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The map label for this gene is groEL [H]

Identifier: 126208486

GI number: 126208486

Start: 1178033

End: 1179676

Strand: Reverse

Name: groEL [H]

Synonym: APL_1012

Alternate gene names: 126208486

Gene position: 1179676-1178033 (Counterclockwise)

Preceding gene: 126208487

Following gene: 126208484

Centisome position: 51.87

GC content: 44.28

Gene sequence:

>1644_bases
ATGGCAGCAAAAGACGTTAAATTCGGTAATGACGCACGTGTAAAAATGTTAAAAGGCGTGAATGTTTTAGCGGATGCGGT
AAAAGTAACTTTAGGCCCGAAAGGTCGTAATGTCGTATTAGATAAAGCATACGGCGCACCAACCATCACTAAAGACGGCG
TGTCGGTTGCACGTGAAATCGAATTGGAAGATAAATTCGAGAATATGGGCGCACAAATGGTAAAAGAAGTGGCGTCAAAA
GCGAACGATGCGGCCGGTGACGGTACGACAACCGCAACTGTTCTTGCTCAAGCAATCGTAAACGAAGGCTTAAAAGCAGT
AGCGGCAGGTATGAATCCGATGGACTTAAAACGCGGTATCGATAAAGCGGTTGTTGCTGTAGTGGAAGAATTAAAAGCGA
TTTCTAAGCCGTGCGAAACTTCAAAAGAAATTGAGCAAGTAGGTACGATTTCAGCAAACTCTGATGAAACCGTAGGTAAA
CTAATTGCGCAAGCAATGGAAAAAGTCGGTAAAGAAGGCGTTATCACCGTTGAAGACGGTACAGGTTTAGATGATGCGTT
AGATGTGGTAGAAGGTATGCAATTTGACCGTGGTTACCTTTCTCCATACTTCATCAACAAACCGGAAGCCGGTACGGTTG
AATTAGAAAATCCATACATTATTTTAGTCGATAAAAAAATCAGCAACATTCGTGAAATCTTACCGGTATTAGAAGCGGTA
GCGAAAGCGGGTAAACCGTTATTAATCGTAGCGGAAGATATCGAAGGCGAAGCGTTAGCAACATTAGTGGTAAATACTAT
GCGAGGTATCGTGAAAGTGGCTGCGGTAAAAGCACCGGGCTTTGGCGATCGTCGTAAAGCAATGTTACAAGATATTGCAA
TTTTAACCGCAGGTACTGTGATTTCGGAAGAAATCGGTATGGAACTTGAGAAAGCGACTCTCGAAGAATTAGGTCAAGCA
AAACGTGTTGTGATCACAAAAGATAACACAACCATTATTGACGGTATCGGTGACGAAGCGCAAATCAAAGCACGAGTAGC
GCAAATTCGCCAACAAATTGAAGATTCGACATCAGATTACGATAAAGAAAAACTTCAAGAGCGTGTTGCAAAATTAGCCT
GTGGTGTTGCGGTAATCAAAGTAGGTGCGGCAACCGAAGTGGCGATGAAAGAGAAAAAAGATCGTGTTGATGATGCGTTA
CACGCAACTCGTGCGGCAGTTGAAGAAGGTATTGTACCGGGAGGCGGTGTTGCGTTAGTGCGTGCGGCTTCTAAAGTTGC
GGCTACTTTAACAGGTGATAACGAAGAGCAAAATGTCGGTATCAAACTTGCGCTTCGTGCGATGGAAGCACCGCTTCGCC
AAATCGTGACTAACGCAGGCGAAGAAGCGTCCGTTGTGGCTCGTAATGTGAAAGACGGTAACGGTAACTACGGTTATAAT
GCCGGTACGGAACAATACGGCGATATGCTTGAGATGGGTATCTTAGATCCGACAAAAGTAACTCGTTCGGCATTACAATT
CGCAGCATCAATTGCAGGTTTAATGATCACGACAGAATGTATGATCACAGATTTACCGAAAGAGGAAAAATTAGATCCGG
CTGCAGCAATGGGCGGCATGGGTGGTATGGGCGGAATGATATAA

Upstream 100 bases:

>100_bases
TCTTTCTGAAAACGATATTTTAGCTATCGTAGAGTAGTGATAAGCGGTCAGTTTTCACTAATTTTTTGCAAATTGAATAA
ATAATTTATAGGAAGAAAAA

Downstream 100 bases:

>100_bases
TTCATCCTCCATTAGTTTGTTCATTAAGACCTCCGAGAAATTTCTCGGAGGTTTTTTTATATTATATCTACATCACATAT
TAGGCAAAATATGAAAAAAA

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein; Protein Cpn60 [H]

Number of amino acids: Translated: 547; Mature: 546

Protein sequence:

>547_residues
MAAKDVKFGNDARVKMLKGVNVLADAVKVTLGPKGRNVVLDKAYGAPTITKDGVSVAREIELEDKFENMGAQMVKEVASK
ANDAAGDGTTTATVLAQAIVNEGLKAVAAGMNPMDLKRGIDKAVVAVVEELKAISKPCETSKEIEQVGTISANSDETVGK
LIAQAMEKVGKEGVITVEDGTGLDDALDVVEGMQFDRGYLSPYFINKPEAGTVELENPYIILVDKKISNIREILPVLEAV
AKAGKPLLIVAEDIEGEALATLVVNTMRGIVKVAAVKAPGFGDRRKAMLQDIAILTAGTVISEEIGMELEKATLEELGQA
KRVVITKDNTTIIDGIGDEAQIKARVAQIRQQIEDSTSDYDKEKLQERVAKLACGVAVIKVGAATEVAMKEKKDRVDDAL
HATRAAVEEGIVPGGGVALVRAASKVAATLTGDNEEQNVGIKLALRAMEAPLRQIVTNAGEEASVVARNVKDGNGNYGYN
AGTEQYGDMLEMGILDPTKVTRSALQFAASIAGLMITTECMITDLPKEEKLDPAAAMGGMGGMGGMI

Sequences:

>Translated_547_residues
MAAKDVKFGNDARVKMLKGVNVLADAVKVTLGPKGRNVVLDKAYGAPTITKDGVSVAREIELEDKFENMGAQMVKEVASK
ANDAAGDGTTTATVLAQAIVNEGLKAVAAGMNPMDLKRGIDKAVVAVVEELKAISKPCETSKEIEQVGTISANSDETVGK
LIAQAMEKVGKEGVITVEDGTGLDDALDVVEGMQFDRGYLSPYFINKPEAGTVELENPYIILVDKKISNIREILPVLEAV
AKAGKPLLIVAEDIEGEALATLVVNTMRGIVKVAAVKAPGFGDRRKAMLQDIAILTAGTVISEEIGMELEKATLEELGQA
KRVVITKDNTTIIDGIGDEAQIKARVAQIRQQIEDSTSDYDKEKLQERVAKLACGVAVIKVGAATEVAMKEKKDRVDDAL
HATRAAVEEGIVPGGGVALVRAASKVAATLTGDNEEQNVGIKLALRAMEAPLRQIVTNAGEEASVVARNVKDGNGNYGYN
AGTEQYGDMLEMGILDPTKVTRSALQFAASIAGLMITTECMITDLPKEEKLDPAAAMGGMGGMGGMI
>Mature_546_residues
AAKDVKFGNDARVKMLKGVNVLADAVKVTLGPKGRNVVLDKAYGAPTITKDGVSVAREIELEDKFENMGAQMVKEVASKA
NDAAGDGTTTATVLAQAIVNEGLKAVAAGMNPMDLKRGIDKAVVAVVEELKAISKPCETSKEIEQVGTISANSDETVGKL
IAQAMEKVGKEGVITVEDGTGLDDALDVVEGMQFDRGYLSPYFINKPEAGTVELENPYIILVDKKISNIREILPVLEAVA
KAGKPLLIVAEDIEGEALATLVVNTMRGIVKVAAVKAPGFGDRRKAMLQDIAILTAGTVISEEIGMELEKATLEELGQAK
RVVITKDNTTIIDGIGDEAQIKARVAQIRQQIEDSTSDYDKEKLQERVAKLACGVAVIKVGAATEVAMKEKKDRVDDALH
ATRAAVEEGIVPGGGVALVRAASKVAATLTGDNEEQNVGIKLALRAMEAPLRQIVTNAGEEASVVARNVKDGNGNYGYNA
GTEQYGDMLEMGILDPTKVTRSALQFAASIAGLMITTECMITDLPKEEKLDPAAAMGGMGGMGGMI

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=532, Percent_Identity=51.5037593984962, Blast_Score=541, Evalue=1e-154,
Organism=Homo sapiens, GI31542947, Length=532, Percent_Identity=51.5037593984962, Blast_Score=541, Evalue=1e-154,
Organism=Homo sapiens, GI5453607, Length=555, Percent_Identity=22.8828828828829, Blast_Score=77, Evalue=5e-14,
Organism=Escherichia coli, GI1790586, Length=532, Percent_Identity=86.2781954887218, Blast_Score=911, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=529, Percent_Identity=52.1739130434783, Blast_Score=547, Evalue=1e-156,
Organism=Caenorhabditis elegans, GI193210679, Length=211, Percent_Identity=51.6587677725119, Blast_Score=214, Evalue=7e-56,
Organism=Saccharomyces cerevisiae, GI6323288, Length=527, Percent_Identity=55.0284629981025, Blast_Score=561, Evalue=1e-160,
Organism=Saccharomyces cerevisiae, GI6322524, Length=162, Percent_Identity=29.0123456790123, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24641193, Length=528, Percent_Identity=52.4621212121212, Blast_Score=558, Evalue=1e-159,
Organism=Drosophila melanogaster, GI24641191, Length=528, Percent_Identity=52.4621212121212, Blast_Score=558, Evalue=1e-159,
Organism=Drosophila melanogaster, GI45550936, Length=528, Percent_Identity=50.9469696969697, Blast_Score=539, Evalue=1e-153,
Organism=Drosophila melanogaster, GI45550132, Length=528, Percent_Identity=50.9469696969697, Blast_Score=539, Evalue=1e-153,
Organism=Drosophila melanogaster, GI45550935, Length=528, Percent_Identity=50.9469696969697, Blast_Score=539, Evalue=1e-153,
Organism=Drosophila melanogaster, GI17864606, Length=541, Percent_Identity=43.4380776340111, Blast_Score=456, Evalue=1e-128,
Organism=Drosophila melanogaster, GI24584129, Length=531, Percent_Identity=36.7231638418079, Blast_Score=344, Evalue=8e-95,
Organism=Drosophila melanogaster, GI19921262, Length=531, Percent_Identity=36.7231638418079, Blast_Score=344, Evalue=8e-95,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 57647; Mature: 57516

Theoretical pI: Translated: 4.61; Mature: 4.61

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAKDVKFGNDARVKMLKGVNVLADAVKVTLGPKGRNVVLDKAYGAPTITKDGVSVAREI
CCCCCCCCCCCHHHHHHHHHHHHHHHHHEEECCCCCEEEEECCCCCCCCCCCCHHHHHHH
ELEDKFENMGAQMVKEVASKANDAAGDGTTTATVLAQAIVNEGLKAVAAGMNPMDLKRGI
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
DKAVVAVVEELKAISKPCETSKEIEQVGTISANSDETVGKLIAQAMEKVGKEGVITVEDG
HHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECC
TGLDDALDVVEGMQFDRGYLSPYFINKPEAGTVELENPYIILVDKKISNIREILPVLEAV
CCCHHHHHHHHCCCCCCCCCCCEEECCCCCCEEEECCCEEEEECCHHHHHHHHHHHHHHH
AKAGKPLLIVAEDIEGEALATLVVNTMRGIVKVAAVKAPGFGDRRKAMLQDIAILTAGTV
HHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
ISEEIGMELEKATLEELGQAKRVVITKDNTTIIDGIGDEAQIKARVAQIRQQIEDSTSDY
HHHHHCCHHHHHHHHHHCCCCEEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHCCCCCC
DKEKLQERVAKLACGVAVIKVGAATEVAMKEKKDRVDDALHATRAAVEEGIVPGGGVALV
CHHHHHHHHHHHHHHHHHEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
RAASKVAATLTGDNEEQNVGIKLALRAMEAPLRQIVTNAGEEASVVARNVKDGNGNYGYN
HHHHHHEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCC
AGTEQYGDMLEMGILDPTKVTRSALQFAASIAGLMITTECMITDLPKEEKLDPAAAMGGM
CCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCHHHHHCCC
GGMGGMI
CCCCCCC
>Mature Secondary Structure 
AAKDVKFGNDARVKMLKGVNVLADAVKVTLGPKGRNVVLDKAYGAPTITKDGVSVAREI
CCCCCCCCCCHHHHHHHHHHHHHHHHHEEECCCCCEEEEECCCCCCCCCCCCHHHHHHH
ELEDKFENMGAQMVKEVASKANDAAGDGTTTATVLAQAIVNEGLKAVAAGMNPMDLKRGI
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
DKAVVAVVEELKAISKPCETSKEIEQVGTISANSDETVGKLIAQAMEKVGKEGVITVEDG
HHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECC
TGLDDALDVVEGMQFDRGYLSPYFINKPEAGTVELENPYIILVDKKISNIREILPVLEAV
CCCHHHHHHHHCCCCCCCCCCCEEECCCCCCEEEECCCEEEEECCHHHHHHHHHHHHHHH
AKAGKPLLIVAEDIEGEALATLVVNTMRGIVKVAAVKAPGFGDRRKAMLQDIAILTAGTV
HHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
ISEEIGMELEKATLEELGQAKRVVITKDNTTIIDGIGDEAQIKARVAQIRQQIEDSTSDY
HHHHHCCHHHHHHHHHHCCCCEEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHCCCCCC
DKEKLQERVAKLACGVAVIKVGAATEVAMKEKKDRVDDALHATRAAVEEGIVPGGGVALV
CHHHHHHHHHHHHHHHHHEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
RAASKVAATLTGDNEEQNVGIKLALRAMEAPLRQIVTNAGEEASVVARNVKDGNGNYGYN
HHHHHHEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCC
AGTEQYGDMLEMGILDPTKVTRSALQFAASIAGLMITTECMITDLPKEEKLDPAAAMGGM
CCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCHHHHHCCC
GGMGGMI
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA