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The map label for this gene is srp54 [H]

Identifier: 126209206

GI number: 126209206

Start: 1977954

End: 1979345

Strand: Direct

Name: srp54 [H]

Synonym: APL_1742

Alternate gene names: 126209206

Gene position: 1977954-1979345 (Clockwise)

Preceding gene: 126209205

Following gene: 126209211

Centisome position: 86.96

GC content: 44.9

Gene sequence:

>1392_bases
ATGTTTGAAAACTTATCCGACAGACTGTCGAAAACTCTACGTAATATCACGGGAAAAGGACGTTTAACCGAAGATAATAT
TAAAGATACGTTACGTGAAGTACGTATGGCGTTACTTGAAGCCGACGTAGCATTACCCGTAGTACGTGAATTTATTAATA
AAGTAAAAGAACGCGCATTAGGTACGGAAGTCAATAAAAGCCTAACGCCCGGTCAAGAATTTCTCAAAATCGTACAAAGC
GAACTTGAAATCGCAATGGGCGAAGCGAATGAGGAATTAAATTTAGCGACCCAACCGCCGGCGGTCATTTTGATGGCGGG
TTTACAAGGTGCGGGTAAAACCACCTCGGTCGGTAAATTAGCAAAATTCCTTAAAGAGCGTCACAAGAAGAAAGTATTAG
TGGTTTCTGCTGACGTTTATCGTCCGGCGGCGATTAAACAGCTTCAAACCTTAGCGGAAGCGTTAAAAGTCGATTTCTTC
CCGACGGAAACCACGCAAAAGCCGGTTGAAATTGCCGAGCTTGCCTTAAAATACGCAAAACTCAATTTCTTTGATGTTTT
AATTGTGGATACCGCAGGTCGTTTACACGTGGACGGCGAGATGATGGAGGAAATCCAGCAAATCCATCGTGTATTAAATC
CGATTGAAACGCTCTTTACCGTGGATGCGATGACCGGTCAAGATGCGGCGAATACGGCAAAAGCCTTTAACGAAGCCTTA
CCGCTTACCGGTGTGATCTTAACCAAAGTGGACGGCGATGCGCGCGGCGGTGCGGCATTATCTATTCGTCAAATTACCGG
TAAACCGATTAAATTCCTCGGTGTGGGCGAGAAAACCGATGCGTTAGAACCGTTCCATCCGGATCGTGTCGCTTCTCGTA
TCCTCGGTATGGGCGACGTATTATCGTTAATTGAAGATTTACAACGCTCGGTCGATCAAGAAAAAGCCGAAAAAATGGCA
CAGAAATTCAAGAAAGGTGACGATTTCACCCTTGAAGATTTCCGTGAACAGCTGATCGAGATGAAGAAAATGGGCGGTAT
GATGTCGATGTTGGATAAACTGCCCGGTGCGAAGAATTTACCTGATCACGTAAAAAATCAGGTGGATGATAAAATGTTCG
TAAAAATGGAAGCGATCATAAACTCTATGACGCTGAAAGAGCGTGCCAATCCGGATATTATTAAAGGTTCTCGCCGTCGT
CGTATTGCGTTAGGTTCCGGCACACAGGTGCAAGACGTAAACAAATTGCTCAAGCAGTTTGATGAAATGCAACGTATGAT
GAAAAAAATGCGTAAAGGCGGTATGGCGAAAATGATGCGCGGTATGAAAGGTATGATGGGTGGCGGTATGGGTGCACTCG
GCGGCTTAGGCAATATGTTCGGTAAACGCTAG

Upstream 100 bases:

>100_bases
GGATTCTTTCCTACAAGAAATGCAAATTTTTTGTATAATAAAGCCATTTTTCCGCATATAAGCGGTCGAATTTCATAAAA
ATTTTGCAAAAGAGAACACT

Downstream 100 bases:

>100_bases
GTCATCATTTATTTCTATCAAATCCCCGTTTAGTTAAACGGGGATTTTTTTATATCCCTTTGTTTTTAGATAAGTGGATT
CTTATTGTAAGCGGTCATAT

Product: signal recognition particle protein (sigma-54 like protein)

