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The map label for this gene is zwf [H]

Identifier: 126208775

GI number: 126208775

Start: 1502152

End: 1503639

Strand: Reverse

Name: zwf [H]

Synonym: APL_1311

Alternate gene names: 126208775

Gene position: 1503639-1502152 (Counterclockwise)

Preceding gene: 126208776

Following gene: 126208774

Centisome position: 66.11

GC content: 44.35

Gene sequence:

>1488_bases
ATGAATATTGAAAATAGTTGTATTGTTATTTTTGGTGCATCGGGCGATTTAACTTTTCGTAAGTTAATTCCGGCACTTTA
TAACTTGTTTAGAGTTGGTCGCTTAGGGCAGCATTTCTCGGTATTGGGCGTAGCGCGTTCCGAATTAACGGACGATTCTT
TCCGTACCAAAATGCGTGATGCGTTAGTTAAATTTGAGAAAGCGCAAGGACAGGAGTTAGAAGACTTCTGTACCCATTTG
TATTATCAAGCGGTAAATACGTCCGATGCCTTGGACTATGCCAAATTATTACCTCGCTTAGACGAATTGCACGACAAATA
CGGCAGTTGCGGTAATACGCTTTATTATCTTTCTACGCCGCCGAGTTTATACGGCGTGATTCCGGAATGTTTAGCCGCAC
ACGGTTTAACCACCGAAGAATACGGCTGGAAACGTATCATCGTCGAAAAACCGTTCGGTTACGATATTAAAACCGCTAAA
GAATTAGACGAGAAAATTCATCATTACTTTGAAGAACATCAAATCTACCGTATCGACCATTATTTAGGTAAGGAAACGGT
TCAAAATTTACTTGTACTTCGTTTCTCAAACGGTTTATTCGAGCCTTTATGGAACCGCAACTTTATCGATTACGTAGAAA
TTACCGGTGCGGAAGCGATCGGCGTAGAGGAACGCGGCGGTTATTATGACGGTTCGGGTGCAATGCGTGATATGTTCCAG
AACCATTTATTACAAGTGTTGGCGATGGTGGCGATGGAACCACCGGCAATTATTAATGCCGATTCAATGCGTGACGAAGT
GGCGAAAGTGCTGCATTGCTTACATCCGCTTACTGCCGAAGATGTAAAAAATAATGTGGTACTCGGACAATATGTAGCGG
GTGAAGTGGATGATCAGATGGTTGCCGGTTACTTAGCAGAAAAAGGCGTACCGGCGGATTCGAATACCGAAACCTATATG
GCGATTAAGTGTGAGATTGATAACTGGCGTTGGGCGGGGGTGCCGTTTTATGTGCGTACCGGTAAACGTTTGCCGACTCG
TGTAACCGAAGTGGTGATTCATTTTAAAACCACGCCGCATCCGGTATTCAGCCAAAATGCGCCGGAAAATAAATTAATTA
TCCGAGTGCAACCGGACGAGGGGATTTCAATGCGTTTCGGCTTGAAAAAACCGGGTGCAGGCTTTGAGGCGAAAGAAGTT
TCCATGGACTTCCGTTATTCCGATTTAAGTTCGGCTTCCAGCCTATTAACCGCTTATGAGCGTTTATTATTAGATGCGTT
AAAAGGCGATGCGACTTTATTCGCGCGTACCGATGCGGTACACGCTTGTTGGAAATTCGTTCAGCCGATTTTAGATTATA
AAGCGGAAAGAGGCAGAGTTTATGAATACGAAGCCGGCACTTGGGGGCCGACCGAAGCGGATAAACTTATCGCCAAACAC
GGTAAAGTTTGGCGTAAACCGTCAGGCGTGATGAAGAAAAAAGTATAA

Upstream 100 bases:

>100_bases
AACAAATTTTTAGATTTAATGCGCAATAGTTATTTGTAATCCTTTTTAAAATGTTACATATTGGTTAAATAATTCATACA
CTTAGGATAAAAAGAAAAAA

Downstream 100 bases:

>100_bases
ATTTAGCAAATAAATCTCCCCCTCTTTAGTAAAGAGGGGGAGATTTGAGTATGAATTAAAAGGAAATGTTAATGAATTAC
ATTACCTTCCAATCCGCTCA

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 495; Mature: 495

Protein sequence:

>495_residues
MNIENSCIVIFGASGDLTFRKLIPALYNLFRVGRLGQHFSVLGVARSELTDDSFRTKMRDALVKFEKAQGQELEDFCTHL
YYQAVNTSDALDYAKLLPRLDELHDKYGSCGNTLYYLSTPPSLYGVIPECLAAHGLTTEEYGWKRIIVEKPFGYDIKTAK
ELDEKIHHYFEEHQIYRIDHYLGKETVQNLLVLRFSNGLFEPLWNRNFIDYVEITGAEAIGVEERGGYYDGSGAMRDMFQ
NHLLQVLAMVAMEPPAIINADSMRDEVAKVLHCLHPLTAEDVKNNVVLGQYVAGEVDDQMVAGYLAEKGVPADSNTETYM
AIKCEIDNWRWAGVPFYVRTGKRLPTRVTEVVIHFKTTPHPVFSQNAPENKLIIRVQPDEGISMRFGLKKPGAGFEAKEV
SMDFRYSDLSSASSLLTAYERLLLDALKGDATLFARTDAVHACWKFVQPILDYKAERGRVYEYEAGTWGPTEADKLIAKH
GKVWRKPSGVMKKKV

Sequences:

>Translated_495_residues
MNIENSCIVIFGASGDLTFRKLIPALYNLFRVGRLGQHFSVLGVARSELTDDSFRTKMRDALVKFEKAQGQELEDFCTHL
YYQAVNTSDALDYAKLLPRLDELHDKYGSCGNTLYYLSTPPSLYGVIPECLAAHGLTTEEYGWKRIIVEKPFGYDIKTAK
ELDEKIHHYFEEHQIYRIDHYLGKETVQNLLVLRFSNGLFEPLWNRNFIDYVEITGAEAIGVEERGGYYDGSGAMRDMFQ
NHLLQVLAMVAMEPPAIINADSMRDEVAKVLHCLHPLTAEDVKNNVVLGQYVAGEVDDQMVAGYLAEKGVPADSNTETYM
AIKCEIDNWRWAGVPFYVRTGKRLPTRVTEVVIHFKTTPHPVFSQNAPENKLIIRVQPDEGISMRFGLKKPGAGFEAKEV
SMDFRYSDLSSASSLLTAYERLLLDALKGDATLFARTDAVHACWKFVQPILDYKAERGRVYEYEAGTWGPTEADKLIAKH
GKVWRKPSGVMKKKV
>Mature_495_residues
MNIENSCIVIFGASGDLTFRKLIPALYNLFRVGRLGQHFSVLGVARSELTDDSFRTKMRDALVKFEKAQGQELEDFCTHL
YYQAVNTSDALDYAKLLPRLDELHDKYGSCGNTLYYLSTPPSLYGVIPECLAAHGLTTEEYGWKRIIVEKPFGYDIKTAK
ELDEKIHHYFEEHQIYRIDHYLGKETVQNLLVLRFSNGLFEPLWNRNFIDYVEITGAEAIGVEERGGYYDGSGAMRDMFQ
NHLLQVLAMVAMEPPAIINADSMRDEVAKVLHCLHPLTAEDVKNNVVLGQYVAGEVDDQMVAGYLAEKGVPADSNTETYM
AIKCEIDNWRWAGVPFYVRTGKRLPTRVTEVVIHFKTTPHPVFSQNAPENKLIIRVQPDEGISMRFGLKKPGAGFEAKEV
SMDFRYSDLSSASSLLTAYERLLLDALKGDATLFARTDAVHACWKFVQPILDYKAERGRVYEYEAGTWGPTEADKLIAKH
GKVWRKPSGVMKKKV

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI108773793, Length=476, Percent_Identity=42.2268907563025, Blast_Score=365, Evalue=1e-101,
Organism=Homo sapiens, GI109389365, Length=476, Percent_Identity=42.2268907563025, Blast_Score=364, Evalue=1e-101,
Organism=Homo sapiens, GI52145310, Length=510, Percent_Identity=27.6470588235294, Blast_Score=153, Evalue=4e-37,
Organism=Escherichia coli, GI1788158, Length=487, Percent_Identity=42.7104722792608, Blast_Score=401, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI17538218, Length=485, Percent_Identity=39.5876288659794, Blast_Score=342, Evalue=2e-94,
Organism=Saccharomyces cerevisiae, GI6324088, Length=486, Percent_Identity=36.0082304526749, Blast_Score=296, Evalue=4e-81,
Organism=Drosophila melanogaster, GI24643352, Length=471, Percent_Identity=38.4288747346072, Blast_Score=316, Evalue=2e-86,
Organism=Drosophila melanogaster, GI24643350, Length=471, Percent_Identity=38.4288747346072, Blast_Score=316, Evalue=2e-86,
Organism=Drosophila melanogaster, GI221513548, Length=490, Percent_Identity=31.4285714285714, Blast_Score=226, Evalue=3e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 56039; Mature: 56039

