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The map label for this gene is ilvC

Identifier: 126209315

GI number: 126209315

Start: 2084660

End: 2086141

Strand: Reverse

Name: ilvC

Synonym: APL_1853

Alternate gene names: 126209315

Gene position: 2086141-2084660 (Counterclockwise)

Preceding gene: 126209320

Following gene: 126209314

Centisome position: 91.72

GC content: 42.51

Gene sequence:

>1482_bases
ATGGCTAACTATTTCAACACATTAAACTTACGTCAAAAATTAGACCAACTCGGTCGTTGCCGTTTTATGGATCGTAACGA
GTTTGCAGACGGCTGCAATTTCTTAAAAGGCAAGAAAATCGTTATCGTAGGTTGTGGTGCGCAAGGTTTAAACCAAGGTT
TAAATATGCGTGATTCCGGTTTAGACATTAGCTATGCGTTACGTGCGGAAGCCATTGCTGAAAAACGTGCGTCATTTACT
CGTGCAACCGAAAACGGTTTCAAAGTCGGCACATACCAAGAATTAATTCCAACCGCTGACTTAGTTATCAACTTAACGCC
GGATAAACAACACTCAAAAGTGGTTGCAGATGTTGTTCCGTTAATGAAACAAGGTTCTGCATTCGGTTACTCGCACGGTT
TCAACATTGTTGAAGAAGGTGAGCAAATTCGTAAAGATATTACCGTAGTAATGACTGCACCAAAATGTCCTGGTACGGAA
GTGCGTGAAGAATATAAACGTGGTTTCGGTGTACCGACACTTATCGCAGTTCACCCTGAAAATGACCCGAAAGGCGAGGG
TATGGCAATCGCAAAAGCGTGGGCATCAGCAACCGGTGGTGACCGTGCGGGCGTATTGGAATCTTCATTCGTAGCGGAAG
TTAAATCCGACTTAATGGGCGAACAAACTATCCTTTGCGGTATGTTACAAGCAGGCTCAATCGTATGTTATGACAAATTA
GTGGCTGACGGTAAAGATCCGGCATACGCAAGCAAATTAATCCAATACGGTTGGGAAACCATTACTGAAGCGTTAAAACA
AGGCGGTATCACATTAATGATGGATCGCTTATCAAACGCTGCGAAAATCCGCGCTTTTGAATTAAGTGAAGAAATCAAAG
TTCAATTAAACGACCTTTACTTAAAACATATGGACGACATCATCAGCGGTGAATTCTCATCAACCATGATGGCTGACTGG
GCAAACGGTGACGTGAACTTATTCAAATGGCGTGAAGAAACCGGTAAAACCGCATTCGAAAATTCACCGAAAGCAGACGG
CATCAAAATTTCCGAACAAGAATACTTTGATAACGGCGTAGTTATGGTTGCAATGGTGAAAGCGGGTGTAGAAATGGCAT
TCGATGCAATGGTTGCAAGCGGTATCTACGAAGAATCTGCATACTATGAGTCATTACACGAATTACCGTTAATCGCAAAT
ACGATCGCTCGTAAACGTTTATACGAAATGAACGTGGTAATTTCAGATACGGCGGAATACGGTAACTACTTATTCTCTCA
TGTTGCAACGCCAATTCTTGCAGAGAAATTAATCCCGATGTTACAAAAAGGCGACTTAGGGGAGCCGACACCTGCTGCTG
AAATCGACAACGTTTACTTACGTGATATCAACGATGCAATCCGTAACCATCCGGTTGAATTAATCGGTCAAGAGTTACGT
GGTTATATGACGGATATGAAACGTATTTCATCGCAAGGTTAA

Upstream 100 bases:

>100_bases
AAACGGCGTATAATCGATTGCATAACAACATAACAATGTGTAAACACAACATCATAAAACAACACACTCAACATCATACA
TATAAATAAGGAAGCACAAA

Downstream 100 bases:

>100_bases
TTAAAAATTAATCAAAAGCCTACTTCGCAAGAAGTGGGCTTTTTGTTATTCAAGCCGCTTACCGCTATCAATGGTAAGTG
ATATGCATAATAGCTTATAA

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase

Number of amino acids: Translated: 493; Mature: 492

Protein sequence:

>493_residues
MANYFNTLNLRQKLDQLGRCRFMDRNEFADGCNFLKGKKIVIVGCGAQGLNQGLNMRDSGLDISYALRAEAIAEKRASFT
RATENGFKVGTYQELIPTADLVINLTPDKQHSKVVADVVPLMKQGSAFGYSHGFNIVEEGEQIRKDITVVMTAPKCPGTE
VREEYKRGFGVPTLIAVHPENDPKGEGMAIAKAWASATGGDRAGVLESSFVAEVKSDLMGEQTILCGMLQAGSIVCYDKL
VADGKDPAYASKLIQYGWETITEALKQGGITLMMDRLSNAAKIRAFELSEEIKVQLNDLYLKHMDDIISGEFSSTMMADW
ANGDVNLFKWREETGKTAFENSPKADGIKISEQEYFDNGVVMVAMVKAGVEMAFDAMVASGIYEESAYYESLHELPLIAN
TIARKRLYEMNVVISDTAEYGNYLFSHVATPILAEKLIPMLQKGDLGEPTPAAEIDNVYLRDINDAIRNHPVELIGQELR
GYMTDMKRISSQG

Sequences:

>Translated_493_residues
MANYFNTLNLRQKLDQLGRCRFMDRNEFADGCNFLKGKKIVIVGCGAQGLNQGLNMRDSGLDISYALRAEAIAEKRASFT
RATENGFKVGTYQELIPTADLVINLTPDKQHSKVVADVVPLMKQGSAFGYSHGFNIVEEGEQIRKDITVVMTAPKCPGTE
VREEYKRGFGVPTLIAVHPENDPKGEGMAIAKAWASATGGDRAGVLESSFVAEVKSDLMGEQTILCGMLQAGSIVCYDKL
VADGKDPAYASKLIQYGWETITEALKQGGITLMMDRLSNAAKIRAFELSEEIKVQLNDLYLKHMDDIISGEFSSTMMADW
ANGDVNLFKWREETGKTAFENSPKADGIKISEQEYFDNGVVMVAMVKAGVEMAFDAMVASGIYEESAYYESLHELPLIAN
TIARKRLYEMNVVISDTAEYGNYLFSHVATPILAEKLIPMLQKGDLGEPTPAAEIDNVYLRDINDAIRNHPVELIGQELR
GYMTDMKRISSQG
>Mature_492_residues
ANYFNTLNLRQKLDQLGRCRFMDRNEFADGCNFLKGKKIVIVGCGAQGLNQGLNMRDSGLDISYALRAEAIAEKRASFTR
ATENGFKVGTYQELIPTADLVINLTPDKQHSKVVADVVPLMKQGSAFGYSHGFNIVEEGEQIRKDITVVMTAPKCPGTEV
REEYKRGFGVPTLIAVHPENDPKGEGMAIAKAWASATGGDRAGVLESSFVAEVKSDLMGEQTILCGMLQAGSIVCYDKLV
ADGKDPAYASKLIQYGWETITEALKQGGITLMMDRLSNAAKIRAFELSEEIKVQLNDLYLKHMDDIISGEFSSTMMADWA
NGDVNLFKWREETGKTAFENSPKADGIKISEQEYFDNGVVMVAMVKAGVEMAFDAMVASGIYEESAYYESLHELPLIANT
IARKRLYEMNVVISDTAEYGNYLFSHVATPILAEKLIPMLQKGDLGEPTPAAEIDNVYLRDINDAIRNHPVELIGQELRG
YMTDMKRISSQG

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family

Homologues:

Organism=Escherichia coli, GI1790210, Length=493, Percent_Identity=79.1075050709939, Blast_Score=793, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6323387, Length=280, Percent_Identity=30, Blast_Score=97, Evalue=6e-21,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ILVC_ACTP2 (A3N3E9)

Other databases:

- EMBL:   CP000569
- RefSeq:   YP_001054540.1
- ProteinModelPortal:   A3N3E9
- SMR:   A3N3E9
- STRING:   A3N3E9
- GeneID:   4849756
- GenomeReviews:   CP000569_GR
- KEGG:   apl:APL_1853
- eggNOG:   COG0059
- HOGENOM:   HBG297205
- OMA:   EKHMDDI
- PhylomeDB:   A3N3E9
- ProtClustDB:   PRK05225
- BioCyc:   APLE416269:APL_1853-MONOMER
- HAMAP:   MF_00435
- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116
- InterPro:   IPR014359
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR21371
- PIRSF:   PIRSF000116
- TIGRFAMs:   TIGR00465

Pfam domain/function: PF01450 IlvC; PF07991 IlvN; SSF48179 6DGDH_C_like

EC number: =1.1.1.86

Molecular weight: Translated: 54394; Mature: 54263

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: NA

Important sites: ACT_SITE 132-132

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANYFNTLNLRQKLDQLGRCRFMDRNEFADGCNFLKGKKIVIVGCGAQGLNQGLNMRDSG
CCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCEEEEEECCCHHHHCCCCCCCCC
LDISYALRAEAIAEKRASFTRATENGFKVGTYQELIPTADLVINLTPDKQHSKVVADVVP
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCEEEEECCCHHHHHHHHHHHH
LMKQGSAFGYSHGFNIVEEGEQIRKDITVVMTAPKCPGTEVREEYKRGFGVPTLIAVHPE
HHHCCCCCCCCCCCCHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHCCCCCEEEEECCC
NDPKGEGMAIAKAWASATGGDRAGVLESSFVAEVKSDLMGEQTILCGMLQAGSIVCYDKL
CCCCCCCEEHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCCEEEEHHH
VADGKDPAYASKLIQYGWETITEALKQGGITLMMDRLSNAAKIRAFELSEEIKVQLNDLY
HCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEEHHHCCCHHEEEEECCHHHHHHHHHHH
LKHMDDIISGEFSSTMMADWANGDVNLFKWREETGKTAFENSPKADGIKISEQEYFDNGV
HHHHHHHHCCCCCHHHEEECCCCCEEEEEECHHHCCCCCCCCCCCCCEEECHHHHHCCCE
VMVAMVKAGVEMAFDAMVASGIYEESAYYESLHELPLIANTIARKRLYEMNVVISDTAEY
EEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHEEEEEECCHHH
GNYLFSHVATPILAEKLIPMLQKGDLGEPTPAAEIDNVYLRDINDAIRNHPVELIGQELR
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHCCHHHHHHHHHHHCCCHHHHHHHHH
GYMTDMKRISSQG
HHHHHHHHHHCCC
>Mature Secondary Structure 
ANYFNTLNLRQKLDQLGRCRFMDRNEFADGCNFLKGKKIVIVGCGAQGLNQGLNMRDSG
CCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCEEEEEECCCHHHHCCCCCCCCC
LDISYALRAEAIAEKRASFTRATENGFKVGTYQELIPTADLVINLTPDKQHSKVVADVVP
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCEEEEECCCHHHHHHHHHHHH
LMKQGSAFGYSHGFNIVEEGEQIRKDITVVMTAPKCPGTEVREEYKRGFGVPTLIAVHPE
HHHCCCCCCCCCCCCHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHCCCCCEEEEECCC
NDPKGEGMAIAKAWASATGGDRAGVLESSFVAEVKSDLMGEQTILCGMLQAGSIVCYDKL
CCCCCCCEEHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCCEEEEHHH
VADGKDPAYASKLIQYGWETITEALKQGGITLMMDRLSNAAKIRAFELSEEIKVQLNDLY
HCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEEHHHCCCHHEEEEECCHHHHHHHHHHH
LKHMDDIISGEFSSTMMADWANGDVNLFKWREETGKTAFENSPKADGIKISEQEYFDNGV
HHHHHHHHCCCCCHHHEEECCCCCEEEEEECHHHCCCCCCCCCCCCCEEECHHHHHCCCE
VMVAMVKAGVEMAFDAMVASGIYEESAYYESLHELPLIANTIARKRLYEMNVVISDTAEY
EEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHEEEEEECCHHH
GNYLFSHVATPILAEKLIPMLQKGDLGEPTPAAEIDNVYLRDINDAIRNHPVELIGQELR
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHCCHHHHHHHHHHHCCCHHHHHHHHH
GYMTDMKRISSQG
HHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA