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The map label for this gene is ddc [H]

Identifier: 126209429

GI number: 126209429

Start: 2202065

End: 2203600

Strand: Direct

Name: ddc [H]

Synonym: APL_1975

Alternate gene names: 126209429

Gene position: 2202065-2203600 (Clockwise)

Preceding gene: 126209428

Following gene: 126209432

Centisome position: 96.82

GC content: 42.64

Gene sequence:

>1536_bases
ATGGCAGATATTTCAAAACACAGACAGTCGCTTTTCTGTAATGATCCGCAATCAATCGCTGATTATGAAAATGCGATGAA
TAATGCGGTGCAAGCGATCAGCGCTTGGTTAAAAAACGACAAAATGTACACAGGTGGCTCAATCAAGCAAATGCGTGCTT
TGATTGATGGCTTTAATCCGTCAAAAGAAGGCGTTGGCGTACAAAAATCGCTTGATCACTTAGTGGAAATTTTCTTAAAA
CCAAGTCTTAAAGTACATCACCCACATTCACTTGCGCATTTACATTGCCCGACAATGGTAACCAGCCAGATTGCGGAAGT
ATTAATTAATGCGACTAACCAGTCAATGGACTCATGGGATCAAAGCCCGGCGGGTTCGATTATGGAGGAACATTTAATTG
ATTGGTTACGTCAAAAAGTTGGCTATGGTGCAGGTACTTCAGGTGTGTTTACTTCAGGCGGTACGCAATCAAACTTAATG
GGCGTATTACTTGCACGTGACTGGGCGATTGCGAAAAACTGGAAAAACGAAGACGGCTCGGAATGGTCAGTGCAACGTGA
CGGTATTCCTGCGGACGCAATGAAAAATGTGAAAGTGGTTTGTTCGGAAAATGCTCACTTCTCAGTGCAAAAAAATATGG
CAATGATGGGGATGGGTTTTCAATCTGTAGTAACAGTACCGTGCAACGAAAACGCTCAAATGGACGTTGTGGCATTAGAA
AAAACATTAGCGGATTTAACCACACAGGGCAAAATCGTTGCTTGTGTGGTGGCAACTGCTGGTACGACTGACGCTGGTGC
GATCGATCCATTAAAAGAAATTCGTGCAATTACTAATAAATTCGATGCATGGTTACACGTAGATGCAGCTTGGGGCGGTG
CGTTATTGCTTTCTAAAGATTTCCGTCATTTCTTAGACGGCATTGAAGAAACCGATTCAATCACCTTAGATTTCCACAAA
CACTTCTTCCAAAGTATTTCGTGTGGTGCGTTCTTATTAAAAGATCAAGCGAACTATCGTTTTATCGATTATAAAGCGGA
TTACCTCAATTCAGAATATGACGAAGCACACGGTGTACCGAACTTAGTAGCGAAATCATTACAAACTACTCGTCGTTTTG
ATGCCTTAAAATTATGGTTTACGGTAGAAGCGTTAGGCGAAGACTTATATGCTTCAATGATTGACCACGGTGTAAAATTA
ACCAAAGAAGTGGAAGGCTACATTAACGCGACTGATGGTTTAGAAATGTTAGTGCCAAGCCAATTCGCTTCGGTGTTATT
CCGTGTGGTACCGCAAGGTTATCCGGCGGAATTTATCGATACCTTAAACCAAAATGTAGCGGACGAACTTTTCGCACGCG
GCGAAGCGAATATCGGTGTAACCAAAGTGGGCGACAAACAATCGCTTAAGATGACTACGTTAAGCCCGATCGCAACCTTG
GAAAATGTGAAAGCGTTATTAGCACAAGTATTAGCGGAAGCGGATCGCATTAAAGATTCGATTGTAAGCGGTACCTACGT
GCCGCCGATTGATTAA

Upstream 100 bases:

