGLRTVKPGIRLKEIGKTIQRYVEKQGFSVVREYCGHGIGTEFHC
CCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCEEC
DPQVLHYNSDDGGVVLQEGMVFTIEPMVNAGKKEIRNMPDGWTVKTKDRSHSAQFEHQIV
CCEEEEEECCCCCEEEECCEEEEEEHHHCCCHHHHHCCCCCCEEEECCCCCCCCCEEEEE
VTKEGCEVMTIRDEEIAEGRISRMMKNV
EEECCCEEEEECCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]