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The map label for this gene is purP [H]

Identifier: 126208691

GI number: 126208691

Start: 1405767

End: 1407062

Strand: Direct

Name: purP [H]

Synonym: APL_1223

Alternate gene names: 126208691

Gene position: 1405767-1407062 (Clockwise)

Preceding gene: 126208690

Following gene: 126208692

Centisome position: 61.81

GC content: 45.91

Gene sequence:

>1296_bases
ATGTTAGAACGTTTGTTCCAATTATCCGAAAAAGGCTCGAATGCCAAAACGGAAATCGTGGCGGGGATTACCACCTTCTT
CACCATGGTTTATATCGTATTCGTCAATCCGTCTATTCTCGGTGTTGCCGGTATGGATACCCAAGTGGTTTTCGTCACCA
CCTGTTTAATCGCCGCATTCGGTACGATTGCGATGGGCTTATTCAGTAACCTTCCTATCGCGCTTGCACCGGCAATGGGT
TTAAATGCGTTTTTCGCCTTTGTGGTAGTACAAAAATTAGGTTACTCATGGCAAGTAGGGATGGGTGCAATTTTCTTAGG
CTCGGTCGGCTTATTCTTATTAACCGTTTTCCAAATTCGTTATTGGTTTATGTCGGCGATTCCGCTCGGTTTACGTGTCG
GTATCGGTGCGGGTATCGGCTTATTTATCGCCCTGATCGGCTTTAAAAATATGGGCTTAGTGGTAGCGAACTCGGCAACC
TTAGTCGCATTGGGCGATCTACACGATCCGAAAGTATTAATGGGTATCTTAGGCTTCTTTATTATTGTCGTTTTAGCGGC
TAAGAGCTTCCATTCGGGTGTATTAATCTCTATTGCGGTTATCACTACCTTAGCCTTAATCTTCGATCCGGCGGTAAGTT
TTAACGGCGTAATGTCGATGCCGCCGAGTTTAGATGCGGTCGTCGGTCAAGTAGATATCGCCGGTGCGCTAGACGTCGGC
TTACTCGGTATTATTTTCTCCTTTATGCTAGTAAACTTATTTGACTCGTCAGGCACATTAATTGCGGTAACTACCAAAGC
CGGTTTTGCCGATAAACAAGGTCGTTTCCCACGTATGAAACAAGCTTTATTAGTGGACAGTACCGCAGCAATGGCGGGTT
CGTTTATGGGAACTTCGGCAATCAGTACTTATATTGAAAGCGGCTCGGGCGTATCGGTCGGCGGTCGTACCGGTTTGACC
GCAGTTACCGTAGGTATCTTATTCCTATTGACTATTTTCTTCTCGCCGCTTGCAGGCGTAGTTCCGGCTTATGCAACCGC
CGGTGCATTAGTCTTCGTCGGGATTTTAATGGCTTCAAGTTTAATTGAAGTGAAATGGGACGACTTAACTGAAGCGACTC
CGGCGTTTATCACCACCGCAATGATGCCGTTTACTTATTCAATTACCGAAGGTATCGCATTCGGCTTTATTTCATATTGC
GTGATGAAGGCCTGTACCGGTCGCTGGAAAGAAATCAATCCGTCGGTAGCGGTAGTTTCTTTACTGTTTATCGCAAAATT
CGTTTGGGTTGGCTAA

Upstream 100 bases:

>100_bases
TTTAGCGGTTCAACTGCTCAACTTAGTGTTGGAATATTAACTTTATCCGCTGCGGAACGTAAAATCGTTCCGTAGTTTCT
TTCTTTTACCTGAGGTTTTT

Downstream 100 bases:

>100_bases
TCTCATCTCACTTAATTCGGAATAGACGAACAGCACGGCATTTTGTAAAAATTTAACAAAATCAAACCGCTTGTCTAGTT
CGTGTATTCCGTATTTTTAA

Product: putative inner membrane protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 431; Mature: 431

Protein sequence:

>431_residues
MLERLFQLSEKGSNAKTEIVAGITTFFTMVYIVFVNPSILGVAGMDTQVVFVTTCLIAAFGTIAMGLFSNLPIALAPAMG
LNAFFAFVVVQKLGYSWQVGMGAIFLGSVGLFLLTVFQIRYWFMSAIPLGLRVGIGAGIGLFIALIGFKNMGLVVANSAT
LVALGDLHDPKVLMGILGFFIIVVLAAKSFHSGVLISIAVITTLALIFDPAVSFNGVMSMPPSLDAVVGQVDIAGALDVG
LLGIIFSFMLVNLFDSSGTLIAVTTKAGFADKQGRFPRMKQALLVDSTAAMAGSFMGTSAISTYIESGSGVSVGGRTGLT
AVTVGILFLLTIFFSPLAGVVPAYATAGALVFVGILMASSLIEVKWDDLTEATPAFITTAMMPFTYSITEGIAFGFISYC
VMKACTGRWKEINPSVAVVSLLFIAKFVWVG

Sequences:

>Translated_431_residues
MLERLFQLSEKGSNAKTEIVAGITTFFTMVYIVFVNPSILGVAGMDTQVVFVTTCLIAAFGTIAMGLFSNLPIALAPAMG
LNAFFAFVVVQKLGYSWQVGMGAIFLGSVGLFLLTVFQIRYWFMSAIPLGLRVGIGAGIGLFIALIGFKNMGLVVANSAT
LVALGDLHDPKVLMGILGFFIIVVLAAKSFHSGVLISIAVITTLALIFDPAVSFNGVMSMPPSLDAVVGQVDIAGALDVG
LLGIIFSFMLVNLFDSSGTLIAVTTKAGFADKQGRFPRMKQALLVDSTAAMAGSFMGTSAISTYIESGSGVSVGGRTGLT
AVTVGILFLLTIFFSPLAGVVPAYATAGALVFVGILMASSLIEVKWDDLTEATPAFITTAMMPFTYSITEGIAFGFISYC
VMKACTGRWKEINPSVAVVSLLFIAKFVWVG
>Mature_431_residues
MLERLFQLSEKGSNAKTEIVAGITTFFTMVYIVFVNPSILGVAGMDTQVVFVTTCLIAAFGTIAMGLFSNLPIALAPAMG
LNAFFAFVVVQKLGYSWQVGMGAIFLGSVGLFLLTVFQIRYWFMSAIPLGLRVGIGAGIGLFIALIGFKNMGLVVANSAT
LVALGDLHDPKVLMGILGFFIIVVLAAKSFHSGVLISIAVITTLALIFDPAVSFNGVMSMPPSLDAVVGQVDIAGALDVG
LLGIIFSFMLVNLFDSSGTLIAVTTKAGFADKQGRFPRMKQALLVDSTAAMAGSFMGTSAISTYIESGSGVSVGGRTGLT
AVTVGILFLLTIFFSPLAGVVPAYATAGALVFVGILMASSLIEVKWDDLTEATPAFITTAMMPFTYSITEGIAFGFISYC
VMKACTGRWKEINPSVAVVSLLFIAKFVWVG

Specific function: High-affinity uptake of adenine [H]

COG id: COG2252

COG function: function code R; Permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. AzgA purine transporter (TC 2.A.1.40) subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790150, Length=430, Percent_Identity=66.5116279069767, Blast_Score=568, Evalue=1e-163,
Organism=Escherichia coli, GI87082309, Length=429, Percent_Identity=65.2680652680653, Blast_Score=568, Evalue=1e-163,
Organism=Escherichia coli, GI1790499, Length=429, Percent_Identity=38.9277389277389, Blast_Score=288, Evalue=3e-79,
Organism=Escherichia coli, GI48994909, Length=431, Percent_Identity=37.122969837587, Blast_Score=260, Evalue=1e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 45246; Mature: 45246

Theoretical pI: Translated: 7.33; Mature: 7.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLERLFQLSEKGSNAKTEIVAGITTFFTMVYIVFVNPSILGVAGMDTQVVFVTTCLIAAF
CHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHH
GTIAMGLFSNLPIALAPAMGLNAFFAFVVVQKLGYSWQVGMGAIFLGSVGLFLLTVFQIR
HHHHHHHHHCCCEEEECHHHHHHHHHHHHHHHCCCCEECCCHHHHHHHHHHHHHHHHHHH
YWFMSAIPLGLRVGIGAGIGLFIALIGFKNMGLVVANSATLVALGDLHDPKVLMGILGFF
HHHHHHCCHHHEECCCCHHHHHHHHHHCCCCCEEEECCCEEEEECCCCCHHHHHHHHHHH
IIVVLAAKSFHSGVLISIAVITTLALIFDPAVSFNGVMSMPPSLDAVVGQVDIAGALDVG
HHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHCCHHCCHHHHHH
LLGIIFSFMLVNLFDSSGTLIAVTTKAGFADKQGRFPRMKQALLVDSTAAMAGSFMGTSA
HHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
ISTYIESGSGVSVGGRTGLTAVTVGILFLLTIFFSPLAGVVPAYATAGALVFVGILMASS
HHHHHHCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIEVKWDDLTEATPAFITTAMMPFTYSITEGIAFGFISYCVMKACTGRWKEINPSVAVVS
HHEEECCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
LLFIAKFVWVG
HHHHHHHHHCC
>Mature Secondary Structure
MLERLFQLSEKGSNAKTEIVAGITTFFTMVYIVFVNPSILGVAGMDTQVVFVTTCLIAAF
CHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHH
GTIAMGLFSNLPIALAPAMGLNAFFAFVVVQKLGYSWQVGMGAIFLGSVGLFLLTVFQIR
HHHHHHHHHCCCEEEECHHHHHHHHHHHHHHHCCCCEECCCHHHHHHHHHHHHHHHHHHH
YWFMSAIPLGLRVGIGAGIGLFIALIGFKNMGLVVANSATLVALGDLHDPKVLMGILGFF
HHHHHHCCHHHEECCCCHHHHHHHHHHCCCCCEEEECCCEEEEECCCCCHHHHHHHHHHH
IIVVLAAKSFHSGVLISIAVITTLALIFDPAVSFNGVMSMPPSLDAVVGQVDIAGALDVG
HHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHCCHHCCHHHHHH
LLGIIFSFMLVNLFDSSGTLIAVTTKAGFADKQGRFPRMKQALLVDSTAAMAGSFMGTSA
HHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
ISTYIESGSGVSVGGRTGLTAVTVGILFLLTIFFSPLAGVVPAYATAGALVFVGILMASS
HHHHHHCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIEVKWDDLTEATPAFITTAMMPFTYSITEGIAFGFISYCVMKACTGRWKEINPSVAVVS
HHEEECCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
LLFIAKFVWVG
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7686882; 9278503 [H]