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The map label for this gene is ccmE

Identifier: 126208832

GI number: 126208832

Start: 1566470

End: 1567015

Strand: Reverse

Name: ccmE

Synonym: APL_1368

Alternate gene names: 126208832

Gene position: 1567015-1566470 (Counterclockwise)

Preceding gene: 126208833

Following gene: 126208831

Centisome position: 68.9

GC content: 42.12

Gene sequence:

>546_bases
ATGAATCCAAGACGTAAATCTCGATTGAAAGTGGTGGTTTCAATCATTTTCGGTGTTGCGGTAGCCGCAGGCTTAATGCT
TTATGCACTAAGTCAAAATATTGACTTATTCTATACGCCATCAGAGATTGTAAATGGTAAAAACGATGATCCAGACCAAA
AACCTGAAGTAGGGCAACGTATCCGTGTGGGCGGAATGGTTGTGGAAGGATCGGTAAAGCGTGATGATAAAACGCTGAAA
GTAGAATTTGAGGCGAATGATATCGGGCCGTCTATCACGGTTGAATATGAAGGGATTTTGCCGGATTTATTCCGTGAAGG
GCAAGGTATTGTAGCGCAAGGGGTTTTAATCGAACCGACTCGTTTAAAAGCTACGGAAGTATTGGCTAAACACGATGAAA
ACTATATGCCGCCGGAGTTAGGCGATAAATTAAAAGAACAGCATGGTGCTGCAGGTATTTCCGAAGCGGATTTAAAAGGT
ACTTCAGCACGTGATAAAGCTGAAATCGAAAGAACATTAAAGACCTTACAAGGGGAAGCTAACTAA

Upstream 100 bases:

>100_bases
AAGAACTGACGGCGGGTATCAAGCAAATTCCTGTTATATTAAGTTATATTCGATTATTTAATATTGTGTGCCGTCGGCAT
ACTTTTAGAAGGTGATTACT

Downstream 100 bases:

>100_bases
TGGTTGCGGAATTAGGTAATTACGCATTGGCACTTGCGTTCGGATTGTCAATTTTTTTGGCAATTTTACCGCTTGTTGGT
GCACAAAAACAGAATAGTAC

Product: cytochrome c-type biogenesis protein CcmE

Products: NA

Alternate protein names: Cytochrome c maturation protein E; Heme chaperone CcmE

Number of amino acids: Translated: 181; Mature: 181

Protein sequence:

>181_residues
MNPRRKSRLKVVVSIIFGVAVAAGLMLYALSQNIDLFYTPSEIVNGKNDDPDQKPEVGQRIRVGGMVVEGSVKRDDKTLK
VEFEANDIGPSITVEYEGILPDLFREGQGIVAQGVLIEPTRLKATEVLAKHDENYMPPELGDKLKEQHGAAGISEADLKG
TSARDKAEIERTLKTLQGEAN

Sequences:

>Translated_181_residues
MNPRRKSRLKVVVSIIFGVAVAAGLMLYALSQNIDLFYTPSEIVNGKNDDPDQKPEVGQRIRVGGMVVEGSVKRDDKTLK
VEFEANDIGPSITVEYEGILPDLFREGQGIVAQGVLIEPTRLKATEVLAKHDENYMPPELGDKLKEQHGAAGISEADLKG
TSARDKAEIERTLKTLQGEAN
>Mature_181_residues
MNPRRKSRLKVVVSIIFGVAVAAGLMLYALSQNIDLFYTPSEIVNGKNDDPDQKPEVGQRIRVGGMVVEGSVKRDDKTLK
VEFEANDIGPSITVEYEGILPDLFREGQGIVAQGVLIEPTRLKATEVLAKHDENYMPPELGDKLKEQHGAAGISEADLKG
TSARDKAEIERTLKTLQGEAN

Specific function: Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH

COG id: COG2332

COG function: function code O; Cytochrome c-type biogenesis protein CcmE

Gene ontology:

Cell location: Cell inner membrane; Single-pass type II membrane protein; Periplasmic side (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CcmE/CycJ family

Homologues:

Organism=Escherichia coli, GI1788525, Length=148, Percent_Identity=57.4324324324324, Blast_Score=170, Evalue=6e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CCME_ACTP2 (A3N216)

Other databases:

- EMBL:   CP000569
- RefSeq:   YP_001054057.1
- ProteinModelPortal:   A3N216
- SMR:   A3N216
- STRING:   A3N216
- GeneID:   4850381
- GenomeReviews:   CP000569_GR
- KEGG:   apl:APL_1368
- eggNOG:   COG2332
- HOGENOM:   HBG296631
- OMA:   KENNRIG
- PhylomeDB:   A3N216
- ProtClustDB:   PRK13165
- BioCyc:   APLE416269:APL_1368-MONOMER
- HAMAP:   MF_01959
- InterPro:   IPR004329
- InterPro:   IPR012340
- Gene3D:   G3DSA:2.40.50.140

Pfam domain/function: PF03100 CcmE; SSF82093 Pyrv/PenolPyrv_Kinase_cat

EC number: NA

Molecular weight: Translated: 19786; Mature: 19786

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: NA

Important sites: BINDING 131-131

Signals:

None

Transmembrane regions:

HASH(0x1e3b3560)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPRRKSRLKVVVSIIFGVAVAAGLMLYALSQNIDLFYTPSEIVNGKNDDPDQKPEVGQR
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHCCCCCCCCCCCCHHCE
IRVGGMVVEGSVKRDDKTLKVEFEANDIGPSITVEYEGILPDLFREGQGIVAQGVLIEPT
EEECCEEEECCCCCCCCEEEEEEECCCCCCEEEEEECCCCHHHHHCCCCEEECCEEECCC
RLKATEVLAKHDENYMPPELGDKLKEQHGAAGISEADLKGTSARDKAEIERTLKTLQGEA
HHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCC
N
H
>Mature Secondary Structure
MNPRRKSRLKVVVSIIFGVAVAAGLMLYALSQNIDLFYTPSEIVNGKNDDPDQKPEVGQR
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHCCCCCCCCCCCCHHCE
IRVGGMVVEGSVKRDDKTLKVEFEANDIGPSITVEYEGILPDLFREGQGIVAQGVLIEPT
EEECCEEEECCCCCCCCEEEEEEECCCCCCEEEEEECCCCHHHHHCCCCEEECCEEECCC
RLKATEVLAKHDENYMPPELGDKLKEQHGAAGISEADLKGTSARDKAEIERTLKTLQGEA
HHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCC
N
H

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA