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The map label for this gene is hisB [H]

Identifier: 126209477

GI number: 126209477

Start: 2250366

End: 2251457

Strand: Direct

Name: hisB [H]

Synonym: APL_2023

Alternate gene names: 126209477

Gene position: 2250366-2251457 (Clockwise)

Preceding gene: 126209476

Following gene: 126209478

Centisome position: 98.94

GC content: 47.16

Gene sequence:

>1092_bases
ATGACACAACCAACCCTATTCATCGACCGTGACGGCACTTTGATTGACGAACCGAAAACCGATTTCCAAATTGATAGCTT
GGAGAAACTCAAACTGGAACGCAATGTGATTCCTGCATTGCTGAAATTAAAAGATCACTACCGTTTTGTGATGGTCAGCA
ATCAGGACGGTTTAGGCACCAGCTCATTTCCGCAAGAGACCTTCGACAAACCGCACAATGCCATGATGGAACTGTTCCGC
TCGCAAGGCATTGAGTTTGATGAAGTGCTAATTTGCCCACACAAGCCTGAAGACAACTGCGATTGTCGCAAACCGAAAAC
CAAACTATTACAAAAATATATCGACCGTGAACTGTTCGATCCTGCCACCAGTTTTGTCATCGGCGACCGTGCAACAGACG
TTCAGTTAGCGGAAAATCTTGGTATTCGTGCTTTGCAATATCACCCTGAAAAATTAAATTGGGATTTAATTGCGGAAAAA
CTGCTGGGCGAAGCCGTGACTAATATCGGCGACCGCCAACCACGCTATGCGGAAGTGGTACGCAAAACCAAAGAGACCGA
CATCAAAGTGCAAGTGTGGCTGGACGAAACCGGCGTGAACGACATCAAAACGGGCGTAGGCTTTTTCGACCATATGCTCG
ACCAAATTGCCACCCACGGCGGTTTCCGTATGAACATCTCGTGCAAAGGCGACCTATGGATTGACGAACATCACACGGTT
GAAGACACCGCCCTTGCCCTCGGTACTGCCTTAAAACAAGCCATCGGCGACAAACGCGGCATTGCCCGCTTTGGTTTTGT
GCTACCAATGGACGAATGCCAAGCTCAATGTGCCATGGATTTATCCGGCAGACCGTTTATTAAATTCAAAGCGGAATTTA
AACGCGATAAAGTCGGCGACTTTAGCACCGAATTGACGGAGCATTTCTTCCAATCCATCGCTTTCACGATGCTTGCCACC
TTGCATATCAAAGCCAAAGGCGACAATGACCACCACAAAATCGAAAGCCTGTTTAAAGTATTCGGCAGAACCTTACGACA
AGCCATTCGCATTGAAGGGAATGAATTGCCGAGTTCGAAAGGGGTTTTATAA

Upstream 100 bases:

>100_bases
CCAGCCACGCTGTGGCTGATAATTAGATAATATAGAGCCGCAGGGCGGCTCGGATTAAGTAGCCCCATACGGCTCGTATG
GGGGGATCACAGGAGCAAAC

Downstream 100 bases:

>100_bases
TCGGAAAATTGTAGGGCGTACTCGTACTACGTACGCCCCAAAGTGCGGTTAATTTTTGCAAGGCTTTTTGGGAAAGTGGT
CGCTTGTAAAACGGTATGAT

Product: imidazole glycerol-phosphate dehydratase/histidinol phosphatase

Products: NA

Alternate protein names: Histidinol-phosphatase; Imidazoleglycerol-phosphate dehydratase; IGPD [H]

Number of amino acids: Translated: 363; Mature: 362

Protein sequence:

>363_residues
MTQPTLFIDRDGTLIDEPKTDFQIDSLEKLKLERNVIPALLKLKDHYRFVMVSNQDGLGTSSFPQETFDKPHNAMMELFR
SQGIEFDEVLICPHKPEDNCDCRKPKTKLLQKYIDRELFDPATSFVIGDRATDVQLAENLGIRALQYHPEKLNWDLIAEK
LLGEAVTNIGDRQPRYAEVVRKTKETDIKVQVWLDETGVNDIKTGVGFFDHMLDQIATHGGFRMNISCKGDLWIDEHHTV
EDTALALGTALKQAIGDKRGIARFGFVLPMDECQAQCAMDLSGRPFIKFKAEFKRDKVGDFSTELTEHFFQSIAFTMLAT
LHIKAKGDNDHHKIESLFKVFGRTLRQAIRIEGNELPSSKGVL

Sequences:

>Translated_363_residues
MTQPTLFIDRDGTLIDEPKTDFQIDSLEKLKLERNVIPALLKLKDHYRFVMVSNQDGLGTSSFPQETFDKPHNAMMELFR
SQGIEFDEVLICPHKPEDNCDCRKPKTKLLQKYIDRELFDPATSFVIGDRATDVQLAENLGIRALQYHPEKLNWDLIAEK
LLGEAVTNIGDRQPRYAEVVRKTKETDIKVQVWLDETGVNDIKTGVGFFDHMLDQIATHGGFRMNISCKGDLWIDEHHTV
EDTALALGTALKQAIGDKRGIARFGFVLPMDECQAQCAMDLSGRPFIKFKAEFKRDKVGDFSTELTEHFFQSIAFTMLAT
LHIKAKGDNDHHKIESLFKVFGRTLRQAIRIEGNELPSSKGVL
>Mature_362_residues
TQPTLFIDRDGTLIDEPKTDFQIDSLEKLKLERNVIPALLKLKDHYRFVMVSNQDGLGTSSFPQETFDKPHNAMMELFRS
QGIEFDEVLICPHKPEDNCDCRKPKTKLLQKYIDRELFDPATSFVIGDRATDVQLAENLGIRALQYHPEKLNWDLIAEKL
LGEAVTNIGDRQPRYAEVVRKTKETDIKVQVWLDETGVNDIKTGVGFFDHMLDQIATHGGFRMNISCKGDLWIDEHHTVE
DTALALGTALKQAIGDKRGIARFGFVLPMDECQAQCAMDLSGRPFIKFKAEFKRDKVGDFSTELTEHFFQSIAFTMLATL
HIKAKGDNDHHKIESLFKVFGRTLRQAIRIEGNELPSSKGVL

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI87082027, Length=364, Percent_Identity=66.4835164835165, Blast_Score=511, Evalue=1e-146,
Organism=Escherichia coli, GI1786399, Length=152, Percent_Identity=30.9210526315789, Blast_Score=75, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6324776, Length=171, Percent_Identity=43.859649122807, Blast_Score=154, Evalue=3e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023214
- InterPro:   IPR006549
- InterPro:   IPR020566
- InterPro:   IPR005954
- InterPro:   IPR006543
- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR013954
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00475 IGPD; PF08645 PNK3P [H]

EC number: =3.1.3.15; =4.2.1.19 [H]

Molecular weight: Translated: 41285; Mature: 41154

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: PS00954 IGP_DEHYDRATASE_1 ; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQPTLFIDRDGTLIDEPKTDFQIDSLEKLKLERNVIPALLKLKDHYRFVMVSNQDGLGT
CCCCCEEEECCCCEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCC
SSFPQETFDKPHNAMMELFRSQGIEFDEVLICPHKPEDNCDCRKPKTKLLQKYIDRELFD
CCCCHHHHCCHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCC
PATSFVIGDRATDVQLAENLGIRALQYHPEKLNWDLIAEKLLGEAVTNIGDRQPRYAEVV
CHHHEEECCCCCHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHH
RKTKETDIKVQVWLDETGVNDIKTGVGFFDHMLDQIATHGGFRMNISCKGDLWIDEHHTV
HHHCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCEEECCCCCH
EDTALALGTALKQAIGDKRGIARFGFVLPMDECQAQCAMDLSGRPFIKFKAEFKRDKVGD
HHHHHHHHHHHHHHHCCCCCHHHHCCCCCHHHHHHHHHCCCCCCCEEEEEHHHCCCCCCC
FSTELTEHFFQSIAFTMLATLHIKAKGDNDHHKIESLFKVFGRTLRQAIRIEGNELPSSK
HHHHHHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
GVL
CCC
>Mature Secondary Structure 
TQPTLFIDRDGTLIDEPKTDFQIDSLEKLKLERNVIPALLKLKDHYRFVMVSNQDGLGT
CCCCEEEECCCCEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCC
SSFPQETFDKPHNAMMELFRSQGIEFDEVLICPHKPEDNCDCRKPKTKLLQKYIDRELFD
CCCCHHHHCCHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCC
PATSFVIGDRATDVQLAENLGIRALQYHPEKLNWDLIAEKLLGEAVTNIGDRQPRYAEVV
CHHHEEECCCCCHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHH
RKTKETDIKVQVWLDETGVNDIKTGVGFFDHMLDQIATHGGFRMNISCKGDLWIDEHHTV
HHHCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCEEECCCCCH
EDTALALGTALKQAIGDKRGIARFGFVLPMDECQAQCAMDLSGRPFIKFKAEFKRDKVGD
HHHHHHHHHHHHHHHCCCCCHHHHCCCCCHHHHHHHHHCCCCCCCEEEEEHHHCCCCCCC
FSTELTEHFFQSIAFTMLATLHIKAKGDNDHHKIESLFKVFGRTLRQAIRIEGNELPSSK
HHHHHHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
GVL
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA