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The map label for this gene is lysA [H]

Identifier: 126208989

GI number: 126208989

Start: 1739123

End: 1740373

Strand: Reverse

Name: lysA [H]

Synonym: APL_1525

Alternate gene names: 126208989

Gene position: 1740373-1739123 (Counterclockwise)

Preceding gene: 126208990

Following gene: 126208988

Centisome position: 76.52

GC content: 44.52

Gene sequence:

>1251_bases
ATGAATCATTTCAATTATAAAAACCAACAACTTTTTGCGGAAGACGTTTCCGTTTCAGACATCATCAATCAATACGGTAC
ACCGGCTTATATCTATTCTCGTGCTACGCTTGAGCGTCATTGGCACGCTTTTGATAAAGCATTCGGCGCACACCCGCACT
TAATTTGTTTTGCGGTAAAATCCAATTCCAATATCGCGCTATTAAATGTAATGGCACGCCTCGGTTCGGGCTTTGATATT
GTGTCGCAAGGCGAACTTGAACGTGTACTTGCCGCCGGCGGCGAGCCGAGCAAAGTGGTATTTTCCGGTGTGGCAAAATC
ACATAGCGAAATTCAACGTGCATTGGAAGTCGGCATTCGTTGTTTTAATATCGAATCCATCGCCGAGTTACACCGTATTA
ATGAAGTCGCCGGTCAATTAGGTAAAATCGCACCGATTTCATTGCGTGTAAATCCGGATGTGGATGCGCACACTCACCCT
TATATTTCCACCGGTTTAAAAGAAAATAAATTCGGGGTAAGCGTAACCCAAGCACGTGAAGTGTACCGTTTAGCCAAAAC
CTTACCGAACGTAAAAATTACCGGTATGGATTGCCATATCGGTTCGCAATTAACCGAATTACAACCGTTTTTAGATGCGA
CCGATCGCTTGATTGTATTAATGGAACAATTAAAAGAAGACGGTATCGAATTACATCACTTGGATTTAGGTGGTGGTTTA
GGCGTGCCGTATAACGGCGAAGAGCCGCCGCATCCGACCGAATATGCCAAAGCGTTACTCGAAAAATTAAAAGGCTATGC
GGATCTTGAGATCATTTTAGAGCCGGGTCGAGCGATCACGGCGAATGCGGGGATTTTAGTCACTAAAGTGGAATACCTTA
AAGCGAATGAAGATCGTAATTTTGCGATTGTCGATACCGGTATGAACGATATGATTCGTCCGGCGCTTTATGAAGCTTAT
ATGCGGATTACCGAGGTGGATCAATCGCTTTCGCGTGAAAAAGCAGTCTATGACGTAGTCGGTCCGATTTGTGAAACTTC
AGACTTTTTAGGTAAAGATAGAGAACTGGCGATTGAACAAGGTGACTTAATTGCAATGCGTTCGGCAGGTGCGTACGGAG
CGGCGATGTCTTCAACCTATAATTCGCGTCCGCAAGCGGTCGAAATTATGGTGGACGGTGATCAGGCTTATTTAATTAAA
GCACGTGCAAGTTTTGCGGACTTGTGGCGTCTAGAGAAATTACTACCGTAA

Upstream 100 bases:

>100_bases
TCACACGTATAACAAGCGGTCGAATTTATTCGATTTTTTGTAAATACAAGTGTAGCGAGTTTGCCGTGGTTTTATTTTTT
CAAACACAACGGACAAATTA

Downstream 100 bases:

>100_bases
TTTTTAAATCATTTGCTTCCTTACGAGATGAGGCAAATAGAAATATTTTAAATTGGAGAAAAGATATGAAACTTTATTGT
TTAAAAGGCGCTTGCTCATT

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 416; Mature: 416

Protein sequence:

>416_residues
MNHFNYKNQQLFAEDVSVSDIINQYGTPAYIYSRATLERHWHAFDKAFGAHPHLICFAVKSNSNIALLNVMARLGSGFDI
VSQGELERVLAAGGEPSKVVFSGVAKSHSEIQRALEVGIRCFNIESIAELHRINEVAGQLGKIAPISLRVNPDVDAHTHP
YISTGLKENKFGVSVTQAREVYRLAKTLPNVKITGMDCHIGSQLTELQPFLDATDRLIVLMEQLKEDGIELHHLDLGGGL
GVPYNGEEPPHPTEYAKALLEKLKGYADLEIILEPGRAITANAGILVTKVEYLKANEDRNFAIVDTGMNDMIRPALYEAY
MRITEVDQSLSREKAVYDVVGPICETSDFLGKDRELAIEQGDLIAMRSAGAYGAAMSSTYNSRPQAVEIMVDGDQAYLIK
ARASFADLWRLEKLLP

Sequences:

