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The map label for this gene is purM

Identifier: 126208567

GI number: 126208567

Start: 1266330

End: 1267367

Strand: Reverse

Name: purM

Synonym: APL_1095

Alternate gene names: 126208567

Gene position: 1267367-1266330 (Counterclockwise)

Preceding gene: 126208572

Following gene: 126208565

Centisome position: 55.72

GC content: 45.57

Gene sequence:

>1038_bases
GTGAGCAATACACAACTTAGTTATAAAGACGCCGGCGTAGATATTCATGCCGGTAACGAATTAGTAGAACGTATTAAAGG
CGATGTGAAACGTACTCGCCGTCCGGAAGTTATGGGCGGTTTAGGCGGTTTCGGAGCGTTATGCGCACTACCGACTAAAT
ATAAAGAACCTATTTTAGTATCGGGTACTGACGGTGTCGGTACGAAATTACGTTTAGCGATTGACCTCAACAAACACGAC
ACTATCGGTCAAGATTTAGTGGCGATGTGCGTAAACGATTTAGTGGTTCAAGGTGCGGAGCCGCTATTCTTCTTAGATTA
CTATGCGACTGGTAAATTAGAAGTGGACGTTGCGGCGGATGTAATCAAAGGTATTGCGGACGGTTGCGAAATTTCAGGCT
GTGCGTTAGTCGGCGGAGAAACGGCGGAAATGCCGGGTATGTATCACGAAGGTGACTACGACTTAGCCGGCTTCTGCGTA
GGCGTAGTAGAAAAATCCGAAATTATCGACGGTTCCGCAGTAAAAGCGGGGGACGTATTACTTGCATTGGCTTCAAGCGG
CCCTCACTCAAACGGTTACTCATTAATTCGTAAAGTGATTGAAGTAAGCGGTGCAAATCCGGCAACCGATACATTAGAAG
GTAAACCGTTAAGCGAGCATTTACTCGCACCGACCAAAATCTATGTAAAATCGGTACTTCAACTGATTAAACAAGCGGAT
GTGCACGCTATCGCTCACTTAACCGGCGGCGGTTTCTGGGAAAATATTCCACGCGTACTTCCAGCGACTGCAAAAGCGGT
CATCGATGAAAAATCATGGGAATGGCCGGCGGCATTCAAATGGTTACAAGAAAAAGGTAACATCAGTCGTTATGAAATGT
ATCGTACCTTTAACTGCGGTGTCGGTATGGTTATCGCATTACCGGAAAAAGACATTGAAACCGCATTAGCCGTATTAAAA
CAAGCAGGCGAAAACGCTTGGGTAATCGGTAAAATTGAAAACCTAGGTGAAGGTTCGGAACAAGTTGAAATCATCTAG

Upstream 100 bases:

>100_bases
ATGAATTTTTTATCCGTATAATTTTATGTTACCTTATTCACGCAAACGATTGCATTGTGTTATAATAAGTTGCATTTTCT
TATTTTTGTTGAGGTTATCT

Downstream 100 bases:

>100_bases
TTTGTAAAAACATTCAGAAATCGGACCGCTTGTAGCTCACTACAAGCGGTTTTTTAGATATGATGATTTAATTTATATTT
GTGTAGCCAATCAATAAATT

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase

Number of amino acids: Translated: 345; Mature: 344

Protein sequence:

>345_residues
MSNTQLSYKDAGVDIHAGNELVERIKGDVKRTRRPEVMGGLGGFGALCALPTKYKEPILVSGTDGVGTKLRLAIDLNKHD
TIGQDLVAMCVNDLVVQGAEPLFFLDYYATGKLEVDVAADVIKGIADGCEISGCALVGGETAEMPGMYHEGDYDLAGFCV
GVVEKSEIIDGSAVKAGDVLLALASSGPHSNGYSLIRKVIEVSGANPATDTLEGKPLSEHLLAPTKIYVKSVLQLIKQAD
VHAIAHLTGGGFWENIPRVLPATAKAVIDEKSWEWPAAFKWLQEKGNISRYEMYRTFNCGVGMVIALPEKDIETALAVLK
QAGENAWVIGKIENLGEGSEQVEII

Sequences:

>Translated_345_residues
MSNTQLSYKDAGVDIHAGNELVERIKGDVKRTRRPEVMGGLGGFGALCALPTKYKEPILVSGTDGVGTKLRLAIDLNKHD
TIGQDLVAMCVNDLVVQGAEPLFFLDYYATGKLEVDVAADVIKGIADGCEISGCALVGGETAEMPGMYHEGDYDLAGFCV
GVVEKSEIIDGSAVKAGDVLLALASSGPHSNGYSLIRKVIEVSGANPATDTLEGKPLSEHLLAPTKIYVKSVLQLIKQAD
VHAIAHLTGGGFWENIPRVLPATAKAVIDEKSWEWPAAFKWLQEKGNISRYEMYRTFNCGVGMVIALPEKDIETALAVLK
QAGENAWVIGKIENLGEGSEQVEII
>Mature_344_residues
SNTQLSYKDAGVDIHAGNELVERIKGDVKRTRRPEVMGGLGGFGALCALPTKYKEPILVSGTDGVGTKLRLAIDLNKHDT
IGQDLVAMCVNDLVVQGAEPLFFLDYYATGKLEVDVAADVIKGIADGCEISGCALVGGETAEMPGMYHEGDYDLAGFCVG
VVEKSEIIDGSAVKAGDVLLALASSGPHSNGYSLIRKVIEVSGANPATDTLEGKPLSEHLLAPTKIYVKSVLQLIKQADV
HAIAHLTGGGFWENIPRVLPATAKAVIDEKSWEWPAAFKWLQEKGNISRYEMYRTFNCGVGMVIALPEKDIETALAVLKQ
AGENAWVIGKIENLGEGSEQVEII

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family

Homologues:

Organism=Homo sapiens, GI4503915, Length=344, Percent_Identity=50.5813953488372, Blast_Score=343, Evalue=2e-94,
Organism=Homo sapiens, GI209869995, Length=344, Percent_Identity=50.5813953488372, Blast_Score=343, Evalue=2e-94,
Organism=Homo sapiens, GI209869993, Length=344, Percent_Identity=50.5813953488372, Blast_Score=343, Evalue=2e-94,
Organism=Escherichia coli, GI1788845, Length=342, Percent_Identity=75.7309941520468, Blast_Score=537, Evalue=1e-154,
Organism=Caenorhabditis elegans, GI17567511, Length=342, Percent_Identity=42.1052631578947, Blast_Score=245, Evalue=2e-65,
Organism=Saccharomyces cerevisiae, GI6321203, Length=339, Percent_Identity=48.377581120944, Blast_Score=312, Evalue=6e-86,
Organism=Drosophila melanogaster, GI24582400, Length=294, Percent_Identity=41.8367346938776, Blast_Score=232, Evalue=3e-61,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PUR5_ACTP2 (A3N1A1)

Other databases:

- EMBL:   CP000569
- RefSeq:   YP_001053792.1
- ProteinModelPortal:   A3N1A1
- SMR:   A3N1A1
- STRING:   A3N1A1
- GeneID:   4850427
- GenomeReviews:   CP000569_GR
- KEGG:   apl:APL_1095
- eggNOG:   COG0150
- HOGENOM:   HBG531222
- OMA:   GIDMIAM
- PhylomeDB:   A3N1A1
- ProtClustDB:   PRK05385
- BioCyc:   APLE416269:APL_1095-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00741_B
- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188
- TIGRFAMs:   TIGR00878

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C; SSF56042 AIR_synth_C; SSF55326 PurM_N-like

EC number: =6.3.3.1

Molecular weight: Translated: 36868; Mature: 36736

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNTQLSYKDAGVDIHAGNELVERIKGDVKRTRRPEVMGGLGGFGALCALPTKYKEPILV
CCCCCCEECCCCEEEECCHHHHHHHHHHHHHCCCCHHHCCCCCHHHHHCCCCCCCCCEEE
SGTDGVGTKLRLAIDLNKHDTIGQDLVAMCVNDLVVQGAEPLFFLDYYATGKLEVDVAAD
ECCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEEECCEEEEHHHHH
VIKGIADGCEISGCALVGGETAEMPGMYHEGDYDLAGFCVGVVEKSEIIDGSAVKAGDVL
HHHHHHCCCCCCCEEEECCCCHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCEE
LALASSGPHSNGYSLIRKVIEVSGANPATDTLEGKPLSEHLLAPTKIYVKSVLQLIKQAD
EEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHCC
VHAIAHLTGGGFWENIPRVLPATAKAVIDEKSWEWPAAFKWLQEKGNISRYEMYRTFNCG
HHEEEEECCCCHHHHHHHHCCHHHHHHHCCCCCCCHHHHHHHHHCCCCCCEEEEEEECCC
VGMVIALPEKDIETALAVLKQAGENAWVIGKIENLGEGSEQVEII
CEEEEEECCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCEEEEC
>Mature Secondary Structure 
SNTQLSYKDAGVDIHAGNELVERIKGDVKRTRRPEVMGGLGGFGALCALPTKYKEPILV
CCCCCEECCCCEEEECCHHHHHHHHHHHHHCCCCHHHCCCCCHHHHHCCCCCCCCCEEE
SGTDGVGTKLRLAIDLNKHDTIGQDLVAMCVNDLVVQGAEPLFFLDYYATGKLEVDVAAD
ECCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEEECCEEEEHHHHH
VIKGIADGCEISGCALVGGETAEMPGMYHEGDYDLAGFCVGVVEKSEIIDGSAVKAGDVL
HHHHHHCCCCCCCEEEECCCCHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCEE
LALASSGPHSNGYSLIRKVIEVSGANPATDTLEGKPLSEHLLAPTKIYVKSVLQLIKQAD
EEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHCC
VHAIAHLTGGGFWENIPRVLPATAKAVIDEKSWEWPAAFKWLQEKGNISRYEMYRTFNCG
HHEEEEECCCCHHHHHHHHCCHHHHHHHCCCCCCCHHHHHHHHHCCCCCCEEEEEEECCC
VGMVIALPEKDIETALAVLKQAGENAWVIGKIENLGEGSEQVEII
CEEEEEECCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA