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The map label for this gene is oadA [H]

Identifier: 126208840

GI number: 126208840

Start: 1577610

End: 1579418

Strand: Direct

Name: oadA [H]

Synonym: APL_1376

Alternate gene names: 126208840

Gene position: 1577610-1579418 (Clockwise)

Preceding gene: 126208839

Following gene: 126208841

Centisome position: 69.36

GC content: 44.44

Gene sequence:

>1809_bases
ATGACTATTCAAAACAAAAAAATTGCGATTACTGATGTTGTTTTACGTGATGCACACCAATCTTTGTTTGCGACACGACT
ACGTTTAGACGATATGTTACCGATTGCGGCTGAATTAGATAAAATCGGCTATTGGTCTTTAGAAGCATGGGGCGGTGCGA
CTTTTGATAGCTGTATCCGTTTTTTAGGCGAAGATCCTTGGGTACGTTTGCGTGAGTTGAAAAAAGCGATTCCAAATACA
CCACTGCAAATGTTATTACGCGGACAAAATTTATTAGGCTACCGTCATTATACGGATGATGTGGTAGATCGCTTTGTGGA
ACGTTGTGTTACCAACGGGATGGATGTGTTCCGTGTGTTTGATGCGTTAAATGACCCTCGCAATATGCAAGCGGCACTAC
AAGCGGTCAAAAAACACGGTGGGCATGCACAAGGTACGTTAAGTTATACCACCAGTCCGGTACACACGTTACAAACGTGG
TTAGACGTAACCGAACAATTATTGGAAATCGGGGTAGATTCTCTCGTTATCAAAGATATGTCAGGTATCTTAACCCCAAT
GGCTGCGTACGAGTTAGTCAGTGAAATTAAAAAACGTTATGACGTAGAACTTCACTTACACTGCCACTCAACCACCGGTA
TGGCGGAAATGGCATTATTAAAAGCGATTGAAGCGGGTATTGACGGTGTAGATACCTCTATTTCTTCAATGTCCGGCACT
TATGGTCATCCGGCAACCGAATCCATCGTGGCAACGCTTCAAGGTACGCCTTACGACACCGGTTTGAACATTCCTCAACT
TGAAAAAATCTCAGCTTATTTCCGTGACGTTCGTAAAAAATATGCGAAGTTTGAAGGGCAATTACGTGGTGTAGACAGCC
GTATTTTAGTCGCACAAGTGCCGGGCGGTATGTTAACCAACCTTGAAAGCCAGTTAAAACAACAAAATGCAAGTGACAAA
CTTGATCTTGTATTACAAGAAATCCCTCGCGTACGTGAAGATCTCGGTAATATTCCGCTTGTTACGCCAACATCTCAAAT
CGTCGGTACCCAAGCAGTAATGAACGTGTTAATGGGCGAGCGCTACAAAACCATCGCCAAAGAAACCGCCGGTATTTTAA
AAGGCGAATACGGTCGCACACCTGCGCCGGTAAATAAAGCATTACAAGATCGTGTACTTGAAGGTGCTGCGCCGATTACC
GATCGTCCGGCAAACCATATCACACCGGAAATCGATAAATTAGTGGCGGAAGTGACCGCACAGGCTAAAGAGAAAGGCAT
TACGCTTTCAGAAAATACGATTGATGACGTGTTAATCGTGGCGTTATTCCAACAAGTCGGTTGGAAATTCTTAGAAAATC
GTAATAATCCGGCTGCCTTCGAACCGGCTCCGACCGCAGAAGTTGCAAAAGAAGCGGCAAAACCGACCGCTTCTCACACA
GCAAAAGCAGGCGAACCAGCCGTTTATACGGTTGAACTTGAAGGCAAAGCCTTTGTAGTGAAAGTCAGTGAAGGTGGTGA
TATTACTAATATTGCACCAACAGCGCCAGCTGCCGCACCACAAGTTGTAGTACCAGCTGCAGCAACCAGTGCAAATGCTG
AACCGGTCAAAGCACCGATGGCAGGTAACATTCTTAAAGTTGAAGTAACCGAAGGTCAACAAGTTGCGGAAGGCGATGTG
TTATTAATTCTTGAAGCAATGAAAATGGAAACACAAATTTGCGCACCAAAAGCCGGTAAAGTTCAAGGCGTTGCGGTAAA
ACAAGGTGATGTCGTTGCCGTTGATCAAGTCTTAATGAATCTTGCTTAA

Upstream 100 bases:

>100_bases
TGTTCCAACTGATAATTTAGACCATTTACGCCCCGTGATTGCGGCTGCTATTGCCCATCATCGTCGTCAACAAGGATTAA
AATAATAGAGGATTTTTATC

Downstream 100 bases:

>100_bases
ACGATAGGGAGTTAATATGGAAGGTATTATCGCTCTGTTTCAGGGTATGGGTATTATGCATATGGAGCTAGGGCAAGCGA
TTATGATTGCGGTCAGCCTG

Product: oxaloacetate decarboxylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 602; Mature: 601

Protein sequence:

>602_residues
MTIQNKKIAITDVVLRDAHQSLFATRLRLDDMLPIAAELDKIGYWSLEAWGGATFDSCIRFLGEDPWVRLRELKKAIPNT
PLQMLLRGQNLLGYRHYTDDVVDRFVERCVTNGMDVFRVFDALNDPRNMQAALQAVKKHGGHAQGTLSYTTSPVHTLQTW
LDVTEQLLEIGVDSLVIKDMSGILTPMAAYELVSEIKKRYDVELHLHCHSTTGMAEMALLKAIEAGIDGVDTSISSMSGT
YGHPATESIVATLQGTPYDTGLNIPQLEKISAYFRDVRKKYAKFEGQLRGVDSRILVAQVPGGMLTNLESQLKQQNASDK
LDLVLQEIPRVREDLGNIPLVTPTSQIVGTQAVMNVLMGERYKTIAKETAGILKGEYGRTPAPVNKALQDRVLEGAAPIT
DRPANHITPEIDKLVAEVTAQAKEKGITLSENTIDDVLIVALFQQVGWKFLENRNNPAAFEPAPTAEVAKEAAKPTASHT
AKAGEPAVYTVELEGKAFVVKVSEGGDITNIAPTAPAAAPQVVVPAAATSANAEPVKAPMAGNILKVEVTEGQQVAEGDV
LLILEAMKMETQICAPKAGKVQGVAVKQGDVVAVDQVLMNLA

Sequences:

>Translated_602_residues
MTIQNKKIAITDVVLRDAHQSLFATRLRLDDMLPIAAELDKIGYWSLEAWGGATFDSCIRFLGEDPWVRLRELKKAIPNT
PLQMLLRGQNLLGYRHYTDDVVDRFVERCVTNGMDVFRVFDALNDPRNMQAALQAVKKHGGHAQGTLSYTTSPVHTLQTW
LDVTEQLLEIGVDSLVIKDMSGILTPMAAYELVSEIKKRYDVELHLHCHSTTGMAEMALLKAIEAGIDGVDTSISSMSGT
YGHPATESIVATLQGTPYDTGLNIPQLEKISAYFRDVRKKYAKFEGQLRGVDSRILVAQVPGGMLTNLESQLKQQNASDK
LDLVLQEIPRVREDLGNIPLVTPTSQIVGTQAVMNVLMGERYKTIAKETAGILKGEYGRTPAPVNKALQDRVLEGAAPIT
DRPANHITPEIDKLVAEVTAQAKEKGITLSENTIDDVLIVALFQQVGWKFLENRNNPAAFEPAPTAEVAKEAAKPTASHT
AKAGEPAVYTVELEGKAFVVKVSEGGDITNIAPTAPAAAPQVVVPAAATSANAEPVKAPMAGNILKVEVTEGQQVAEGDV
LLILEAMKMETQICAPKAGKVQGVAVKQGDVVAVDQVLMNLA
>Mature_601_residues
TIQNKKIAITDVVLRDAHQSLFATRLRLDDMLPIAAELDKIGYWSLEAWGGATFDSCIRFLGEDPWVRLRELKKAIPNTP
LQMLLRGQNLLGYRHYTDDVVDRFVERCVTNGMDVFRVFDALNDPRNMQAALQAVKKHGGHAQGTLSYTTSPVHTLQTWL
DVTEQLLEIGVDSLVIKDMSGILTPMAAYELVSEIKKRYDVELHLHCHSTTGMAEMALLKAIEAGIDGVDTSISSMSGTY
GHPATESIVATLQGTPYDTGLNIPQLEKISAYFRDVRKKYAKFEGQLRGVDSRILVAQVPGGMLTNLESQLKQQNASDKL
DLVLQEIPRVREDLGNIPLVTPTSQIVGTQAVMNVLMGERYKTIAKETAGILKGEYGRTPAPVNKALQDRVLEGAAPITD
RPANHITPEIDKLVAEVTAQAKEKGITLSENTIDDVLIVALFQQVGWKFLENRNNPAAFEPAPTAEVAKEAAKPTASHTA
KAGEPAVYTVELEGKAFVVKVSEGGDITNIAPTAPAAAPQVVVPAAATSANAEPVKAPMAGNILKVEVTEGQQVAEGDVL
LILEAMKMETQICAPKAGKVQGVAVKQGDVVAVDQVLMNLA

Specific function: Lyase and sodium transporter [H]

COG id: COG5016

COG function: function code C; Pyruvate/oxaloacetate carboxyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotinyl-binding domain [H]

Homologues:

Organism=Homo sapiens, GI106049528, Length=636, Percent_Identity=32.2327044025157, Blast_Score=293, Evalue=3e-79,
Organism=Homo sapiens, GI106049295, Length=636, Percent_Identity=32.2327044025157, Blast_Score=293, Evalue=3e-79,
Organism=Homo sapiens, GI106049292, Length=636, Percent_Identity=32.2327044025157, Blast_Score=293, Evalue=3e-79,
Organism=Caenorhabditis elegans, GI17562816, Length=622, Percent_Identity=35.3697749196142, Blast_Score=326, Evalue=2e-89,
Organism=Saccharomyces cerevisiae, GI6319695, Length=635, Percent_Identity=32.755905511811, Blast_Score=310, Evalue=6e-85,
Organism=Saccharomyces cerevisiae, GI6321376, Length=628, Percent_Identity=31.8471337579618, Blast_Score=294, Evalue=3e-80,
Organism=Drosophila melanogaster, GI24652212, Length=626, Percent_Identity=33.5463258785943, Blast_Score=310, Evalue=2e-84,
Organism=Drosophila melanogaster, GI24652210, Length=626, Percent_Identity=33.5463258785943, Blast_Score=310, Evalue=2e-84,
Organism=Drosophila melanogaster, GI24652214, Length=626, Percent_Identity=33.5463258785943, Blast_Score=310, Evalue=2e-84,
Organism=Drosophila melanogaster, GI19921944, Length=626, Percent_Identity=33.5463258785943, Blast_Score=310, Evalue=2e-84,
Organism=Drosophila melanogaster, GI24652216, Length=626, Percent_Identity=33.5463258785943, Blast_Score=310, Evalue=2e-84,
Organism=Drosophila melanogaster, GI281363050, Length=626, Percent_Identity=33.5463258785943, Blast_Score=309, Evalue=3e-84,
Organism=Drosophila melanogaster, GI24652224, Length=626, Percent_Identity=33.5463258785943, Blast_Score=309, Evalue=3e-84,
Organism=Drosophila melanogaster, GI24652222, Length=626, Percent_Identity=33.5463258785943, Blast_Score=309, Evalue=3e-84,
Organism=Drosophila melanogaster, GI24652220, Length=626, Percent_Identity=33.5463258785943, Blast_Score=309, Evalue=3e-84,
Organism=Drosophila melanogaster, GI24652218, Length=626, Percent_Identity=33.5463258785943, Blast_Score=309, Evalue=3e-84,
Organism=Drosophila melanogaster, GI24582381, Length=153, Percent_Identity=29.4117647058824, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR001882
- InterPro:   IPR000089
- InterPro:   IPR003379
- InterPro:   IPR005776
- InterPro:   IPR000891
- InterPro:   IPR011053 [H]

Pfam domain/function: PF00364 Biotin_lipoyl; PF00682 HMGL-like; PF02436 PYC_OADA [H]

EC number: =4.1.1.3 [H]

Molecular weight: Translated: 65222; Mature: 65091

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: PS50991 PYR_CT ; PS50968 BIOTINYL_LIPOYL ; PS00188 BIOTIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIQNKKIAITDVVLRDAHQSLFATRLRLDDMLPIAAELDKIGYWSLEAWGGATFDSCIR
CCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCEEEECCCCCCHHHHHH
FLGEDPWVRLRELKKAIPNTPLQMLLRGQNLLGYRHYTDDVVDRFVERCVTNGMDVFRVF
HHCCCCHHHHHHHHHHCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHH
DALNDPRNMQAALQAVKKHGGHAQGTLSYTTSPVHTLQTWLDVTEQLLEIGVDSLVIKDM
HHHCCCHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHCHHHHHHHHH
SGILTPMAAYELVSEIKKRYDVELHLHCHSTTGMAEMALLKAIEAGIDGVDTSISSMSGT
HHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHHHHCCCCCCCHHHHCCCC
YGHPATESIVATLQGTPYDTGLNIPQLEKISAYFRDVRKKYAKFEGQLRGVDSRILVAQV
CCCCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHCCCCCEEEEEEC
PGGMLTNLESQLKQQNASDKLDLVLQEIPRVREDLGNIPLVTPTSQIVGTQAVMNVLMGE
CCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCEECCCHHHHHHHHHHHHHHHH
RYKTIAKETAGILKGEYGRTPAPVNKALQDRVLEGAAPITDRPANHITPEIDKLVAEVTA
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHH
QAKEKGITLSENTIDDVLIVALFQQVGWKFLENRNNPAAFEPAPTAEVAKEAAKPTASHT
HHHHCCCEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCHHHC
AKAGEPAVYTVELEGKAFVVKVSEGGDITNIAPTAPAAAPQVVVPAAATSANAEPVKAPM
CCCCCCEEEEEEECCCEEEEEECCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCC
AGNILKVEVTEGQQVAEGDVLLILEAMKMETQICAPKAGKVQGVAVKQGDVVAVDQVLMN
CCCEEEEEECCCCEECCCCEEEEEHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHH
LA
CC
>Mature Secondary Structure 
TIQNKKIAITDVVLRDAHQSLFATRLRLDDMLPIAAELDKIGYWSLEAWGGATFDSCIR
CCCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCEEEECCCCCCHHHHHH
FLGEDPWVRLRELKKAIPNTPLQMLLRGQNLLGYRHYTDDVVDRFVERCVTNGMDVFRVF
HHCCCCHHHHHHHHHHCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHH
DALNDPRNMQAALQAVKKHGGHAQGTLSYTTSPVHTLQTWLDVTEQLLEIGVDSLVIKDM
HHHCCCHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHCHHHHHHHHH
SGILTPMAAYELVSEIKKRYDVELHLHCHSTTGMAEMALLKAIEAGIDGVDTSISSMSGT
HHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHHHHCCCCCCCHHHHCCCC
YGHPATESIVATLQGTPYDTGLNIPQLEKISAYFRDVRKKYAKFEGQLRGVDSRILVAQV
CCCCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHCCCCCEEEEEEC
PGGMLTNLESQLKQQNASDKLDLVLQEIPRVREDLGNIPLVTPTSQIVGTQAVMNVLMGE
CCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCEECCCHHHHHHHHHHHHHHHH
RYKTIAKETAGILKGEYGRTPAPVNKALQDRVLEGAAPITDRPANHITPEIDKLVAEVTA
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHH
QAKEKGITLSENTIDDVLIVALFQQVGWKFLENRNNPAAFEPAPTAEVAKEAAKPTASHT
HHHHCCCEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCHHHC
AKAGEPAVYTVELEGKAFVVKVSEGGDITNIAPTAPAAAPQVVVPAAATSANAEPVKAPM
CCCCCCEEEEEEECCCEEEEEECCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCC
AGNILKVEVTEGQQVAEGDVLLILEAMKMETQICAPKAGKVQGVAVKQGDVVAVDQVLMN
CCCEEEEEECCCCEECCCCEEEEEHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHH
LA
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2454915 [H]