>Translated_416_residues
MNHFNYKNQQLFAEDVSVSDIINQYGTPAYIYSRATLERHWHAFDKAFGAHPHLICFAVKSNSNIALLNVMARLGSGFDI
VSQGELERVLAAGGEPSKVVFSGVAKSHSEIQRALEVGIRCFNIESIAELHRINEVAGQLGKIAPISLRVNPDVDAHTHP
YISTGLKENKFGVSVTQAREVYRLAKTLPNVKITGMDCHIGSQLTELQPFLDATDRLIVLMEQLKEDGIELHHLDLGGGL
GVPYNGEEPPHPTEYAKALLEKLKGYADLEIILEPGRAITANAGILVTKVEYLKANEDRNFAIVDTGMNDMIRPALYEAY
MRITEVDQSLSREKAVYDVVGPICETSDFLGKDRELAIEQGDLIAMRSAGAYGAAMSSTYNSRPQAVEIMVDGDQAYLIK
ARASFADLWRLEKLLP
>Mature_416_residues
MNHFNYKNQQLFAEDVSVSDIINQYGTPAYIYSRATLERHWHAFDKAFGAHPHLICFAVKSNSNIALLNVMARLGSGFDI
VSQGELERVLAAGGEPSKVVFSGVAKSHSEIQRALEVGIRCFNIESIAELHRINEVAGQLGKIAPISLRVNPDVDAHTHP
YISTGLKENKFGVSVTQAREVYRLAKTLPNVKITGMDCHIGSQLTELQPFLDATDRLIVLMEQLKEDGIELHHLDLGGGL
GVPYNGEEPPHPTEYAKALLEKLKGYADLEIILEPGRAITANAGILVTKVEYLKANEDRNFAIVDTGMNDMIRPALYEAY
MRITEVDQSLSREKAVYDVVGPICETSDFLGKDRELAIEQGDLIAMRSAGAYGAAMSSTYNSRPQAVEIMVDGDQAYLIK
ARASFADLWRLEKLLP

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=358, Percent_Identity=24.8603351955307, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI16506287, Length=345, Percent_Identity=25.7971014492754, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI22538418, Length=362, Percent_Identity=25.9668508287293, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI21361583, Length=362, Percent_Identity=25.9668508287293, Blast_Score=80, Evalue=5e-15,
Organism=Escherichia coli, GI1789203, Length=410, Percent_Identity=31.4634146341463, Blast_Score=169, Evalue=5e-43,
Organism=Escherichia coli, GI1789307, Length=267, Percent_Identity=23.9700374531835, Blast_Score=63, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17562780, Length=362, Percent_Identity=23.4806629834254, Blast_Score=83, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6322664, Length=362, Percent_Identity=24.3093922651934, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24586472, Length=338, Percent_Identity=26.0355029585799, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24586474, Length=396, Percent_Identity=24.4949494949495, Blast_Score=82, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 45928; Mature: 45928

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNHFNYKNQQLFAEDVSVSDIINQYGTPAYIYSRATLERHWHAFDKAFGAHPHLICFAVK
CCCCCCCCCHHHHHCCCHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHCCCCCEEEEEEEE
SNSNIALLNVMARLGSGFDIVSQGELERVLAAGGEPSKVVFSGVAKSHSEIQRALEVGIR
CCCCEEHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCE
CFNIESIAELHRINEVAGQLGKIAPISLRVNPDVDAHTHPYISTGLKENKFGVSVTQARE
EECHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHCCCCCCCCCCCHHHHHH
VYRLAKTLPNVKITGMDCHIGSQLTELQPFLDATDRLIVLMEQLKEDGIELHHLDLGGGL
HHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCC
GVPYNGEEPPHPTEYAKALLEKLKGYADLEIILEPGRAITANAGILVTKVEYLKANEDRN
CCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCEEEECCCEEEEEEEEHCCCCCCC
FAIVDTGMNDMIRPALYEAYMRITEVDQSLSREKAVYDVVGPICETSDFLGKDRELAIEQ
EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCEEEEEC
GDLIAMRSAGAYGAAMSSTYNSRPQAVEIMVDGDQAYLIKARASFADLWRLEKLLP
CCEEEEECCCCCHHHHHCCCCCCCCEEEEEEECCCEEEEEEHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNHFNYKNQQLFAEDVSVSDIINQYGTPAYIYSRATLERHWHAFDKAFGAHPHLICFAVK
CCCCCCCCCHHHHHCCCHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHCCCCCEEEEEEEE
SNSNIALLNVMARLGSGFDIVSQGELERVLAAGGEPSKVVFSGVAKSHSEIQRALEVGIR
CCCCEEHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCE
CFNIESIAELHRINEVAGQLGKIAPISLRVNPDVDAHTHPYISTGLKENKFGVSVTQARE
EECHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHCCCCCCCCCCCHHHHHH
VYRLAKTLPNVKITGMDCHIGSQLTELQPFLDATDRLIVLMEQLKEDGIELHHLDLGGGL
HHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCC
GVPYNGEEPPHPTEYAKALLEKLKGYADLEIILEPGRAITANAGILVTKVEYLKANEDRN
CCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCEEEECCCEEEEEEEEHCCCCCCC
FAIVDTGMNDMIRPALYEAYMRITEVDQSLSREKAVYDVVGPICETSDFLGKDRELAIEQ
EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCEEEEEC
GDLIAMRSAGAYGAAMSSTYNSRPQAVEIMVDGDQAYLIKARASFADLWRLEKLLP
CCEEEEECCCCCHHHHHCCCCCCCCEEEEEEECCCEEEEEEHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]