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The map label for this gene is lipB [H]

Identifier: 126209058

GI number: 126209058

Start: 1821631

End: 1822287

Strand: Reverse

Name: lipB [H]

Synonym: APL_1594

Alternate gene names: 126209058

Gene position: 1822287-1821631 (Counterclockwise)

Preceding gene: 126209059

Following gene: 126209057

Centisome position: 80.12

GC content: 41.86

Gene sequence:

>657_bases
ATGAATCAACTTATTGTTCGCCAACTTGGTGTGCAGCCTTATGAAGAAATCTGGCATCAAATGCAAGATTTTACCGATAA
TCGTAATGAAAATACTGCGGATGAAATTTGGTTAGTACAGCATCCCTCGGTGTTTACTCAAGGTTCTGCCGGTAAGCCGG
AACATTTACTCAATCCGACCAATATTCCTGTGGTGCAAACCGATCGCGGCGGGCAAATTACCTACCACGGCGAAGGTCAG
CAGGTCATGTATGTGTTGATTGATATTAAGCGTTTAAAAGCACAAGGCAAAGACGTTTCGGTACGAGATTTGGTAACCGC
TTTGGAGCAGTGCGTAGTAAAAACTTTAGCGGATTATGGGATTGAGGGTTATCCGAAGCCGGATGCGCCGGGCGTGTATA
TTAACGGTAAGAAAATCTGTTCGTTAGGGTTGCGTATTCGTCAAGGGCGTTCGTTTCACGGTTTGGCGTTTAATGTGAAT
ATGGATTTAACGCCGTTTAGAAATATTAATCCGTGCGGTTATGCCGGATTAGAAATGACCCAATTAAAAGATTATATTGC
CGAATCGGAAGCTCAATGCGATTTAGTTTCCCCTAAATTAGTTGCGCACTTTTACAACATTTTAGGGTATAATGCACAAC
AAATTATTAACAAATAA

Upstream 100 bases:

>100_bases
CATATCGACCAAGTCGAAACGCTTTATGTCGAGCTTGCTAAAATTTCAGGCGTGAGAATGGTCTTATAATAAGTCACTCA
TTCCGAACGGAGATAATCTG

Downstream 100 bases:

>100_bases
TGTGTAGTCAATATTTGCCCGTTAAGAGCAAATCATCAGAATTATAATATCTGTGTGTCGGGGCGGAGTTATCTCCGCCC
TTTAACATTGCATAGAGAAG

Product: lipoate-protein ligase B

Products: NA

Alternate protein names: Lipoate-protein ligase B; Lipoyl/octanoyl transferase; Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase [H]

Number of amino acids: Translated: 218; Mature: 218

Protein sequence:

>218_residues
MNQLIVRQLGVQPYEEIWHQMQDFTDNRNENTADEIWLVQHPSVFTQGSAGKPEHLLNPTNIPVVQTDRGGQITYHGEGQ
QVMYVLIDIKRLKAQGKDVSVRDLVTALEQCVVKTLADYGIEGYPKPDAPGVYINGKKICSLGLRIRQGRSFHGLAFNVN
MDLTPFRNINPCGYAGLEMTQLKDYIAESEAQCDLVSPKLVAHFYNILGYNAQQIINK

Sequences:

>Translated_218_residues
MNQLIVRQLGVQPYEEIWHQMQDFTDNRNENTADEIWLVQHPSVFTQGSAGKPEHLLNPTNIPVVQTDRGGQITYHGEGQ
QVMYVLIDIKRLKAQGKDVSVRDLVTALEQCVVKTLADYGIEGYPKPDAPGVYINGKKICSLGLRIRQGRSFHGLAFNVN
MDLTPFRNINPCGYAGLEMTQLKDYIAESEAQCDLVSPKLVAHFYNILGYNAQQIINK
>Mature_218_residues
MNQLIVRQLGVQPYEEIWHQMQDFTDNRNENTADEIWLVQHPSVFTQGSAGKPEHLLNPTNIPVVQTDRGGQITYHGEGQ
QVMYVLIDIKRLKAQGKDVSVRDLVTALEQCVVKTLADYGIEGYPKPDAPGVYINGKKICSLGLRIRQGRSFHGLAFNVN
MDLTPFRNINPCGYAGLEMTQLKDYIAESEAQCDLVSPKLVAHFYNILGYNAQQIINK

Specific function: Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate

COG id: COG0321

COG function: function code H; Lipoate-protein ligase B

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lipB family [H]

Homologues:

Organism=Homo sapiens, GI221554520, Length=222, Percent_Identity=30.6306306306306, Blast_Score=69, Evalue=3e-12,
Organism=Escherichia coli, GI87081767, Length=207, Percent_Identity=59.4202898550725, Blast_Score=259, Evalue=7e-71,
Organism=Saccharomyces cerevisiae, GI6323268, Length=156, Percent_Identity=31.4102564102564, Blast_Score=78, Evalue=1e-15,
Organism=Drosophila melanogaster, GI21355483, Length=151, Percent_Identity=31.7880794701987, Blast_Score=72, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004143
- InterPro:   IPR000544
- InterPro:   IPR020605 [H]

Pfam domain/function: PF03099 BPL_LipA_LipB [H]

EC number: =2.3.1.181 [H]

Molecular weight: Translated: 24532; Mature: 24532

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS01313 LIPB

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQLIVRQLGVQPYEEIWHQMQDFTDNRNENTADEIWLVQHPSVFTQGSAGKPEHLLNPT
CCHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCHHEEEEECCCEEECCCCCCCHHCCCCC
NIPVVQTDRGGQITYHGEGQQVMYVLIDIKRLKAQGKDVSVRDLVTALEQCVVKTLADYG
CCCEEEECCCCEEEECCCCCEEEEEEEEHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCC
IEGYPKPDAPGVYINGKKICSLGLRIRQGRSFHGLAFNVNMDLTPFRNINPCGYAGLEMT
CCCCCCCCCCEEEECCHHHEECCEEEECCCCCCCEEEEECCCCCCCCCCCCCCCCCCHHH
QLKDYIAESEAQCDLVSPKLVAHFYNILGYNAQQIINK
HHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCHHHHHCC
>Mature Secondary Structure
MNQLIVRQLGVQPYEEIWHQMQDFTDNRNENTADEIWLVQHPSVFTQGSAGKPEHLLNPT
CCHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCHHEEEEECCCEEECCCCCCCHHCCCCC
NIPVVQTDRGGQITYHGEGQQVMYVLIDIKRLKAQGKDVSVRDLVTALEQCVVKTLADYG
CCCEEEECCCCEEEECCCCCEEEEEEEEHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCC
IEGYPKPDAPGVYINGKKICSLGLRIRQGRSFHGLAFNVNMDLTPFRNINPCGYAGLEMT
CCCCCCCCCCEEEECCHHHEECCEEEECCCCCCCEEEEECCCCCCCCCCCCCCCCCCHHH
QLKDYIAESEAQCDLVSPKLVAHFYNILGYNAQQIINK
HHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA