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The map label for this gene is grxC [C]

Identifier: 126208946

GI number: 126208946

Start: 1696909

End: 1697643

Strand: Direct

Name: grxC [C]

Synonym: APL_1482

Alternate gene names: 126208946

Gene position: 1696909-1697643 (Clockwise)

Preceding gene: 126208939

Following gene: 126208947

Centisome position: 74.61

GC content: 43.95

Gene sequence:

>735_bases
ATGTCTTTAAAAGATATGACGGGTCAAAAAGTACCTAACGTAACCTTCCACACACGTCAAGGCGATGCTTGGGTCGATGT
AACCACAGCGGAATTATTCGATAATAAAACCGTTATCGTTTTCTCACTTCCGGGCGCATTTACCCCGACTTGTTCATCAA
CTCACTTACCGCGTTATAACGAATTAGCGTGCGAATTTAAAGCGGCGGGTGTCGATGACATTCTCTGTATGTCTGTTAAT
GATACATTCGTAATGAACGCATGGAAAGCGGACCAAGAATCTGAAAACGTTACGGTAATTCCGGACGGTAACGGTGAATT
TACCGAAGGCATGGGTATGTTGGTCGGTAAAGAAGACTTAGGTTTCGGTAAACGTTCATGGCGTTATTCTATGCTCGTGA
AAAACGGCGTAGTTGAAAAAATGTTCATCGAGCCGCAAGAACCGGGCGATCCGTTCAAAGTATCCGATGCAGATACCATG
ATGAAATATTTAGTCCAAGGTTGGGCGCCGAAAGAATCGGTATCAATCATCACTAAACCGGGCTGTCCTTTCTGCGCGAA
AGCCAAAGCGTTATTAAAAGAGAAAGGTTATACTTTTGAAGAAATCGTATTAGGTCGCGACGCTTCAACAATTTCCGTAC
GTGCGATTACCGGTAAAACATCGGTTCCGCAAGTATTCATCGGCGGTAAATACATCGGCGGTAGCGACGATTTAGCCGCA
TATTTTGCAAAATAA

Upstream 100 bases:

>100_bases
ATGACTGTTTTCCTATTAATTAAATAGGATGAATTATGGCATATTTAGGTGTAGAATGCGTGCGGTTTTTGAAAAACATT
ATGTAAAATAGGAGATTTTT

Downstream 100 bases:

>100_bases
TCGGCAAAATTGGCATAGTAGACAAAAAGGTTGGTAAAAAGTGGGTTAAAGCCTTATAGTACAAGGCTTTAACCTACCTT
TTTGAAATATGAATAAAAAC

Product: hybrid peroxiredoxin HyPrx5

Products: NA

Alternate protein names: Thioredoxin reductase [H]

Number of amino acids: Translated: 244; Mature: 243

Protein sequence:

>244_residues
MSLKDMTGQKVPNVTFHTRQGDAWVDVTTAELFDNKTVIVFSLPGAFTPTCSSTHLPRYNELACEFKAAGVDDILCMSVN
DTFVMNAWKADQESENVTVIPDGNGEFTEGMGMLVGKEDLGFGKRSWRYSMLVKNGVVEKMFIEPQEPGDPFKVSDADTM
MKYLVQGWAPKESVSIITKPGCPFCAKAKALLKEKGYTFEEIVLGRDASTISVRAITGKTSVPQVFIGGKYIGGSDDLAA
YFAK

Sequences:

>Translated_244_residues
MSLKDMTGQKVPNVTFHTRQGDAWVDVTTAELFDNKTVIVFSLPGAFTPTCSSTHLPRYNELACEFKAAGVDDILCMSVN
DTFVMNAWKADQESENVTVIPDGNGEFTEGMGMLVGKEDLGFGKRSWRYSMLVKNGVVEKMFIEPQEPGDPFKVSDADTM
MKYLVQGWAPKESVSIITKPGCPFCAKAKALLKEKGYTFEEIVLGRDASTISVRAITGKTSVPQVFIGGKYIGGSDDLAA
YFAK
>Mature_243_residues
SLKDMTGQKVPNVTFHTRQGDAWVDVTTAELFDNKTVIVFSLPGAFTPTCSSTHLPRYNELACEFKAAGVDDILCMSVND
TFVMNAWKADQESENVTVIPDGNGEFTEGMGMLVGKEDLGFGKRSWRYSMLVKNGVVEKMFIEPQEPGDPFKVSDADTMM
KYLVQGWAPKESVSIITKPGCPFCAKAKALLKEKGYTFEEIVLGRDASTISVRAITGKTSVPQVFIGGKYIGGSDDLAAY
FAK

Specific function: The Disulfide Bond Functions As An Electron Carrier In The Glutathione-Dependent Synthesis Of Deoxyribonucleotides By The Enzyme Ribonucleotide Reductase. In Addition, It Is Also Involved In Reducing Some Disulfides In A Coupled System With Glutathione R

COG id: COG0678

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutaredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI6912238, Length=146, Percent_Identity=37.6712328767123, Blast_Score=95, Evalue=7e-20,
Organism=Escherichia coli, GI1790039, Length=73, Percent_Identity=45.2054794520548, Blast_Score=67, Evalue=1e-12,
Organism=Drosophila melanogaster, GI78706776, Length=125, Percent_Identity=45.6, Blast_Score=104, Evalue=4e-23,
Organism=Drosophila melanogaster, GI78709078, Length=125, Percent_Identity=45.6, Blast_Score=104, Evalue=4e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011767
- InterPro:   IPR002109
- InterPro:   IPR011906
- InterPro:   IPR014025
- InterPro:   IPR013740
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00462 Glutaredoxin; PF08534 Redoxin [H]

EC number: =1.11.1.15 [H]

Molecular weight: Translated: 26701; Mature: 26570

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLKDMTGQKVPNVTFHTRQGDAWVDVTTAELFDNKTVIVFSLPGAFTPTCSSTHLPRYN
CCCCCCCCCCCCCEEEEECCCCEEEEEEEHHHHCCCEEEEEECCCCCCCCCCCCCCCCCH
ELACEFKAAGVDDILCMSVNDTFVMNAWKADQESENVTVIPDGNGEFTEGMGMLVGKEDL
HHEEEEECCCCCEEEEEECCCEEEEEEECCCCCCCCEEEEECCCCCCCCCCEEEEECCCC
GFGKRSWRYSMLVKNGVVEKMFIEPQEPGDPFKVSDADTMMKYLVQGWAPKESVSIITKP
CCCCCCEEEEEEECCCCEEEEEECCCCCCCCEEECCHHHHHHHHHHCCCCCCCEEEEECC
GCPFCAKAKALLKEKGYTFEEIVLGRDASTISVRAITGKTSVPQVFIGGKYIGGSDDLAA
CCCHHHHHHHHHHHCCCCHHHEEECCCCCEEEEEEEECCCCCCEEEECCEEECCCCCHHH
YFAK
EECC
>Mature Secondary Structure 
SLKDMTGQKVPNVTFHTRQGDAWVDVTTAELFDNKTVIVFSLPGAFTPTCSSTHLPRYN
CCCCCCCCCCCCEEEEECCCCEEEEEEEHHHHCCCEEEEEECCCCCCCCCCCCCCCCCH
ELACEFKAAGVDDILCMSVNDTFVMNAWKADQESENVTVIPDGNGEFTEGMGMLVGKEDL
HHEEEEECCCCCEEEEEECCCEEEEEEECCCCCCCCEEEEECCCCCCCCCCEEEEECCCC
GFGKRSWRYSMLVKNGVVEKMFIEPQEPGDPFKVSDADTMMKYLVQGWAPKESVSIITKP
CCCCCCEEEEEEECCCCEEEEEECCCCCCCCEEECCHHHHHHHHHHCCCCCCCEEEEECC
GCPFCAKAKALLKEKGYTFEEIVLGRDASTISVRAITGKTSVPQVFIGGKYIGGSDDLAA
CCCHHHHHHHHHHHCCCCHHHEEECCCCCEEEEEEEECCCCCCEEEECCEEECCCCCHHH
YFAK
EECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800; 10675023 [H]