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The map label for this gene is hemH

Identifier: 126209395

GI number: 126209395

Start: 2170615

End: 2171574

Strand: Reverse

Name: hemH

Synonym: APL_1937

Alternate gene names: 126209395

Gene position: 2171574-2170615 (Counterclockwise)

Preceding gene: 126209399

Following gene: 126209394

Centisome position: 95.48

GC content: 42.6

Gene sequence:

>960_bases
ATGAATACAAATAAAATCGGCGTATTACTTGCCAATCTCGGTACGCCTGACGAACCGACAACTCCTGCGGTAAAACGTTA
CCTTAAGCAATTTTTAAGCGATCCTCGCGTGATCGATTTACCTAAATTCAAATGGCAATTTATCTTAAATTATATGATCC
TACCGAAAAGATCACCTAAAGTCGCTAAACTTTATCGTGAGATCTGGACGGAACAGGGTTCGCCTTTACTGGCGATCTCT
CGCCAACAACAACAAGCTTTACAGGATTACTTTAACCGCCAAAATCAAAACGTTTTGGTGGAGCTTGGTATGAGTTACGG
TAATCCGAGTATCGAAAGTGCAACCGATCGCCTGATTAAAGCCGGCGTAAGTAAAATTATCGTATTACCGCTTTATCCGC
AATACAGCAGCACGACAACCGCCTCGGTATTAGATGCGTTTGCCCGCGGCTTAACGCAACAGCGTAATATCGTTCCGTTC
GAGTTTATTCATAGCTATCACAACGATCCGCTTTATATTCAAGCGTTAGCTAATACGATCCGATTGGCTGACGATGAAAA
ATTATTGTTCTCGTTCCACGGTATTCCGAAACGTTACCAAACCGAGGGCGATTTTTATCCGGAACACTGCCAGAAAACCG
CACAGTTAGTCGCAGATAAACTATCGCTCTCCAATGAGCAATGGCTAGTGACTTATCAATCTCGTTTCGGTGATGAAGAG
TGGCTACAACCTTATACCGATGAAACCTTAGAAAAATTACCGAGTCAAGGGGTGAAAAAAATTGCGGTAATTTGCGCCGG
CTTTTCTGCGGATTGTTTAGAAACATTGGAAGAAATCGCTGAGGAAAACAAAGAAAACTTCCTTAATGCAGGCGGACAAT
CCTATCGCTATATTCCTGCGTTAAACGCCAATACCGATCACATCAACGCATTAGCTAAGTTAATCGAAGCGAAAATCTAA

Upstream 100 bases:

>100_bases
ATTGCCTATCTCTGTAATCAACACAAAAATTCTATTTGTTTTCAGACCTAAATTAACGCAAAATTCATTTATTTCGATCC
ATATTTAATGAGTCTTATTT

Downstream 100 bases:

>100_bases
CAACAAGCGGTCATATTTTCCGATTTTTTTACATTTTTAAAACGTAAAAAGACACGAAAATATGACCGCCTATCCTTTTC
CTCAATAACATTTCGTTTTT

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase

Number of amino acids: Translated: 319; Mature: 319

Protein sequence:

>319_residues
MNTNKIGVLLANLGTPDEPTTPAVKRYLKQFLSDPRVIDLPKFKWQFILNYMILPKRSPKVAKLYREIWTEQGSPLLAIS
RQQQQALQDYFNRQNQNVLVELGMSYGNPSIESATDRLIKAGVSKIIVLPLYPQYSSTTTASVLDAFARGLTQQRNIVPF
EFIHSYHNDPLYIQALANTIRLADDEKLLFSFHGIPKRYQTEGDFYPEHCQKTAQLVADKLSLSNEQWLVTYQSRFGDEE
WLQPYTDETLEKLPSQGVKKIAVICAGFSADCLETLEEIAEENKENFLNAGGQSYRYIPALNANTDHINALAKLIEAKI

Sequences:

