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The map label for this gene is coaA

Identifier: 126208977

GI number: 126208977

Start: 1729917

End: 1730867

Strand: Direct

Name: coaA

Synonym: APL_1513

Alternate gene names: 126208977

Gene position: 1729917-1730867 (Clockwise)

Preceding gene: 126208975

Following gene: 126208978

Centisome position: 76.06

GC content: 40.17

Gene sequence:

>951_bases
ATGAGCCTGCAAAAATCAAACAAAATCACACCATTTTTAACTTTTGATCGTCAAAAATGGGCCGAATTACGTAAATCCGT
CCCGCTAAAATTGACCGAACAAGATCTCAAACCGCTACTCGGTTTTAATGAAGACCTTTCTTTAGATGAAGTAAGCACTA
TTTATTTACCGCTTGCCCGTTTAATTAACTACTATATTGAAGAAAACTTAAAACGTCAGACCGTATTACACCGCTTTCTT
GACGTTGCGTCACCGAAAGTACCTTATATTATCAGTATCGCCGGCAGCGTATCGGTCGGCAAAAGCACTTCGGCACGTAT
TTTACAGGCCTTACTGTCGCAATGGCCGAGCGAACGTAAAGTCGATTTGATTACGACGGACGGTTTTTTATATCCGCTGA
CAACATTACAAGAAAAAGATTTGCTTAAACGCAAAGGCTTTCCCGAATCATACGATATTCATCGCTTAATTCAGTTCGTC
TCCGATATTAAATCGGGTAAACGTCATATCCAAGCGCCGATTTACTCACACTTAACTTATGACATTATTCCCGATCAATA
TAATGTGGTTGATCAGCCGGATATTGTGATTTTAGAAGGTTTAAACGTACTACAAAGCGGTATGAATTACCCGTCAAGTC
CGCATAACGTATTCGTTTCGGATTTTGTCGATTTTTCTATTTATGTCGATGCCGATGAAGATTTGCTTAAAGAATGGTAT
GTCGCTCGTTTTTTAAAATTCCGCCGCAGTGCGTTTTCCGATCCGAACGCTTACTTCCATCATTATTCCAAACTTTCGGA
ACAGGAAGCCATTCGAACCGCTTCGAGCATTTGGGATGAAATTAACGGTTTGAATTTAAAACAAAATATTCTGCCGAGCC
GCGAACGCGCAAACTTAATATTAATAAAAGGCGAGGACCATGCGATTCAGACGGTGAAGCTTCGTAAATAA

Upstream 100 bases:

>100_bases
TAAGATAAAACGTCCTATTTTTAGATTTATATTGTATATTTGTACCCCAGCTTTTCTAAGAAAAGCATACTATTGCATCG
GAAAACTAGAGAATTTGGCT

Downstream 100 bases:

>100_bases
CGAAAAATATGATGATAGCAACGTATCGCATAATTAATCTAAAATACCGACAATTAATAGGCGATCAATAGCTAAATTTT
TGTTAAGCTAACCGCCTGTT

Product: pantothenate kinase

Products: NA

Alternate protein names: Pantothenic acid kinase

Number of amino acids: Translated: 316; Mature: 315

Protein sequence:

>316_residues
MSLQKSNKITPFLTFDRQKWAELRKSVPLKLTEQDLKPLLGFNEDLSLDEVSTIYLPLARLINYYIEENLKRQTVLHRFL
DVASPKVPYIISIAGSVSVGKSTSARILQALLSQWPSERKVDLITTDGFLYPLTTLQEKDLLKRKGFPESYDIHRLIQFV
SDIKSGKRHIQAPIYSHLTYDIIPDQYNVVDQPDIVILEGLNVLQSGMNYPSSPHNVFVSDFVDFSIYVDADEDLLKEWY
VARFLKFRRSAFSDPNAYFHHYSKLSEQEAIRTASSIWDEINGLNLKQNILPSRERANLILIKGEDHAIQTVKLRK

Sequences:

>Translated_316_residues
MSLQKSNKITPFLTFDRQKWAELRKSVPLKLTEQDLKPLLGFNEDLSLDEVSTIYLPLARLINYYIEENLKRQTVLHRFL
DVASPKVPYIISIAGSVSVGKSTSARILQALLSQWPSERKVDLITTDGFLYPLTTLQEKDLLKRKGFPESYDIHRLIQFV
SDIKSGKRHIQAPIYSHLTYDIIPDQYNVVDQPDIVILEGLNVLQSGMNYPSSPHNVFVSDFVDFSIYVDADEDLLKEWY
VARFLKFRRSAFSDPNAYFHHYSKLSEQEAIRTASSIWDEINGLNLKQNILPSRERANLILIKGEDHAIQTVKLRK
>Mature_315_residues
SLQKSNKITPFLTFDRQKWAELRKSVPLKLTEQDLKPLLGFNEDLSLDEVSTIYLPLARLINYYIEENLKRQTVLHRFLD
VASPKVPYIISIAGSVSVGKSTSARILQALLSQWPSERKVDLITTDGFLYPLTTLQEKDLLKRKGFPESYDIHRLIQFVS
DIKSGKRHIQAPIYSHLTYDIIPDQYNVVDQPDIVILEGLNVLQSGMNYPSSPHNVFVSDFVDFSIYVDADEDLLKEWYV
ARFLKFRRSAFSDPNAYFHHYSKLSEQEAIRTASSIWDEINGLNLKQNILPSRERANLILIKGEDHAIQTVKLRK

Specific function: Coenzyme A (CoA) biosynthesis; first step. [C]

COG id: COG1072

COG function: function code H; Panthothenate kinase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic pantothenate kinase family

Homologues:

Organism=Escherichia coli, GI1790409, Length=316, Percent_Identity=64.5569620253165, Blast_Score=445, Evalue=1e-126,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COAA_ACTP2 (A3N2G1)

Other databases:

- EMBL:   CP000569
- RefSeq:   YP_001054202.1
- ProteinModelPortal:   A3N2G1
- SMR:   A3N2G1
- STRING:   A3N2G1
- GeneID:   4850403
- GenomeReviews:   CP000569_GR
- KEGG:   apl:APL_1513
- eggNOG:   COG1072
- HOGENOM:   HBG732538
- OMA:   GLNVLQP
- PhylomeDB:   A3N2G1
- ProtClustDB:   PRK05439
- BioCyc:   APLE416269:APL_1513-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00215
- InterPro:   IPR004566
- InterPro:   IPR006083
- PANTHER:   PTHR10285:SF7
- PIRSF:   PIRSF000545
- TIGRFAMs:   TIGR00554

Pfam domain/function: PF00485 PRK

EC number: =2.7.1.33

Molecular weight: Translated: 36457; Mature: 36326

Theoretical pI: Translated: 7.92; Mature: 7.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
0.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
0.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLQKSNKITPFLTFDRQKWAELRKSVPLKLTEQDLKPLLGFNEDLSLDEVSTIYLPLAR
CCCCCCCCCCCEEEECHHHHHHHHHCCCCEECHHHHHHHHCCCCCCCHHHHHHHHHHHHH
LINYYIEENLKRQTVLHRFLDVASPKVPYIISIAGSVSVGKSTSARILQALLSQWPSERK
HHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCC
VDLITTDGFLYPLTTLQEKDLLKRKGFPESYDIHRLIQFVSDIKSGKRHIQAPIYSHLTY
EEEEEECCEEECHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHCEE
DIIPDQYNVVDQPDIVILEGLNVLQSGMNYPSSPHNVFVSDFVDFSIYVDADEDLLKEWY
EECCCCCCCCCCCCEEEECCHHHHHHCCCCCCCCCCEEEECCEEEEEEECCCHHHHHHHH
VARFLKFRRSAFSDPNAYFHHYSKLSEQEAIRTASSIWDEINGLNLKQNILPSRERANLI
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCEE
LIKGEDHAIQTVKLRK
EEECCCCEEEEEEECC
>Mature Secondary Structure 
SLQKSNKITPFLTFDRQKWAELRKSVPLKLTEQDLKPLLGFNEDLSLDEVSTIYLPLAR
CCCCCCCCCCEEEECHHHHHHHHHCCCCEECHHHHHHHHCCCCCCCHHHHHHHHHHHHH
LINYYIEENLKRQTVLHRFLDVASPKVPYIISIAGSVSVGKSTSARILQALLSQWPSERK
HHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCC
VDLITTDGFLYPLTTLQEKDLLKRKGFPESYDIHRLIQFVSDIKSGKRHIQAPIYSHLTY
EEEEEECCEEECHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHCEE
DIIPDQYNVVDQPDIVILEGLNVLQSGMNYPSSPHNVFVSDFVDFSIYVDADEDLLKEWY
EECCCCCCCCCCCCEEEECCHHHHHHCCCCCCCCCCEEEECCEEEEEEECCCHHHHHHHH
VARFLKFRRSAFSDPNAYFHHYSKLSEQEAIRTASSIWDEINGLNLKQNILPSRERANLI
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCCEE
LIKGEDHAIQTVKLRK
EEECCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA