BacMap

Definition	Actinobacillus pleuropneumoniae serovar 5b str. L20 chromosome, complete genome.
Accession	NC_009053
Length	2,274,482

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The map label for this gene is fhuC [H]

Identifier: 126209467

GI number: 126209467

Start: 2238869

End: 2239549

Strand: Direct

Name: fhuC [H]

Synonym: APL_2013

Alternate gene names: 126209467

Gene position: 2238869-2239549 (Clockwise)

Preceding gene: 126209463

Following gene: 126209468

Centisome position: 98.43

GC content: 43.61

Gene sequence:

>681_bases
GTGTACGGTTTAATCGGACACAATGGTTCGGGTAAATCTACATTCATTAAATTATTGGCAAAACAAGAACAAGTATCGGC
GGGTAAAATTCTGTTTAATCGGCAAGAACTTAGTCGATGGTCATCACGAGAATTTGCCAAACAAGTCGCTTATCTTCCGC
AACATCTTCCGCAAGCTACCAATCTGACCGCCAGAGAGCTTATCGCCATGGGGCGTTATGCGTGGAACGGTTTATTCGGT
TCCAATAAACAAAAAGATCATGAAGCTATCGAACGAGCTTTAGCCTTAACCCATACCGAGCAGTTTGCCGAGCAGTTGGT
AGATACGCTTTCCGGCGGTGAGCGTTCTCGCATTTGGCTGGCAATGTTATTGGCGCAACAAAGCAAATTCTTGTTGTTGG
ACGAACCGCTTGCTGCCTTAGATATTGCTCATCAGGTGGAAGTGATGGAATTGGTCAAAAAATTAGCGCACGAGCTGAAT
TTAGGTGTGATTATCGTGATTCACGATATTAATTTGGCGGCACGTTATTGTGATCAGTTGGTGGCATTGCATGGCGGCAA
ATTATTAGCGCAGGGTGATGCGTTTGAGATTGTAAACAGCCCGAAATTAAAACAAATTTACGGTATTGATCTGAATGTGA
TCGAACACCCTGAAACCAAACGACCAGTGAGTTTTTATTGA

Upstream 100 bases:

>100_bases
TTTATTCGGAGCTATTGTGTTTTTAATTGAAAATGCGACTTTTGCTATTCCTAGCCGAACTTTACTCCATTCGATTTCTT
TGCAATTCGAGCAGGGTAAG

Downstream 100 bases:

>100_bases
TGAAACGACTTATTTTTTTACCTCGGAACACACAGAAACACACGGAAAATATTTATCGTATTTTCCGTGGGGTTCTGTGT
AATTCTGTGGTTAAAACGCT

Product: ferrichrome ABC transporter ATP-binding protein

Products: NA

Alternate protein names: Ferric hydroxamate uptake protein C; Ferrichrome transport ATP-binding protein FhuC; Iron(III)-hydroxamate import ATP-binding protein FhuC [H]

Number of amino acids: Translated: 226; Mature: 226

Protein sequence:

>226_residues
MYGLIGHNGSGKSTFIKLLAKQEQVSAGKILFNRQELSRWSSREFAKQVAYLPQHLPQATNLTARELIAMGRYAWNGLFG
SNKQKDHEAIERALALTHTEQFAEQLVDTLSGGERSRIWLAMLLAQQSKFLLLDEPLAALDIAHQVEVMELVKKLAHELN
LGVIIVIHDINLAARYCDQLVALHGGKLLAQGDAFEIVNSPKLKQIYGIDLNVIEHPETKRPVSFY

Sequences:

>Translated_226_residues
MYGLIGHNGSGKSTFIKLLAKQEQVSAGKILFNRQELSRWSSREFAKQVAYLPQHLPQATNLTARELIAMGRYAWNGLFG
SNKQKDHEAIERALALTHTEQFAEQLVDTLSGGERSRIWLAMLLAQQSKFLLLDEPLAALDIAHQVEVMELVKKLAHELN
LGVIIVIHDINLAARYCDQLVALHGGKLLAQGDAFEIVNSPKLKQIYGIDLNVIEHPETKRPVSFY
>Mature_226_residues
MYGLIGHNGSGKSTFIKLLAKQEQVSAGKILFNRQELSRWSSREFAKQVAYLPQHLPQATNLTARELIAMGRYAWNGLFG
SNKQKDHEAIERALALTHTEQFAEQLVDTLSGGERSRIWLAMLLAQQSKFLLLDEPLAALDIAHQVEVMELVKKLAHELN
LGVIIVIHDINLAARYCDQLVALHGGKLLAQGDAFEIVNSPKLKQIYGIDLNVIEHPETKRPVSFY

Specific function: Part of the ABC transporter complex FhuCDB involved in iron(3+)-hydroxamate import. Responsible for energy coupling to the transport system [H]

COG id: COG1120

COG function: function code PH; ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Homo sapiens, GI116734710, Length=208, Percent_Identity=25.9615384615385, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI153792144, Length=191, Percent_Identity=25.6544502617801, Blast_Score=65, Evalue=7e-11,
Organism=Homo sapiens, GI6005701, Length=190, Percent_Identity=25.7894736842105, Blast_Score=64, Evalue=8e-11,
Organism=Homo sapiens, GI47078218, Length=191, Percent_Identity=24.0837696335079, Blast_Score=64, Evalue=9e-11,
Organism=Escherichia coli, GI1786345, Length=223, Percent_Identity=55.1569506726457, Blast_Score=262, Evalue=1e-71,
Organism=Escherichia coli, GI1786803, Length=220, Percent_Identity=38.1818181818182, Blast_Score=174, Evalue=3e-45,
Organism=Escherichia coli, GI1790739, Length=225, Percent_Identity=34.6666666666667, Blast_Score=156, Evalue=1e-39,
Organism=Escherichia coli, GI1786398, Length=205, Percent_Identity=29.2682926829268, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1790544, Length=216, Percent_Identity=29.1666666666667, Blast_Score=91, Evalue=5e-20,
Organism=Escherichia coli, GI87081791, Length=211, Percent_Identity=29.8578199052133, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI1788761, Length=198, Percent_Identity=29.7979797979798, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1788002, Length=223, Percent_Identity=31.390134529148, Blast_Score=87, Evalue=8e-19,
Organism=Escherichia coli, GI1789032, Length=205, Percent_Identity=28.780487804878, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI48994883, Length=213, Percent_Identity=27.2300469483568, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1787029, Length=200, Percent_Identity=27, Blast_Score=83, Evalue=1e-17,
Organism=Escherichia coli, GI1789963, Length=210, Percent_Identity=26.1904761904762, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1787370, Length=204, Percent_Identity=27.9411764705882, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1787758, Length=199, Percent_Identity=27.1356783919598, Blast_Score=81, Evalue=6e-17,
Organism=Escherichia coli, GI1789593, Length=208, Percent_Identity=28.3653846153846, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1789890, Length=206, Percent_Identity=27.6699029126214, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI87081709, Length=201, Percent_Identity=24.8756218905473, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1787712, Length=209, Percent_Identity=30.1435406698565, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI87081834, Length=198, Percent_Identity=30.8080808080808, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1789891, Length=196, Percent_Identity=28.5714285714286, Blast_Score=78, Evalue=4e-16,
Organism=Escherichia coli, GI1789864, Length=216, Percent_Identity=28.2407407407407, Blast_Score=77, Evalue=6e-16,
Organism=Escherichia coli, GI1788450, Length=209, Percent_Identity=26.7942583732057, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1789873, Length=191, Percent_Identity=28.7958115183246, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI145693107, Length=219, Percent_Identity=25.1141552511416, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1787548, Length=215, Percent_Identity=25.5813953488372, Blast_Score=76, Evalue=1e-15,
Organism=Escherichia coli, GI48994997, Length=211, Percent_Identity=27.0142180094787, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1789962, Length=206, Percent_Identity=24.7572815533981, Blast_Score=74, Evalue=7e-15,
Organism=Escherichia coli, GI1788506, Length=212, Percent_Identity=26.4150943396226, Blast_Score=73, Evalue=1e-14,
Organism=Escherichia coli, GI1790467, Length=205, Percent_Identity=24.390243902439, Blast_Score=72, Evalue=2e-14,
Organism=Escherichia coli, GI48994943, Length=199, Percent_Identity=26.6331658291457, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1787759, Length=231, Percent_Identity=24.2424242424242, Blast_Score=71, Evalue=6e-14,
Organism=Escherichia coli, GI1788165, Length=181, Percent_Identity=28.7292817679558, Blast_Score=71, Evalue=6e-14,
Organism=Escherichia coli, GI1787500, Length=208, Percent_Identity=24.5192307692308, Blast_Score=70, Evalue=9e-14,
Organism=Escherichia coli, GI1786253, Length=196, Percent_Identity=28.0612244897959, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI87081782, Length=192, Percent_Identity=27.6041666666667, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1786698, Length=193, Percent_Identity=29.5336787564767, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1787089, Length=197, Percent_Identity=26.3959390862944, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI87082267, Length=198, Percent_Identity=24.2424242424242, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1788225, Length=213, Percent_Identity=27.6995305164319, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1786872, Length=205, Percent_Identity=27.3170731707317, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI1787547, Length=206, Percent_Identity=26.2135922330097, Blast_Score=67, Evalue=8e-13,
Organism=Escherichia coli, GI1787792, Length=199, Percent_Identity=25.6281407035176, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1786703, Length=194, Percent_Identity=31.9587628865979, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1788472, Length=191, Percent_Identity=24.6073298429319, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1790162, Length=212, Percent_Identity=27.3584905660377, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1789672, Length=203, Percent_Identity=26.1083743842365, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1787164, Length=185, Percent_Identity=30.2702702702703, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI87082268, Length=198, Percent_Identity=26.7676767676768, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1787143, Length=201, Percent_Identity=25.3731343283582, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1788897, Length=199, Percent_Identity=25.1256281407035, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1790190, Length=208, Percent_Identity=24.0384615384615, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI1788644, Length=205, Percent_Identity=26.3414634146341, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI1788210, Length=203, Percent_Identity=23.6453201970443, Blast_Score=61, Evalue=8e-11,
Organism=Escherichia coli, GI1787105, Length=206, Percent_Identity=27.1844660194175, Blast_Score=60, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI71983516, Length=207, Percent_Identity=27.536231884058, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71983523, Length=207, Percent_Identity=27.536231884058, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71983510, Length=207, Percent_Identity=27.536231884058, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17510237, Length=207, Percent_Identity=26.5700483091787, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17569145, Length=200, Percent_Identity=27.5, Blast_Score=67, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI115533608, Length=194, Percent_Identity=25.7731958762887, Blast_Score=67, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI71992285, Length=201, Percent_Identity=26.865671641791, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17541710, Length=201, Percent_Identity=28.3582089552239, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI193202349, Length=207, Percent_Identity=26.0869565217391, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI25146777, Length=204, Percent_Identity=26.9607843137255, Blast_Score=64, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI71984940, Length=195, Percent_Identity=28.7179487179487, Blast_Score=64, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17569143, Length=200, Percent_Identity=26.5, Blast_Score=64, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6324498, Length=236, Percent_Identity=25.8474576271186, Blast_Score=73, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6322640, Length=209, Percent_Identity=28.7081339712919, Blast_Score=71, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6320296, Length=196, Percent_Identity=22.9591836734694, Blast_Score=63, Evalue=4e-11,
Organism=Drosophila melanogaster, GI28573571, Length=189, Percent_Identity=28.5714285714286, Blast_Score=70, Evalue=7e-13,
Organism=Drosophila melanogaster, GI28573573, Length=189, Percent_Identity=28.5714285714286, Blast_Score=70, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24582014, Length=191, Percent_Identity=23.5602094240838, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24582012, Length=191, Percent_Identity=23.5602094240838, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI85725262, Length=211, Percent_Identity=26.0663507109005, Blast_Score=68, Evalue=6e-12,
Organism=Drosophila melanogaster, GI116007184, Length=189, Percent_Identity=26.4550264550265, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI221500365, Length=189, Percent_Identity=26.4550264550265, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI45552199, Length=205, Percent_Identity=28.780487804878, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24581407, Length=205, Percent_Identity=28.780487804878, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24581409, Length=196, Percent_Identity=28.5714285714286, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24661270, Length=198, Percent_Identity=24.7474747474747, Blast_Score=65, Evalue=5e-11,
Organism=Drosophila melanogaster, GI21355589, Length=198, Percent_Identity=24.7474747474747, Blast_Score=65, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24650855, Length=191, Percent_Identity=26.1780104712042, Blast_Score=64, Evalue=8e-11,
Organism=Drosophila melanogaster, GI24650853, Length=191, Percent_Identity=26.1780104712042, Blast_Score=64, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR003593 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: =3.6.3.34 [H]

Molecular weight: Translated: 25335; Mature: 25335

Theoretical pI: Translated: 7.85; Mature: 7.85

Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYGLIGHNGSGKSTFIKLLAKQEQVSAGKILFNRQELSRWSSREFAKQVAYLPQHLPQAT
CCCCCCCCCCCHHHHHHHHHHHHHHCCCHHEECHHHHHHHHHHHHHHHHHHHHHHCCCCC
NLTARELIAMGRYAWNGLFGSNKQKDHEAIERALALTHTEQFAEQLVDTLSGGERSRIWL
CHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
AMLLAQQSKFLLLDEPLAALDIAHQVEVMELVKKLAHELNLGVIIVIHDINLAARYCDQL
HHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHH
VALHGGKLLAQGDAFEIVNSPKLKQIYGIDLNVIEHPETKRPVSFY
HHHCCCEEEECCCCEEECCCCCCCEEECCCEEEECCCCCCCCCCCC
>Mature Secondary Structure
MYGLIGHNGSGKSTFIKLLAKQEQVSAGKILFNRQELSRWSSREFAKQVAYLPQHLPQAT
CCCCCCCCCCCHHHHHHHHHHHHHHCCCHHEECHHHHHHHHHHHHHHHHHHHHHHCCCCC
NLTARELIAMGRYAWNGLFGSNKQKDHEAIERALALTHTEQFAEQLVDTLSGGERSRIWL
CHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
AMLLAQQSKFLLLDEPLAALDIAHQVEVMELVKKLAHELNLGVIIVIHDINLAARYCDQL
HHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHH
VALHGGKLLAQGDAFEIVNSPKLKQIYGIDLNVIEHPETKRPVSFY
HHHCCCEEEECCCCEEECCCCCCCEEECCCEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 3301821; 2823072; 8202364; 9278503 [H]