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The map label for this gene is qacE [H]

Identifier: 126209071

GI number: 126209071

Start: 1835493

End: 1835822

Strand: Reverse

Name: qacE [H]

Synonym: APL_1607

Alternate gene names: 126209071

Gene position: 1835822-1835493 (Counterclockwise)

Preceding gene: 126209072

Following gene: 126209069

Centisome position: 80.71

GC content: 46.67

Gene sequence:

>330_bases
ATGAATCCTTGGGTTTTACTAGGCTTTGCGATTGTTATTGAAGTGATTGGCAGTAATTGCATTAAGGCAAGCGAAGGTTT
TAGCAAACCGCTACCGACAGCGGTGGCGATTGGTGCTTTTGTGATCGCGTTGTATTTGCTATCGGTGATTACCAAAACAT
TACCGATTGGTATTGTTTATGCGGTGTGGTCGGGTGTCGGTATCGTGCTAACCGCCATTGTGGCGTATTTCGCTTTCGGG
CAAAAACCGGATTTGGCGGGCTTTATCGGTATGGGAATGATTATTGCCGGCGTGTTGGTGATTAACCTGTTCTCAAAGGC
ATCCGCCTAA

Upstream 100 bases:

>100_bases
ACGCGCAATCTAATTTTATTAATTTGAAAAGCGGTTGGATTTTGCTGAAAATTTGCAAAAAATGAGCAAAATCCAACCGC
TTTTGTTTTCGGAGAAGTTG

Downstream 100 bases:

>100_bases
TTTGCGAGTGTGATACAAGCGGTTGATTTTCGGAAGAATTTTGCAAATTTTTCTTCAAAATCAACCGCTTGTTTTTGCTT
AAGGCTGGTCGCCGGCTAAC

Product: putative drug resistance protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Quaternary ammonium determinant E [H]

Number of amino acids: Translated: 109; Mature: 109

Protein sequence:

>109_residues
MNPWVLLGFAIVIEVIGSNCIKASEGFSKPLPTAVAIGAFVIALYLLSVITKTLPIGIVYAVWSGVGIVLTAIVAYFAFG
QKPDLAGFIGMGMIIAGVLVINLFSKASA

Sequences:

>Translated_109_residues
MNPWVLLGFAIVIEVIGSNCIKASEGFSKPLPTAVAIGAFVIALYLLSVITKTLPIGIVYAVWSGVGIVLTAIVAYFAFG
QKPDLAGFIGMGMIIAGVLVINLFSKASA
>Mature_109_residues
MNPWVLLGFAIVIEVIGSNCIKASEGFSKPLPTAVAIGAFVIALYLLSVITKTLPIGIVYAVWSGVGIVLTAIVAYFAFG
QKPDLAGFIGMGMIIAGVLVINLFSKASA

Specific function: Multidrug exporter. Is implicated for the resistance to bacteriocidal quaternary ammonium compounds [H]

COG id: COG2076

COG function: function code P; Membrane transporters of cations and cationic drugs

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the small multidrug resistance (SMR) protein family [H]

Homologues:

Organism=Escherichia coli, GI1786755, Length=108, Percent_Identity=46.2962962962963, Blast_Score=98, Evalue=1e-22,
Organism=Escherichia coli, GI87082378, Length=103, Percent_Identity=29.126213592233, Blast_Score=59, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000390 [H]

Pfam domain/function: PF00893 Multi_Drug_Res [H]

EC number: NA

Molecular weight: Translated: 11302; Mature: 11302

Theoretical pI: Translated: 9.14; Mature: 9.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPWVLLGFAIVIEVIGSNCIKASEGFSKPLPTAVAIGAFVIALYLLSVITKTLPIGIVY
CCCHHHHHHHHHHHHHHCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVWSGVGIVLTAIVAYFAFGQKPDLAGFIGMGMIIAGVLVINLFSKASA
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNPWVLLGFAIVIEVIGSNCIKASEGFSKPLPTAVAIGAFVIALYLLSVITKTLPIGIVY
CCCHHHHHHHHHHHHHHCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVWSGVGIVLTAIVAYFAFGQKPDLAGFIGMGMIIAGVLVINLFSKASA
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8494372 [H]