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The map label for this gene is pgl [H]

Identifier: 126208774

GI number: 126208774

Start: 1501382

End: 1502080

Strand: Reverse

Name: pgl [H]

Synonym: APL_1310

Alternate gene names: 126208774

Gene position: 1502080-1501382 (Counterclockwise)

Preceding gene: 126208775

Following gene: 126208773

Centisome position: 66.04

GC content: 41.92

Gene sequence:

>699_bases
ATGAATTACATTACCTTCCAATCCGCTCAACAAGCGGTGGAAAAAATCGCACAAGAATTTGTGTTATACAGTCAATTAAA
CCGTTCGGTACATATTTCCTTATCCGGCGGTTCAACCCCTAAATTACTGTTTAAAACGTTAGCGCAAGCACCGTTCAATA
GCGAAATTCAATGGCAAAATCTGCACTTTTGGTGGGGCGATGATCGTATGGTACTGCCGACTGATCCGGAAAGTAATTAC
GGTGAAGTGCAAAAGTTACTCTTCGATCATATTCAAATTCCTCAACAAAATATCCATCGTATTCGCGGTGAAGAACCGGT
AGAACAAGAACTTGCAAGATTTTCGCAAGAATTGACCGCTTGCGTACCTGATTTAGCTTTTGATTGGATCATTCTCGGGA
TGGGCAATGACGGTCATACCGCTTCGCTTTTCCCTCATCAAACCGATTTTAATGACCCGAATGTGGCGGTTATTGCTAAA
CATCCTGAAAGCGGTCAAATTCGTATTTCAAAAACCGCTAAATTGCTTGAGCAAGCGAAACGTATTACTTACTTAGTCAC
AGGTGCGGCAAAAGCGGAAATATTAAAGGAAATCCGTGAAACAGAGGCGGAAAAATTACCGTATCCGGTAGCTCGTATTA
AAGCGAGAAACGGGGTAACCGAGTGGTATTTAGATCGAGAAGCGGCAAAATTATTATAG

Upstream 100 bases:

>100_bases
CGTCAGGCGTGATGAAGAAAAAAGTATAAATTTAGCAAATAAATCTCCCCCTCTTTAGTAAAGAGGGGGAGATTTGAGTA
TGAATTAAAAGGAAATGTTA

Downstream 100 bases:

>100_bases
TTTGTAGATTATGAATGAAATTCATAATTTAGCTTAATATTTTTCAATGCCGTTATTGCAGATTTGCATTGTTCTTTGCA
ATTGTTTCATTTAGGATTCC

Product: 6-phosphogluconolactonase

Products: NA

Alternate protein names: 6PGL [H]

Number of amino acids: Translated: 232; Mature: 232

Protein sequence:

>232_residues
MNYITFQSAQQAVEKIAQEFVLYSQLNRSVHISLSGGSTPKLLFKTLAQAPFNSEIQWQNLHFWWGDDRMVLPTDPESNY
GEVQKLLFDHIQIPQQNIHRIRGEEPVEQELARFSQELTACVPDLAFDWIILGMGNDGHTASLFPHQTDFNDPNVAVIAK
HPESGQIRISKTAKLLEQAKRITYLVTGAAKAEILKEIRETEAEKLPYPVARIKARNGVTEWYLDREAAKLL

Sequences:

>Translated_232_residues
MNYITFQSAQQAVEKIAQEFVLYSQLNRSVHISLSGGSTPKLLFKTLAQAPFNSEIQWQNLHFWWGDDRMVLPTDPESNY
GEVQKLLFDHIQIPQQNIHRIRGEEPVEQELARFSQELTACVPDLAFDWIILGMGNDGHTASLFPHQTDFNDPNVAVIAK
HPESGQIRISKTAKLLEQAKRITYLVTGAAKAEILKEIRETEAEKLPYPVARIKARNGVTEWYLDREAAKLL
>Mature_232_residues
MNYITFQSAQQAVEKIAQEFVLYSQLNRSVHISLSGGSTPKLLFKTLAQAPFNSEIQWQNLHFWWGDDRMVLPTDPESNY
GEVQKLLFDHIQIPQQNIHRIRGEEPVEQELARFSQELTACVPDLAFDWIILGMGNDGHTASLFPHQTDFNDPNVAVIAK
HPESGQIRISKTAKLLEQAKRITYLVTGAAKAEILKEIRETEAEKLPYPVARIKARNGVTEWYLDREAAKLL

Specific function: Hydrolysis of 6-phosphogluconolactone to 6- phosphogluconate [H]

COG id: COG0363

COG function: function code G; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily [H]

Homologues:

Organism=Homo sapiens, GI52145310, Length=207, Percent_Identity=35.7487922705314, Blast_Score=132, Evalue=3e-31,
Organism=Homo sapiens, GI6912586, Length=211, Percent_Identity=32.7014218009479, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI115533058, Length=213, Percent_Identity=30.5164319248826, Blast_Score=86, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI115533060, Length=213, Percent_Identity=30.5164319248826, Blast_Score=86, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6321687, Length=233, Percent_Identity=31.3304721030043, Blast_Score=98, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6321957, Length=212, Percent_Identity=29.2452830188679, Blast_Score=91, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6324362, Length=215, Percent_Identity=29.3023255813954, Blast_Score=83, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6319918, Length=213, Percent_Identity=28.6384976525822, Blast_Score=80, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24641119, Length=246, Percent_Identity=28.8617886178862, Blast_Score=78, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005900
- InterPro:   IPR006148 [H]

Pfam domain/function: PF01182 Glucosamine_iso [H]

EC number: =3.1.1.31 [H]

Molecular weight: Translated: 26424; Mature: 26424

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNYITFQSAQQAVEKIAQEFVLYSQLNRSVHISLSGGSTPKLLFKTLAQAPFNSEIQWQN
CCEEEHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHCCCCCCCEEEEE
LHFWWGDDRMVLPTDPESNYGEVQKLLFDHIQIPQQNIHRIRGEEPVEQELARFSQELTA
EEEEECCCEEEECCCCCCCHHHHHHHHHHHHCCCHHHHHHCCCCCCHHHHHHHHHHHHHH
CVPDLAFDWIILGMGNDGHTASLFPHQTDFNDPNVAVIAKHPESGQIRISKTAKLLEQAK
HHHHHHEEEEEEEECCCCCEEEECCCCCCCCCCCEEEEEECCCCCCEEEHHHHHHHHHHH
RITYLVTGAAKAEILKEIRETEAEKLPYPVARIKARNGVTEWYLDREAAKLL
HHEEEEECHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCHHHHCCHHHHHCC
>Mature Secondary Structure
MNYITFQSAQQAVEKIAQEFVLYSQLNRSVHISLSGGSTPKLLFKTLAQAPFNSEIQWQN
CCEEEHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHCCCCCCCEEEEE
LHFWWGDDRMVLPTDPESNYGEVQKLLFDHIQIPQQNIHRIRGEEPVEQELARFSQELTA
EEEEECCCEEEECCCCCCCHHHHHHHHHHHHCCCHHHHHHCCCCCCHHHHHHHHHHHHHH
CVPDLAFDWIILGMGNDGHTASLFPHQTDFNDPNVAVIAKHPESGQIRISKTAKLLEQAK
HHHHHHEEEEEEEECCCCCEEEECCCCCCCCCCCEEEEEECCCCCCEEEHHHHHHHHHHH
RITYLVTGAAKAEILKEIRETEAEKLPYPVARIKARNGVTEWYLDREAAKLL
HHEEEEECHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCHHHHCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9020051 [H]