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 463; Mature: 463

Protein sequence:

>463_residues
MFENLSDRLSKTLRNITGKGRLTEDNIKDTLREVRMALLEADVALPVVREFINKVKERALGTEVNKSLTPGQEFLKIVQS
ELEIAMGEANEELNLATQPPAVILMAGLQGAGKTTSVGKLAKFLKERHKKKVLVVSADVYRPAAIKQLQTLAEALKVDFF
PTETTQKPVEIAELALKYAKLNFFDVLIVDTAGRLHVDGEMMEEIQQIHRVLNPIETLFTVDAMTGQDAANTAKAFNEAL
PLTGVILTKVDGDARGGAALSIRQITGKPIKFLGVGEKTDALEPFHPDRVASRILGMGDVLSLIEDLQRSVDQEKAEKMA
QKFKKGDDFTLEDFREQLIEMKKMGGMMSMLDKLPGAKNLPDHVKNQVDDKMFVKMEAIINSMTLKERANPDIIKGSRRR
RIALGSGTQVQDVNKLLKQFDEMQRMMKKMRKGGMAKMMRGMKGMMGGGMGALGGLGNMFGKR

Sequences:

>Translated_463_residues
MFENLSDRLSKTLRNITGKGRLTEDNIKDTLREVRMALLEADVALPVVREFINKVKERALGTEVNKSLTPGQEFLKIVQS
ELEIAMGEANEELNLATQPPAVILMAGLQGAGKTTSVGKLAKFLKERHKKKVLVVSADVYRPAAIKQLQTLAEALKVDFF
PTETTQKPVEIAELALKYAKLNFFDVLIVDTAGRLHVDGEMMEEIQQIHRVLNPIETLFTVDAMTGQDAANTAKAFNEAL
PLTGVILTKVDGDARGGAALSIRQITGKPIKFLGVGEKTDALEPFHPDRVASRILGMGDVLSLIEDLQRSVDQEKAEKMA
QKFKKGDDFTLEDFREQLIEMKKMGGMMSMLDKLPGAKNLPDHVKNQVDDKMFVKMEAIINSMTLKERANPDIIKGSRRR
RIALGSGTQVQDVNKLLKQFDEMQRMMKKMRKGGMAKMMRGMKGMMGGGMGALGGLGNMFGKR
>Mature_463_residues
MFENLSDRLSKTLRNITGKGRLTEDNIKDTLREVRMALLEADVALPVVREFINKVKERALGTEVNKSLTPGQEFLKIVQS
ELEIAMGEANEELNLATQPPAVILMAGLQGAGKTTSVGKLAKFLKERHKKKVLVVSADVYRPAAIKQLQTLAEALKVDFF
PTETTQKPVEIAELALKYAKLNFFDVLIVDTAGRLHVDGEMMEEIQQIHRVLNPIETLFTVDAMTGQDAANTAKAFNEAL
PLTGVILTKVDGDARGGAALSIRQITGKPIKFLGVGEKTDALEPFHPDRVASRILGMGDVLSLIEDLQRSVDQEKAEKMA
QKFKKGDDFTLEDFREQLIEMKKMGGMMSMLDKLPGAKNLPDHVKNQVDDKMFVKMEAIINSMTLKERANPDIIKGSRRR
RIALGSGTQVQDVNKLLKQFDEMQRMMKKMRKGGMAKMMRGMKGMMGGGMGALGGLGNMFGKR

