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The map label for this gene is cysQ [H]

Identifier: 126208776

GI number: 126208776

Start: 1503711

End: 1504526

Strand: Reverse

Name: cysQ [H]

Synonym: APL_1312

Alternate gene names: 126208776

Gene position: 1504526-1503711 (Counterclockwise)

Preceding gene: 126208777

Following gene: 126208775

Centisome position: 66.15

GC content: 43.63

Gene sequence:

>816_bases
ATGCAACCATTAAATTCAACGCTGTTGGAAGCGGTTAAACGGATTGCGATAGAAGCGGGAGAGCACCTTAAACGTTTTTA
TCAGTGTTCGGTACAGGTCAAAATCAAAGCGGATCATACGCCGGTTACGGAGGCGGATCTGTTTATCAGCCAATTCGTAA
CGGAAAAACTTCGTCAATTAACGCCGGACGTGCCGATTTTATCCGAAGAAAATTGCAATATCGCATTAGCGGATCGACAA
ACTTGGCAAGAATATTGGATCATTGATCCGTTAGACGGGACGCAACAATTTATTGATCGTACCGATCAATTTTCTGTGGT
AATCGGTTTAGTGCAAGATCATCGCCCGGTGTTAGGTGTGATCCATTCTCCGATTTTAGCGAAGACTTATTTTGCTATGG
CGGGAAACGGCGCATTTTTGCAAGAAAACGGCGAAATTCGACAGCTTGTCGGACATCAGGGCTTACTTCAGGATAATCGC
TTGAAGATTACGATGGGTGCATCTGCACAGCAGGCGGTATTAAATTCGGTAGATAAATCTTATCAAGCGGAAATCTTCCA
ATACGGTTCAAGCAGTTTAAAAGCGGGTTTACTTGCCGAAGGTAAAGCGGATTGTTACGTACGTTTCGGCGATACCGGAG
AATGGGATACGGCGGTTGCCGAAGTATTACTTTCGGAAGTAGGCGGCAAAATTTTTAATTTGAAGTTTGAGCCGCTTACT
TATAATCGGCGTTCAACTTTTATCAACCCCTATTTCGTGATGGTGGCGGATAAGCATTTGGCTTGGGAACAAATTTTTAG
ATTTAATGCGCAATAG

Upstream 100 bases:

>100_bases
ATTACTGGCTGATCCGAATTTTGCGGAATCAAGAAATTTATCCGCTCTGTTTATGCTAAGAGATTATCTGGCAAGCGGTC
GGAAATAAGGGAATTTTAGT

Downstream 100 bases:

>100_bases
TTATTTGTAATCCTTTTTAAAATGTTACATATTGGTTAAATAATTCATACACTTAGGATAAAAAGAAAAAAATGAATATT
GAAAATAGTTGTATTGTTAT

Product: CysQ-like protein

Products: NA

Alternate protein names: 3'(2'),5-bisphosphonucleoside 3'(2')-phosphohydrolase; 3'-phosphoadenosine 5'-phosphate phosphatase; PAP phosphatase; DPNPase [H]

Number of amino acids: Translated: 271; Mature: 271

Protein sequence:

>271_residues
MQPLNSTLLEAVKRIAIEAGEHLKRFYQCSVQVKIKADHTPVTEADLFISQFVTEKLRQLTPDVPILSEENCNIALADRQ
TWQEYWIIDPLDGTQQFIDRTDQFSVVIGLVQDHRPVLGVIHSPILAKTYFAMAGNGAFLQENGEIRQLVGHQGLLQDNR
LKITMGASAQQAVLNSVDKSYQAEIFQYGSSSLKAGLLAEGKADCYVRFGDTGEWDTAVAEVLLSEVGGKIFNLKFEPLT
YNRRSTFINPYFVMVADKHLAWEQIFRFNAQ

Sequences:

>Translated_271_residues
MQPLNSTLLEAVKRIAIEAGEHLKRFYQCSVQVKIKADHTPVTEADLFISQFVTEKLRQLTPDVPILSEENCNIALADRQ
TWQEYWIIDPLDGTQQFIDRTDQFSVVIGLVQDHRPVLGVIHSPILAKTYFAMAGNGAFLQENGEIRQLVGHQGLLQDNR
LKITMGASAQQAVLNSVDKSYQAEIFQYGSSSLKAGLLAEGKADCYVRFGDTGEWDTAVAEVLLSEVGGKIFNLKFEPLT
YNRRSTFINPYFVMVADKHLAWEQIFRFNAQ
>Mature_271_residues
MQPLNSTLLEAVKRIAIEAGEHLKRFYQCSVQVKIKADHTPVTEADLFISQFVTEKLRQLTPDVPILSEENCNIALADRQ
TWQEYWIIDPLDGTQQFIDRTDQFSVVIGLVQDHRPVLGVIHSPILAKTYFAMAGNGAFLQENGEIRQLVGHQGLLQDNR
LKITMGASAQQAVLNSVDKSYQAEIFQYGSSSLKAGLLAEGKADCYVRFGDTGEWDTAVAEVLLSEVGGKIFNLKFEPLT
YNRRSTFINPYFVMVADKHLAWEQIFRFNAQ

Specific function: Converts 3'(2')-phosphoadenosine 5'-phosphate (PAP) to AMP. May also convert adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) [H]

COG id: COG1218

COG function: function code P; 3'-Phosphoadenosine 5'-phosphosulfate (PAPS) 3'-phosphatase

Gene ontology:

Cell location: Cytoplasm. Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the inositol monophosphatase family [H]

Homologues:

Organism=Homo sapiens, GI7657236, Length=240, Percent_Identity=28.75, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI221625487, Length=238, Percent_Identity=27.3109243697479, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI5031789, Length=261, Percent_Identity=26.0536398467433, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI116812595, Length=249, Percent_Identity=24.0963855421687, Blast_Score=66, Evalue=3e-11,
Organism=Escherichia coli, GI1790659, Length=252, Percent_Identity=36.1111111111111, Blast_Score=145, Evalue=4e-36,
Organism=Escherichia coli, GI1788882, Length=230, Percent_Identity=28.695652173913, Blast_Score=75, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI193202572, Length=224, Percent_Identity=26.3392857142857, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI193202570, Length=233, Percent_Identity=26.6094420600858, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI71995905, Length=167, Percent_Identity=26.9461077844311, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71995897, Length=167, Percent_Identity=26.9461077844311, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6320493, Length=201, Percent_Identity=26.865671641791, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24664922, Length=271, Percent_Identity=28.0442804428044, Blast_Score=81, Evalue=8e-16,
Organism=Drosophila melanogaster, GI21357957, Length=234, Percent_Identity=29.0598290598291, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24664918, Length=234, Percent_Identity=29.4871794871795, Blast_Score=78, Evalue=7e-15,
Organism=Drosophila melanogaster, GI21357329, Length=233, Percent_Identity=26.6094420600858, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24664926, Length=238, Percent_Identity=26.4705882352941, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21357303, Length=211, Percent_Identity=27.4881516587678, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006240
- InterPro:   IPR020583
- InterPro:   IPR000760
- InterPro:   IPR020550 [H]

Pfam domain/function: PF00459 Inositol_P [H]

EC number: =3.1.3.7 [H]

Molecular weight: Translated: 30529; Mature: 30529

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQPLNSTLLEAVKRIAIEAGEHLKRFYQCSVQVKIKADHTPVTEADLFISQFVTEKLRQL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHH
TPDVPILSEENCNIALADRQTWQEYWIIDPLDGTQQFIDRTDQFSVVIGLVQDHRPVLGV
CCCCCCCCCCCCCEEEECCCCCCCEEEECCCCHHHHHHCCCCCCEEEEEEHHCCCCHHHH
IHSPILAKTYFAMAGNGAFLQENGEIRQLVGHQGLLQDNRLKITMGASAQQAVLNSVDKS
HHCHHHHHHHHHHCCCCCEEECCCHHHHHHCCCCCCCCCCEEEEECCCHHHHHHHHHHHH
YQAEIFQYGSSSLKAGLLAEGKADCYVRFGDTGEWDTAVAEVLLSEVGGKIFNLKFEPLT
HHHHHHHHCCCHHCCCEEECCCCCEEEEECCCCCHHHHHHHHHHHHHCCEEEEEEECCEE
YNRRSTFINPYFVMVADKHLAWEQIFRFNAQ
CCCCCCCCCCEEEEEECCHHHHHHHHHCCCC
>Mature Secondary Structure
MQPLNSTLLEAVKRIAIEAGEHLKRFYQCSVQVKIKADHTPVTEADLFISQFVTEKLRQL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHH
TPDVPILSEENCNIALADRQTWQEYWIIDPLDGTQQFIDRTDQFSVVIGLVQDHRPVLGV
CCCCCCCCCCCCCEEEECCCCCCCEEEECCCCHHHHHHCCCCCCEEEEEEHHCCCCHHHH
IHSPILAKTYFAMAGNGAFLQENGEIRQLVGHQGLLQDNRLKITMGASAQQAVLNSVDKS
HHCHHHHHHHHHHCCCCCEEECCCHHHHHHCCCCCCCCCCEEEEECCCHHHHHHHHHHHH
YQAEIFQYGSSSLKAGLLAEGKADCYVRFGDTGEWDTAVAEVLLSEVGGKIFNLKFEPLT
HHHHHHHHCCCHHCCCEEECCCCCEEEEECCCCCHHHHHHHHHHHHHCCEEEEEEECCEE
YNRRSTFINPYFVMVADKHLAWEQIFRFNAQ
CCCCCCCCCCEEEEEECCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9020051 [H]