Click here to switch to the map view.

The map label for this gene is menB [H]

Identifier: 126209286

GI number: 126209286

Start: 2046349

End: 2047206

Strand: Reverse

Name: menB [H]

Synonym: APL_1824

Alternate gene names: 126209286

Gene position: 2047206-2046349 (Counterclockwise)

Preceding gene: 126209287

Following gene: 126209285

Centisome position: 90.01

GC content: 46.85

Gene sequence:

>858_bases
ATGTTATATCCAAGTGAAGAATTTCTTTATGCTCCGATTACGTGGGTAGATCATAGCGAAGGTTACACTGACATTCGTTA
CCATAAATCAACCGACGGTATTGCGAAAATTACCATCAATCGTCCTGAAGTACGTAACGCCTTCCGTCCTCAAACGGTTA
AAGAAATGATCCATGCTTTCGCCGATGCGCGCTTTGACGAAAAAATCGGGGTTATCGTATTAACCGGTGAAGGCGAATAC
GCATTCTGTGCCGGCGGCGACCAAAAAATTCGCGGTGACTACGGCGGTTATAAAGACGACAGCGGCGTTCATCATTTAAA
CGTGTTGCAGTTCCAACGTGATATTCGTACTTGTCCGAAACCGGTTGTGGCAATGGTGGCAGGCTATGCGGTTGGCGGTG
GTCACGTGTTACATATGATGTGTGACTTAACGATTGCGGCGGATAACGCAAAATTCGGTCAAACCGGCCCGAAAGTGGGT
TCATTTGACGGCGGCTGGGGCGCAAGCTATATGGCGCGTATCGTCGGCCAGAAAAAAGCGCGTGAAATTTGGTTCTTATG
CCGTATGTACGATGCGCAAGAAGCATTAAATATGGGCTTAGTGAATACCGTTGTGCCTTATGCGGATCTTGAAAAAGAAA
CCGTGCGTTGGTGCCGTGAAATGTTACAAAACAGCCCGATCGCATTACGTTGCTTAAAAGCGGCGTTAAATGCGGACTGT
GACGGTCAAGCGGGTCTGCAAGAATTAGCGGGCAACGCAACCATGTTATTCTATATGACGGAAGAAGGTCAGGAAGGTCG
TAACGCATTCAATGAAAAACGTGAACCTGACTTCAGTAAATTTAAACGTAATCCGTAA

Upstream 100 bases:

>100_bases
TTTTACAAAATTTGACCGCTTATTTTCTCGTGAATCCCTCTCAATTCGGCTATAATTGCCCGAATTTTTTATACTTTATA
CACATTAAAAAGGAACTCCA

Downstream 100 bases:

>100_bases
TGCCTTCTATTACCTCCCCCTATAACGGGGAGGTGCTGACAAGCGGTCCGATTCGCTGACTTTTTTGCAAATAATTTTAT
GTCAAACAACCAAACTCAAA

Product: naphthoate synthase

Products: NA

Alternate protein names: DHNA-CoA synthase [H]

Number of amino acids: Translated: 285; Mature: 285

Protein sequence:

>285_residues
MLYPSEEFLYAPITWVDHSEGYTDIRYHKSTDGIAKITINRPEVRNAFRPQTVKEMIHAFADARFDEKIGVIVLTGEGEY
AFCAGGDQKIRGDYGGYKDDSGVHHLNVLQFQRDIRTCPKPVVAMVAGYAVGGGHVLHMMCDLTIAADNAKFGQTGPKVG
SFDGGWGASYMARIVGQKKAREIWFLCRMYDAQEALNMGLVNTVVPYADLEKETVRWCREMLQNSPIALRCLKAALNADC
DGQAGLQELAGNATMLFYMTEEGQEGRNAFNEKREPDFSKFKRNP

Sequences:

>Translated_285_residues
MLYPSEEFLYAPITWVDHSEGYTDIRYHKSTDGIAKITINRPEVRNAFRPQTVKEMIHAFADARFDEKIGVIVLTGEGEY
AFCAGGDQKIRGDYGGYKDDSGVHHLNVLQFQRDIRTCPKPVVAMVAGYAVGGGHVLHMMCDLTIAADNAKFGQTGPKVG
SFDGGWGASYMARIVGQKKAREIWFLCRMYDAQEALNMGLVNTVVPYADLEKETVRWCREMLQNSPIALRCLKAALNADC
DGQAGLQELAGNATMLFYMTEEGQEGRNAFNEKREPDFSKFKRNP
>Mature_285_residues
MLYPSEEFLYAPITWVDHSEGYTDIRYHKSTDGIAKITINRPEVRNAFRPQTVKEMIHAFADARFDEKIGVIVLTGEGEY
AFCAGGDQKIRGDYGGYKDDSGVHHLNVLQFQRDIRTCPKPVVAMVAGYAVGGGHVLHMMCDLTIAADNAKFGQTGPKVG
SFDGGWGASYMARIVGQKKAREIWFLCRMYDAQEALNMGLVNTVVPYADLEKETVRWCREMLQNSPIALRCLKAALNADC
DGQAGLQELAGNATMLFYMTEEGQEGRNAFNEKREPDFSKFKRNP

Specific function: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA) [H]

COG id: COG0447

COG function: function code H; Dihydroxynaphthoic acid synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=245, Percent_Identity=33.0612244897959, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI31542718, Length=256, Percent_Identity=31.640625, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI4502327, Length=253, Percent_Identity=30.8300395256917, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI45643119, Length=209, Percent_Identity=30.622009569378, Blast_Score=85, Evalue=6e-17,
Organism=Homo sapiens, GI260275230, Length=209, Percent_Identity=30.622009569378, Blast_Score=85, Evalue=6e-17,
Organism=Homo sapiens, GI260274832, Length=209, Percent_Identity=30.622009569378, Blast_Score=85, Evalue=7e-17,
Organism=Homo sapiens, GI213417737, Length=224, Percent_Identity=25.4464285714286, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI157694516, Length=224, Percent_Identity=25.4464285714286, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI70995211, Length=239, Percent_Identity=29.2887029288703, Blast_Score=74, Evalue=1e-13,
Organism=Escherichia coli, GI1788597, Length=285, Percent_Identity=87.0175438596491, Blast_Score=533, Evalue=1e-153,
Organism=Escherichia coli, GI1787659, Length=245, Percent_Identity=33.0612244897959, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI221142681, Length=255, Percent_Identity=30.5882352941176, Blast_Score=98, Evalue=6e-22,
Organism=Escherichia coli, GI87082183, Length=253, Percent_Identity=28.4584980237154, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI1787660, Length=260, Percent_Identity=29.6153846153846, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1788682, Length=229, Percent_Identity=25.3275109170306, Blast_Score=67, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17554946, Length=248, Percent_Identity=33.0645161290323, Blast_Score=115, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI25145438, Length=260, Percent_Identity=33.0769230769231, Blast_Score=113, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17540714, Length=240, Percent_Identity=26.6666666666667, Blast_Score=107, Evalue=7e-24,
Organism=Caenorhabditis elegans, GI17535521, Length=245, Percent_Identity=27.7551020408163, Blast_Score=81, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17549921, Length=198, Percent_Identity=29.2929292929293, Blast_Score=78, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17560910, Length=203, Percent_Identity=30.0492610837438, Blast_Score=74, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17534483, Length=264, Percent_Identity=26.8939393939394, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17536985, Length=217, Percent_Identity=28.110599078341, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI20129971, Length=249, Percent_Identity=36.144578313253, Blast_Score=122, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24653477, Length=249, Percent_Identity=36.144578313253, Blast_Score=122, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24653139, Length=261, Percent_Identity=29.1187739463602, Blast_Score=108, Evalue=3e-24,
Organism=Drosophila melanogaster, GI21357171, Length=178, Percent_Identity=32.5842696629214, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI19922422, Length=199, Percent_Identity=28.643216080402, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24654903, Length=183, Percent_Identity=28.9617486338798, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24650670, Length=174, Percent_Identity=32.183908045977, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376
- InterPro:   IPR010198 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.1.3.36 [H]

Molecular weight: Translated: 31842; Mature: 31842

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLYPSEEFLYAPITWVDHSEGYTDIRYHKSTDGIAKITINRPEVRNAFRPQTVKEMIHAF
CCCCCCCCEEECEEEEECCCCCCEEEEECCCCCEEEEEECCHHHHHCCCCHHHHHHHHHH
ADARFDEKIGVIVLTGEGEYAFCAGGDQKIRGDYGGYKDDSGVHHLNVLQFQRDIRTCPK
HCCCCCCCCCEEEEECCCCEEEECCCCCEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCH
PVVAMVAGYAVGGGHVLHMMCDLTIAADNAKFGQTGPKVGSFDGGWGASYMARIVGQKKA
HHHHHHHHHCCCCHHHEEHHHHEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
REIWFLCRMYDAQEALNMGLVNTVVPYADLEKETVRWCREMLQNSPIALRCLKAALNADC
HHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCC
DGQAGLQELAGNATMLFYMTEEGQEGRNAFNEKREPDFSKFKRNP
CCCHHHHHHCCCCEEEEEECCCCCCHHHHHHHCCCCCHHHHCCCC
>Mature Secondary Structure
MLYPSEEFLYAPITWVDHSEGYTDIRYHKSTDGIAKITINRPEVRNAFRPQTVKEMIHAF
CCCCCCCCEEECEEEEECCCCCCEEEEECCCCCEEEEEECCHHHHHCCCCHHHHHHHHHH
ADARFDEKIGVIVLTGEGEYAFCAGGDQKIRGDYGGYKDDSGVHHLNVLQFQRDIRTCPK
HCCCCCCCCCEEEEECCCCEEEECCCCCEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCH
PVVAMVAGYAVGGGHVLHMMCDLTIAADNAKFGQTGPKVGSFDGGWGASYMARIVGQKKA
HHHHHHHHHCCCCHHHEEHHHHEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
REIWFLCRMYDAQEALNMGLVNTVVPYADLEKETVRWCREMLQNSPIALRCLKAALNADC
HHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCC
DGQAGLQELAGNATMLFYMTEEGQEGRNAFNEKREPDFSKFKRNP
CCCHHHHHHCCCCEEEEEECCCCCCHHHHHHHCCCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]