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The map label for this gene is fhuD [H]

Identifier: 126209468

GI number: 126209468

Start: 2239666

End: 2240505

Strand: Direct

Name: fhuD [H]

Synonym: APL_2014

Alternate gene names: 126209468

Gene position: 2239666-2240505 (Clockwise)

Preceding gene: 126209467

Following gene: 126209469

Centisome position: 98.47

GC content: 46.55

Gene sequence:

>840_bases
TTGCTTTTTTTTGTAATATCTTGCGGGGTGAAGGCAAAATCTTTTGCGACCTTGGATTGGACGGTGGCAGAAACGTTAAT
TGCGTTGGGTGAGAAGCCGGTGGCGGTCGGTGATGTAAAAAGTTATCAGCAGTGGGTCGGTGAACCGGCGTTACCGAATG
ATACCTTAGATCTCGGGGTACGAATGCAACCGAATCCGGAGCTGATTCTTACTTTAAAACAGGGCGATCACGATTTGCAT
TTTATTAATAGCAGTTTTTACGCCCAAGCCACCGCAACGCTTGAGCCGTTTTCCTCTGTAACATTAGTCGATTTTTATAC
GGAAGGCGATGCTTGGCAAAATATTGTGAATGCTAGCCGTAAAGTCGCGTTTATTGCGGATAAACAAGCGGAATTTGAAG
CATTAATGACAAGCTATTGGCAAAAAATTGATGAAATTCGACCGCTTGTTCAGCCTTATTTGGAGCGCCCGATTGCCTTA
GTACAGTTTATTGATACGCGCCATTTACGCATTTATGCCGCAAATAGTCCGTTTGGTGCGGTGTTATCACAACTCGGCTT
TCACAATGCGTGGAGCGGTTCGCAAAATGCATGGGGCTTTGAGACGATTGATGTCACTCAGTTAGCCAAACTTGCGCCGA
ATAGCCGTTTAGTGGTGGTAAAACCGTATCCGGCGAATATCGGTTCCGCCTTGCGTTACAACACCTTGTGGCAACATTTA
GCCATGGCGAAAGATCCGTTAATTTTACCGGCGGTGTGGACATTCGGCGGTATTCCTTCCGCCCAACGCTTTGCCGAAAT
GTTTGCTAACGGATTATTGCACGGAGGCGAGCAATGGTAA

Upstream 100 bases:

>100_bases
TTTACCTCGGAACACACAGAAACACACGGAAAATATTTATCGTATTTTCCGTGGGGTTCTGTGTAATTCTGTGGTTAAAA
CGCTACAAGCGGTCGTTTTT

Downstream 100 bases:

>100_bases
AAGCGAGCAAATTATTGTTCAGCGGATTAGCCGTGCTATTTTTCGGACTGTTTCTGAGCGTATTAATGCTACAACTGCCG
GACGGAAGCGGATTAGCTTC

Product: ABC-type Fe3+-hydroxamate transport system, periplasmic component; FhuD

Products: ADP; phosphate; iron (III) hydroxamate [Cytoplasm] [C]

Alternate protein names: Ferric hydroxamate uptake protein D; Ferrichrome-binding periplasmic protein; Iron(III)-hydroxamate-binding protein fhuD [H]

Number of amino acids: Translated: 279; Mature: 279

Protein sequence:

>279_residues
MLFFVISCGVKAKSFATLDWTVAETLIALGEKPVAVGDVKSYQQWVGEPALPNDTLDLGVRMQPNPELILTLKQGDHDLH
FINSSFYAQATATLEPFSSVTLVDFYTEGDAWQNIVNASRKVAFIADKQAEFEALMTSYWQKIDEIRPLVQPYLERPIAL
VQFIDTRHLRIYAANSPFGAVLSQLGFHNAWSGSQNAWGFETIDVTQLAKLAPNSRLVVVKPYPANIGSALRYNTLWQHL
AMAKDPLILPAVWTFGGIPSAQRFAEMFANGLLHGGEQW

Sequences:

>Translated_279_residues
MLFFVISCGVKAKSFATLDWTVAETLIALGEKPVAVGDVKSYQQWVGEPALPNDTLDLGVRMQPNPELILTLKQGDHDLH
FINSSFYAQATATLEPFSSVTLVDFYTEGDAWQNIVNASRKVAFIADKQAEFEALMTSYWQKIDEIRPLVQPYLERPIAL
VQFIDTRHLRIYAANSPFGAVLSQLGFHNAWSGSQNAWGFETIDVTQLAKLAPNSRLVVVKPYPANIGSALRYNTLWQHL
AMAKDPLILPAVWTFGGIPSAQRFAEMFANGLLHGGEQW
>Mature_279_residues
MLFFVISCGVKAKSFATLDWTVAETLIALGEKPVAVGDVKSYQQWVGEPALPNDTLDLGVRMQPNPELILTLKQGDHDLH
FINSSFYAQATATLEPFSSVTLVDFYTEGDAWQNIVNASRKVAFIADKQAEFEALMTSYWQKIDEIRPLVQPYLERPIAL
VQFIDTRHLRIYAANSPFGAVLSQLGFHNAWSGSQNAWGFETIDVTQLAKLAPNSRLVVVKPYPANIGSALRYNTLWQHL
AMAKDPLILPAVWTFGGIPSAQRFAEMFANGLLHGGEQW

Specific function: Part of the ABC transporter complex fhuCDB involved in iron(3+)-hydroxamate import. Binds the iron(3+)-hydroxamate complex and transfers it to the membrane-bound permease. Required for the transport of all iron(3+)-hydroxamate siderophores such as ferrich

COG id: COG0614

COG function: function code P; ABC-type Fe3+-hydroxamate transport system, periplasmic component

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Fe/B12 periplasmic-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786346, Length=276, Percent_Identity=27.8985507246377, Blast_Score=110, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008091
- InterPro:   IPR002491 [H]

Pfam domain/function: PF01497 Peripla_BP_2 [H]

EC number: NA

Molecular weight: Translated: 31058; Mature: 31058

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: PS50983 FE_B12_PBP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLFFVISCGVKAKSFATLDWTVAETLIALGEKPVAVGDVKSYQQWVGEPALPNDTLDLGV
CEEEEEECCCCCCCEEEEHHHHHHHHHHHCCCCCEECCHHHHHHHCCCCCCCCCCCEECE
RMQPNPELILTLKQGDHDLHFINSSFYAQATATLEPFSSVTLVDFYTEGDAWQNIVNASR
EECCCCCEEEEEECCCCEEEEECCCCEEEEEEEECCCCCEEEEEEEECCHHHHHHHHCCC
KVAFIADKQAEFEALMTSYWQKIDEIRPLVQPYLERPIALVQFIDTRHLRIYAANSPFGA
EEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCEEEEEECCCCHHH
VLSQLGFHNAWSGSQNAWGFETIDVTQLAKLAPNSRLVVVKPYPANIGSALRYNTLWQHL
HHHHHCCCCCCCCCCCCCCCEEECHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHH
AMAKDPLILPAVWTFGGIPSAQRFAEMFANGLLHGGEQW
HHHCCCEEEEHHHHCCCCCHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MLFFVISCGVKAKSFATLDWTVAETLIALGEKPVAVGDVKSYQQWVGEPALPNDTLDLGV
CEEEEEECCCCCCCEEEEHHHHHHHHHHHCCCCCEECCHHHHHHHCCCCCCCCCCCEECE
RMQPNPELILTLKQGDHDLHFINSSFYAQATATLEPFSSVTLVDFYTEGDAWQNIVNASR
EECCCCCEEEEEECCCCEEEEECCCCEEEEEEEECCCCCEEEEEEEECCHHHHHHHHCCC
KVAFIADKQAEFEALMTSYWQKIDEIRPLVQPYLERPIALVQFIDTRHLRIYAANSPFGA
EEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCEEEEEECCCCHHH
VLSQLGFHNAWSGSQNAWGFETIDVTQLAKLAPNSRLVVVKPYPANIGSALRYNTLWQHL
HHHHHCCCCCCCCCCCCCCCEEECHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHH
AMAKDPLILPAVWTFGGIPSAQRFAEMFANGLLHGGEQW
HHHCCCEEEEHHHHCCCCCHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; iron (III) hydroxamate [Periplasm]; H2O [C]

Specific reaction: ATP + iron (III) hydroxamate [Periplasm] + H2O = ADP + phosphate + iron (III) hydroxamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3301821; 2823072; 8202364; 9278503; 7651325; 10742172 [H]