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The map label for this gene is aqpZ [H]

Identifier: 126208921

GI number: 126208921

Start: 1671115

End: 1671801

Strand: Reverse

Name: aqpZ [H]

Synonym: APL_1457

Alternate gene names: 126208921

Gene position: 1671801-1671115 (Counterclockwise)

Preceding gene: 126208922

Following gene: 126208920

Centisome position: 73.5

GC content: 47.02

Gene sequence:

>687_bases
ATGAAAAAATATTTTGCCGAATTTTTCGGTACGTTTTGGTTAGTTTTCGGCGGTTGCGGTAGTGCGGTTTTAGCGGCGGG
TATTCCTGAGTTAGGCATCGGCTATGCCGGCGTATCATTGGCATTCGGTTTAACCGTATTAACGATGGCTTATGCGGTAG
GTCATATTTCCGGCGGCCACTTTAATCCGGCGGTATCTATCGGTTTATTGGTCGGCGGTCGTTTTAACGCCAAAGACTTA
GTGCCTTATATCGTTGCACAAGTTATCGGTGCAATTGCAGCGGCGGCGGTGTTATACACGATTGCTTCGGGCGCAGCAGG
CTTTGATGTTACGGCAGGTTTTGCAAGTAACGGTTTTGCGGAACATTCGCCGCACGGTTATTCAATGGCTGCGGCATTAG
TAATTGAAGTCGTATTAACCGCATTTTTCTTAATTATCATTATGGGTGCGACCGATAAACGTGCACCGGCAGGTTTTGCT
CCGATTGCGATCGGCTTAGCCTTAACGTTAATTCACTTAATTTCCATTCCGGTAACCAATACTTCGGTCAATCCGGCTCG
TTCAACCGGTGTCGCCTTATTCCAAGGATCTTGGGCGATTGAGCAATTATGGTTGTTCTGGGTCGCGCCGATTTTAGGTG
CGATTATCGGCGCATTAGCCTATCGTTTTATTGCCGAAGAAAAATAA

Upstream 100 bases:

>100_bases
AACTATTAAGCATTCTTGGAGATAAACTATCTTAACGGATAGTGATTGGAAAGCACTGGCACTTAAGTGCCATTTAATCT
TTAATATTAAGGAAAAAAGA

Downstream 100 bases:

>100_bases
GCTCTAATCTCTTATAATACAGTGCCGTTTCGGCACTGTATATCGAACATCGGACAAATAGGATAAAAATGAAATCGCTA
TTCAAAATCTTTATCATAGC

Product: aquaporin Z

Products: H2O [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 228; Mature: 228

Protein sequence:

>228_residues
MKKYFAEFFGTFWLVFGGCGSAVLAAGIPELGIGYAGVSLAFGLTVLTMAYAVGHISGGHFNPAVSIGLLVGGRFNAKDL
VPYIVAQVIGAIAAAAVLYTIASGAAGFDVTAGFASNGFAEHSPHGYSMAAALVIEVVLTAFFLIIIMGATDKRAPAGFA
PIAIGLALTLIHLISIPVTNTSVNPARSTGVALFQGSWAIEQLWLFWVAPILGAIIGALAYRFIAEEK

Sequences:

>Translated_228_residues
MKKYFAEFFGTFWLVFGGCGSAVLAAGIPELGIGYAGVSLAFGLTVLTMAYAVGHISGGHFNPAVSIGLLVGGRFNAKDL
VPYIVAQVIGAIAAAAVLYTIASGAAGFDVTAGFASNGFAEHSPHGYSMAAALVIEVVLTAFFLIIIMGATDKRAPAGFA
PIAIGLALTLIHLISIPVTNTSVNPARSTGVALFQGSWAIEQLWLFWVAPILGAIIGALAYRFIAEEK
>Mature_228_residues
MKKYFAEFFGTFWLVFGGCGSAVLAAGIPELGIGYAGVSLAFGLTVLTMAYAVGHISGGHFNPAVSIGLLVGGRFNAKDL
VPYIVAQVIGAIAAAAVLYTIASGAAGFDVTAGFASNGFAEHSPHGYSMAAALVIEVVLTAFFLIIIMGATDKRAPAGFA
PIAIGLALTLIHLISIPVTNTSVNPARSTGVALFQGSWAIEQLWLFWVAPILGAIIGALAYRFIAEEK

Specific function: Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response

COG id: COG0580

COG function: function code G; Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MIP/aquaporin (TC 1.A.8) family [H]

Homologues:

