Click here to switch to the map view.

The map label for this gene is pdxH

Identifier: 126209463

GI number: 126209463

Start: 2233758

End: 2234387

Strand: Direct

Name: pdxH

Synonym: APL_2009

Alternate gene names: 126209463

Gene position: 2233758-2234387 (Clockwise)

Preceding gene: 126209462

Following gene: 126209467

Centisome position: 98.21

GC content: 46.51

Gene sequence:

>630_bases
ATGGATCTACACAACATCCGAGAAGATTATAGTAAACAAGAACTATCTCAAGCGAATTGCCATGCAGACCCGATTCAGCA
ATTCGAACAGTGGCTAGAGGAAGCGATTACCGCTAAAGCGAATGAGCCAACGGCGATGAATGTTGCCACCGTTCTTGACG
GCAAACCGACCAGCCGTATTGTGTTATTAAAAGAGGTGAATCCAAACGGCTTTGTGTTTTTTACCAATTATCAAAGCCGT
AAAGGGCAAGCGATTGAGCAAAATCCTTATGTCGCATTAACCTTTTTCTGGGCGGAATTGGAACGTTCGGTACGGATTGA
AGGGCGGATTGAAAAAATTTCAGCCGAGCAATCCGACAACTATTTTGCCAGCCGACCTTACACTAGTCGAGTCGGTGCTT
GGGCGAGCAATCAAAGCCAAGTGTTATCCAGCAAAAGTGAATTAGTCGCAAAAGCGGCATTGATTGCGGCGAAACACCCG
TTACACGTGCCTCGCCCGCCGCATTGGGGCGGTTATATCGTATTACCGGAACGTATTGAATTTTGGCAAGGCAGACCAAG
TCGTTTGCACGATCGTATTTGTTATCGCCTTGTGGAAGGTGCATGGCATAAAGAAAGATTATCGCCGTAA

Upstream 100 bases:

>100_bases
CTTCTGAAGCAGCAAAGTCTGCGTAATACAAGCGGTTGAATTTTTGCAAAATTTTGCGGAAATTCGACCGCTTTTGTTTT
CTAGTTTGTAGAGGAAAAAC

Downstream 100 bases:

>100_bases
GACGGCAGAGATAAAAAATGGTGGGATTTCCCACCATTTTTGTTGATTTGCCTGAATTAGTCTAAAGACTTTTAGTCGGC
TAATTTTGTACCGTACAGAT

Product: pyridoxamine 5'-phosphate oxidase

Products: NA

Alternate protein names: PNP/PMP oxidase; PNPOx; Pyridoxal 5'-phosphate synthase

Number of amino acids: Translated: 209; Mature: 209

Protein sequence:

>209_residues
MDLHNIREDYSKQELSQANCHADPIQQFEQWLEEAITAKANEPTAMNVATVLDGKPTSRIVLLKEVNPNGFVFFTNYQSR
KGQAIEQNPYVALTFFWAELERSVRIEGRIEKISAEQSDNYFASRPYTSRVGAWASNQSQVLSSKSELVAKAALIAAKHP
LHVPRPPHWGGYIVLPERIEFWQGRPSRLHDRICYRLVEGAWHKERLSP

Sequences:

>Translated_209_residues
MDLHNIREDYSKQELSQANCHADPIQQFEQWLEEAITAKANEPTAMNVATVLDGKPTSRIVLLKEVNPNGFVFFTNYQSR
KGQAIEQNPYVALTFFWAELERSVRIEGRIEKISAEQSDNYFASRPYTSRVGAWASNQSQVLSSKSELVAKAALIAAKHP
LHVPRPPHWGGYIVLPERIEFWQGRPSRLHDRICYRLVEGAWHKERLSP
>Mature_209_residues
MDLHNIREDYSKQELSQANCHADPIQQFEQWLEEAITAKANEPTAMNVATVLDGKPTSRIVLLKEVNPNGFVFFTNYQSR
KGQAIEQNPYVALTFFWAELERSVRIEGRIEKISAEQSDNYFASRPYTSRVGAWASNQSQVLSSKSELVAKAALIAAKHP
LHVPRPPHWGGYIVLPERIEFWQGRPSRLHDRICYRLVEGAWHKERLSP

Specific function: Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)