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=444, Percent_Identity=32.2072072072072, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI226371618, Length=346, Percent_Identity=34.971098265896, Blast_Score=191, Evalue=2e-48,
Organism=Homo sapiens, GI89061728, Length=165, Percent_Identity=36.3636363636364, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI23308697, Length=315, Percent_Identity=26.984126984127, Blast_Score=105, Evalue=9e-23,
Organism=Homo sapiens, GI295424842, Length=315, Percent_Identity=26.984126984127, Blast_Score=105, Evalue=1e-22,
Organism=Escherichia coli, GI1788963, Length=450, Percent_Identity=78.2222222222222, Blast_Score=692, Evalue=0.0,
Organism=Escherichia coli, GI1789874, Length=254, Percent_Identity=37.4015748031496, Blast_Score=158, Evalue=6e-40,
Organism=Caenorhabditis elegans, GI17539958, Length=484, Percent_Identity=29.3388429752066, Blast_Score=191, Evalue=9e-49,
Organism=Caenorhabditis elegans, GI193206261, Length=214, Percent_Identity=34.1121495327103, Blast_Score=103, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6325345, Length=478, Percent_Identity=33.2635983263598, Blast_Score=224, Evalue=2e-59,
Organism=Drosophila melanogaster, GI17647949, Length=433, Percent_Identity=29.3302540415704, Blast_Score=179, Evalue=3e-45,
Organism=Drosophila melanogaster, GI24641198, Length=220, Percent_Identity=29.5454545454545, Blast_Score=100, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 51261; Mature: 51261

Theoretical pI: Translated: 10.12; Mature: 10.12

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
6.3 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
6.3 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFENLSDRLSKTLRNITGKGRLTEDNIKDTLREVRMALLEADVALPVVREFINKVKERAL
CCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GTEVNKSLTPGQEFLKIVQSELEIAMGEANEELNLATQPPAVILMAGLQGAGKTTSVGKL
CHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHH
AKFLKERHKKKVLVVSADVYRPAAIKQLQTLAEALKVDFFPTETTQKPVEIAELALKYAK
HHHHHHHHHCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHH
LNFFDVLIVDTAGRLHVDGEMMEEIQQIHRVLNPIETLFTVDAMTGQDAANTAKAFNEAL
HCCEEEEEEECCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHC
PLTGVILTKVDGDARGGAALSIRQITGKPIKFLGVGEKTDALEPFHPDRVASRILGMGDV
CCCEEEEEECCCCCCCCCEEEEEECCCCCEEEEECCCCCCCCCCCCHHHHHHHHHCHHHH
LSLIEDLQRSVDQEKAEKMAQKFKKGDDFTLEDFREQLIEMKKMGGMMSMLDKLPGAKNL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCHHHHHHHHCCCCCCC
PDHVKNQVDDKMFVKMEAIINSMTLKERANPDIIKGSRRRRIALGSGTQVQDVNKLLKQF
CHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHH
DEMQRMMKKMRKGGMAKMMRGMKGMMGGGMGALGGLGNMFGKR
HHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCC
>Mature Secondary Structure
MFENLSDRLSKTLRNITGKGRLTEDNIKDTLREVRMALLEADVALPVVREFINKVKERAL
CCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GTEVNKSLTPGQEFLKIVQSELEIAMGEANEELNLATQPPAVILMAGLQGAGKTTSVGKL
CHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHH
AKFLKERHKKKVLVVSADVYRPAAIKQLQTLAEALKVDFFPTETTQKPVEIAELALKYAK
HHHHHHHHHCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHH
LNFFDVLIVDTAGRLHVDGEMMEEIQQIHRVLNPIETLFTVDAMTGQDAANTAKAFNEAL
HCCEEEEEEECCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHC
PLTGVILTKVDGDARGGAALSIRQITGKPIKFLGVGEKTDALEPFHPDRVASRILGMGDV
CCCEEEEEECCCCCCCCCEEEEEECCCCCEEEEECCCCCCCCCCCCHHHHHHHHHCHHHH
LSLIEDLQRSVDQEKAEKMAQKFKKGDDFTLEDFREQLIEMKKMGGMMSMLDKLPGAKNL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCHHHHHHHHCCCCCCC
PDHVKNQVDDKMFVKMEAIINSMTLKERANPDIIKGSRRRRIALGSGTQVQDVNKLLKQF
CHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHH
DEMQRMMKKMRKGGMAKMMRGMKGMMGGGMGALGGLGNMFGKR
HHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]