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The map label for this gene is fabB [H]

Identifier: 126208527

GI number: 126208527

Start: 1227296

End: 1228516

Strand: Direct

Name: fabB [H]

Synonym: APL_1055

Alternate gene names: 126208527

Gene position: 1227296-1228516 (Clockwise)

Preceding gene: 126208520

Following gene: 126208528

Centisome position: 53.96

GC content: 47.17

Gene sequence:

>1221_bases
ATGAAAAGAGTCGTTATCACTGGTTTAGGCGTTATTTCTAGTATCGGTAACAATAAAGAAGAAGTTTTAGCTTCATTAAA
AGAAGGTAAATCAGGTATTGAATTCGTTCCTGAATTTGCTGAAGTCGGTATGCGCAGCCAAGTTGCCGGCACAATTAAGT
TAAATCCGGCGGAATTAATTGACCGTAAAGTCTATCGTTTTATGGGGGATGCCGCCGCTTACGCTTATCTTTCAATGAAA
GAAGCTATCGAAGATTCAGGTTTAACCGAAGATCAAGTATCAAACGATCGTACCGGTTTGGTTATCGGTGCGGGTACCGG
TTCGGCACACAGCCAATTAGTAGCTTGTGATGCGGTACGCGGCCCGCGCGGCGTGAAAGCGGTCGGCCCTTATGCGGTAA
CTAAAACGATGGCGTCAAGCGTATCGGCATGTTTAGCGACTCCGTATAAAATCCGCGGCGTAAACTACTCAATCAGCTCG
GCATGTGCGACTTCCGCTCACTGTATCGGCCATGCAATGGAATTAATCCAATTAGGTAAACAAGACGTAGTATTTGCCGG
CGGTGCGGAAGAACTTTCCTGGGAATGCGCAACCGAATTCGATGCGATGGGTGCGGTTTCAACCAAATATAACGATAACC
CGACTAAAGCAAGCCGTGCTTACGACGCAAACCGTGACGGTTTCGTTATCGCAGGCGGCGGTGCGGTGGTTGTCGTTGAA
GAATTAGAACACGCTCTTGCGCGCGGTGCGAAAATCTATGCGGAAATCGTAGGTTACGGTGCGACTTCTGACGGTTATGA
TATGGTTGCGCCAAGCGGTGAAGGTGCGGAACGTTGTATGAAACAAGCGTTAGCAACGGTAAACGGCGAAGTGGAATACA
TTAACGTACACGGTACTTCTACACCGGTCGGCGATGTAAAAGAATTAGGTGCAATTAAAAACGTATTCGGTGATAAGAGC
CCGGCGATTTCATCGACCAAATCAATGACAGGTCACTCTTTAGGGGCTGCAGGCGCACACGAAGCAATCTACTCGTTATT
AATGTTAGAGAACGGCTTTATCGCTCCAAGCATTAACATCGAAACCTTAGACGAACAAGCGGAAGGCTTAAATATCGTGA
CCGAGCGTCAAGACAAAGCACTTACAACTGTAATGTCAAACAGCTTCGGCTTCGGCGGTACGAACGCTTGCTTAGTATTC
CAAAAATACAACGGCCAATAG

Upstream 100 bases:

>100_bases
TAAAATCATGTAAAATACATAAGTTTTAGTAGCTTACTTTAGCGAACAAGTGTAAGCTGAATCTAATATCTTACGAAATC
AATCTGATGAAGGAAACAAA

Downstream 100 bases:

>100_bases
ACAACCATATAAAGTAAAAAAAGTGCGTTTAATACGCACTTTTTTAATATCCTAAGCGGTCGGATTTTTCTCCTTTTTTG
CAAGAAATATAAAAAATTAA

Product: 3-oxoacyl-(acyl carrier protein) synthase I

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase I; Beta-ketoacyl-ACP synthase I; KAS I [H]

Number of amino acids: Translated: 406; Mature: 406

Protein sequence:

>406_residues
MKRVVITGLGVISSIGNNKEEVLASLKEGKSGIEFVPEFAEVGMRSQVAGTIKLNPAELIDRKVYRFMGDAAAYAYLSMK
EAIEDSGLTEDQVSNDRTGLVIGAGTGSAHSQLVACDAVRGPRGVKAVGPYAVTKTMASSVSACLATPYKIRGVNYSISS
ACATSAHCIGHAMELIQLGKQDVVFAGGAEELSWECATEFDAMGAVSTKYNDNPTKASRAYDANRDGFVIAGGGAVVVVE
ELEHALARGAKIYAEIVGYGATSDGYDMVAPSGEGAERCMKQALATVNGEVEYINVHGTSTPVGDVKELGAIKNVFGDKS
PAISSTKSMTGHSLGAAGAHEAIYSLLMLENGFIAPSINIETLDEQAEGLNIVTERQDKALTTVMSNSFGFGGTNACLVF
QKYNGQ

Sequences:

>Translated_406_residues
MKRVVITGLGVISSIGNNKEEVLASLKEGKSGIEFVPEFAEVGMRSQVAGTIKLNPAELIDRKVYRFMGDAAAYAYLSMK
EAIEDSGLTEDQVSNDRTGLVIGAGTGSAHSQLVACDAVRGPRGVKAVGPYAVTKTMASSVSACLATPYKIRGVNYSISS
ACATSAHCIGHAMELIQLGKQDVVFAGGAEELSWECATEFDAMGAVSTKYNDNPTKASRAYDANRDGFVIAGGGAVVVVE
ELEHALARGAKIYAEIVGYGATSDGYDMVAPSGEGAERCMKQALATVNGEVEYINVHGTSTPVGDVKELGAIKNVFGDKS
PAISSTKSMTGHSLGAAGAHEAIYSLLMLENGFIAPSINIETLDEQAEGLNIVTERQDKALTTVMSNSFGFGGTNACLVF
QKYNGQ
>Mature_406_residues
MKRVVITGLGVISSIGNNKEEVLASLKEGKSGIEFVPEFAEVGMRSQVAGTIKLNPAELIDRKVYRFMGDAAAYAYLSMK
EAIEDSGLTEDQVSNDRTGLVIGAGTGSAHSQLVACDAVRGPRGVKAVGPYAVTKTMASSVSACLATPYKIRGVNYSISS
ACATSAHCIGHAMELIQLGKQDVVFAGGAEELSWECATEFDAMGAVSTKYNDNPTKASRAYDANRDGFVIAGGGAVVVVE
ELEHALARGAKIYAEIVGYGATSDGYDMVAPSGEGAERCMKQALATVNGEVEYINVHGTSTPVGDVKELGAIKNVFGDKS
PAISSTKSMTGHSLGAAGAHEAIYSLLMLENGFIAPSINIETLDEQAEGLNIVTERQDKALTTVMSNSFGFGGTNACLVF
QKYNGQ

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=417, Percent_Identity=35.2517985611511, Blast_Score=210, Evalue=1e-54,
Organism=Homo sapiens, GI41872631, Length=336, Percent_Identity=28.5714285714286, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI223972627, Length=137, Percent_Identity=44.5255474452555, Blast_Score=97, Evalue=3e-20,
Organism=Escherichia coli, GI1788663, Length=403, Percent_Identity=74.1935483870968, Blast_Score=609, Evalue=1e-176,
Organism=Escherichia coli, GI1787337, Length=414, Percent_Identity=40.8212560386473, Blast_Score=266, Evalue=1e-72,
Organism=Caenorhabditis elegans, GI71983541, Length=423, Percent_Identity=34.2789598108747, Blast_Score=192, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI71983535, Length=266, Percent_Identity=39.4736842105263, Blast_Score=160, Evalue=8e-40,
Organism=Caenorhabditis elegans, GI212642053, Length=371, Percent_Identity=26.4150943396226, Blast_Score=105, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17550940, Length=367, Percent_Identity=26.7029972752044, Blast_Score=92, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6320904, Length=449, Percent_Identity=30.9576837416481, Blast_Score=182, Evalue=1e-46,
Organism=Drosophila melanogaster, GI24644341, Length=421, Percent_Identity=38.2422802850356, Blast_Score=249, Evalue=3e-66,
Organism=Drosophila melanogaster, GI19920632, Length=336, Percent_Identity=26.4880952380952, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI221330659, Length=336, Percent_Identity=26.4880952380952, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI24581345, Length=425, Percent_Identity=24.4705882352941, Blast_Score=95, Evalue=8e-20,

Paralogues:

None

Copy number: 24024 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 30,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.41 [H]

Molecular weight: Translated: 42470; Mature: 42470

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRVVITGLGVISSIGNNKEEVLASLKEGKSGIEFVPEFAEVGMRSQVAGTIKLNPAELI
CCEEEEECCHHHHHCCCCHHHHHHHHHCCCCCHHCCCHHHHCCCHHHCCEEEEECHHHHH
DRKVYRFMGDAAAYAYLSMKEAIEDSGLTEDQVSNDRTGLVIGAGTGSAHSQLVACDAVR
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCEEEEECCCCCCCCEEEEEECCC
GPRGVKAVGPYAVTKTMASSVSACLATPYKIRGVNYSISSACATSAHCIGHAMELIQLGK
CCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCEEHHHHHHHHHHHHHHHHHHHHCCC
QDVVFAGGAEELSWECATEFDAMGAVSTKYNDNPTKASRAYDANRDGFVIAGGGAVVVVE
CCEEEECCCHHCCHHHHHHHHHCCCEECCCCCCCCHHHHCCCCCCCCEEEECCCEEEEHH
ELEHALARGAKIYAEIVGYGATSDGYDMVAPSGEGAERCMKQALATVNGEVEYINVHGTS
HHHHHHHCCHHEEEHHHCCCCCCCCCEEECCCCCHHHHHHHHHHHHCCCCEEEEEEECCC
TPVGDVKELGAIKNVFGDKSPAISSTKSMTGHSLGAAGAHEAIYSLLMLENGFIAPSINI
CCCCHHHHHHHHHHHHCCCCCCCCCHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCC
ETLDEQAEGLNIVTERQDKALTTVMSNSFGFGGTNACLVFQKYNGQ
EECCHHHCCCEEEECCCHHHHHHHHHCCCCCCCCCEEEEEEECCCC
>Mature Secondary Structure
MKRVVITGLGVISSIGNNKEEVLASLKEGKSGIEFVPEFAEVGMRSQVAGTIKLNPAELI
CCEEEEECCHHHHHCCCCHHHHHHHHHCCCCCHHCCCHHHHCCCHHHCCEEEEECHHHHH
DRKVYRFMGDAAAYAYLSMKEAIEDSGLTEDQVSNDRTGLVIGAGTGSAHSQLVACDAVR
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCEEEEECCCCCCCCEEEEEECCC
GPRGVKAVGPYAVTKTMASSVSACLATPYKIRGVNYSISSACATSAHCIGHAMELIQLGK
CCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCEEHHHHHHHHHHHHHHHHHHHHCCC
QDVVFAGGAEELSWECATEFDAMGAVSTKYNDNPTKASRAYDANRDGFVIAGGGAVVVVE
CCEEEECCCHHCCHHHHHHHHHCCCEECCCCCCCCHHHHCCCCCCCCEEEECCCEEEEHH
ELEHALARGAKIYAEIVGYGATSDGYDMVAPSGEGAERCMKQALATVNGEVEYINVHGTS
HHHHHHHCCHHEEEHHHCCCCCCCCCEEECCCCCHHHHHHHHHHHHCCCCEEEEEEECCC
TPVGDVKELGAIKNVFGDKSPAISSTKSMTGHSLGAAGAHEAIYSLLMLENGFIAPSINI
CCCCHHHHHHHHHHHHCCCCCCCCCHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCC
ETLDEQAEGLNIVTERQDKALTTVMSNSFGFGGTNACLVFQKYNGQ
EECCHHHCCCEEEECCCHHHHHHHHHCCCCCCCCCEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]