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The map label for this gene is fhuB [H]

Identifier: 126209469

GI number: 126209469

Start: 2240499

End: 2242451

Strand: Direct

Name: fhuB [H]

Synonym: APL_2015

Alternate gene names: 126209469

Gene position: 2240499-2242451 (Clockwise)

Preceding gene: 126209468

Following gene: 126209470

Centisome position: 98.51

GC content: 45.26

Gene sequence:

>1953_bases
ATGGTAAAAGCGAGCAAATTATTGTTCAGCGGATTAGCCGTGCTATTTTTCGGACTGTTTCTGAGCGTATTAATGCTACA
ACTGCCGGACGGAAGCGGATTAGCTTCGCTATTTTTGCCGAGTGAAAATCTGGAACTACTGCTGATTCAAAGTTATAGCT
TACCGCGTATTGTGATGGCATTACTTGCCGGCGGAATTTTAGGCTTAGCAAGCTTATTATTACAGCAAGTGATGGCGAAT
CCGTTGGCGTCGGATAATACGCTTGGCATTAGTAGCGGTGCGCAATTCGCCTTATTTTTAACCGCGATTTTTTTACCGGA
TTGGTTGGAATACGGCTCAAGTGCGGTCGCATTAATCGGTGCGGCACTCAGCCTGATTTTAGTGTTGAGTTTGGCGATGC
GAAAAACAATGTCGCCTTTATTGCTGATCCTTGCCGGCTTAGTGGTAAATCTGTATTTCGGTTCGTTTTCCGCATTAATG
ATGCTGTTTTATCCGGAAGAATCGCGAGGTTTGGCGCAATGGGGCGCCGGTTCTTTAGTGCAAGAAAGTTGGCGAGATTC
CTTATTATTGATGGTTCAAACCATACCGGCTTTGTTATTTATCGCTTTATTTATTCGTCCGCTCACTATTTTGGCGTTAA
ATGATGCGAATGCACAGAGTTTAGGCGTACCGGTCGCAAAATTGCGGGTTATTGGCGTATTGATTGCGGCATTTTTAATT
GCGGTTGTAGTGGCGAAAGTCGGTATGTTGGGGTTTATCGGCTTGGCTTCGGCAACTATCGTTCGCCAACTGCATATTCG
CCGTTTTAGTCATCAGCTATGTGCCGCTTTTGTGCTCGGTGCGTTATTGTTGGCGAATACGGATTTGCTGTTACAGTTAT
TTGCCTTTTTTAGCGATATTCATTTACCGACCGGTGCGGTGGTCGCATTATTAGGTACGCCGTTGTTGCTTTGGCTGATG
TTTAGTGCTTTACCGCATACCGGACGTTTACAGCAAACGGATTCGCAAAAAATTCGTCAATTTCGACCGCTTGTTCTTAT
TTTGATACTCGGCGGTTTAGCGTTGGCAATTTGTTTAGCGTTATTTGTCGGCAAAGGGATAAACGGCTGGCAATGGACGC
AACAAAGCGAATTGATTGCATTGCGCCTCCCTCGTTTAATGGTAGCGATAGCGGTCGGGATTTTACTGTCGGTCGCCGGT
GTGATTTTACAGCGTTTGACTTTAAACCCGATGGCGAGTCCCGAATTATTGGGAGTGTCTTCCGGCACTTCAATGGGGGT
TTTAGCCGCTTTATTTCTGTTTGGTGTACAGCAAACGGAATGGTTTTGGTTGGCAGGGATTCTCGGTGCTTGTGCTGCAT
TATTGGTATTAACTGCAATCAATCAGCGCAGCGGTATGTTGCCGGAAAAAGTATTGCTGACCGGTATTAGCTTATCGGCA
TTATTCGATACGTTGCAACGTTTAGCGATTGCCAGCGGTGATCCCCGAGCGAATCAGTTGATTGCCTGGACATCCGGTTC
AACCCAAAATGTGAGTAATGAATTGGCTATCGGCTTGCTAGCGGTCAGTTTTGCACTACTTTTTGCAAGTTTGATTTTCA
GCCGTTGGCTTGCTTTACTGGCGTTACAAGCGCCGATGGCACAATCGCTCGGTTTAAATTTAAAACAGGTTCGCTGGTGT
TTAATTTTATTTAGTGCGTTATTAACGGCACTAGCGACCTTGGTTATCGGGCCGTTAAGTTTTATCGGTTTACTTGTACC
GCAAATGGTACGTTTTTTAGGGGTAAAAAAAGCTCCGCAACAGATTTTGATTTCAGCCTGTTTGGGCGGATTAATTATGT
CACTTGCCGACTGGCTCGGCAGGCAGTTATTGTTTCCGTATGAAATTCCGGCGGGCTTAGTCGCCACATTAGTCGGCGGA
ACTTATTTCTTATTAATGCTAAGAAGAGTTTAA

Upstream 100 bases:

>100_bases
ATCCGTTAATTTTACCGGCGGTGTGGACATTCGGCGGTATTCCTTCCGCCCAACGCTTTGCCGAAATGTTTGCTAACGGA
TTATTGCACGGAGGCGAGCA

Downstream 100 bases:

>100_bases
CCTTCACAATTTAAAAAATTCTTAACAACATTTTAGGGTGAATAAAATGAAAAAAACGTTTTTCTATTCAACAGTCGCTT
CGGCAGTTGCCTTAGCTATC

Product: iron-hydroxamate transporter permease subunit

Products: ADP; phosphate; iron (III) hydroxamate [Cytoplasm] [C]

Alternate protein names: Ferric hydroxamate uptake protein B; Ferrichrome transport system permease protein fhuB; Ferrichrome uptake protein fhuB; Iron(III)-hydroxamate import system permease protein fhuB [H]

Number of amino acids: Translated: 650; Mature: 650

Protein sequence:

>650_residues
MVKASKLLFSGLAVLFFGLFLSVLMLQLPDGSGLASLFLPSENLELLLIQSYSLPRIVMALLAGGILGLASLLLQQVMAN
PLASDNTLGISSGAQFALFLTAIFLPDWLEYGSSAVALIGAALSLILVLSLAMRKTMSPLLLILAGLVVNLYFGSFSALM
MLFYPEESRGLAQWGAGSLVQESWRDSLLLMVQTIPALLFIALFIRPLTILALNDANAQSLGVPVAKLRVIGVLIAAFLI
AVVVAKVGMLGFIGLASATIVRQLHIRRFSHQLCAAFVLGALLLANTDLLLQLFAFFSDIHLPTGAVVALLGTPLLLWLM
FSALPHTGRLQQTDSQKIRQFRPLVLILILGGLALAICLALFVGKGINGWQWTQQSELIALRLPRLMVAIAVGILLSVAG
VILQRLTLNPMASPELLGVSSGTSMGVLAALFLFGVQQTEWFWLAGILGACAALLVLTAINQRSGMLPEKVLLTGISLSA
LFDTLQRLAIASGDPRANQLIAWTSGSTQNVSNELAIGLLAVSFALLFASLIFSRWLALLALQAPMAQSLGLNLKQVRWC
LILFSALLTALATLVIGPLSFIGLLVPQMVRFLGVKKAPQQILISACLGGLIMSLADWLGRQLLFPYEIPAGLVATLVGG
TYFLLMLRRV

Sequences:

>Translated_650_residues
MVKASKLLFSGLAVLFFGLFLSVLMLQLPDGSGLASLFLPSENLELLLIQSYSLPRIVMALLAGGILGLASLLLQQVMAN
PLASDNTLGISSGAQFALFLTAIFLPDWLEYGSSAVALIGAALSLILVLSLAMRKTMSPLLLILAGLVVNLYFGSFSALM
MLFYPEESRGLAQWGAGSLVQESWRDSLLLMVQTIPALLFIALFIRPLTILALNDANAQSLGVPVAKLRVIGVLIAAFLI
AVVVAKVGMLGFIGLASATIVRQLHIRRFSHQLCAAFVLGALLLANTDLLLQLFAFFSDIHLPTGAVVALLGTPLLLWLM
FSALPHTGRLQQTDSQKIRQFRPLVLILILGGLALAICLALFVGKGINGWQWTQQSELIALRLPRLMVAIAVGILLSVAG
VILQRLTLNPMASPELLGVSSGTSMGVLAALFLFGVQQTEWFWLAGILGACAALLVLTAINQRSGMLPEKVLLTGISLSA
LFDTLQRLAIASGDPRANQLIAWTSGSTQNVSNELAIGLLAVSFALLFASLIFSRWLALLALQAPMAQSLGLNLKQVRWC
LILFSALLTALATLVIGPLSFIGLLVPQMVRFLGVKKAPQQILISACLGGLIMSLADWLGRQLLFPYEIPAGLVATLVGG
TYFLLMLRRV
>Mature_650_residues
MVKASKLLFSGLAVLFFGLFLSVLMLQLPDGSGLASLFLPSENLELLLIQSYSLPRIVMALLAGGILGLASLLLQQVMAN
PLASDNTLGISSGAQFALFLTAIFLPDWLEYGSSAVALIGAALSLILVLSLAMRKTMSPLLLILAGLVVNLYFGSFSALM
MLFYPEESRGLAQWGAGSLVQESWRDSLLLMVQTIPALLFIALFIRPLTILALNDANAQSLGVPVAKLRVIGVLIAAFLI
AVVVAKVGMLGFIGLASATIVRQLHIRRFSHQLCAAFVLGALLLANTDLLLQLFAFFSDIHLPTGAVVALLGTPLLLWLM
FSALPHTGRLQQTDSQKIRQFRPLVLILILGGLALAICLALFVGKGINGWQWTQQSELIALRLPRLMVAIAVGILLSVAG
VILQRLTLNPMASPELLGVSSGTSMGVLAALFLFGVQQTEWFWLAGILGACAALLVLTAINQRSGMLPEKVLLTGISLSA
LFDTLQRLAIASGDPRANQLIAWTSGSTQNVSNELAIGLLAVSFALLFASLIFSRWLALLALQAPMAQSLGLNLKQVRWC
LILFSALLTALATLVIGPLSFIGLLVPQMVRFLGVKKAPQQILISACLGGLIMSLADWLGRQLLFPYEIPAGLVATLVGG
TYFLLMLRRV

Specific function: Part of the ABC transporter complex fhuCDB involved in iron(3+)-hydroxamate import. Responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786347, Length=630, Percent_Identity=37.4603174603175, Blast_Score=319, Evalue=4e-88,
Organism=Escherichia coli, GI1790741, Length=272, Percent_Identity=36.0294117647059, Blast_Score=119, Evalue=7e-28,
Organism=Escherichia coli, GI1790740, Length=311, Percent_Identity=32.1543408360129, Blast_Score=116, Evalue=6e-27,
Organism=Escherichia coli, GI1788004, Length=282, Percent_Identity=31.5602836879433, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI1786805, Length=273, Percent_Identity=31.1355311355311, Blast_Score=83, Evalue=6e-17,
Organism=Escherichia coli, GI1786804, Length=269, Percent_Identity=30.1115241635688, Blast_Score=81, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522
- InterPro:   IPR006311 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 69463; Mature: 69463

Theoretical pI: Translated: 10.25; Mature: 10.25

Prosite motif: PS00211 ABC_TRANSPORTER_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKASKLLFSGLAVLFFGLFLSVLMLQLPDGSGLASLFLPSENLELLLIQSYSLPRIVMA
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCEEEEECCCHHHHHHH
LLAGGILGLASLLLQQVMANPLASDNTLGISSGAQFALFLTAIFLPDWLEYGSSAVALIG
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHH
AALSLILVLSLAMRKTMSPLLLILAGLVVNLYFGSFSALMMLFYPEESRGLAQWGAGSLV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCHHH
QESWRDSLLLMVQTIPALLFIALFIRPLTILALNDANAQSLGVPVAKLRVIGVLIAAFLI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCHHHCCCHHHHHHHHHHHHHHHH
AVVVAKVGMLGFIGLASATIVRQLHIRRFSHQLCAAFVLGALLLANTDLLLQLFAFFSDI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHH
HLPTGAVVALLGTPLLLWLMFSALPHTGRLQQTDSQKIRQFRPLVLILILGGLALAICLA
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LFVGKGINGWQWTQQSELIALRLPRLMVAIAVGILLSVAGVILQRLTLNPMASPELLGVS
HHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEECC
SGTSMGVLAALFLFGVQQTEWFWLAGILGACAALLVLTAINQRSGMLPEKVLLTGISLSA
CCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCHHHH
LFDTLQRLAIASGDPRANQLIAWTSGSTQNVSNELAIGLLAVSFALLFASLIFSRWLALL
HHHHHHHHHHCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALQAPMAQSLGLNLKQVRWCLILFSALLTALATLVIGPLSFIGLLVPQMVRFLGVKKAPQ
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
QILISACLGGLIMSLADWLGRQLLFPYEIPAGLVATLVGGTYFLLMLRRV
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MVKASKLLFSGLAVLFFGLFLSVLMLQLPDGSGLASLFLPSENLELLLIQSYSLPRIVMA
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCEEEEECCCHHHHHHH
LLAGGILGLASLLLQQVMANPLASDNTLGISSGAQFALFLTAIFLPDWLEYGSSAVALIG
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHH
AALSLILVLSLAMRKTMSPLLLILAGLVVNLYFGSFSALMMLFYPEESRGLAQWGAGSLV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCHHH
QESWRDSLLLMVQTIPALLFIALFIRPLTILALNDANAQSLGVPVAKLRVIGVLIAAFLI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCHHHCCCHHHHHHHHHHHHHHHH
AVVVAKVGMLGFIGLASATIVRQLHIRRFSHQLCAAFVLGALLLANTDLLLQLFAFFSDI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHH
HLPTGAVVALLGTPLLLWLMFSALPHTGRLQQTDSQKIRQFRPLVLILILGGLALAICLA
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LFVGKGINGWQWTQQSELIALRLPRLMVAIAVGILLSVAGVILQRLTLNPMASPELLGVS
HHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEECC
SGTSMGVLAALFLFGVQQTEWFWLAGILGACAALLVLTAINQRSGMLPEKVLLTGISLSA
CCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCHHHH
LFDTLQRLAIASGDPRANQLIAWTSGSTQNVSNELAIGLLAVSFALLFASLIFSRWLALL
HHHHHHHHHHCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALQAPMAQSLGLNLKQVRWCLILFSALLTALATLVIGPLSFIGLLVPQMVRFLGVKKAPQ
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
QILISACLGGLIMSLADWLGRQLLFPYEIPAGLVATLVGGTYFLLMLRRV
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; iron (III) hydroxamate [Periplasm]; H2O [C]

Specific reaction: ATP + iron (III) hydroxamate [Periplasm] + H2O = ADP + phosphate + iron (III) hydroxamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11677609; 10103258 [H]