>Translated_319_residues
MNTNKIGVLLANLGTPDEPTTPAVKRYLKQFLSDPRVIDLPKFKWQFILNYMILPKRSPKVAKLYREIWTEQGSPLLAIS
RQQQQALQDYFNRQNQNVLVELGMSYGNPSIESATDRLIKAGVSKIIVLPLYPQYSSTTTASVLDAFARGLTQQRNIVPF
EFIHSYHNDPLYIQALANTIRLADDEKLLFSFHGIPKRYQTEGDFYPEHCQKTAQLVADKLSLSNEQWLVTYQSRFGDEE
WLQPYTDETLEKLPSQGVKKIAVICAGFSADCLETLEEIAEENKENFLNAGGQSYRYIPALNANTDHINALAKLIEAKI
>Mature_319_residues
MNTNKIGVLLANLGTPDEPTTPAVKRYLKQFLSDPRVIDLPKFKWQFILNYMILPKRSPKVAKLYREIWTEQGSPLLAIS
RQQQQALQDYFNRQNQNVLVELGMSYGNPSIESATDRLIKAGVSKIIVLPLYPQYSSTTTASVLDAFARGLTQQRNIVPF
EFIHSYHNDPLYIQALANTIRLADDEKLLFSFHGIPKRYQTEGDFYPEHCQKTAQLVADKLSLSNEQWLVTYQSRFGDEE
WLQPYTDETLEKLPSQGVKKIAVICAGFSADCLETLEEIAEENKENFLNAGGQSYRYIPALNANTDHINALAKLIEAKI

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family

Homologues:

Organism=Homo sapiens, GI60499025, Length=330, Percent_Identity=30.3030303030303, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI60499021, Length=330, Percent_Identity=30.3030303030303, Blast_Score=117, Evalue=1e-26,
Organism=Escherichia coli, GI1786681, Length=322, Percent_Identity=53.7267080745342, Blast_Score=333, Evalue=1e-92,
Organism=Saccharomyces cerevisiae, GI6324750, Length=333, Percent_Identity=26.7267267267267, Blast_Score=93, Evalue=6e-20,
Organism=Drosophila melanogaster, GI17864156, Length=329, Percent_Identity=27.6595744680851, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24651774, Length=264, Percent_Identity=28.7878787878788, Blast_Score=92, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEMH_ACTP2 (A3N3M9)

Other databases:

- EMBL:   CP000569
- RefSeq:   YP_001054620.1
- STRING:   A3N3M9
- GeneID:   4850278
- GenomeReviews:   CP000569_GR
- KEGG:   apl:APL_1937
- eggNOG:   COG0276
- HOGENOM:   HBG697135
- OMA:   TIEEIGM
- PhylomeDB:   A3N3M9
- ProtClustDB:   CLSK965681
- BioCyc:   APLE416269:APL_1937-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00323
- InterPro:   IPR001015
- InterPro:   IPR019772
- PANTHER:   PTHR11108
- TIGRFAMs:   TIGR00109

Pfam domain/function: PF00762 Ferrochelatase

EC number: =4.99.1.1

Molecular weight: Translated: 36280; Mature: 36280

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTNKIGVLLANLGTPDEPTTPAVKRYLKQFLSDPRVIDLPKFKWQFILNYMILPKRSPK
CCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHCCCCCCH
VAKLYREIWTEQGSPLLAISRQQQQALQDYFNRQNQNVLVELGMSYGNPSIESATDRLIK
HHHHHHHHHHCCCCCEEEECHHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHH
AGVSKIIVLPLYPQYSSTTTASVLDAFARGLTQQRNIVPFEFIHSYHNDPLYIQALANTI
HCHHHEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCEEHHHHHHHH
RLADDEKLLFSFHGIPKRYQTEGDFYPEHCQKTAQLVADKLSLSNEQWLVTYQSRFGDEE
HCCCCCHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEHHHCCCHH
WLQPYTDETLEKLPSQGVKKIAVICAGFSADCLETLEEIAEENKENFLNAGGQSYRYIPA
HCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEC
LNANTDHINALAKLIEAKI
CCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNTNKIGVLLANLGTPDEPTTPAVKRYLKQFLSDPRVIDLPKFKWQFILNYMILPKRSPK
CCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHCCCCCCH
VAKLYREIWTEQGSPLLAISRQQQQALQDYFNRQNQNVLVELGMSYGNPSIESATDRLIK
HHHHHHHHHHCCCCCEEEECHHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHH
AGVSKIIVLPLYPQYSSTTTASVLDAFARGLTQQRNIVPFEFIHSYHNDPLYIQALANTI
HCHHHEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCEEHHHHHHHH
RLADDEKLLFSFHGIPKRYQTEGDFYPEHCQKTAQLVADKLSLSNEQWLVTYQSRFGDEE
HCCCCCHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEHHHCCCHH
WLQPYTDETLEKLPSQGVKKIAVICAGFSADCLETLEEIAEENKENFLNAGGQSYRYIPA
HCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEC
LNANTDHINALAKLIEAKI
CCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA