Click here to switch to the map view.

The map label for this gene is htrA [C]

Identifier: 126208759

GI number: 126208759

Start: 1482162

End: 1483556

Strand: Direct

Name: htrA [C]

Synonym: APL_1293

Alternate gene names: 126208759

Gene position: 1482162-1483556 (Clockwise)

Preceding gene: 126208751

Following gene: 126208762

Centisome position: 65.16

GC content: 43.23

Gene sequence:

>1395_bases
ATGAATAGAGTAATGAAAAAATCAATTTTAGCTTCATTATTATTAGGTCTAGGTTTATTTTCAACGCCGGCGACGACTTT
TGCCACTTTACCGATTGCCATTGACGGGCAAACAATGCCCAGCCTTGCGCCGATGATAGAAAAAGTACGTCCTGCGGTAG
TAAGTATTGCGGTTGAAGGGAAAACACAAGCGGGAAAAACCCAATATCGCCGTGATATTCCGGAAGAATTCGAATTTTTC
TTTGGACCGGATATGTTCGGTGAACGCAGTGCGCCACGTAATTTCCGAGGGCAAGGATCCGGCGCGATCATCAATGCCGA
AAAAGGTTATGTGATTACCAATAACCACGTAATCAAGGATGCGGATAAAATTACTATTAAACTTGAAGACGGTCGTGAAT
TTAAAGCGAAATTAGTCGGTGCGGATCCGTTATCCGACGTGGCATTAGTACAAATGGAAAACCCGAAAGATTTAATCGAA
TTAAAATTTGCCGACTCGGATAAATTGCGCGTCGGTGATTTTAGTGTAGCAATCGGCAATCCGTTCGGTTTAGGTCAAAC
CGTAACATCCGGTATTATCTCCGCATTAGGACGTTCGACCGGTAGTATCGACGAAGGTTATGAAAGCTATATTCAAACGG
ATGCTGCGGTAAACCAAGGTAACTCTGGCGGTCCGTTAATCAATTTAAACGGTGAATTAATCGGTATTAATACGGCGATT
ATCTCTCCGAGCGGTGGGAATGCGGGCATTGCTTTCGCAATTCCGAGTAATATGGCGAATAGCCTTGTACAACAAATTAT
CGAATTCGGTGAAGTGAAACGCGGTATGTTGGGTATTAAAGGCGGTGAATTAAATGCCGATCTTGCAAAAGAGTTTAATA
TCAGCGCACAACAAGGTGCATTTATCAGCGAAGTGTTTGCTGATTCGGCTGCAGCTAAAGCCGGCTTAAAAGCAGGCGAT
GTTATTACTGAAATTAACGGTCAAAAAATCCGTAGTTTCAGTGAATTACGTGCAAAAGTTGCAACGTCCGGCGTAGGTAA
AGAAATCGAGCTAACTTATTTACGTGACGGTAAAACGGAAAAAGCGAAAGTGACTTTACAAGCGGAACAAGGTAAAAGCG
TAAGCGCAACCACGAAGGACATTCTCCCCGGACTTAAAGGGGCGGAATTAACTAACTTCGATAAAGATCGCGTTAAAGGC
GTCGCGATTGCGAAAGTAGAAAAAGGCTCGTTAGCGGAACAACGCGGTTTGGCGGAAGGCGATGTGATTGTCGGGGTAAA
CCGCATTGCTGTAGAAAATCTTACGCAATTACGTCAAGTCTTAGATTCAAAACCGTCTGTCGTTGCCCTTAATATTTTAC
GTAACGGCGCAAACTTTTACTTAATTCTTCAATAA

Upstream 100 bases:

>100_bases
TTTTTAAAGGAACTGCCACCAAATTAAGTGGTCTGAGGAAACGCGAGTAACAATGCGAACTCGTTTTATTGTTGCACACA
ACTTAAAAGGATAAATATAA

Downstream 100 bases:

>100_bases
AAACGAAGCATAAAAAATCCCACCGTTGGTGGGATTTTTTATTTAAGCACTTGCACAAAATCTAGCGTTTCGTATTTAAA
TTTAAAACCTTCTTGCCGTA

Product: periplasmic serine protease do/hhoA-like precursor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 464; Mature: 464

Protein sequence:

>464_residues
MNRVMKKSILASLLLGLGLFSTPATTFATLPIAIDGQTMPSLAPMIEKVRPAVVSIAVEGKTQAGKTQYRRDIPEEFEFF
FGPDMFGERSAPRNFRGQGSGAIINAEKGYVITNNHVIKDADKITIKLEDGREFKAKLVGADPLSDVALVQMENPKDLIE
LKFADSDKLRVGDFSVAIGNPFGLGQTVTSGIISALGRSTGSIDEGYESYIQTDAAVNQGNSGGPLINLNGELIGINTAI
ISPSGGNAGIAFAIPSNMANSLVQQIIEFGEVKRGMLGIKGGELNADLAKEFNISAQQGAFISEVFADSAAAKAGLKAGD
VITEINGQKIRSFSELRAKVATSGVGKEIELTYLRDGKTEKAKVTLQAEQGKSVSATTKDILPGLKGAELTNFDKDRVKG
VAIAKVEKGSLAEQRGLAEGDVIVGVNRIAVENLTQLRQVLDSKPSVVALNILRNGANFYLILQ

Sequences:

>Translated_464_residues
MNRVMKKSILASLLLGLGLFSTPATTFATLPIAIDGQTMPSLAPMIEKVRPAVVSIAVEGKTQAGKTQYRRDIPEEFEFF
FGPDMFGERSAPRNFRGQGSGAIINAEKGYVITNNHVIKDADKITIKLEDGREFKAKLVGADPLSDVALVQMENPKDLIE
LKFADSDKLRVGDFSVAIGNPFGLGQTVTSGIISALGRSTGSIDEGYESYIQTDAAVNQGNSGGPLINLNGELIGINTAI
ISPSGGNAGIAFAIPSNMANSLVQQIIEFGEVKRGMLGIKGGELNADLAKEFNISAQQGAFISEVFADSAAAKAGLKAGD
VITEINGQKIRSFSELRAKVATSGVGKEIELTYLRDGKTEKAKVTLQAEQGKSVSATTKDILPGLKGAELTNFDKDRVKG
VAIAKVEKGSLAEQRGLAEGDVIVGVNRIAVENLTQLRQVLDSKPSVVALNILRNGANFYLILQ
>Mature_464_residues
MNRVMKKSILASLLLGLGLFSTPATTFATLPIAIDGQTMPSLAPMIEKVRPAVVSIAVEGKTQAGKTQYRRDIPEEFEFF
FGPDMFGERSAPRNFRGQGSGAIINAEKGYVITNNHVIKDADKITIKLEDGREFKAKLVGADPLSDVALVQMENPKDLIE
LKFADSDKLRVGDFSVAIGNPFGLGQTVTSGIISALGRSTGSIDEGYESYIQTDAAVNQGNSGGPLINLNGELIGINTAI
ISPSGGNAGIAFAIPSNMANSLVQQIIEFGEVKRGMLGIKGGELNADLAKEFNISAQQGAFISEVFADSAAAKAGLKAGD
VITEINGQKIRSFSELRAKVATSGVGKEIELTYLRDGKTEKAKVTLQAEQGKSVSATTKDILPGLKGAELTNFDKDRVKG
VAIAKVEKGSLAEQRGLAEGDVIVGVNRIAVENLTQLRQVLDSKPSVVALNILRNGANFYLILQ

Specific function: Protease With A Shared Specificity With Degp. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=310, Percent_Identity=36.1290322580645, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI22129776, Length=345, Percent_Identity=33.6231884057971, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI24308541, Length=310, Percent_Identity=30.9677419354839, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI7019477, Length=262, Percent_Identity=34.7328244274809, Blast_Score=140, Evalue=3e-33,
Organism=Escherichia coli, GI1789629, Length=465, Percent_Identity=54.6236559139785, Blast_Score=470, Evalue=1e-134,
Organism=Escherichia coli, GI1786356, Length=461, Percent_Identity=53.3622559652928, Blast_Score=465, Evalue=1e-132,
Organism=Escherichia coli, GI1789630, Length=276, Percent_Identity=40.9420289855072, Blast_Score=187, Evalue=1e-48,
Organism=Drosophila melanogaster, GI24646839, Length=312, Percent_Identity=31.4102564102564, Blast_Score=135, Evalue=6e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.-

Molecular weight: Translated: 49200; Mature: 49200

Theoretical pI: Translated: 6.21; Mature: 6.21

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRVMKKSILASLLLGLGLFSTPATTFATLPIAIDGQTMPSLAPMIEKVRPAVVSIAVEG
CCHHHHHHHHHHHHHHCCCCCCCCHHEEEEEEEECCCCCCHHHHHHHHHCCEEEEEEECC
KTQAGKTQYRRDIPEEFEFFFGPDMFGERSAPRNFRGQGSGAIINAEKGYVITNNHVIKD
CCCCCCHHHHHCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEECCCCEEEECCEEEEC
ADKITIKLEDGREFKAKLVGADPLSDVALVQMENPKDLIELKFADSDKLRVGDFSVAIGN
CCEEEEEEECCCCEEEEEECCCCCCCEEEEEECCCCCEEEEEECCCCCEEECEEEEEECC
PFGLGQTVTSGIISALGRSTGSIDEGYESYIQTDAAVNQGNSGGPLINLNGELIGINTAI
CCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEECCEEEEEEEEE
ISPSGGNAGIAFAIPSNMANSLVQQIIEFGEVKRGMLGIKGGELNADLAKEFNISAQQGA
EECCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHCCEECCCCCCCHHHHHHCCCCHHCCC
FISEVFADSAAAKAGLKAGDVITEINGQKIRSFSELRAKVATSGVGKEIELTYLRDGKTE
HHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCC
KAKVTLQAEQGKSVSATTKDILPGLKGAELTNFDKDRVKGVAIAKVEKGSLAEQRGLAEG
EEEEEEEECCCCCCCCCHHHHCCCCCCCCCCCCCHHHHCEEEEEEECCCCCHHHCCCCCC
DVIVGVNRIAVENLTQLRQVLDSKPSVVALNILRNGANFYLILQ
CEEEEEHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCEEEEEC
>Mature Secondary Structure
MNRVMKKSILASLLLGLGLFSTPATTFATLPIAIDGQTMPSLAPMIEKVRPAVVSIAVEG
CCHHHHHHHHHHHHHHCCCCCCCCHHEEEEEEEECCCCCCHHHHHHHHHCCEEEEEEECC
KTQAGKTQYRRDIPEEFEFFFGPDMFGERSAPRNFRGQGSGAIINAEKGYVITNNHVIKD
CCCCCCHHHHHCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEECCCCEEEECCEEEEC
ADKITIKLEDGREFKAKLVGADPLSDVALVQMENPKDLIELKFADSDKLRVGDFSVAIGN
CCEEEEEEECCCCEEEEEECCCCCCCEEEEEECCCCCEEEEEECCCCCEEECEEEEEECC
PFGLGQTVTSGIISALGRSTGSIDEGYESYIQTDAAVNQGNSGGPLINLNGELIGINTAI
CCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEECCEEEEEEEEE
ISPSGGNAGIAFAIPSNMANSLVQQIIEFGEVKRGMLGIKGGELNADLAKEFNISAQQGA
EECCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHCCEECCCCCCCHHHHHHCCCCHHCCC
FISEVFADSAAAKAGLKAGDVITEINGQKIRSFSELRAKVATSGVGKEIELTYLRDGKTE
HHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCC
KAKVTLQAEQGKSVSATTKDILPGLKGAELTNFDKDRVKGVAIAKVEKGSLAEQRGLAEG
EEEEEEEECCCCCCCCCHHHHCCCCCCCCCCCCCHHHHCEEEEEEECCCCCHHHCCCCCC
DVIVGVNRIAVENLTQLRQVLDSKPSVVALNILRNGANFYLILQ
CEEEEEHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]