Organism=Homo sapiens, GI37694062, Length=234, Percent_Identity=37.6068376068376, Blast_Score=126, Evalue=1e-29,
Organism=Homo sapiens, GI4502183, Length=227, Percent_Identity=37.8854625550661, Blast_Score=125, Evalue=2e-29,
Organism=Homo sapiens, GI4502179, Length=225, Percent_Identity=35.1111111111111, Blast_Score=125, Evalue=4e-29,
Organism=Homo sapiens, GI6912506, Length=225, Percent_Identity=36.4444444444444, Blast_Score=118, Evalue=4e-27,
Organism=Homo sapiens, GI4755125, Length=230, Percent_Identity=33.9130434782609, Blast_Score=110, Evalue=9e-25,
Organism=Homo sapiens, GI4502181, Length=230, Percent_Identity=33.9130434782609, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI86792455, Length=224, Percent_Identity=32.1428571428571, Blast_Score=99, Evalue=2e-21,
Organism=Homo sapiens, GI157266307, Length=247, Percent_Identity=33.1983805668016, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI45446752, Length=208, Percent_Identity=31.7307692307692, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI22538420, Length=242, Percent_Identity=26.0330578512397, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI4826645, Length=252, Percent_Identity=27.7777777777778, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI297307120, Length=102, Percent_Identity=36.2745098039216, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI4502187, Length=240, Percent_Identity=27.5, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI297307116, Length=102, Percent_Identity=36.2745098039216, Blast_Score=65, Evalue=7e-11,
Organism=Homo sapiens, GI297307118, Length=102, Percent_Identity=36.2745098039216, Blast_Score=64, Evalue=9e-11,
Organism=Escherichia coli, GI1787101, Length=228, Percent_Identity=75.8771929824561, Blast_Score=320, Evalue=4e-89,
Organism=Escherichia coli, GI1790362, Length=251, Percent_Identity=31.0756972111554, Blast_Score=89, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI71993722, Length=237, Percent_Identity=29.535864978903, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71994009, Length=240, Percent_Identity=30.8333333333333, Blast_Score=81, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI71992966, Length=235, Percent_Identity=29.3617021276596, Blast_Score=77, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17531429, Length=253, Percent_Identity=30.0395256916996, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17531431, Length=253, Percent_Identity=30.0395256916996, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17558372, Length=239, Percent_Identity=29.7071129707113, Blast_Score=70, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6321054, Length=99, Percent_Identity=41.4141414141414, Blast_Score=65, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24652747, Length=225, Percent_Identity=36, Blast_Score=131, Evalue=3e-31,
Organism=Drosophila melanogaster, GI45551084, Length=225, Percent_Identity=36, Blast_Score=131, Evalue=3e-31,
Organism=Drosophila melanogaster, GI24652751, Length=224, Percent_Identity=36.6071428571429, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI19922038, Length=224, Percent_Identity=36.6071428571429, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI17136672, Length=226, Percent_Identity=29.2035398230088, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24762342, Length=235, Percent_Identity=27.2340425531915, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI45550503, Length=229, Percent_Identity=25.764192139738, Blast_Score=74, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24762346, Length=228, Percent_Identity=29.3859649122807, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24762348, Length=228, Percent_Identity=29.3859649122807, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI20130305, Length=228, Percent_Identity=29.3859649122807, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24762344, Length=228, Percent_Identity=29.3859649122807, Blast_Score=74, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012269
- InterPro:   IPR000425
- InterPro:   IPR022357 [H]

Pfam domain/function: PF00230 MIP [H]

EC number: NA

Molecular weight: Translated: 23525; Mature: 23525

Theoretical pI: Translated: 7.07; Mature: 7.07

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00221 MIP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKYFAEFFGTFWLVFGGCGSAVLAAGIPELGIGYAGVSLAFGLTVLTMAYAVGHISGGH
CHHHHHHHHHHHHHHHHCCHHHHHHCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
FNPAVSIGLLVGGRFNAKDLVPYIVAQVIGAIAAAAVLYTIASGAAGFDVTAGFASNGFA
CCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCCCC
EHSPHGYSMAAALVIEVVLTAFFLIIIMGATDKRAPAGFAPIAIGLALTLIHLISIPVTN
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCC
TSVNPARSTGVALFQGSWAIEQLWLFWVAPILGAIIGALAYRFIAEEK
CCCCCCHHCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKKYFAEFFGTFWLVFGGCGSAVLAAGIPELGIGYAGVSLAFGLTVLTMAYAVGHISGGH
CHHHHHHHHHHHHHHHHCCHHHHHHCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
FNPAVSIGLLVGGRFNAKDLVPYIVAQVIGAIAAAAVLYTIASGAAGFDVTAGFASNGFA
CCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCCCC
EHSPHGYSMAAALVIEVVLTAFFLIIIMGATDKRAPAGFAPIAIGLALTLIHLISIPVTN
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCC
TSVNPARSTGVALFQGSWAIEQLWLFWVAPILGAIIGALAYRFIAEEK
CCCCCCHHCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: H2O [Periplasm] [C]

Specific reaction: H2O [Periplasm] = H2O [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 14500782 [H]