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIENSCIVIFGASGDLTFRKLIPALYNLFRVGRLGQHFSVLGVARSELTDDSFRTKMRD
CCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHH
ALVKFEKAQGQELEDFCTHLYYQAVNTSDALDYAKLLPRLDELHDKYGSCGNTLYYLSTP
HHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECC
PSLYGVIPECLAAHGLTTEEYGWKRIIVEKPFGYDIKTAKELDEKIHHYFEEHQIYRIDH
CHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCEEEHHH
YLGKETVQNLLVLRFSNGLFEPLWNRNFIDYVEITGAEAIGVEERGGYYDGSGAMRDMFQ
HHCHHHHHHHHHHHCCCCCCCHHHCCCCEEEEEECCCCEECCCCCCCEECCCHHHHHHHH
NHLLQVLAMVAMEPPAIINADSMRDEVAKVLHCLHPLTAEDVKNNVVLGQYVAGEVDDQM
HHHHHHHHHHHCCCCCEECCHHHHHHHHHHHHHHCCCCHHHHCCCEEEEEHHCCCCCHHH
VAGYLAEKGVPADSNTETYMAIKCEIDNWRWAGVPFYVRTGKRLPTRVTEVVIHFKTTPH
HHHHHHHCCCCCCCCCCEEEEEEEEECCEEECCCCEEEECCCCCHHHHEEEEEEEECCCC
PVFSQNAPENKLIIRVQPDEGISMRFGLKKPGAGFEAKEVSMDFRYSDLSSASSLLTAYE
CCCCCCCCCCEEEEEECCCCCCEEEECCCCCCCCCCHHHEEECCCCCHHHHHHHHHHHHH
RLLLDALKGDATLFARTDAVHACWKFVQPILDYKAERGRVYEYEAGTWGPTEADKLIAKH
HHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHC
GKVWRKPSGVMKKKV
CCHHCCCCCCHHCCC
>Mature Secondary Structure
MNIENSCIVIFGASGDLTFRKLIPALYNLFRVGRLGQHFSVLGVARSELTDDSFRTKMRD
CCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHH
ALVKFEKAQGQELEDFCTHLYYQAVNTSDALDYAKLLPRLDELHDKYGSCGNTLYYLSTP
HHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECC
PSLYGVIPECLAAHGLTTEEYGWKRIIVEKPFGYDIKTAKELDEKIHHYFEEHQIYRIDH
CHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCEEEHHH
YLGKETVQNLLVLRFSNGLFEPLWNRNFIDYVEITGAEAIGVEERGGYYDGSGAMRDMFQ
HHCHHHHHHHHHHHCCCCCCCHHHCCCCEEEEEECCCCEECCCCCCCEECCCHHHHHHHH
NHLLQVLAMVAMEPPAIINADSMRDEVAKVLHCLHPLTAEDVKNNVVLGQYVAGEVDDQM
HHHHHHHHHHHCCCCCEECCHHHHHHHHHHHHHHCCCCHHHHCCCEEEEEHHCCCCCHHH
VAGYLAEKGVPADSNTETYMAIKCEIDNWRWAGVPFYVRTGKRLPTRVTEVVIHFKTTPH
HHHHHHHCCCCCCCCCCEEEEEEEEECCEEECCCCEEEECCCCCHHHHEEEEEEEECCCC
PVFSQNAPENKLIIRVQPDEGISMRFGLKKPGAGFEAKEVSMDFRYSDLSSASSLLTAYE
CCCCCCCCCCEEEEEECCCCCCEEEECCCCCCCCCCHHHEEECCCCCHHHHHHHHHHHHH
RLLLDALKGDATLFARTDAVHACWKFVQPILDYKAERGRVYEYEAGTWGPTEADKLIAKH
HHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHC
GKVWRKPSGVMKKKV
CCHHCCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]