>100_bases
TGCTTTATTTGAGCCACGCTGTGGCTCTTTTTATATCCTAGCTCCAACGGGGCTGAGTTTAATTAACCTAGCGCGGCTCG
TGCTAGGTACGAGAGAAAAA

Downstream 100 bases:

>100_bases
TCGGTAAAACTTTAGCTAAAAAAGACCGCTTATAAGCGGTCTTTTTTATGCGTTATAGCTATTTTTTAATCAAATAGCGT
AAAGTCGCACCGTCTTGTTC

Product: L-2,4-diaminobutyrate decarboxylase

Products: NA

Alternate protein names: DABA decarboxylase; DABA-DC [H]

Number of amino acids: Translated: 511; Mature: 510

Protein sequence:

>511_residues
MADISKHRQSLFCNDPQSIADYENAMNNAVQAISAWLKNDKMYTGGSIKQMRALIDGFNPSKEGVGVQKSLDHLVEIFLK
PSLKVHHPHSLAHLHCPTMVTSQIAEVLINATNQSMDSWDQSPAGSIMEEHLIDWLRQKVGYGAGTSGVFTSGGTQSNLM
GVLLARDWAIAKNWKNEDGSEWSVQRDGIPADAMKNVKVVCSENAHFSVQKNMAMMGMGFQSVVTVPCNENAQMDVVALE
KTLADLTTQGKIVACVVATAGTTDAGAIDPLKEIRAITNKFDAWLHVDAAWGGALLLSKDFRHFLDGIEETDSITLDFHK
HFFQSISCGAFLLKDQANYRFIDYKADYLNSEYDEAHGVPNLVAKSLQTTRRFDALKLWFTVEALGEDLYASMIDHGVKL
TKEVEGYINATDGLEMLVPSQFASVLFRVVPQGYPAEFIDTLNQNVADELFARGEANIGVTKVGDKQSLKMTTLSPIATL
ENVKALLAQVLAEADRIKDSIVSGTYVPPID

Sequences:

>Translated_511_residues
MADISKHRQSLFCNDPQSIADYENAMNNAVQAISAWLKNDKMYTGGSIKQMRALIDGFNPSKEGVGVQKSLDHLVEIFLK
PSLKVHHPHSLAHLHCPTMVTSQIAEVLINATNQSMDSWDQSPAGSIMEEHLIDWLRQKVGYGAGTSGVFTSGGTQSNLM
GVLLARDWAIAKNWKNEDGSEWSVQRDGIPADAMKNVKVVCSENAHFSVQKNMAMMGMGFQSVVTVPCNENAQMDVVALE
KTLADLTTQGKIVACVVATAGTTDAGAIDPLKEIRAITNKFDAWLHVDAAWGGALLLSKDFRHFLDGIEETDSITLDFHK
HFFQSISCGAFLLKDQANYRFIDYKADYLNSEYDEAHGVPNLVAKSLQTTRRFDALKLWFTVEALGEDLYASMIDHGVKL
TKEVEGYINATDGLEMLVPSQFASVLFRVVPQGYPAEFIDTLNQNVADELFARGEANIGVTKVGDKQSLKMTTLSPIATL
ENVKALLAQVLAEADRIKDSIVSGTYVPPID
>Mature_510_residues
ADISKHRQSLFCNDPQSIADYENAMNNAVQAISAWLKNDKMYTGGSIKQMRALIDGFNPSKEGVGVQKSLDHLVEIFLKP
SLKVHHPHSLAHLHCPTMVTSQIAEVLINATNQSMDSWDQSPAGSIMEEHLIDWLRQKVGYGAGTSGVFTSGGTQSNLMG
VLLARDWAIAKNWKNEDGSEWSVQRDGIPADAMKNVKVVCSENAHFSVQKNMAMMGMGFQSVVTVPCNENAQMDVVALEK
TLADLTTQGKIVACVVATAGTTDAGAIDPLKEIRAITNKFDAWLHVDAAWGGALLLSKDFRHFLDGIEETDSITLDFHKH
FFQSISCGAFLLKDQANYRFIDYKADYLNSEYDEAHGVPNLVAKSLQTTRRFDALKLWFTVEALGEDLYASMIDHGVKLT
KEVEGYINATDGLEMLVPSQFASVLFRVVPQGYPAEFIDTLNQNVADELFARGEANIGVTKVGDKQSLKMTTLSPIATLE
NVKALLAQVLAEADRIKDSIVSGTYVPPID

Specific function: Unknown

COG id: COG0076

COG function: function code E; Glutamate decarboxylase and related PLP-dependent proteins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the group II decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI194294551, Length=369, Percent_Identity=30.8943089430894, Blast_Score=175, Evalue=7e-44,
Organism=Homo sapiens, GI197383062, Length=466, Percent_Identity=27.4678111587983, Blast_Score=169, Evalue=4e-42,
Organism=Homo sapiens, GI197276620, Length=433, Percent_Identity=27.7136258660508, Blast_Score=166, Evalue=3e-41,
Organism=Homo sapiens, GI4503875, Length=433, Percent_Identity=27.7136258660508, Blast_Score=166, Evalue=3e-41,
Organism=Homo sapiens, GI58331246, Length=428, Percent_Identity=27.3364485981308, Blast_Score=166, Evalue=6e-41,
Organism=Homo sapiens, GI92110055, Length=407, Percent_Identity=25.5528255528256, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI4503281, Length=408, Percent_Identity=25.7352941176471, Blast_Score=129, Evalue=7e-30,
Organism=Homo sapiens, GI132814448, Length=408, Percent_Identity=25.7352941176471, Blast_Score=129, Evalue=7e-30,
Organism=Caenorhabditis elegans, GI17555682, Length=498, Percent_Identity=27.5100401606426, Blast_Score=159, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI71993062, Length=438, Percent_Identity=27.3972602739726, Blast_Score=155, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI71993058, Length=428, Percent_Identity=27.5700934579439, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17534817, Length=425, Percent_Identity=24.7058823529412, Blast_Score=115, Evalue=8e-26,
Organism=Caenorhabditis elegans, GI17534819, Length=425, Percent_Identity=24.7058823529412, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI71981211, Length=455, Percent_Identity=20.6593406593407, Blast_Score=101, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI71981217, Length=464, Percent_Identity=20.9051724137931, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17551992, Length=465, Percent_Identity=21.505376344086, Blast_Score=97, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI133931025, Length=389, Percent_Identity=21.3367609254499, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI17136594, Length=466, Percent_Identity=28.5407725321888, Blast_Score=168, Evalue=7e-42,
Organism=Drosophila melanogaster, GI21356415, Length=433, Percent_Identity=27.2517321016166, Blast_Score=146, Evalue=3e-35,
Organism=Drosophila melanogaster, GI24657193, Length=401, Percent_Identity=27.6807980049875, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24657185, Length=401, Percent_Identity=27.6807980049875, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24657188, Length=401, Percent_Identity=27.6807980049875, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI221476190, Length=423, Percent_Identity=26.241134751773, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24585143, Length=423, Percent_Identity=26.241134751773, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24585139, Length=423, Percent_Identity=26.241134751773, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24652373, Length=425, Percent_Identity=25.8823529411765, Blast_Score=125, Evalue=9e-29,
Organism=Drosophila melanogaster, GI17136190, Length=367, Percent_Identity=26.158038147139, Blast_Score=119, Evalue=5e-27,
Organism=Drosophila melanogaster, GI24585135, Length=339, Percent_Identity=26.2536873156342, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24586044, Length=415, Percent_Identity=24.3373493975904, Blast_Score=108, Evalue=8e-24,
Organism=Drosophila melanogaster, GI28573972, Length=440, Percent_Identity=22.7272727272727, Blast_Score=94, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002129
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR021115 [H]

Pfam domain/function: PF00282 Pyridoxal_deC [H]

EC number: =4.1.1.86 [H]

Molecular weight: Translated: 56094; Mature: 55963

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS00392 DDC_GAD_HDC_YDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADISKHRQSLFCNDPQSIADYENAMNNAVQAISAWLKNDKMYTGGSIKQMRALIDGFNP
CCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCHHHHHHHHCCCCC
SKEGVGVQKSLDHLVEIFLKPSLKVHHPHSLAHLHCPTMVTSQIAEVLINATNQSMDSWD
CCCCCCHHHHHHHHHHHHHCCCCEECCCCCHHHEECHHHHHHHHHHHHHHHCCCCHHHCC
QSPAGSIMEEHLIDWLRQKVGYGAGTSGVFTSGGTQSNLMGVLLARDWAIAKNWKNEDGS
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCEECCCCHHHHHHHHHHHCHHHHCCCCCCCCC
EWSVQRDGIPADAMKNVKVVCSENAHFSVQKNMAMMGMGFQSVVTVPCNENAQMDVVALE
CCEEECCCCCHHHHCCEEEEECCCCCEEHHCCHHHHCCCHHHEEEECCCCCCCEEHHHHH
KTLADLTTQGKIVACVVATAGTTDAGAIDPLKEIRAITNKFDAWLHVDAAWGGALLLSKD
HHHHHHCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHCCEEEEECCCCCHHHHHHH
FRHFLDGIEETDSITLDFHKHFFQSISCGAFLLKDQANYRFIDYKADYLNSEYDEAHGVP
HHHHHCCCCCCCCEEEHHHHHHHHHHCCCEEEEECCCCEEEEEEEHHHCCCCHHHHCCCH
NLVAKSLQTTRRFDALKLWFTVEALGEDLYASMIDHGVKLTKEVEGYINATDGLEMLVPS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHEECCCCHHHHHHH
QFASVLFRVVPQGYPAEFIDTLNQNVADELFARGEANIGVTKVGDKQSLKMTTLSPIATL
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCEEEECCCHHHHH
ENVKALLAQVLAEADRIKDSIVSGTYVPPID
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
ADISKHRQSLFCNDPQSIADYENAMNNAVQAISAWLKNDKMYTGGSIKQMRALIDGFNP
CCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCHHHHHHHHCCCCC
SKEGVGVQKSLDHLVEIFLKPSLKVHHPHSLAHLHCPTMVTSQIAEVLINATNQSMDSWD
CCCCCCHHHHHHHHHHHHHCCCCEECCCCCHHHEECHHHHHHHHHHHHHHHCCCCHHHCC
QSPAGSIMEEHLIDWLRQKVGYGAGTSGVFTSGGTQSNLMGVLLARDWAIAKNWKNEDGS
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCEECCCCHHHHHHHHHHHCHHHHCCCCCCCCC
EWSVQRDGIPADAMKNVKVVCSENAHFSVQKNMAMMGMGFQSVVTVPCNENAQMDVVALE
CCEEECCCCCHHHHCCEEEEECCCCCEEHHCCHHHHCCCHHHEEEECCCCCCCEEHHHHH
KTLADLTTQGKIVACVVATAGTTDAGAIDPLKEIRAITNKFDAWLHVDAAWGGALLLSKD
HHHHHHCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHCCEEEEECCCCCHHHHHHH
FRHFLDGIEETDSITLDFHKHFFQSISCGAFLLKDQANYRFIDYKADYLNSEYDEAHGVP
HHHHHCCCCCCCCEEEHHHHHHHHHHCCCEEEEECCCCEEEEEEEHHHCCCCHHHHCCCH
NLVAKSLQTTRRFDALKLWFTVEALGEDLYASMIDHGVKLTKEVEGYINATDGLEMLVPS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHEECCCCHHHHHHH
QFASVLFRVVPQGYPAEFIDTLNQNVADELFARGEANIGVTKVGDKQSLKMTTLSPIATL
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCEEEECCCHHHHH
ENVKALLAQVLAEADRIKDSIVSGTYVPPID
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800; 9514614 [H]