COG id: COG0259

COG function: function code H; Pyridoxamine-phosphate oxidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyridoxamine 5'-phosphate oxidase family

Homologues:

Organism=Homo sapiens, GI8922498, Length=202, Percent_Identity=42.0792079207921, Blast_Score=169, Evalue=1e-42,
Organism=Escherichia coli, GI1787926, Length=207, Percent_Identity=45.4106280193237, Blast_Score=174, Evalue=5e-45,
Organism=Caenorhabditis elegans, GI17553712, Length=221, Percent_Identity=37.10407239819, Blast_Score=150, Evalue=4e-37,
Organism=Saccharomyces cerevisiae, GI6319509, Length=208, Percent_Identity=40.3846153846154, Blast_Score=154, Evalue=1e-38,
Organism=Drosophila melanogaster, GI45551845, Length=205, Percent_Identity=47.8048780487805, Blast_Score=163, Evalue=6e-41,
Organism=Drosophila melanogaster, GI24644901, Length=205, Percent_Identity=47.8048780487805, Blast_Score=163, Evalue=8e-41,
Organism=Drosophila melanogaster, GI24644903, Length=170, Percent_Identity=34.1176470588235, Blast_Score=82, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PDXH_ACTP2 (A3N3U7)

Other databases:

- EMBL:   CP000569
- RefSeq:   YP_001054688.1
- ProteinModelPortal:   A3N3U7
- SMR:   A3N3U7
- STRING:   A3N3U7
- GeneID:   4850510
- GenomeReviews:   CP000569_GR
- KEGG:   apl:APL_2009
- eggNOG:   COG0259
- HOGENOM:   HBG327559
- OMA:   FTFFTNY
- PhylomeDB:   A3N3U7
- ProtClustDB:   PRK05679
- BioCyc:   APLE416269:APL_2009-MONOMER
- HAMAP:   MF_01629
- InterPro:   IPR000659
- InterPro:   IPR019740
- InterPro:   IPR019576
- InterPro:   IPR011576
- InterPro:   IPR012349
- InterPro:   IPR009002
- Gene3D:   G3DSA:2.30.110.10
- PANTHER:   PTHR10851
- PIRSF:   PIRSF000190
- TIGRFAMs:   TIGR00558

Pfam domain/function: PF10590 PNPOx_C; PF01243 Pyridox_oxidase; SSF50475 FMN_binding

EC number: =1.4.3.5

Molecular weight: Translated: 23957; Mature: 23957

Theoretical pI: Translated: 8.23; Mature: 8.23

Prosite motif: PS01064 PYRIDOX_OXIDASE

Important sites: BINDING 59-59 BINDING 62-62 BINDING 64-64 BINDING 81-81 BINDING 121-121 BINDING 125-125 BINDING 129-129

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLHNIREDYSKQELSQANCHADPIQQFEQWLEEAITAKANEPTAMNVATVLDGKPTSRI
CCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCEE
VLLKEVNPNGFVFFTNYQSRKGQAIEQNPYVALTFFWAELERSVRIEGRIEKISAEQSDN
EEEEECCCCEEEEEECCCCCCCCCCCCCCCEEEEEEEEHHHHCEEECCHHEECCCCCCCC
YFASRPYTSRVGAWASNQSQVLSSKSELVAKAALIAAKHPLHVPRPPHWGGYIVLPERIE
EEECCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCHHH
FWQGRPSRLHDRICYRLVEGAWHKERLSP
HHCCCHHHHHHHHHHHHHHCCCCHHCCCC
>Mature Secondary Structure
MDLHNIREDYSKQELSQANCHADPIQQFEQWLEEAITAKANEPTAMNVATVLDGKPTSRI
CCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCEE
VLLKEVNPNGFVFFTNYQSRKGQAIEQNPYVALTFFWAELERSVRIEGRIEKISAEQSDN
EEEEECCCCEEEEEECCCCCCCCCCCCCCCEEEEEEEEHHHHCEEECCHHEECCCCCCCC
YFASRPYTSRVGAWASNQSQVLSSKSELVAKAALIAAKHPLHVPRPPHWGGYIVLPERIE
EEECCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCHHH
FWQGRPSRLHDRICYRLVEGAWHKERLSP
HHCCCHHHHHHHHHHHHHHCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA