Click here to switch to the map view.

The map label for this gene is fur [H]

Identifier: 126208686

GI number: 126208686

Start: 1402628

End: 1403077

Strand: Reverse

Name: fur [H]

Synonym: APL_1218

Alternate gene names: 126208686

Gene position: 1403077-1402628 (Counterclockwise)

Preceding gene: 126208687

Following gene: 126208685

Centisome position: 61.69

GC content: 38.44

Gene sequence:

>450_bases
ATGTCTGAAGAAAATGCAAAACTTCTTAAAAGTGTAGGTTTGAAAGTTACTGAGCCTCGTTTGACCATCCTTGCGTTAAT
GCAGCAACATCGCGAACAAATGCAACATTTTTCTGCCGAGGATATTTATAAAATTTTATTAGAGCATGGTTCCGATATCG
GTTTGGCAACGGTTTACCGCGTATTAAACCAATTTGAAGAGGTCGGTATTTTACTTCGCCATAACTTTGATGCGAATAAA
GCGGTATTCGAGCTTAACGTAGAGCAAGAACACGATCATATTATCTGTATGGATTGCGGTAAGGTATTCGAGTTTAAAGA
TCCGGATATCGAACGCCGTCAGCGTGAAATCAGCGAACAGCACGGTATGAAATTAGCGACGCACAGTTTATATCTCTATG
CGAAATGTAGCGATATTTCACATTGTGATTCTTCAAAAGATAAAAAATAA

Upstream 100 bases:

>100_bases
TTAACCGGTGAACGTGTAAACCGTTGGTGTAAACAGATCTTTGATGAGATGTGCTTAGATCAGTTAGCATAATGAATATA
AGAGAGAAGGGTAACAAGTT

Downstream 100 bases:

>100_bases
TTTATCTTATCGTTCAGTATAAAGCAGACATATACCGAAGGTTTTGCAGGCCTTCGGTTTTGTGTTATCTAAAGGATATG
AAATTAAGCGGTTGTTTTGT

Product: ferric uptake regulation protein

Products: NA

Alternate protein names: Ferric uptake regulator [H]

Number of amino acids: Translated: 149; Mature: 148

Protein sequence:

>149_residues
MSEENAKLLKSVGLKVTEPRLTILALMQQHREQMQHFSAEDIYKILLEHGSDIGLATVYRVLNQFEEVGILLRHNFDANK
AVFELNVEQEHDHIICMDCGKVFEFKDPDIERRQREISEQHGMKLATHSLYLYAKCSDISHCDSSKDKK

Sequences:

>Translated_149_residues
MSEENAKLLKSVGLKVTEPRLTILALMQQHREQMQHFSAEDIYKILLEHGSDIGLATVYRVLNQFEEVGILLRHNFDANK
AVFELNVEQEHDHIICMDCGKVFEFKDPDIERRQREISEQHGMKLATHSLYLYAKCSDISHCDSSKDKK
>Mature_148_residues
SEENAKLLKSVGLKVTEPRLTILALMQQHREQMQHFSAEDIYKILLEHGSDIGLATVYRVLNQFEEVGILLRHNFDANKA
VFELNVEQEHDHIICMDCGKVFEFKDPDIERRQREISEQHGMKLATHSLYLYAKCSDISHCDSSKDKK

Specific function: Acts as a global negative controlling element, employing Fe(2+) as a cofactor to bind the operator of the repressed genes [H]

COG id: COG0735

COG function: function code P; Fe2+/Zn2+ uptake regulation proteins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Fur family [H]

Homologues:

Organism=Escherichia coli, GI1786899, Length=135, Percent_Identity=57.037037037037, Blast_Score=164, Evalue=2e-42,

Paralogues:

None

Copy number: 3432 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002481 [H]

Pfam domain/function: PF01475 FUR [H]

EC number: NA

Molecular weight: Translated: 17287; Mature: 17156

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEENAKLLKSVGLKVTEPRLTILALMQQHREQMQHFSAEDIYKILLEHGSDIGLATVYR
CCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCHHHHHH
VLNQFEEVGILLRHNFDANKAVFELNVEQEHDHIICMDCGKVFEFKDPDIERRQREISEQ
HHHHHHHHCHHHCCCCCCCCEEEEEECCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHH
HGMKLATHSLYLYAKCSDISHCDSSKDKK
CCCEEEHHEEEEEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
SEENAKLLKSVGLKVTEPRLTILALMQQHREQMQHFSAEDIYKILLEHGSDIGLATVYR
CCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCHHHHHH
VLNQFEEVGILLRHNFDANKAVFELNVEQEHDHIICMDCGKVFEFKDPDIERRQREISEQ
HHHHHHHHCHHHCCCCCCCCEEEEEECCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHH
HGMKLATHSLYLYAKCSDISHCDSSKDKK
CCCEEEHHEEEEEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8918243 [H]