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The map label for this gene is yrbG [H]

Identifier: 126208820

GI number: 126208820

Start: 1553553

End: 1554515

Strand: Direct

Name: yrbG [H]

Synonym: APL_1356

Alternate gene names: 126208820

Gene position: 1553553-1554515 (Clockwise)

Preceding gene: 126208814

Following gene: 126208823

Centisome position: 68.3

GC content: 45.17

Gene sequence:

>963_bases
ATGTTATACGCTTCACTTGCCATTGTAATCGGCTTAATTTTACTCGTCTGGAGCGCGGATAAATTTGTAGAGGGTGCGGC
TTCTTCCGCCCGTCATTTCGGCATGTCTCCGCTTTTAATCGGTATCGTGATTGTCGGTTTCGGCACCTCGGCGCCGGAAA
TGTTGGTATCCGCCTCTTCGGCACTAAAAGGCGCTTCGGGGATTGCGCTCGGTAACGCTTACGGATCCAATATCACTAAT
ATTGCGCTTATCTTAGGGGTTACCGCCTTAATCAAACCGATTATTGTCGCTTCCGAAGTGATTAAGAAAGAACTGCCTAT
GTTAATTTTAATTACGTTAGTGTCAGCGTATATGCTGTTCGATGCGCAAGTCACCCAAATAGAAGCGGTCATTTTATTGA
TTATTTTTGCCGTTTATATGGGATGGACAATATGGGTCGCATTGCGCACAAAAAATGACACGCTTGCTCAAACGGAATCT
TTAAATGAAGAGAGATTGCCGATTGGCAAAGCACTCTTCTGGGTCGTTATAGGTTTACTATTTTTAATGGCAAGTTCCCA
ATTGCTTGTTTGGGGAGCGGTCGAAATCGCCAAATATTTCGGCGTGAGCGATTTAGTTATCGGTTTAACCATTGTAGCGG
TCGGCACGTCATTACCTGAACTGGCCTCTTCGATTATTGCCGCCCGTAAAGGCGAGTCCGATCTTGCTTTAGGAAATATT
GTCGGATCAAATTTATTTAATACGTTAGCAGTGGTCGGGATTGCCGGCGCTATCGAACCGATGCAAGTGGAAGCGGAGGT
GTTCTCCCGTGATATGCTCGTGATGTTGGCGGTAACCGTTCTGCTATTTTTCTTTGCGTTTAGCTTCCGTAAAAGAGCGG
GCAGAATTAATCGGGCGGAAGGTGCGATTCTCTTTATATGCTATGTCGCCTACACTTTATATCTGTTAAAAACAGCGGTT
TAA

Upstream 100 bases:

>100_bases
TTTTAATCGCTGAACTCGTTACTTTCATAGCACCTTCCTTATAGTTAATTATCAAAAATTAACCTATACTATACGCCCAT
TTAATTTATTAGGAAATATG

Downstream 100 bases:

>100_bases
AGAGCCGAATAAAATAAATCAAGCGGTCGTTTTTCTTGGAGACTTTGCAAAAATCTTCGGAAAAACGACCGCTTGTTTTA
ACGTACCGTTTTGTTTTTAT

Product: putative sodium/calcium exchange protein

Products: Na (I) [Cytoplasm]; Ca (II) [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 320; Mature: 320

Protein sequence:

>320_residues
MLYASLAIVIGLILLVWSADKFVEGAASSARHFGMSPLLIGIVIVGFGTSAPEMLVSASSALKGASGIALGNAYGSNITN
IALILGVTALIKPIIVASEVIKKELPMLILITLVSAYMLFDAQVTQIEAVILLIIFAVYMGWTIWVALRTKNDTLAQTES
LNEERLPIGKALFWVVIGLLFLMASSQLLVWGAVEIAKYFGVSDLVIGLTIVAVGTSLPELASSIIAARKGESDLALGNI
VGSNLFNTLAVVGIAGAIEPMQVEAEVFSRDMLVMLAVTVLLFFFAFSFRKRAGRINRAEGAILFICYVAYTLYLLKTAV

Sequences:

>Translated_320_residues
MLYASLAIVIGLILLVWSADKFVEGAASSARHFGMSPLLIGIVIVGFGTSAPEMLVSASSALKGASGIALGNAYGSNITN
IALILGVTALIKPIIVASEVIKKELPMLILITLVSAYMLFDAQVTQIEAVILLIIFAVYMGWTIWVALRTKNDTLAQTES
LNEERLPIGKALFWVVIGLLFLMASSQLLVWGAVEIAKYFGVSDLVIGLTIVAVGTSLPELASSIIAARKGESDLALGNI
VGSNLFNTLAVVGIAGAIEPMQVEAEVFSRDMLVMLAVTVLLFFFAFSFRKRAGRINRAEGAILFICYVAYTLYLLKTAV
>Mature_320_residues
MLYASLAIVIGLILLVWSADKFVEGAASSARHFGMSPLLIGIVIVGFGTSAPEMLVSASSALKGASGIALGNAYGSNITN
IALILGVTALIKPIIVASEVIKKELPMLILITLVSAYMLFDAQVTQIEAVILLIIFAVYMGWTIWVALRTKNDTLAQTES
LNEERLPIGKALFWVVIGLLFLMASSQLLVWGAVEIAKYFGVSDLVIGLTIVAVGTSLPELASSIIAARKGESDLALGNI
VGSNLFNTLAVVGIAGAIEPMQVEAEVFSRDMLVMLAVTVLLFFFAFSFRKRAGRINRAEGAILFICYVAYTLYLLKTAV

Specific function: Unknown

COG id: COG0530

COG function: function code P; Ca2+/Na+ antiporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium/potassium/calcium exchanger family [H]

Homologues:

Organism=Homo sapiens, GI45504369, Length=158, Percent_Identity=29.746835443038, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI4759128, Length=76, Percent_Identity=40.7894736842105, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI300796347, Length=90, Percent_Identity=37.7777777777778, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI9966787, Length=90, Percent_Identity=37.7777777777778, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI31563526, Length=91, Percent_Identity=35.1648351648352, Blast_Score=65, Evalue=6e-11,
Organism=Escherichia coli, GI1789587, Length=327, Percent_Identity=37.3088685015291, Blast_Score=179, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI193208990, Length=90, Percent_Identity=41.1111111111111, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI115532296, Length=72, Percent_Identity=45.8333333333333, Blast_Score=64, Evalue=8e-11,
Organism=Drosophila melanogaster, GI24583109, Length=162, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24583111, Length=162, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004481
- InterPro:   IPR004837 [H]

Pfam domain/function: PF01699 Na_Ca_ex [H]

EC number: NA

Molecular weight: Translated: 34124; Mature: 34124

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLYASLAIVIGLILLVWSADKFVEGAASSARHFGMSPLLIGIVIVGFGTSAPEMLVSASS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHH
ALKGASGIALGNAYGSNITNIALILGVTALIKPIIVASEVIKKELPMLILITLVSAYMLF
HHCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
DAQVTQIEAVILLIIFAVYMGWTIWVALRTKNDTLAQTESLNEERLPIGKALFWVVIGLL
HHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCHHHHHHCCCCCCCCHHHHHHHHHHHHH
FLMASSQLLVWGAVEIAKYFGVSDLVIGLTIVAVGTSLPELASSIIAARKGESDLALGNI
HHHHCCCEEEHHHHHHHHHHCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHH
VGSNLFNTLAVVGIAGAIEPMQVEAEVFSRDMLVMLAVTVLLFFFAFSFRKRAGRINRAE
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
GAILFICYVAYTLYLLKTAV
CHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLYASLAIVIGLILLVWSADKFVEGAASSARHFGMSPLLIGIVIVGFGTSAPEMLVSASS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHH
ALKGASGIALGNAYGSNITNIALILGVTALIKPIIVASEVIKKELPMLILITLVSAYMLF
HHCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
DAQVTQIEAVILLIIFAVYMGWTIWVALRTKNDTLAQTESLNEERLPIGKALFWVVIGLL
HHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCHHHHHHCCCCCCCCHHHHHHHHHHHHH
FLMASSQLLVWGAVEIAKYFGVSDLVIGLTIVAVGTSLPELASSIIAARKGESDLALGNI
HHHHCCCEEEHHHHHHHHHHCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHH
VGSNLFNTLAVVGIAGAIEPMQVEAEVFSRDMLVMLAVTVLLFFFAFSFRKRAGRINRAE
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
GAILFICYVAYTLYLLKTAV
CHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Periplasm]; Ca (II) [Cytoplasm] [C]

Specific reaction: Na (I) [Periplasm] + Ca (II) [Cytoplasm] = Na (I) [Cytoplasm] + Ca (II) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9278503 [H]