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The map label for this gene is folB [H]

Identifier: 126208806

GI number: 126208806

Start: 1542407

End: 1542760

Strand: Direct

Name: folB [H]

Synonym: APL_1342

Alternate gene names: 126208806

Gene position: 1542407-1542760 (Clockwise)

Preceding gene: 126208804

Following gene: 126208807

Centisome position: 67.81

GC content: 41.24

Gene sequence:

>354_bases
ATGGCGGATAAAGTTTTTATTCACGAATTGACAGCTTTTGCTTCCATCGGTGCTTATGATTGGGAACATACGATCAAGCA
ACGCTTAGTGTTTAATATTGAAATGGAATGGGATTTTACCAAAGCGGTAGCAACGGATGACGTGCAATATTGCTTAAATT
ATGCGGAAGTCTCGGAAAAAATATTAGCCTTTGTCGAATCCAAACCTTTTAAGTTGGTTGAAACCGTCGCCCATCAAGTC
GCGGATTTCTTACAGAACACTTATGCTATTCGCGCCTTACGTATCGAATTACATAAACCGAAAGCGGTCGCGCAAGCAAG
TAGCGTCGGTGTGATTGTAGAACGAGGTATTTAA

Upstream 100 bases:

>100_bases
ACTATTAACAAATAGACGGTAATACTCATAAATTGTCCTTCAATTGGCGTTCTATGCTATATTCTCGGCAATGTTATCAC
AAACTGATTAAGGAACTAAA

Downstream 100 bases:

>100_bases
CAAATATTCTTTTTAAACCTTTTATCCGATAAGTAAGATCTTCATCACTATAGGAGTGCTTATTTGCGGTTATAATAAGC
CCCCGTCAAACAGAGGAGCA

Product: dihydroneopterin aldolase

Products: NA

Alternate protein names: DHNA [H]

Number of amino acids: Translated: 117; Mature: 116

Protein sequence:

>117_residues
MADKVFIHELTAFASIGAYDWEHTIKQRLVFNIEMEWDFTKAVATDDVQYCLNYAEVSEKILAFVESKPFKLVETVAHQV
ADFLQNTYAIRALRIELHKPKAVAQASSVGVIVERGI

Sequences:

>Translated_117_residues
MADKVFIHELTAFASIGAYDWEHTIKQRLVFNIEMEWDFTKAVATDDVQYCLNYAEVSEKILAFVESKPFKLVETVAHQV
ADFLQNTYAIRALRIELHKPKAVAQASSVGVIVERGI
>Mature_116_residues
ADKVFIHELTAFASIGAYDWEHTIKQRLVFNIEMEWDFTKAVATDDVQYCLNYAEVSEKILAFVESKPFKLVETVAHQVA
DFLQNTYAIRALRIELHKPKAVAQASSVGVIVERGI

Specific function: Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin [H]

COG id: COG1539

COG function: function code H; Dihydroneopterin aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHNA family [H]

Homologues:

Organism=Escherichia coli, GI87082204, Length=114, Percent_Identity=51.7543859649123, Blast_Score=123, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6324073, Length=120, Percent_Identity=30, Blast_Score=61, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006156
- InterPro:   IPR006157 [H]

Pfam domain/function: PF02152 FolB [H]

EC number: =4.1.2.25 [H]

Molecular weight: Translated: 13288; Mature: 13157

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADKVFIHELTAFASIGAYDWEHTIKQRLVFNIEMEWDFTKAVATDDVQYCLNYAEVSEK
CCCHHHHHHHHHHHHCCCCCHHHHHHHHHEEEEEECCCHHHHHHHHHHHHHHHHHHHHHH
ILAFVESKPFKLVETVAHQVADFLQNTYAIRALRIELHKPKAVAQASSVGVIVERGI
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCHHHHHHCCCCEEEECCC
>Mature Secondary Structure 
ADKVFIHELTAFASIGAYDWEHTIKQRLVFNIEMEWDFTKAVATDDVQYCLNYAEVSEK
CCHHHHHHHHHHHHCCCCCHHHHHHHHHEEEEEECCCHHHHHHHHHHHHHHHHHHHHHH
ILAFVESKPFKLVETVAHQVADFLQNTYAIRALRIELHKPKAVAQASSVGVIVERGI
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCHHHHHHCCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]